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カタログ番号 | 製品名 | 別名 | ターゲット |
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T8473 | MLS000532223 | Rho , Ras | |
MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM). | |||
T23372 | SMIFH2 | Others | |
SMIFH2 is formin homology 2 (FH2) domains inhibitor. | |||
T2029 | Bohemine | ERK , CDK | |
Bohemine is a cyclin-dependent kinase inhibitor. | |||
T10460 | Batabulin | T138067 | Apoptosis , Microtubule Associated |
Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to ce... | |||
T21785 | AG957 | Bcr-Abl | |
Tyrphostin AG957, a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors[1]. | |||
T4451 | Estramustine phosphate sodium | Ro 21-8837/001,Estramustine phosphate disodium | Apoptosis , Microtubule Associated |
Estramustine phosphate sodium (Ro 21-8837/001) is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle. | |||
T24494 | MP265 | MP-265,MP 265 | Others |
MP265 disrupts the MreB cytoskeleton and has antiproliferative effects. | |||
T19512 | Phalloidin | Others | |
Phalloidin is a mushroom-derived toxin which used to label F-actin of the cytoskeleton with fluorochrome . | |||
T28001 | MDK-6983 | MDK-6983,Compound 6k,Autophagy inhibitor 6k,MDK6983 | Autophagy |
MDK-6983 (MDK-6983) is an inhibitor of autophagy and disrupts the dynamics of actin cytoskeleton in human melanoma cells. | |||
T3580 | FIPI | 5-Fluoro-2-indolyl deschlorohalopemide | Phospholipase , Autophagy |
FIPI (5-Fluoro-2-indolyl deschlorohalopemide) is a derivative of halopemide which potently inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC50 = 20 nM); prevents PLD regulation of F-actin cytoskeleton reorganization, cell s... | |||
T26075 | Rhizopodin | ||
Rhizopodin is a potent natural macrolide antibiotic that effectively affects the actin cytoskeleton at nanomolar concentrations. | |||
T28469 | PT-262 | PT 262 | |
PT-262 is a ROCK (Rho-associated coiled-coil forming protein kinase) inhibitor. It induces cytoskeleton remodeling and migration inhibition in lung carcinoma cells. | |||
TP2249 | Flutax 1 | Others | |
A fluorescent taxol derivative used for direct imaging of the microtubule cytoskeleton | |||
T24994 | MreB Perturbing Compound A22 hydrochloride | A22 hydrochloride,MreB Perturbing Compound A22 | |
A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been proved to be an antibiotic adjuvant. A22 inhibition of MreB disrupts the bacterial actin cytoskeleton, which can cause an increase in cell permea... | |||
T16387 | Ombrabulin | AVE8062,AC7700 | Microtubule Associated |
Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells. | |||
T41196 | Phalloidin-FITC | ||
Phalloidin-FITC is a green fluorescent cytoskeleton stain. Binds and labels F-actin. For most fluorescent imaging applications, cells should be fixed and permeablilized. Excitation/emission maxima λ ~496/516 nm. | |||
T29205 | Zarilamide | Zarilamid | |
Zarilamide is inhibitor of the nuclear division in germinating zoospore cysts of Phytophthora capsici. Zarilamide destructs the microtubule cytoskeleton, resulting in a consequent inhibition of mitosis. | |||
T68708 | Denibulin HCl | ||
Denibulin (MN-029) is a novel vascular-disrupting agent that reversibly inhibits microtubule assembly, resulting in disruption of the cytoskeleton of tumor vascular endothelial cells. The results of preclinical study dem... | |||
T78591 | Zoxamide | RH-7281 | |
Zoxamide (RH-7281) is an oomycete-specific fungicide that impedes nuclear division in Phytophthora capsici germlings and disrupts the microtubule cytoskeleton [1] [2]. | |||
T72552 | Antitumor agent-88 | ||
Antitumor agent-88, a competitive inhibitor of CYP1A1 (K i: 1.4 μM), demonstrates significant antimitotic activity by arresting cells in the G2/M phase and disrupting the microtubule network and cytoskeleton in CYP1A1-ex... | |||
T26821 | BIPM | ||
BIPM is a potent inhibitor of Rho-associated protein kinase 2 (ROCK2). Exposure of SH-SY5Y cells to BIPM led to significant changes in cell migration, actin stress fibers and neurite length. BIPM significantly inhibits p... | |||
T36402 | Kibdelone C | ||
Kibdelone C is a member of a family of natural heterocyclic polyketides first isolated from a soil actinomycete, Kibdelosporangium. Kibdelones have been described as having potent and selective cytotoxicity against a pan... | |||
T69813 | AZD-6126 | ||
AZD6126, also known as ANG-453, a water-soluble phosphate prodrug of N-acetylcolchinol with potential antiangiogenesis and antineoplastic activities. AZD-6126 is an angiogenesis inhibitor and tubulin inhibitor potentiall... | |||
T82877 | Biotin-myelin basic protein (94-102) | ||
Biotin-myelin basic protein (94-102) is a peptide fragment crucial for myelin adhesion within the nervous system, facilitating myelination. This protein contributes to signal transduction by interacting as a membrane act... | |||
T16386 | Ombrabulin hydrochloride | AVE8062 (hydrochloride),AC7700 (hydrochloride) | Microtubule Associated |
Ombrabulin hydrochloride is a synthetic, selective CA-4 phosphate ester or derivative of Ombrabulin to disrupt the tubulin cytoskeleton of endothelial cells and has antivascular effects. Ombrabulin is a tubulin polymeriz... | |||
T80253 | S3 Fragment | ||
S3 Fragment is a biologically active peptide featuring the amino-terminal phosphorylation site unique to Xenopus ADF/cofilin, which is the target of LIM kinase (LIMK) phosphorylation. LIMK1, a pivotal regulator of the ac... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
TN1417 | Azadirachtin | Apoptosis , Antifection | |
Azadirachtin has antifungal activity, used as an insecticide. | |||
T20945 | 2,4-D | Hedonal,Macondray,2,4-D acid,Chloroxone | DNA/RNA Synthesis |
2,4-Dichlorophenoxyacetic acid (Hedonal) is a synthetic auxin used as a plant growth regulator and also used as a supplement in plant cell culture media. It is an active ingredient in herbicides used to disrupts the acti... | |||
T3S1471 | Cucurbitacin IIA | Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA | Apoptosis , Survivin |
1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a ... | |||
T5S1981 | Alpha-Cyperone | (+)-α-Cyperone,α-Cyperone | Others , Endogenous Metabolite |
1. alpha-Cyperone (α-Cyperone) is a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium. 2. alpha-Cyperone significantly inhibited PGE2 production by suppressing the LPS-induced... | |||
TN4178 | Gyrophoric acid | cAMP | |
Vulpinic and gyrophoric acids are known as ultraviolet filters for natural lichen populations, they can effectively prevent cytotoxic, apoptotic and cytoskeleton alterative activities of 2.5 J/cm(2) UVB in a dose-depende... | |||
T35782 | Swinholide A | MK-7684 | Antifungal |
Swinholide A is a polyketone compound that can be extracted from sponges and binds to actin to dimerize actin with Kd of about 50 nM. Swinholide A is a cytotoxin that stabilizes actin dimers and severs actin filaments. S... |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPH-02619 | CKAP4 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
High-affinity epithelial cell surface receptor for APF.; Mediates the anchoring of the endoplasmic reticulum to microtubules. | |||
TMPH-02620 | CKAP4 Protein, Mouse, Recombinant (His & MBP) | Mouse | Baculovirus |
High-affinity epithelial cell surface receptor for APF.; Mediates the anchoring of the endoplasmic reticulum to microtubules. | |||
TMPY-02953 | TEM8/ANTXR1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
ANTXR1 contains 1 VWFA domain and belongs to the ATR family. ATR (Ataxia telangiectasia and Rad3 related) and ATM (Ataxia telangiectasia mutated) are closely related kinases that are activated by DNA damage. They are ser... | |||
TMPH-00010 | MMP-14 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tiss... | |||
TMPY-04396 | C-ABL/ABL1 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy... | |||
TMPY-02205 | Beta-Catenin Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
beta-Catenin, also known as CTNNB1, is a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain, which is specialized for protein-protein binding. It is p... | |||
TMPY-05717 | Integrin alpha V beta 8 Protein, Human, Recombinant (His) | Human | HEK293 |
Integrin alpha V beta 8 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. ITGAVB8 does not appear to assume different activation states; and the cytoplasmic tail does not connect to the cyto... | |||
TMPJ-00327 | M-CSF/CSF1 Protein, Human, Recombinant (His) | Human | Human Cells |
Macrophage Colony-Stimulating Factors (m-csf) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and th... | |||
TMPY-00871 | LAYN Protein, Human, Recombinant (hFc) | Human | HEK293 |
Layilin recently characterized as a 55 kDa transmembrane protein with homology to C-type lectins, is present in numerous cell lines and tissue extracts. As one of the adaptor proteins, talin mediates the interactions bet... | |||
TMPY-02709 | P-Selectin Protein, Human, Recombinant (His) | Human | HEK293 |
P selectin (SELP) is a 140kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. SELP mediates rapid rolling of leukocyte rolling over vascular surfaces during the in... | |||
TMPY-04330 | Mer Protein, Human, Recombinant | Human | HEK293 |
Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-li... | |||
TMPY-00882 | Mer Protein, Human, Recombinant (His & hFc) | Human | HEK293 |
Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-li... | |||
TMPY-01357 | S100A9 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that... | |||
TMPH-03028 | HMW3 Protein, Mycoplasma pneumoniae, Recombinant (His & Myc) | Mycoplasma pneumoniae | E. coli |
Component of the cytoskeleton-like structure which stabilizes the shape of the wall-less mycoplasma. This cytoskeleton-like network of accessory proteins containing HMW proteins 1 to 5 allows the proper anchoring of cyta... | |||
TMPH-02512 | TEM8/ANTXR1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskel... | |||
TMPH-03033 | P200 Protein, Mycoplasma pneumoniae, Recombinant (His & Myc) | Mycoplasma pneumoniae | E. coli |
Protein cytoskeleton-associated which plays a role in gliding motility and perhaps also in mucociliary clearance. | |||
TMPH-02513 | TEM8/ANTXR1 Protein, Mouse, Recombinant (His & Myc) | Mouse | HEK293 |
Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskel... | |||
TMPH-03027 | HMW1 Protein, Mycoplasma pneumoniae, Recombinant (His & Myc) | Mycoplasma pneumoniae | E. coli |
Component of the cytoskeleton-like structure which stabilizes the shape of the wall-less Mycoplasma. This cytoskeleton-like network of accessory proteins containing HMW proteins 1 to 5 allows the proper anchoring of cyta... | |||
TMPH-02935 | TMSB10 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. | |||
TMPH-01704 | RAE1 Protein, Human, Recombinant (GST) | Human | E. coli |
Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. | |||
TMPY-03600 | TPM4 Protein, Human, Recombinant (His) | Human | HEK293 |
TPM4, also known as tropomyosin 4, is a member of the tropomyosin family. Members of this family are actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-mu... | |||
TMPH-01226 | CRMP1 Protein, Human, Recombinant | Human | E. coli |
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance. During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F... | |||
TMPH-02130 | SPTAN1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. | |||
TMPJ-01333 | TEM8/ANTXR1 Protein, Human, Recombinant (His) | Human | Human Cells |
Anthrax Toxin Receptor 1 (ANTXR1) is a single-pass type I membrane protein that belongs to the ATR family. ANTXR1 contains one VWFA domain and binds PA through the VWA domain. ANTXR1 is highly expressed in tumor endothel... | |||
TMPH-01751 | Nephrin/NPHS1 Protein, Human, Recombinant (His) | Human | E. coli |
Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role ... | |||
TMPH-02161 | Synapsin-1 Protein, Human, Recombinant (GST) | Human | E. coli |
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for... | |||
TMPH-02202 | TMSB10 Protein, Human, Recombinant (GST) | Human | E. coli |
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. | |||
TMPH-01228 | DPYSL3 Protein, Human, Recombinant (His) | Human | E. coli |
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. | |||
TMPY-03984 | TPM1 Protein, Human, Recombinant (His) | Human | E. coli |
TPM1, also known as tropomyosin-1, is a member of the tropomyosin family. Members of this family are highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth m... | |||
TMPH-01227 | DPYSL2 Protein, Human, Recombinant (His) | Human | Yeast |
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the... | |||
TMPH-01875 | Plexin-B1 Protein, Human, Recombinant (His) | Human | E. coli |
Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. ... | |||
TMPH-02252 | TPM3 Protein, Human, Recombinant (GST) | Human | E. coli |
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contra... | |||
TMPJ-01188 | CORO6 Protein, Human, Recombinant (His) | Human | E. coli |
Coronin 6, a newly identified member of the coronin family, is highly enriched at adult NMJs and regulates AChR clustering via modulating the interaction between receptors and the actin cytoskeletal network. Coronins are... | |||
TMPH-03212 | TPM1 Protein, Rabbit, Recombinant (His & Myc) | Rabbit | Baculovirus |
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contra... | |||
TMPJ-00045 | Podoplanin Protein, Human, Recombinant (hFc) | Human | Human Cells |
Podoplanin is a type-1 transmembrane protein that belongs to Podoplanin family. PDPN expressed in various specialized cell types throughout the body. It highly expressed in placenta, lung, skeletal muscle and brain, weak... | |||
TMPK-00937 | CKAP4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated | Human | E. coli |
Cytoskeleton-associated protein 4 (CKAP4) is located in the rough endoplasmic reticulum (ER) and plays an important role in stabilizing the structure of ER. Meanwhile, CKAP4 is also found to act as an activated receptor ... | |||
TMPK-00936 | CKAP4 Protein, Human, Recombinant (His) | Human | E. coli |
Cytoskeleton-associated protein 4 (CKAP4) is located in the rough endoplasmic reticulum (ER) and plays an important role in stabilizing the structure of ER. Meanwhile, CKAP4 is also found to act as an activated receptor ... | |||
TMPH-03096 | Profilin 2 Protein, Phleum pratense, Recombinant (His & Myc) | Phleum pratense | E. coli |
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the forma... | |||
TMPJ-00016 | GABARAP Protein, Human, Recombinant (GST) | Human | E. coli |
Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged... | |||
TMPH-01876 | Plexin-B1 Protein, Human, Recombinant (mFc) | Human | HEK293 |
Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. ... | |||
TMPH-03280 | Dystrophin Protein, Rat, Recombinant (His) | Rat | Yeast |
Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variet... | |||
TMPH-03202 | DAG1 Protein, Rabbit, Recombinant (His) | Rabbit | E. coli |
The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epi... | |||
TMPY-03399 | KLHL2 Protein, Human, Recombinant (GST) | Human | E. coli |
KLHL2 (Kelch Like Family Member 2) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. KLHL2 contains 1 BTB (POZ) domain and 6 Kelch repeats. It is widely expressed in the brain, esophagu... | |||
TMPY-02106 | GAP43 Protein, Human, Recombinant (His) | Human | HEK293 |
Neuromodulin, also known as Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-5, pp46 and GAP43, is a cell membrane protein which belongs to theneuromodulin family. Neuromodulin / G... | |||
TMPH-03213 | TPM1 Protein, Rabbit, Recombinant (E. coli, His & Myc) | Rabbit | E. coli |
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contra... | |||
TMPH-02967 | UPK3A Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differe... | |||
TMPH-01365 | SNTG1 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May participate in... | |||
TMPH-02253 | TPM2 Protein, Human, Recombinant (His) | Human | E. coli |
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contra... | |||
TMPJ-00015 | GABARAP Protein, Human, Recombinant (His & hFc) | Human | E. coli |
Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged... | |||
TMPH-01342 | Filamin-A Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplas... | |||
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カタログ番号 | 製品名 | ||
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L1310 | Cytoskeletal Signaling Pathway Compound Library | 759 compounds | |
A unique collection of 759 cytoskeleton-related compounds, can be used for HTS and HCS; |