|
T19185 |
Aldosterone-d8
|
Aldosterone D8 |
Others
|
|
Aldosterone D8, a deuterium-labeled variant of Aldosterone produced in the adrenal zona glomerulosa, regulates blood pressure. |
|
T36381 |
Aldosterone 21-sulfate (sodium salt)
|
|
|
|
Aldosterone 21-sulfate is a metabolite of the steroid hormone aldosterone .1It reduces the sodium-to-potassium ratio in rat urine when administered at doses ranging from 10 to 100 μg, indicating mineralocorticoid activit... |
|
T29852 |
Aldosterone-3-(O-carboxymethyl)oximino-(2-iodohistamine)
|
|
|
|
Aldosterone-3-(O-carboxymethyl)oximino-(2-iodohistamine) is a biochemical. |
|
T4316 |
ML365
|
|
Potassium Channel
|
|
ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3). |
|
T0293 |
Metyrapone
|
NSC-25265,Su-4885 |
Others
,
P450
,
Dehydrogenase
,
Autophagy
|
|
Metyrapone (NSC-25265) is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME. |
|
T1410 |
Torsemide
|
AC-4464,JDL-464,Torasemide |
Na-K-Cl cotransporter
|
|
Torsemide (AC-4464) is an anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop diuretics, is extensively protein bound in plasma and h... |
|
T0083 |
Eplerenone
|
Epoxymexrenone,CGP 30083,SC-66110 |
Glucocorticoid Receptor
|
|
Eplerenone (CGP 30083) is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension. Eplerenone therapy has been associated with transient elevations in serum aminotransferase ... |
|
T4277 |
Osilodrostat
|
LCI699 |
Glucocorticoid Receptor
,
Others
,
Hydroxylase
|
|
Osilodrostat (LCI699) (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM). |
|
T0476 |
Spironolactone
|
SC9420,Abbolactone |
Glucocorticoid Receptor
,
Androgen Receptor
,
Autophagy
|
|
Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist. |
|
T13881 |
Dicirenone
|
SC26304 |
ATPase
,
Glucocorticoid Receptor
|
|
Dicirenone (SC26304) inhibits the Mineralocorticoid receptor (MR), aldosterone regulation of the urinary K+:Na+ ratio, and aldosterone binding to renal cytoplasmic and nuclear receptors. |
|
T61373 |
Baxdrostat
|
|
Others
|
|
Baxdrostat is an aldosterone synthase inhibitor. |
|
T71664 |
Mespirenone
|
|
Others
|
|
Mespirenone is a spironolactone derivative and aldosterone antagonist with diuretic effects. |
|
T3096 |
Canrenoate potassium
|
Potassium aldadiene,Canrenoic acid potassium salt,Potassium canrenoate,Soldactone |
Glucocorticoid Receptor
|
|
Canrenoate potassium (Soldactone) is a synthetic pregnadiene derivative with anti-aldosterone activity. |
|
T1866 |
AT-56
|
|
Others
,
PGE Synthase
|
|
AT56, a specific inhibitor of prostaglandin D2 synthase enzymatic activity, blunted adipogenic aldosterone effects. |
|
T6262 |
Evacetrapib
|
LY2484595 |
CETP
|
|
Evacetrapib (LY2484595) (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pressure. Phase 3. |
|
TP1295 |
Angiotensin I (human, mouse, rat)
|
Angiotensin 1 Human |
Others
|
|
Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensin II, cleaved by the angiotensin-converting enzyme (ACE).Angiotensin is a peptide hormone that causes vasoconstriction and an in... |
|
T1484L |
Perindopril erbumine
|
S9490-3,Perindopril tert-butylamine salt |
Apoptosis
,
RAAS
,
MRP
|
|
Perindopril erbumine (S9490-3) is the tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, Perindopril er... |
|
T70242 |
SC 8109
|
|
|
|
SC 8109 is an aldosterone antagonist. |
|
T62747 |
Lorundrostat
|
|
|
|
Lorundrostat is an aldosterone synthase inhibitor. |
|
T69041 |
SC 11927
|
|
|
|
SC 11927 is an aldosterone antagonist. |
|
T68699 |
Oxprenoate Free Base
|
|
|
|
Oxprenoate Free Base is a mineralocorticoid receptor (MR) antagonist, inhibiting aldosterone production and secretion. |
|
T26157 |
RU 752
|
RU-752,RU752 |
|
|
RU 752 is an antagonist of mineralocorticoid receptor that inhibits aldosterone synthesis. |
|
T69273 |
Mexrenoate potassium
|
|
|
|
Mexrenoate potassium is a steroidal aldosterone antagonist and antihypertensive. |
|
T14664 |
BI 689648
|
|
Others
|
|
|
|
T69705 |
SC 19886
|
|
|
|
SC 19886 is an antimineralocorticoid that acts as a potent inhibitor of aldosterone biosynthesis. |
|
T61372 |
(S)-Baxdrostat
|
|
|
|
(S)-Baxdrostat is an S-enantiomer of Baxdrostat, which functions as an inhibitor of aldosterone synthase [1]. |
|
T69284 |
SC 23133
|
|
|
|
SC 23133 is an antimineralocorticoid that is known to induce a marked but reversible inhibition of aldosterone biosynthesis. |
|
T38424 |
(R)-Fadrozole
|
FAD286,(R)-CGS 16949A free base,(R)-Fadrozole |
|
|
(R)-Fadrozole ((R)-CGS 16949A; FAD286) is a potent nonsteroidal inhibitor. (R)-Fadrozole also inhibits human placental aromatase (pIC 50 = 6.17) and aldosterone biosynthesis. (R)-Fadrozole reverses cardiac fibrosis in sp... |
|
T68009 |
Prorenoate
|
|
|
|
Prorenoate is a steroidal aldosterone antagonist with potassium-sparing diuretic activity. Prorenoate antagonizes the activity of aldosterone at the mineralocorticoid receptor in the nephron and thereby prevents sodium r... |
|
T34430 |
RU 24411
|
RU24411,RU-24411 |
|
|
RU 24411 is a synthetic 19-nor steroid compound. RU 24411 appeared as capable of stimulation of sodium transport as aldosterone in the absence of glucose. |
|
T80687 |
γ3-MSH
|
|
|
|
γ3-MSH, originating from the N-terminal segment of pro-opiomelanocortin (POMC), induces aldosterone secretion in cultured human adrenal tumor cells [1]. |
|
T76646 |
Acetyl-ACTH (7-24) (human, bovine, rat)
|
|
|
|
Acetyl-ACTH (7-24) (human, bovine, rat) effectively inhibits the secretion of corticosterone and aldosterone triggered by ACTH stimulation [1]. |
|
T83495 |
[D-Pro4,D-Trp7,9] Substance P (4-11)
|
|
|
|
[D-Pro4,D-Trp7,9] Substance P (4-11) acts as a potent antagonist to Substance P, significantly reducing plasma aldosterone (ALDO) concentrations[1]. |
|
TP1209 |
BNP (1-32), rat TFA (133448-20-1 free base)
|
Brain Natriuretic Peptide (BNP) (1-32), rat TFA,BNP (1-32), rat TFA |
|
|
Acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeos... |
|
T19631 |
PD 109488
|
PD-109488,Quinapril Diketopiperazine,PD109488 |
|
|
PD 109488 is a metabolite of quinapril and is a derivative of Quinapril that acts as an ACE inhibitor. Inhibition of ACE prevents the conversion of signaling peptide angiotensin I into angiotensin II, which acts as a pot... |
|
T31845 |
Forasartan
|
SC52458,SC 52458,SC-52458 |
|
|
Forasartan is a non - peptide angiotensin II receptor antagonist with antihypertensive activity. Forasartan and angiotensin II compete to bind AT1 receptor subtypes in vascular smooth muscle, thereby blocking angiotensin... |
|
T76334 |
Cenderitide
|
|
|
|
Cenderitide, a natriuretic peptide (NP) that combines C-type natriuretic peptide (CNP) with the C-terminus of Dendroaspis natriuretic peptide (DNP), serves as a potent agonist of the particulate guanylyl cyclase receptor... |
|
T71787 |
Deserpidine hydrochloride
|
|
|
|
Deserpidine hydrochloride is the salf form of Deserpidine (free base), which is an antihypertensive drug related to reserpine which occurs naturally in Rauwolfia canescens. Deserpidine is a competitive inhibitor of the a... |
|
T68765 |
Spirorenone
|
|
|
|
Spirorenone is an androstadienone derivative as a highly effective aldosterone antagonist. Spirorenone is 8.6 times as potent as spironolactone, but showed a lower affinity for the mineralocorticoid receptors. In phase I... |
|
T83501 |
[Deamino-Pen1,Val4,D-Arg8]-vasopressin
|
|
Vasopressin Receptor
|
|
[Deamino-Pen1,Val4,D-Arg8]-vasopressin (AVP-A) is an antagonist of arginine-vasopressin (AVP). It effectively reduces plasma aldosterone concentration in rats and is utilized in studying the growth and steroidogenic capa... |
|
T68808 |
11-Dehydrocorticosterone
|
|
|
|
11-Dehydrocorticosterone is an endogenous mineralocorticoid. It increases Na+/K+-ATPase mRNA expression in vascular smooth muscle cells and inhibits aldosterone action in B. marinus toad bladder tissue in a concentration... |
|
T73896 |
Glucose-6-phosphate dehydrogenase
|
|
|
|
Glucose-6-phosphate dehydrogenase, the crucial rate-limiting enzyme in the pentose phosphate pathway, plays a vital role in generating NADPH. This compound is indispensable for numerous critical cellular functions such a... |
|
T22573 |
Angiotensin 1/2 (2-7)
|
|
Others
|
|
Angiotensin I/II (2-7) is a peptide that contains the amino acids 2-7 and is converted from Angiotensin I/II peptide. Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood press... |
|
T74142 |
Angiotensin II human TFA
|
|
|
|
Angiotensin II human TFA, a potent vasoconstrictor within the renin/angiotensin system, plays a pivotal role in human blood pressure regulation primarily through interactions with the G-protein-coupled receptors Angioten... |
