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T16526 |
Phorbol 12,13-dibutyrate
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PDBu,Phorbol dibutyrate |
PKC
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Phorbol 12,13-dibutyrate is a PKC activator. It also is a potent skin tumor promoter. |
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T26386 |
4alpha-PDD
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4α-Phorbol 12,13-didecanoate |
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4alpha-PDD activates transient receptor potential vanilloid 4 (TRPV4) channels and is inactive for signaling through PKC. |
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T36696 |
DMBA
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7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzy... |
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T28975 |
Tigilanol tiglate
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EBC-46,EBC 46,EBC46 |
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Tigilanol tiglate is a phorbol ester and acts as a protein kinase C regulator along with other related compounds. |
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T68654 |
Sapintoxin D
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Sapintoxin D is a fluorescent phorbol ester and selective activator of protein kinase C. |
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T37278 |
2-chloro Stearic Acid
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2-chloro Stearic acid is a bioactive fatty acid that accumulates in primary human monocytes and neutrophils as well as murine neutrophils stimulated with phorbol 12-myristate 13-acetate . It induces DNA release from prim... |
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T37983 |
GM 1489
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GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. It reduces 5-aza-2'-deoxycytidine-induc... |
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T36412 |
Multiflorenol
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Multiflorenol is a triterpene that has been found in T. kirilowii seeds.1 It inhibits in vitro activation of Epstein-Barr virus early antigen (EBV-EA) induced by the tumor promoter phorbol 12-myristate 13-acetate in a co... |
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T36320 |
C6 L-threo Ceramide (d18:1/6:0)
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C6 L-threo Ceramide (d18:1/6:0) |
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C6 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 L-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlik... |
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T37321 |
RN-9893 (hydrochloride)
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RN-9893 is an antagonist of transient receptor potential vanilloid 4 (TRPV4; IC50s = 0.42 and 0.66 μM, respectively, for the human and rat receptors).1 It is selective for TRPV4 over TRPV1, TRPV3, and TRPM8 (IC50s = 10, ... |
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T69244 |
Betulonaldehyde
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Betulonaldehyde is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found in Betula. It is active against P. falciparum (IC50 = 3.36 µg/ml) and cytotoxic to NCI H1... |
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T35927 |
C2 L-threo Ceramide (d18:1/2:0)
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C2 L-threo Ceramide (d18:1/2:0) |
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C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration o... |
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T37565 |
C6 D-threo Ceramide (d18:1/6:0)
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C6 D-threo Ceramide (d18:1/6:0) |
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C6 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 D-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlik... |
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T37564 |
C4 Ceramide (d18:1/4:0)
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C4 Ceramide (d18:1/4:0),Cer(d18:1/4:0) |
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C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. [1] [2] [3] It inhibits IL-4 production by 16% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used... |
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T37439 |
C18 Globotriaosylceramide (d18:1/18:0)
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C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide . It inhibits aggregation of human neutrophils induced by phorbol 12-myristate 13-acetat... |
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T81451 |
PKCd (8-17)
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PKCd (8-17) is a bioactive peptide originating from the V1 domain of protein kinase C (PKC)d. It impedes phorbol 12-myristate 13-acetate (PMA)-stimulated PKCd translocation and activation, which mitigates ischemic injury... |
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T36235 |
5-Chlorouracil
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5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil . In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic.1 Uracil is chlorinated at the 5 position in a cell... |
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T83728 |
Tat-AKAP79 (326-336) TFA
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Tat-A-kinase Anchor Protein 79 (326-336) |
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Tat-AKAP79 (326-336) is a peptide that links the HIV-1 Tat protein transduction domain with an 11-amino acid sequence from A-kinase anchor protein 79 (AKAP79). This compound effectively inhibits the activation-induced se... |
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T36221 |
2-chloro Palmitic Acid
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2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic aci... |
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T83701 |
TRPV1-Tat TFA
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Transient Receptor Potential Vanilloid 1-Tat,736-745-Tat |
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TRPV1-Tat, a peptide antagonist targeting transient receptor potential vanilloid 1 (TRPV1), is composed of amino acids 736-745 derived from TRPV1's A-kinase anchor protein (AKAP)-binding domain, combined with the HIV Tat... |
