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T18883 |
2-Di-1-ASP
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|
Others
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|
2-Di-1-ASP is a mono-stryryl dye and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. It has selective for G-quadruplex (G4) and double-stranded DNA. |
|
T4470 |
Pyridostatin TFA
|
|
DNA/RNA Synthesis
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|
Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2. |
|
T60028 |
MM41
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|
DNA/RNA Synthesis
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|
MM41 is a human telomeric and gene promoter DNA quadruplex stabilizer with an IC50 of <10 nM against the MIA PaCa-2 pancreatic cancer cell line. |
|
T7409 |
360A
|
|
DNA/RNA Synthesis
,
Telomerase
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|
360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM). |
|
T13174 |
TMPyP4 tosylate
|
TMP 1363 |
DNA/RNA Synthesis
,
Telomerase
|
|
TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines. |
|
T74613 |
G-quadruplex DNA fluorescence probe 1
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|
|
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Compound E1, also known as G-quadruplex DNA fluorescence probe 1, is a selective fluorescent probe targeting G-quadruplex DNA. It possesses the ability to penetrate membranes and enter living cells, demonstrating low cyt... |
|
T1899 |
Pyridostatin
|
RR82,Pyridostatin Trifluoroacetate Salt |
DNA/RNA Synthesis
|
|
Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres. |
|
T13584 |
BMVC-8C3O
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|
DNA/RNA Synthesis
|
|
BMVC-8C3O, a DNA G-quadruplex (G4) ligand, induces the topological conversion from non-parallel to parallel forms in human telomeric DNA G4s. |
|
T10352 |
APTO-253
|
LOR-253,LT-253 |
Apoptosis
,
c-Myc
,
KLF
|
|
APTO-253 (LOR-253) inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates anticancer activity through the induction of the K... |
|
T16703 |
Quarfloxin
|
CX-3543 |
DNA/RNA Synthesis
|
|
Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-... |
|
T10574 |
BMVC
|
|
Telomerase
|
|
BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities. BMVC inhibits Taq DNA polymerase (IC50: ~2.5 μM). |
|
T30745 |
Carboxy-pyridostatin
|
|
|
|
Carboxy-pyridostatin, as a fluorescent probe, can target G-quadruplex structures and trap cytoplasmic RNA G-quadruplex structures in cells. |
|
T19212 |
BMVC2
|
o-BMVC |
Others
|
|
BMVC2 (o-BMVC), a carbazole derivative of BMVC, is a G-quadruplex (G4) stabilizer. |
|
T26892 |
Braco-19
|
|
|
|
Braco-19 is a G-quadruplex ligand, it inhibits the growth of tumor. |
|
T32014 |
GTC365
|
GTC 365,NSC 177365,GTC-365,NSC-177365,NSC177365 |
|
|
GTC365 is an hTERT transcriptional repressor that acts in the early stages of the G-quadruplex folding pathway. |
|
T28942 |
Telomestatin
|
SOT 095,GM95,(R)-Telomestatin,GM 95,GM-95 |
|
|
Telomestatin is an inhibitor of the telomerase, it induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region. |
|
T13504 |
360A iodide
|
360 A iodide |
Telomerase
|
|
360A iodide is a selective stabilizer of G-quadruplex and inhibits telomerase activity (IC50: 300 nM in TRAP-G4 assay). |
|
T13817 |
Phen-DC3
|
|
Others
|
|
Phen-DC3 is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases (IC50s of 65±6 and 50±10 nM, respectively). |
|
T33894 |
PBP2
|
PBP-2,PBP 2 |
|
|
PBP2 is a selective inducer of G-quadruplex structures from the unstructured single-stranded DNA conformations. PBP2 downregulates BCL-2 gene expression in cancer cells. |
|
T26872 |
BMVC4
|
BMVC 4,BMVC-4 |
|
|
BMVC4 is a G-quadruplex stabilizer. BMVC4 induces senescence by activation of pathways of response to DNA damage that was independent of its telomerase inhibitory activity. |
|
T25255 |
CL67
|
CL-67,CL 67 |
|
|
CL67 is a hypoxia-inducible factor pathway inhibitor. It acts by binding to a G-quadruplex higher-order structure in the HIF promoter sequence in vitro. |
|
T13817L |
Phen-DC3 Trifluoromethanesulfonate
|
Phen-DC3 Triflate |
Others
|
|
|
|
T74961 |
Anticancer agent 84
|
|
|
|
Anticancer Agent 84, a cancer research compound, inhibits c-MYC transcription by stabilizing the G-quadruplex (G4) structure, offering potential for cancer investigation [1]. |
|
T72571 |
Antitumor agent-84
|
|
|
|
Antitumor Agent-84, a G-quadruplex (G4)-ligand, stabilizes various G4-DNA structures, demonstrating highly effective antitumor properties. |
|
T72572 |
Antitumor agent-85
|
|
|
|
Antitumor agent-85, a G-quadruplex (G4)-ligand, stabilizes various G4-DNA structures and possesses potent anti-tumor properties. |
|
T37218 |
N-methyl Mesoporphyrin IX
|
|
|
|
N-methyl Mesoporphyrin IX is a widely used G-quadruplex DNA-specific fluorescent binder that effectively monitors Aβ fibrillation. N-methyl Mesoporphyrin IX is sensitive to G-quadruplex DNA and unreactive to duplex, trip... |
|
T73264 |
L2H2-6OTD
|
|
|
|
L2H2-6OTD, a telomeric inhibitor analogue characterized by containing one to four G-quadruplex binding loops, exhibits telomerase inhibitory activity with an IC 50 value of 15 nM. |
|
T63765 |
L5-DA
|
|
|
|
L5-DA is a G-quadruplex (G4) ligand that selectively stabilizes G4s. L5-DA exhibits significant cytotoxicity to HeLa cells with an IC50 value of 4.3 μM. L5-DA stabilizes G4s in HeLa cells and can block the cell cycle and... |
|
T74460 |
C-Myc inhibitor 5
|
|
|
|
c-Myc Inhibitor 5 (DA3) is a fluorescent bispurine compound with a long-chain bridge that selectively binds to the c-MYC G-quadruplex, exhibiting a dissociation constant (K D) of 16 μM. Unlike other G4-driven oncogenes, ... |
|
T74539 |
DIZ-3
|
|
|
|
DIZ-3, a selective multimeric G-quadruplex (G4) ligand, employs a G4-ligand-dimerizing approach to intercalate into the G4-G4 interface, thereby stabilizing its higher-order structure. This compound effectively induces c... |
|
T72201 |
Pyridostatin hydrochloride
|
RR82 hydrochloride |
|
|
Pyridostatin (RR82) hydrochloride, a G-quadruplex DNA stabilizing agent (Kd = 490 nM), induces replication- and transcription-dependent DNA damage, promoting growth arrest in human cancer cells. It specifically targets t... |
