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T63919 |
IKKβ-IN-1
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IKKβ-IN-1 is a potent, orally active inhibitor of IkappaB (IKK-β) (IC50: 0.20 μM). IKKβ-IN-1 reduces the inhibition of PGE2 and TNF-α production in murine macrophages. IKKβ-IN-1 protects mice from infection shock-induced... |
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T6150 |
TAK-715
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p38 MAPK
,
Casein Kinase
,
JNK
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TAK-715 is a p38 MAPK inhibitor for p38α. |
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TQ0306 |
MLN120B
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IκB/IKK
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MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM). |
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T5209 |
INH14
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IκB/IKK
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INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ). |
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T8910 |
2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC
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IκB/IKK
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2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ. |
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T6141 |
IMD-0354
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IKK2 Inhibitor V,IMD 0354 |
IκB/IKK
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IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway. |
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T125120 |
Cyclo(L-Pro-L-Val)
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IκB/IKK
,
NOS
,
NF-κB
,
COX
,
Antibacterial
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Cyclo(L-Pro-L-Val), a 2,5-diketopiperazine extracted from the fruits of Mycobacterium chiliolyticum AZ2 and Mycobacterium leprae, possesses anti-inflammatory activity and virulence activity against phytopathogenic microo... |
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T14567 |
BI605906
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IκB/IKK
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BI605906 is an inhibitor of IKKβ. When assayed at 0.1 mM ATP, the IC50 value is 380 nM. |
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T14669 |
BMS-066
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IκB/IKK
,
Tyrosine Kinases
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T10237 |
ACHP Hydrochloride
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IKK-2 Inhibitor VIII |
IκB/IKK
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T23137 |
PF 184
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Others
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IKKβ inhibitor |
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T10472L |
Bay 65-1942 free base
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IκB/IKK
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T14508 |
Bay 65-1942 hydrochloride
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IκB/IKK
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Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ. |
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T10472 |
Bay 65-1942 (R form)
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Bay 65-1942 R form |
Others
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Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor. |
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T61059 |
IKK-IN-4
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IKK-IN-4 is a potent and selective inhibitor of IkappaB kinase 2 with IC 50 values of 45 and 650 nM against IKKβ and IKKα, respectively [1]. |
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T71747 |
IKKß-IN-124
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IKKß-IN-124 is an allosteric inhibitor of IκBα phosphorylation and NF-κB transcriptional activity through selective capture of the inactive conformation and hence blockade of IKKβ S177/S181 phosphorylation. |
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T37449 |
SR 12460
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SR 12460 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1It inhibits T... |
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T40700 |
IKK-IN-3
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IKK-IN-3 is a highly potent and selective inhibitor of IkappaB kinase 2 (IKK2 or IKKβ). It exhibits impressive inhibitory activity against IKK2 (IC50 = 19 nM), while also demonstrating significant efficacy against IKK1 (... |
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T39199 |
ML 120B dihydrochloride
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ML120B dihydrochloride |
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MLN120B dihydrochloride (ML120B dihydrochloride) is a highly potent, orally active inhibitor of IKKβ. It competitively binds to ATP and exhibits an impressive IC50 value of 60 nM. This compound effectively suppresses the... |
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T78371 |
Ac2-26 ammonium
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Ac2-26 ammonium, an N-terminal peptide of annexin 1, exhibits anti-inflammatory properties, reduces IKKβ protein levels in lysosomes via chaperone-mediated autophagy (CMA), improves lung ischemia-reperfusion injury outco... |
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T76024 |
IKKγ NBD Inhibitory Peptide TFA
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IKKγ NBD Inhibitory Peptide TFA is a specific NF-κB inhibitor that functions by hindering the interaction between the IKKγ/NEMO-binding domain (NBD) and IKKα and IKKβ. This action effectively prevents TNF-α-induced NF-kB... |
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T38158 |
StA-IFN-1
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StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 μM in a GFP reporter assay for IFN induction similar to TPCA-1 , which specifically inhibits the IKKβ component of the IFN ind... |
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T83670 |
F1 TFA
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Tat-IKIP (46-60),Tat-Inhibitor of NF-κB Kinase-interacting Peptide |
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F1, an anti-inflammatory peptide, incorporates the HIV-1 Tat protein transduction domain linked with a 15-amino acid sequence from residues 46-60 of the inhibitor of NF-κB kinase-interacting peptide (IKIP). It effectivel... |
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T36408 |
Rhein-13C4
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Rhein-13C4 |
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Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerei... |
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T36192 |
CAY10682
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(±)-Nutlin-3 blocks the interaction of p53 with its negative regulator Mdm2 (IC50 = 90 nM), inducing the expression of p53-regulated genes and blocking the growth of tumor xenografts in vivo. CAY10682 is a pyrrolo[3,4c]p... |
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T11573 |
HPN-01
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Others
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HPN-01 is a selective IKK inhibitor (pIC50s: 6.4, 7.0, and <4.8 for IKK-α, IKK-β, and IKK-ε). HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, ErbB2, EGFR, GS... |
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T15243 |
Ertiprotafib
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PTP 112 |
Phosphatase
,
PPAR
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Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ). |
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T36779 |
NG 25 (hydrochloride hydrate)
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NG 25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1 (IC50s = 21.7 and 149 nM, respectively).1It also inhibits the Src family kinases Src and LYN (IC50s = 113 and 12.9 nM, respectively) and Abl family kinase... |
