|
T23498 |
UNC3230
|
UNC 3230 |
Others
|
|
UNC3230 is a potent, selective and ATP-competitive PIP5K1C inhibitor with an IC50 of ~41 nM. UNC3230(UNC 3230) also inhibits PIP4K2C. |
|
T3105 |
PFK-158
|
|
Apoptosis
,
Glucokinase
,
Autophagy
|
|
PFK-158 is an effective and specific inhibitor PFKFB3. |
|
T6816 |
DASA-58
|
|
PKM
|
|
DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator. |
|
T3268 |
Mildronate
|
Kvaterin,Meldonium,Quaterin |
Hydroxylase
|
|
Mildronate (Meldonium) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption. |
|
T7717 |
Sodium 2-oxopropanoate
|
Sodium pyruvate |
Reactive Oxygen Species
,
Endogenous Metabolite
|
|
Sodium 2-oxopropanoate (Sodium pyruvate) is a antioxidant potentially used to treatment of chronic obstructive pulmonary disease. |
|
T5882 |
3-Bromopyruvic acid
|
Hexokinase II Inhibitor II, 3-BP,Bromopyruvic acid |
Apoptosis
,
Hexokinase
,
Autophagy
|
|
3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinu... |
|
T19826 |
Rabeprazole
|
LY307640 |
Potassium Channel
,
STAT
|
|
Rabeprazole (LY307640) is an H+/K+-ATPase inhibitor that inhibits cell proliferation in gastric epithelial cells by targeting STAT3-mediated glycolysis and can be used in the study of gastric ulcers. |
|
T20974 |
IR-780 Iodide
|
IR 780 iodide |
Others
|
|
IR-780 Iodide (IR 780 iodide), a near‐infrared fluorescent dye, is used for the exclusive characterization of human CSCs through the HIF‐1α/glycolysis dependent mitochondrial transporter ABCB10's activity. |
|
T37185 |
D-(-)-3-Phosphoglyceric acid disodium
|
3-Phospho-D-glyceric acid disodium |
Others
|
|
D-(-)-3-Phosphoglyceric acid disodium (3-Phospho-D-glyceric acid disodium) is an intermediate in several biological pathways, most notably glycolysis/gluconeogenesis and the biosynthesis of serine, glycine, and threonine... |
|
T3317 |
SZL P1-41
|
|
Apoptosis
,
Others
,
E1/E2/E3 Enzyme
|
|
SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediate... |
|
T8732 |
CTPI-2
|
|
Others
,
Mitochondrial Metabolism
|
|
CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with(KD : 3.5 μM). CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 exhibits anti-tumor activity.CTPI-2 ha... |
|
T4103 |
(L)-Sodium lactate
|
Sodium L-Lactate |
Others
|
|
(L)-Sodium lactate (Sodium L-Lactate) is produced from pyruvate by the enzyme Lactate Dehydrogenase. Lactate production occurs during anaerobic glycolysis or in proliferatively active cells. L-Lactic Acid occurs in small... |
|
T71612 |
SU086
|
|
|
|
SU086 an inhibitor of HSP90, impairs glycolysis and represents a treatment strategy for advanced prostate cancer |
|
T26395 |
6-Benzylthioinosine
|
6-BT,6Benzylthioinosine,6-Bn-thioinosine |
|
|
6-Benzylthioinosine, a broad-spectrum metabolic inhibitor, inhibits glucose uptake, decreases glycolysis and ATP concentration with minimal changes in ROS and mitochondrial respiration. |
|
T19126 |
3-Phosphoglyceric acid barium
|
|
Others
|
|
3-Phosphoglyceric acid barium is a metabolic intermediate in both glycolysis and the Calvin cycle. It is involved in alveolar macrophage epigenetic regulation. |
|
T28049 |
MJE3
|
MJE 3,MJE-3 |
|
|
MJE3 is an inhibitor of phosphoglycerate mutase-1 (PGAM1), it displays antiproliferative effects in human breast cancer cells by inhibiting glycolysis. |
|
T39984 |
PKM2-IN-3
|
PKM2-IN-3 |
|
|
PKM2-IN-3 is a potent PKM2 kinase inhibitor, displaying an IC 50 value of 4.1 μM. The compound effectively suppresses PKM2-mediated glycolysis and NLRP3 activation, thereby exerting an anti-neuroinflammatory effect. |
|
T71436 |
D561-0775
|
|
|
|
D561-0775 is a direct AMPK agonist, showing potential anti-cancer activity via inducing apoptosis, cell cycle arrest, suppressing glycolysis and cholesterol synthesis after activation of AMPK in gefitinib-resistant H1975... |
|
T37521 |
DL-Glyceraldehyde 3-phosphate
|
3-Phosphoglyceraldehyde |
|
|
DL-Glyceraldehyde-3-phosphate (GADP) is an intermediate in several metabolic pathways, including glycolysis and gluconeogenesis. In glycolysis, it can be derived from fructose 1,6-bisphosphate by fructose bisphosphate al... |
|
T36037 |
CBR-470-2
|
|
|
|
CBR-470-2, a glycine-substituted analog, exhibits the capacity to activate NRF2 signaling, making it a valuable compound for investigating glycolysis modulation in scientific research [1]. |
|
T10966 |
DC-5163
|
|
Others
|
|
DC-5163 is a potent inhibitor of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with IC50 of 176.3 nM and Kd of 3.192 μM. DC-5163 selectively inhibits cancer cell proliferation and induces apoptosis, and partially inhi... |
|
T37502 |
Sn-Glycerol 3-phosphate lithium
|
|
|
|
sn-Glycerol 3-phosphate lithium is synthesized via the cytosolic glycerol 3-phosphate dehydrogenase pathway. This process involves the conversion of dihydroxyacetone phosphate to sn-Glycerol 3-phosphate using NADH, which... |
|
T70418 |
TLN-232
|
|
|
|
TLN-232, also known as CAP-232, is a synthetic cyclic heptapeptide with potential antineoplastic activity. Pyruvate kinase (PK) inhibitor TLN-232 targets pyruvate kinase M2 (M2PK), which may disrupt tumor cell anaerobic ... |
|
T6759L |
AP-III-a4 hydrochloride (1177827-73-4 free base)
|
ENOblock hydrochloride,AP-III-a4 hydrochloride |
Others
|
|
AP-III-a4 hydrochloride (ENOblock hydrochloride) is a novel small molecule which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity (IC50=0.576 uM); inhibit cancer cell metastasi... |
|
T74941 |
D-Glyceraldehyde 3-phosphate
|
|
|
|
D-Glyceraldehyde 3-phosphate (Triose phosphate), a pivotal molecule in cellular metabolism, serves as a crucial intermediate in both glycolysis and gluconeogenesis, and as a sugar derivative in the Calvin cycle. Addition... |
|
T72092 |
2-Deoxy-D-glucose 6-phosphate disodium
|
|
|
|
2-Deoxy-D-glucose 6-phosphate disodium, a derivative of glucose analog 2-Deoxy-D-glucose, is synthesized in mammalian cells through hexokinase activity on 2-DG. It functions as a competitive inhibitor of glucose metaboli... |
|
T83389 |
2-Deoxy-D-galactose
|
|
|
|
2-Deoxy-D-galactose, a glucose analog, impedes glycolysis, thereby inhibiting tumor growth, and interferes with fucosylation of glycomacromolecules, which impairs memory consolidation in learning tasks. Additionally, thi... |
|
T36871 |
5-Octyl-α-ketoglutarate
|
|
|
|
In addition to its role in the Krebs cycle, α-ketoglutarate (2-oxoglutarate) has roles as a substrate or modulator of enzymes. 5-Octyl-α-ketoglutarate, also known as α-ketoglutarate octyl ester, is a stable, cell-permeab... |
|
T79286 |
TRAP1-IN-2
|
|
HSP
|
|
TRAP1-IN-2, also known as compound 36, is a selective degrader of the TRAP1 client protein that does not affect Hsp90-cytosolic clients. It inhibits oxidative phosphorylation (OXPHOS) and shifts cellular metabolism towar... |
|
T79369 |
ZMF-23
|
|
PAK
|
|
ZMF-23, a PAK1/HDAC6 dual inhibitor, suppresses PAK1 and HDAC6-mediated aerobic glycolysis and cellular migration while inducing TNF-α-regulated necroptosis and augmenting apoptosis. The compound effectively hampers the ... |
|
T77253 |
β-Nicotinamide adenine dinucleotide reduced dipotassium
|
|
|
|
β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally active, reduced coenzyme that functions as a donor of ADP-ribose units in ADP-ribosylation reactions, and as a precursor of cyclic ADP-ribose. It also ... |
|
T37355 |
CAY10703
|
|
|
|
Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria. Inhibition of PDHK shifts cell metabolism from glycolysis ... |
|
T73615 |
β-Galactosidase
|
|
|
|
β-Galactosidase, a glycoside hydrolase, breaks down β-glycosidic bonds in galactose and its derivatives. In E. coli, it is encoded by the lacZ gene, playing a crucial role in the lac operon induction system. This enzyme ... |
|
T81446 |
PKM2 activator 6
|
|
|
|
Compound Z10 (PKM2 activator 6) serves as both a PKM2 activator and a PDK1 inhibitor, exhibiting dissociation constants (K D ) of 121 μM and 19.6 μM, respectively. It promotes apoptosis in colorectal cells while suppress... |
|
T76122 |
Phosphoglycerate kinase
|
|
|
|
Phosphoglycerate kinase (PGK) is a glycolytic enzyme that catalyzes the reversible transfer of phosphate groups from 1,3-bisphosphoglycerate (1,3-BPG) to ADP, resulting in the production of 3-phosphoglycerate (3-PG) and ... |
|
T35683 |
2-deoxy-D-Glucose-13C6
|
2-deoxy-D-Glucose-13C6 |
|
|
2-deoxy-D-Glucose-13C6is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2It inhibits h... |
|
T83889 |
C-02
|
|
|
|
C-02, a proteolysis-targeting chimera (PROTAC) that combines the hexokinase inhibitor lonidamine with the cereblon ligand thalidomide, effectively induces the degradation of hexokinase 2 in 786-O and PANC-1 cells at a co... |
