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T12747 |
ROCK2-IN-2
|
|
ROCK
|
|
|
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T79832 |
ROCK2-IN-6
|
|
ROCK
|
|
ROCK2-IN-6 (Comp A) is a selective inhibitor of ROCK2, applicable in the study and treatment of ROCK-mediated, autoimmune, and inflammatory diseases [1]. |
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T81261 |
ROCK2-IN-7
|
|
ROCK
|
|
ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis. It exhibits its efficacy in targeting ROCK2 enzymes within HaCaT cells and has demonstrated beneficial effects in a psoriasi... |
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T73117 |
ROCK2-IN-5
|
|
|
|
ROCK2-IN-5, a compound integrating structural elements from the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids, exhibits a favorable multitarget profile and tolerability. It shows potential ... |
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T78205 |
ROCK2-IN-6 hydrochloride
|
|
ROCK
|
|
ROCK2-IN-6 hydrochloride (Comp A) serves as a selective inhibitor of ROCK2, applicable for research into ROCK-mediated diseases, autoimmune disorders, and inflammation [1]. |
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T3518 |
GSK269962A
|
GSK269962B,GSK 269962,GSK269962A HCl |
ROCK
,
S6 Kinase
|
|
GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively. |
|
T6867 |
Belumosudil
|
KD025,Rezurock,ROCK inhibitor,SLx-2119 |
ROCK
|
|
Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM). |
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TQ0187 |
SR-3677
|
|
ROCK
,
Autophagy
|
|
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM). |
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T15798 |
LX7101
|
|
ROCK
,
LIM Kinase
,
PKA
|
|
LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM). |
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T12746 |
ROCK inhibitor-2
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ROCK
|
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ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively). |
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T4276L |
Hydroxyfasudil
|
Hydroxy-Fasudil,HA-1100 |
ROCK
,
PKA
|
|
Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively). |
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T13419 |
ROCK-IN-1
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|
ROCK
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ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurological disorders and inflammation-related diseases. |
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T22037 |
AS 1892802
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ROCK
|
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AS 1892802 is a potent and selective inhibitor of ROCK. AS 1892802 exibits IC50 values of 52nM, 57nM and 122 nM for human ROCK2, rat ROCK2 and human ROCK1, respectively. The onset of antinociceptive effect of AS 1892802 ... |
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T1898 |
RKI-1447
|
RKI1447 |
ROCK
|
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RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities. |
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TQ0319 |
Ripasudil
|
K-115,Ripasudil hydrochloride dihydrate |
ROCK
|
|
Ripasudil (Ripasudil hydrochloride dihydrate) (K-115) hydrochloride dihydrate is a specific ROCK inhibitor (IC50s: 51/19 nM for ROCK1/ROCK2). |
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T14960 |
Chroman 1
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ROCK
|
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Chroman 1 is an inhibitor of ROCK2 (IC50: 1 nM). |
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T69665 |
Zelasudil
|
|
|
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Zelasudil, a Rho-associated (ROCK) kinase inhibitor, demonstrates a binding affinity for ROCK2. |
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T7301 |
BDP5290
|
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ROCK
|
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BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.) |
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T12721 |
Rho-Kinase-IN-1
|
|
ROCK
|
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Rho-Kinase-IN-1 is an inhibitor of ROCK with Kis of 30.5 nM and 3.9 nM for ROCK1 and ROCK2, respectively. Rho-Kinase-IN-1 can be used in studies about excessive cell proliferation, remodeling, edema and inflammation dise... |
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T4276 |
Hydroxyfasudil Hydrochloride
|
Hydroxyfasudil (HA-1100) HCl,HA 1100 hydrochloride |
ROCK
|
|
Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM). |
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T23308 |
SAR407899 hydrochloride
|
|
ROCK
|
|
ATP-competitive ROCK inhibitor |
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T60924 |
Verosudil
|
AR-12286 |
ROCK
|
|
Verosudil (AR-12286) is a highly potent Rho kinase (ROCK) inhibitor with a Ki of 2 and 2 nM against ROCK1 and ROCK2, respectively. AR-12286 reverses steroid-induced intraocular pressure in mice by decreasing intraocular ... |
|
T1606 |
Fasudil
|
HA-1077,AT877 |
ROCK
,
Serine/threonin kinase
,
Calcium Channel
,
PKA
,
PKC
,
Autophagy
|
|
Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK. |
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T39555 |
Belumosudil mesylate
|
SLx-2119mesylate,KD025 mesylate |
|
|
Belumosudil mesylate (KD025 mesylate) is a compound that selectively inhibits ROCK2, demonstrating IC50 values of 105 nM for ROCK2 and 24 μM for ROCK1. It possesses anti-fibrotic properties. |
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T16855 |
SB-772077B dihydrochloride
|
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ROCK
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SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively). |
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T79077 |
ROCK-IN-6
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ROCK
|
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ROCK-IN-6, a selective ROCK2 inhibitor, exhibits potent inhibition with an IC50 of 2.19 nM and holds promise for research into glaucoma and retinal diseases [1]. |
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T70024 |
BA-1049
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|
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BA-1049 is a selective ROCK2 inhibitor. |
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T74808 |
THK01
|
|
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THK01, a potent ROCK2 inhibitor, exhibits IC50 values of 5.7 nM for ROCK2 and 923 nM for ROCK1, respectively. It effectively targets the ROCK2-STAT3 signaling pathway to inhibit breast cancer metastasis, making it valuab... |
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T39519 |
GSK269962A hydrochloride
|
GSK 269962 hydrochloride |
|
|
GSK269962A hydrochloride (GSK 269962 hydrochloride) is a highly potent inhibitor of ROCK1 and ROCK2, with IC50 values of 1.6 nM and 4 nM, respectively, for recombinant human isoforms. This compound exhibits both anti-inf... |
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T2633 |
GSK429286A
|
RHO-15 |
ROCK
|
|
GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM). |
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T7391 |
SAR407899
|
|
ROCK
,
Rho
|
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SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries. |
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T39944 |
HSD1590
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|
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HSD1590 is a highly effective and potent inhibitor of ROCK1 and ROCK2, with IC50 values of 1.22 nM and 0.51 nM, respectively. It demonstrates exceptional binding affinity to ROCK, with Kd values below 2 nM. Moreover, HSD... |
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T61905 |
RKI-1447 dihydrochloride
|
|
|
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RKI 1447 dihydrochloride is an effective and selective ROCK inhibitor (ROCK1 IC50=14.5 nM, ROCK2 IC50=6.2 nM). RKI 1447 dihydrochloride can inhibit the growth of colorectal cancer cells and promote cell apoptosis. |
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T63506 |
Chroman 1 dihydrochloride
|
|
|
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Chroman 1 dihydrochloride is a selective and potent inhibitor of ROCK, acting more strongly on ROCK2 (IC50: 1 pM) than ROCK1 (IC50: 52 pM) and also inhibiting MRCK activity (IC50: 150 nM). |
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T26821 |
BIPM
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|
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BIPM is a potent inhibitor of Rho-associated protein kinase 2 (ROCK2). Exposure of SH-SY5Y cells to BIPM led to significant changes in cell migration, actin stress fibers and neurite length. BIPM significantly inhibits p... |
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T61497 |
Rho-Kinase-IN-2
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|
|
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Rho-Kinase-IN-2 (Compound 23) is an orally active and selective inhibitor of Rho Kinase (ROCK), which can penetrate the central nervous system (CNS). It exhibits a high affinity for ROCK2 with an inhibition constant (IC5... |
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T14989 |
CMPD101
|
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ROCK
,
GRK
,
PKC
|
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CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with I... |
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TQ0110 |
ROCK-IN-2
|
TC-S 7001,Azaindole 1 |
ROCK
|
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ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2. |
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T61382 |
Fasudil dihydrochloride
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|
|
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Fasudil dihydrochloride, also known as HA-1077 and AT877, is a nonspecific inhibitor of RhoA/ROCK. It exhibits inhibitory effects on protein kinases, including ROCK1 with a Ki value of 0.33 μM, as well as ROCK2, PKA, PKC... |
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T1725 |
Y-27632 dihydrochloride
|
Y-27632 2HCl |
ROCK
,
Apoptosis
|
|
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells. |
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T71119 |
Netarsudil free base
|
|
|
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Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Hum... |
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T7492 |
Ripasudil free base
|
K-115 (free base) |
ROCK
,
Antibacterial
|
|
Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent. |
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T7552 |
H-1152
|
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ROCK
|
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H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM). |
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T2482 |
AT13148
|
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ROCK
,
SGK
,
Akt
,
PKA
,
S6 Kinase
|
|
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II. |
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T35328 |
H-1152 dihydrochloride
|
H-1152 2HCl,H-1152 dihydrochloride |
ROCK
|
|
H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA, PKC, PKG, Aurora A and CaMKII with IC50 ... |
|
T27089 |
CRT0066854
|
CRT0066854 HCl,CRT-0066854 HCl,CRT 0066854,CRT-0066854 |
|
|
CRT-0066854 is a PKCι and PKCζ inhibitor. CRT0066854 was able to restore polarized morphogenesis in the dysplastic H-Ras spheroids. |
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T15428 |
Uprosertib hydrochloride
|
GSK2141795 (hydrochloride) |
Others
|
|
Uprosertib hydrochloride is a potent and selective inhibitor of pan-Akt (IC50: 180/328/38 nM for Akt1/Akt2/Akt3, respectively). |
