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T7369L |
Gemigliptin Tartrate(911637-19-9 free base)
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LC15-0444 tartrate |
Proteasome
,
DPP-4
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|
Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibit... |
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T11877 |
LR-90
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Others
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LR-90, an advanced glycation end product (AGE) inhibitor, is utilized in diabetic animal model research. This compound effectively suppresses inflammatory responses in human monocytes. |
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T7143 |
Alagebrium chloride
|
ALT711 |
Others
,
Endogenous Metabolite
|
|
Alagebrium chloride (ALT711) is an advanced glycation end product (AGE) inhibitor, and has proven effective in reducing systolic blood pressure and providing therapeutic benefit for patients with diastolic |
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T8583 |
Tenilsetam
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3-(2-thienyl)- (9CI),Piperazinone |
Others
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Tenilsetam (Piperazinone) is an endonuclease modulator; a nootropic agent and advanced glycation end product (AGE) inhibitor having potential for Alzheimer's disease (AD) treatment. |
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T2507 |
Azeliragon
|
TTP488 |
Beta Amyloid
,
advanced glycation end products
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|
Azeliragon (TTP488) is an antagonist at the Receptor for Advanced Glycation End products; is evaluated as a potential treatment for patients with mild-to-moderate Alzheimer_acute_s disease (AD). |
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T32098L |
Homocarnosine acetate
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|
GABA Receptor
,
Endogenous Metabolite
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|
Homocarnosine acetate is a dipeptide unique to brain consisting of γ-aminobutyric acid (GABA) and histidine. Homocarnosine acetate has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition o... |
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TP1935L1 |
RAGE antagonist peptide acetate
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|
Beta Amyloid
|
|
RAGE antagonist peptide acetate is an advanced antagonist of glycation end products (RAGE). RAGE antagonist peptide acetate possesses anti-tumor and anti-inflammatory activities. RAGE antagonist peptide acetate prevents ... |
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T39115 |
ABR-238901
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|
TLR
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|
ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products) and TLR4 (toll-like receptor 4). ABR-238901 has potential a... |
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T22243 |
Anserine
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L-Anserine |
Endogenous Metabolite
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|
Anserine (L-Anserine) is a dipeptide containing β-alanine and histidine, which can be found in the skeletal muscle and brain of mammals and birds. Anserine is not cleaved by serum carnosinase and act as biochemical buffe... |
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T9948 |
NecroX-7
|
LC-280126,LC28-0126,LC28 0126 |
NADPH-oxidase
|
|
NecroX-7 (LC-280126) is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing ... |
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T29819 |
Alagebrium bromide
|
ALT-711,ALT 711,ALT711 |
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|
Alagebrium is a advanced glycation endproducts (AGE) cross-link breaker. |
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T70059 |
ALT-946 HCl
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|
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ALT-946 HCl is an inhibitor of advanced glycation that has been shown to improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat. |
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T68794 |
ALT-946 free base
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|
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ALT-946 free base is an inhibitor of advanced glycation that has been shown to improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat. |
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T34066 |
Pimagedine
|
Monoaminoguanidine,Imino semicarbazide,Guanyl hydrazine,Aminate base,Aminoguanidine |
|
|
Pimagedine is a prototype therapeutic agent for the prevention of formation of advanced glycation endproducts. Pimagedine reacts rapidly with α,β-dicarbonyl compounds such as methylglyoxal, glyoxal, and 3-deoxyglucosone ... |
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T2507L2 |
Azeliragon HCl
|
TTP488 HCl,Azeliragon hydrochloride,TTP 488,Azeliragon dihydrochloride,TTP-488 |
|
|
Azeliragon is a potent and orally active inhibitor of RAGE (receptor for advanced glycation endproducts), a pattern recognition receptor, which affects the movement of amyloid, an Alzheimer's-associated protein, into the... |
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T20229 |
L-Erythrose
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L-(+)-Erythrose |
|
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L(+)-Erythrose is an aldotetrose rare sugar. It may be used in glycation studies and as a reference compound in tetrose carbohydrate separation and quantitation analysis. It also can be used to help identify and characte... |
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T73932 |
Fructosyl-lysine dihydrochloride
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|
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Fructosyl-lysine dihydrochloride (Fructoselysine), an Amadori glycation product, forms through the Maillard reaction between glucose and lysine. This compound serves as the precursor to glucosepane, a lysine–arginine pro... |
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TP1935 |
RAGE antagonist peptide
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|
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Receptor for advanced glycation end products (RAGE) antagonist. Blocks S100P, S100A4 and HMGB-1 mediated RAGE activation in vitro and in vivo. Inhibits growth and metastasis of rat glioma tumors. Reduces cell growth and ... |
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T35890 |
Pentosidine
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|
|
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Advanced glycation end products (AGEs) are compounds formed by non-enzymatic chemical reactions following the bonding of sugars to proteins or lipids during diabetes, uremia, aging, rheumatic arthritis, and other conditi... |
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T69380 |
Cinnamic acid, hydrazide
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|
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Cinnamic acid, hydrazide is an unsaturated carboxylic acid and precursor to aspartame via enzyme-catalysed amination to phenylalanine. Cinnamic acid may be useful in prevention or treatment of Diabetes through various me... |
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T73818 |
Homocarnosine TFA
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|
|
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Homocarnosine TFA, a unique dipeptide of γ-aminobutyric acid (GABA) and histidine found in the brain, acts as an inhibitory neuromodulator synthesized from GABA within neurons. It exhibits anticonvulsant effects [1], and... |
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T72824 |
RAGE/SERT-IN-1
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|
|
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RAGE/SERT-IN-1 is a potent, orally active inhibitor of advanced glycation end products (RAGE) and serotonin transporter (SERT), with IC50 values of 8.26 μM and 31.09 nM, respectively. It demonstrates a significant neurop... |
