|
T0676 |
Hydroxyurea
|
Hydroxycarbamide,nsc32065,nci-c04831 |
Apoptosis
,
HIV Protease
,
DNA/RNA Synthesis
,
Autophagy
|
|
Hydroxyurea (Hydroxycarbamide), an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. |
|
T10208 |
A-69412
|
N-1-(Fur-3-ylethyl)-N-hydroxyurea |
Lipoxygenase
|
|
A-69412 (N-1-(Fur-3-ylethyl)-N-hydroxyurea) is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase. It has the potential to treat ulcerative colitis and asthma, and possibly other inflammatory and allergic... |
|
T6612 |
NU6027
|
|
ATM/ATR
,
DNA-PK
,
CDK
|
|
NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors. |
|
T0477 |
Zileuton
|
Abbott 64077,A 64077 |
Ferroptosis
,
Lipoxygenase
,
COX
|
|
Zileuton (A 64077) is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; ca... |
|
T4570 |
Pipobroman
|
Vercyte,A-8103,Amedel |
Others
,
DNA Alkylator/Crosslinker
|
|
Pipobroman (Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV) and essential thrombocythemia (ET). Pipobroman allows, wit... |
|
T68398 |
MI-223
|
|
|
|
MI-223 is an inhibitor of Mcl-1-stimulated homologous recombination (HR) DNA repair, which leads to sensitization of cancer cells to hydroxyurea- or olaparib-induced DNA replication stress. |
