|
T3015 |
Olaparib
|
AZD2281,KU0059436 |
Mitophagy
,
PARP
,
Autophagy
|
|
Olaparib (KU0059436) is a small molecule inhibitor of PARP1/PARP2 (IC50=5/1 nM), with weak inhibitory activity against PARP tankyrase-1 (IC50=1.5 μM), and is selective and orally active. Olaparib exhibits autophagy and m... |
|
T4471 |
E7449
|
Stenoparib,UNII-9X5A2QIA7C |
Others
,
PARP
|
|
E7449 (UNII-9X5A2QIA7C) is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ～50 and ～50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate. |
|
T22988 |
MK-4827 Racemate
|
Niraparib Racemate,2-(4-piperidin-3-ylphenyl)indazole-7-carboxamide |
PARP
|
|
MK-4827 Racemate (Niraparib Racemate) is a selective PARP1 and PARP2 inhibitor with IC50s of 3.8 nM and 2.1 nM, respectively, over 330-fold selectivity for PARP3, V-PARP and Tank1. |
|
T6892 |
Niraparib tosylate
|
MK-4827 (tosylate),MK 4827 tosylate,Niraparib (MK-4827) tosylate |
Apoptosis
,
PARP
|
|
Niraparib tosylate (MK-4827 (tosylate))(with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor. |
|
T6366 |
A-966492
|
|
PARP
|
|
A-96649 is a new-type and effective inhibitor. The Ki of A-966492 for PARP1 and PARP2 is 1 nM and 1.5 nM, respectively. |
|
T2105 |
Veliparib dihydrochloride
|
ABT-888 dihydrochloride |
PARP
,
Autophagy
|
|
Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. |
|
T6181 |
UPF 1069
|
|
PARP
|
|
UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1. |
|
T3231 |
Niraparib
|
MK-4827 |
Apoptosis
,
Others
,
PARP
|
|
Niraparib (MK-4827) is a PARP inhibitor that selectively inhibits PARP1 and PARP2 (IC50=3.8/2.1 nM). Niraparib has antitumor activity, inhibits DNA damage repair, and induces apoptosis. |
|
T9430 |
Venadaparib
|
NOV140101,IDX-1197 |
PARP
|
|
Venadaparib (NOV140101) (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib is insensitive to PARP-5. Venadaparib prevents the... |
|
T63228 |
Simmiparib
|
SMOCL-9112 |
Apoptosis
,
PARP
|
|
Simmiparib (SMOCL-9112) is a novel and potent PARP1 and PARP2 inhibitor, a derivative of Olaparib.Simmiparib induces DNA double-strand breaks (DSBs) and cell cycle arrest in homologous recombination repair (HR)-deficient... |
|
T5058 |
Pamiparib
|
BGB-290 |
PARP
|
|
Pamiparib (BGB-290) is an orally active, potent, highly selective PARP inhibitor(IC50 of 0.9 nM and 0.5 nM for PARP1 and PARP2, respectively). It has potent PARP trapping, and capability to penetrate the brain, and can b... |
|
T73007 |
PARP10-IN-2
|
|
PARP
|
|
PARP10-IN-2 is a potent inhibitor of PARP10, a mono-ADP-ribosyltransferase, with an IC50 value of 3.64 μM for human PARP10.PARP10-IN-2 also inhibited PARP2 and PARP15, with IC50 values of 27 μM and 11 μM, respectively. |
|
T67932 |
PARP10-IN-3
|
|
PARP
|
|
PARP10-IN-3 is a potent and selective mono-Adp-ribotransferase PARP10 inhibitor that inhibits human PARP10 (IC50:480 nM). PARP10-IN-3 also inhibited human PARP2 and human PARP15 with IC50 values of 1.7 μM. |
|
T2484 |
AZD-2461
|
|
PARP
|
|
AZD2461 is a novel PARP inhibitor. |
|
T6253 |
Talazoparib
|
LT-673,BMN-673 |
PARP
|
|
Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM). |
|
T2591 |
Veliparib
|
ABT-888,NSC 737664 |
PARP
,
Autophagy
|
|
Veliparib (ABT-888) (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy. |
|
T3353 |
Niraparib hydrochloride
|
MK-4827 hydrochloride,MK-4827 (hydrochloride) |
Apoptosis
,
Others
,
PARP
|
|
Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Niraparib hydrochloride inhibits PARP activity, enhancing the accumulation of... |
|
T7896 |
BYK204165
|
RT-017290 |
PARP
|
|
BYK204165 (RT-017290) is a potent PARP inhibitor (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay) |
|
T6768 |
AZ6102
|
|
PARP
,
Wnt/beta-catenin
|
|
AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells. |
|
T73027 |
PARP-2-IN-3
|
|
Apoptosis
,
PARP
|
|
PARP-2-IN-3 is used as a potent PARP-2 inhibitor (IC50=0.07 μM) with anti-tumor activity that induces apoptosis and necrosis in cancer cells, and can be used for the study of breast cancer.CAS 번호128-52-56-8 |
|
T41176 |
PARPYnD
|
|
|
|
PARPYnD is a potent photoaffinity probe for poly(ADP-ribose) polymerase (PARP) (IC50 values for PARP2, PARP1 and PARP6 are 6, 38 and 230 nM, respectively). PARPYnD labels PARP1 and PARP2 in the cell when an N3 functional... |
|
T73523 |
OUL245
|
|
|
|
OUL245, a 7-Hydroxy derivative, selectively inhibits PARP2 with an IC50 of 44 nM. Additionally, it exhibits inhibition against other PARP and TNKS enzymes, displaying IC50 values ranging from 2.9 to 8.8 μM. |
|
T4472 |
NMS-P118
|
|
PARP
|
|
NMS-P118 is a potent, selective and orally available Inhibitor of PARP-1 for cancer therapy. |
|
T60410 |
ART-IN-1
|
|
|
|
ART-IN-1 (compound 7) is a selective inhibitor of PARP with IC 50 s of 19, 22, 2.4, >100, 1.1 μM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively [1]. |
|
T9610 |
PARP1-IN-5 dihydrochloride
|
|
PARP
|
|
PARP1-IN-5 dihydrochloride is an orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer. |
|
T22749 |
DR2313
|
DR 2313 |
PARP
|
|
DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective. |
|
T36702 |
CAY10753
|
|
|
|
CAY10753 is an inhibitor of tankyrase 2 (TNKS2; IC50= 0.3 nM).1It is selective for TNKS2 over TNKS1 (IC50= 6.1 nM), as well as poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s = 89.6 and 37.8 nM, respectively). CAY... |
|
T72017 |
6(5H)-Phenanthridinone
|
|
|
|
6(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2. It decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells. 6(5H)-Phenanthridinone reduces NF-κ... |
|
T72437 |
PARP1/2/TNKS1/2-IN-1
|
|
Apoptosis
,
PARP
,
Wnt/beta-catenin
|
|
PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1 and TNKS2.PARP1/2/TNKS1/2-IN-1 has potential anti-tumor activity and induces apoptosis. |
|
T12365 |
PARP/PI3K-IN-1
|
|
PARP
,
PI3K
|
|
PARP/PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antiproliferative activities for the study of breast, pancreatic ... |
|
T78157 |
PARP-1-IN-3
|
|
Apoptosis
,
PARP
|
|
PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.PARP-1-IN-3 has potential anti-inflammatory activity, induces apoptosis, and arrests the cell... |
|
T12364 |
PARP-2-IN-1
|
|
Others
|
|
PARP-2-IN-1 is a potent and selective inhibitor of PARP-2(IC50 of 11.5 nM). |
|
T39147 |
Venadaparib hydrochloride
|
IDX-1197 hydrochloride |
|
|
Venadaparib hydrochloride (IDX-1197) is a potent and selective PARP inhibitor that exhibits significant anticancer properties. It is particularly effective in solid tumor research. |
|
T11992 |
Mefuparib hydrochloride
|
MPH |
PARP
|
|
Mefuparib hydrochloride induces apoptosis and possesses prominent anticancer activity in vitro and in vivo. Mefuparib hydrochloride (MPH) is an orally active, substrate-competitive and selective PARP1/2 inhibitor with IC... |
|
T79667 |
YCH1899
|
|
PARP
|
|
YCH1899, an orally active PARP inhibitor, demonstrates potent inhibition of PARP1/2 with an IC50 of less than 0.001 nM. It shows marked antiproliferative efficacy against Olaparib-resistant (Capan-1/OP) and Talazoparib-r... |
