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Search Results for " indoleamine "

ターゲット

Indoleamine 2,3-Dioxygenase (IDO) IDO Indoleamine 2,3-Dioxygenase (IDO)

42

阻害剤

9

天然化合物

4

リコンビナントタンパク質

カタログ番号 製品名 別名 ターゲット
T11615 IDO-IN-12 IDO , Indoleamine 2,3-Dioxygenase (IDO)
IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).
T11901 IDO1-IN-5 IDO , Indoleamine 2,3-Dioxygenase (IDO)
IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
T11616 IDO-IN-13 GS-4361 IDO , Indoleamine 2,3-Dioxygenase (IDO)
IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).
T10199 GNF-PF-3777 8-Nitrotryptanthrin IDO , Indoleamine 2,3-Dioxygenase (IDO)
GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).
T9164 BMS-986242 BMS986242 IDO , Indoleamine 2,3-Dioxygenase (IDO)
BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
T2647 IDO5L INCB024360 analogue,INCB14943 IDO , Indoleamine 2,3-Dioxygenase (IDO)
IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).
T4532 Linrodostat BMS-986205 IDO , Indoleamine 2,3-Dioxygenase (IDO)
Linrodostat (BMS-986205) is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.
T4307 PF-06840003 EOS200271,PF 06840003 IDO , Indoleamine 2,3-Dioxygenase (IDO)
PF-06840003 (EOS200271) is a specific and oral active IDO-1 inhibitor.
TQ0071 Navoximod GDC-0919,NLG-​919 Indoleamine 2,3-Dioxygenase (IDO)
Navoximod (GDC-0919) (NLG- 919, GDC-0919) is a potent indoleamine-(2,3)-dioxygenase (IDO) pathway inhibitor (Ki/EC50: 7 nM/75 nM).
T7181 IDO-IN-1 Indoleamine 2,3-Dioxygenase (IDO)
IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor( IC50 values of 59 and 12 nM for human IDO enzymatic activity and HeLa cell assays, respectively.)
T3548 Epacadostat INCB 024360,IDO Inhibitor 1 IDO , Indoleamine 2,3-Dioxygenase (IDO)
Epacadostat (INCB 024360) is an oral-available inhibitor of indoleamine 2, 3-dioxygenase (IDO1), increasing the proliferation and activation of various immune cells and reducing tumor-associated regulatory T cells.
T1847 Necrostatin-1 Nec-1,Necrostatin 1 Indoleamine 2,3-Dioxygenase (IDO) , Ferroptosis , Autophagy , RIP kinase
Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity. Necrostatin-1 inhibits TNF-α-induced necrotic apoptosis. Necrostatin-1 also inhibits IDO.
T1806 IDO-IN-7 NLG919,Navoximod,NLG-919 analogue,GDC-0919 Indoleamine 2,3-Dioxygenase (IDO)
IDO-IN-7 (NLG-919 analogue) is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.
T4142 PCC0208009 IDO inhibitor 1,DO-IN-2,IDO-IN-2 Indoleamine 2,3-Dioxygenase (IDO)
PCC0208009 (IDO-IN-2) is an IDO inhibitor.
T6543 Indoximod NLG-8189,Indoximod (NLG-8189）,1-Methyl-D-tryptophan Indoleamine 2,3-Dioxygenase (IDO)
Indoximod (Indoximod (NLG-8189)) is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2, 3-dioxygenase (IDO), which degrades the essential amino acid tryptophan...
T39476 NLG802 Indoleamine 2,3-Dioxygenase (IDO)
NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.
T20513 IDO1-IN-1 IDO1 inhibitor 1,2 HzBTZ,IDO1IN1,2-HzBTZ,IDO1-inhibitor-1 IDO
IDO1-IN-1 (2 HzBTZ) is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
T7660 IDO inhibitor 1 Indoleamine 2,3-Dioxygenase (IDO)
IDO inhibitor 1 is an potent inhibitor of indoleamine-2,3 dioxygenase (IDO) ( IC50 <100 nM).with potential immunomodulating and antineoplastic activities.
T50089 2-(5,7-dichloro-1H-indol-3-yl)ethan-1-amine Others
2-(5,7-dichloro-1H-indol-3-yl)ethan-1-amine is an indoleamine compound that is structurally similar to serotonin. It is a selective agonist at the 5-HT2A receptor and has potential applications in neuroscience.
T61202 TDO-IN-1 Others
TDO-IN-1 is an orally active, potent, and selective inhibitor of tryptophan 2,3-dioxygenase (TDO), which inhibits indoleamine-2,3-dioxygenase.TDO-IN-1 has antitumor activity and is able to act by reversing local immune t...
T70189 Navoximod phosphate
Navoximod phosphate is an indoleamine 2,3-dioxygenase (IDO) inhibitor, immunomodulator and antineoplastic.
T11622 IDO-IN-9 IDO
IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).
T11617 IDO-IN-3 IDO
IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).
T11621 IDO-IN-8 NLG-1487 IDO
IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T11620 IDO-IN-6 NLG-1486 IDO
IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.
T11618 IDO-IN-4 Others
IDO-IN-4 is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor.
T74992 NU223612
NU223612 is a potent PROTAC (PROTACs) specifically targeting and degrading indoleamine 2,3-dioxygenase 1 (IDO1) (Indoleamine 2,3-Dioxygenase (IDO)) via CRBN-mediated proteasomal degradation, demonstrating a binding affin...
T11619 IDO-IN-5 NLG-1489 IDO
IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T11614 IDO-IN-11 IDO
IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).
T73437 DP00477
DP00477, a potent inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), exhibits an inhibitory concentration (IC50) of 7.0 µM. This compound holds promise for cancer research applications.
T60698 Roxyl-9
Roxyl-9 is an inhibitor of IDO1 (Indoleamine 2,3-dioxygenase 1) [1].
T82082 IDO1-IN-23 Indoleamine 2,3-Dioxygenase (IDO)
IDO1-IN-23 (compound 41) is a potent inhibitor of human indoleamine 2,3-dioxygenase 1 (IDO1), exhibiting an IC50 of 13 μM [1].
T11623 IDO/TDO-IN-1 Others
IDO/TDO-IN-1 is an orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50s: 9.7 and 47 nM).
T39888 IDO1-IN-7 IDO1-IN-7
IDO1-IN-7, a potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, exhibits high potency with an IC 50 of 6.1 nM in the cellular assay (SKOV3). Apart from its inhibitory properties, IDO1-IN-7 also demonstr...
T12668 (Rac)-IDO1-IN-5 Others
(Rac)-IDO1-IN-5 is a racemate of IDO1-IN-5, a potent, selective, and brain-penetrating inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity. It specifically binds to apo-IDO1, which lacks heme, instead of mature he...
T60266 (Rac)-Indoximod
(Rac)-Indoximod (1-Methyl-DL-tryptophan) is a potent inhibitor of indoleamine 2,3-dioxygenase (IDO). Combined treatment with IFN-γ and (Rac)-Indoximod significantly suppresses the activity of α-SMA-expressing human cardi...
T76560 Imsamotide
Imsamotide (IDO194-214), an Indoleamine 2,3-Dioxygenase (IDO) peptide characterized by the sequence DTLLKALLEIASCLEKALQVF (IDO194-214), functions as both an immunological agent for active immunization and an antineoplast...
T63814 IDO2-IN-1
IDO2-IN-1 is a potent, orally active indoleamine 2,3-dioxygenase 2 (IDO2) inhibitor, exhibiting an IC50 value of 112 nM. It is applicable in research related to inflammatory autoimmunity [1].
T37329 PROTAC IDO1 Degrader-1 PROTAC IDO1 Degrader-1
PROTAC IDO1 Degrader-1, a pioneering compound, efficiently targets indoleamine 2,3-dioxygenase 1 (IDO1) for ubiquitination and degradation by recruiting IDO1 to the CRBN E3 ligase, thereby facilitating its entry into the...
T69944 NLG802 HCl
NLG802 is an orally bioavailable prodrug of indoximod, a methylated tryptophan, with immune checkpoint inhibitory and antineoplastic activities. Upon oral administration, the indoximod prodrug NLG802 is converted to indo...
T73581 HI5
HI5, a potent inhibitor of tubulin and indoleamine 2,3-dioxygenase (IDO), exhibits an inhibitory concentration (IC50) of 70 nM in HeLa cells. It suppresses IDO expression, reduces kynurenine production, and enhances T ce...
T36645 CAY10763 CAY10763
CAY10763 is a dual inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50= 46 nM) and STAT3 activation.1It binds to STAT3 (Kd= 530 nM) and selectively reduces the levels of STAT3 phosphorylated at the tyrosine in position...

Compounds

IDO-IN-12
T11615
Synonym:
Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)
IDO1-IN-5
T11901
Synonym:
Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)
IDO-IN-13
T11616
Synonym: GS-4361
Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)
GNF-PF-3777
T10199
Synonym: 8-Nitrotryptanthrin
Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)
BMS-986242
T9164
Synonym: BMS986242
Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)
IDO5L
T2647
Synonym: INCB024360 analogue,INCB14943
Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)
Linrodostat
T4532
Synonym: BMS-986205
Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)
PF-06840003
T4307
Synonym: EOS200271,PF 06840003
Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)
Navoximod
TQ0071
Synonym: GDC-0919,NLG-​919
Target: Indoleamine 2,3-Dioxygenase (IDO)
IDO-IN-1
T7181
Synonym:
Target: Indoleamine 2,3-Dioxygenase (IDO)
Epacadostat
T3548
Synonym: INCB 024360,IDO Inhibitor 1
Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)
Necrostatin-1
T1847
Synonym: Nec-1,Necrostatin 1
Target: Indoleamine 2,3-Dioxygenase (IDO), Ferroptosis, Autophagy, RIP kinase
IDO-IN-7
T1806
Synonym: NLG919,Navoximod,NLG-919 analogue,GDC-0919
Target: Indoleamine 2,3-Dioxygenase (IDO)
PCC0208009
T4142
Synonym: IDO inhibitor 1,DO-IN-2,IDO-IN-2
Target: Indoleamine 2,3-Dioxygenase (IDO)
Indoximod
T6543
Synonym: NLG-8189,Indoximod (NLG-8189）,1-Methyl-D-tryptophan
Target: Indoleamine 2,3-Dioxygenase (IDO)
NLG802
T39476
Synonym:
Target: Indoleamine 2,3-Dioxygenase (IDO)
IDO1-IN-1
T20513
Synonym: IDO1 inhibitor 1,2 HzBTZ,IDO1IN1,2-HzBTZ,IDO1-inhibitor-1
Target: IDO
IDO inhibitor 1
T7660
Synonym:
Target: Indoleamine 2,3-Dioxygenase (IDO)
2-(5,7-dichloro-1H-indol-3-yl)ethan-1-amine
T50089
Synonym:
Target: Others
TDO-IN-1
T61202
Synonym:
Target: Others
Navoximod phosphate
T70189
Synonym:
Target:
IDO-IN-9
T11622
Synonym:
Target: IDO
IDO-IN-3
T11617
Synonym:
Target: IDO
IDO-IN-8
T11621
Synonym: NLG-1487
Target: IDO
IDO-IN-6
T11620
Synonym: NLG-1486
Target: IDO
IDO-IN-4
T11618
Synonym:
Target: Others
NU223612
T74992
Synonym:
Target:
IDO-IN-5
T11619
Synonym: NLG-1489
Target: IDO
IDO-IN-11
T11614
Synonym:
Target: IDO
DP00477
T73437
Synonym:
Target:
Roxyl-9
T60698
Synonym:
Target:
IDO1-IN-23
T82082
Synonym:
Target: Indoleamine 2,3-Dioxygenase (IDO)
IDO/TDO-IN-1
T11623
Synonym:
Target: Others
IDO1-IN-7
T39888
Synonym: IDO1-IN-7
Target:
(Rac)-IDO1-IN-5
T12668
Synonym:
Target: Others
(Rac)-Indoximod
T60266
Synonym:
Target:
Imsamotide
T76560
Synonym:
Target:
IDO2-IN-1
T63814
Synonym:
Target:
PROTAC IDO1 Degrader-1
T37329
Synonym: PROTAC IDO1 Degrader-1
Target:
NLG802 HCl
T69944
Synonym:
Target:
HI5
T73581
Synonym:
Target:
CAY10763
T36645
Synonym: CAY10763
Target:
カタログ番号 製品名 別名 ターゲット
T4S0051 Coptisine sulfate Indoleamine 2,3-Dioxygenase (IDO)
1. Coptisine sulfate has growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program.
T3S1967 (S)-Indoximod N-ME-Tryptophan,Abrine,L-Abrine Others , Indoleamine 2,3-Dioxygenase (IDO)
(S)-Indoximod (L-Abrine) exhibits inhibition of rabbit small intestine indoleamine 2, 3-dioxygenase, competitive inhibition of IDO, reduction of Foxp3 protein expression in tumor of C57BL/6 mouse allografted with mouse L...
T5S0053 Coptisine Coptisin Indoleamine 2,3-Dioxygenase (IDO)
1. Coptisine (Coptisin) treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myocardial I/R likely through suppressing myocardial ...
T2718 Palmatine chloride Others , Indoleamine 2,3-Dioxygenase (IDO) , Aurora Kinase
Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.
T5S0802 Palmatine Berbericinine,Burasaine Indoleamine 2,3-Dioxygenase (IDO) , AChR , AChE , Aurora Kinase
1. Palmatine (Burasaine) is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has been used in the treatment of jaundice, dysentery,...
T5S0056 Coptisine chloride Q-100696,NSC-119754 Indoleamine 2,3-Dioxygenase (IDO) , Influenza Virus , Antibacterial
1. Coptisine chloride (NSC-119754) can be absorbed across intestinal epithelial cells, and completely absorbed compounds.
T8214 Kushenol E Flemiphilippinin D IDO , Indoleamine 2,3-Dioxygenase (IDO)
Kushenol E (Flemiphilippinin D) is a class of flavonoids isolated from Sophora flavescens. It is a non-competitive IDO1 inhibitor (IC50: 7.7 μM, Ki: 9.5 μM), has anti-tumor activity.
T13515 5-Methoxytryptophol 2-(5-Methoxy-1H-indol-3-yl)ethanol,Methoxytryptophol Endogenous Metabolite
5-Methoxytryptophol (2-(5-Methoxy-1H-indol-3-yl)ethanol) is a pineal indoleamine derived from serotonin shown to be biologically active in a number of species.
T72508 Palmatine hydroxide
Palmatine hydroxide is an orally active, irreversible inhibitor of indoleamine 2,3-dioxygenase 1 (IDO-1), demonstrating IC50 values of 3 μM for HEK 293-hIDO-1 and 157μM for rhIDO-1. Additionally, it uncompetitively inhib...

天然物製品

Coptisine sulfate
T4S0051
Synonym:
Target: Indoleamine 2,3-Dioxygenase (IDO)
(S)-Indoximod
T3S1967
Synonym: N-ME-Tryptophan,Abrine,L-Abrine
Target: Others, Indoleamine 2,3-Dioxygenase (IDO)
Coptisine
T5S0053
Synonym: Coptisin
Target: Indoleamine 2,3-Dioxygenase (IDO)
Palmatine chloride
T2718
Synonym:
Target: Others, Indoleamine 2,3-Dioxygenase (IDO), Aurora Kinase
Palmatine
T5S0802
Synonym: Berbericinine,Burasaine
Target: Indoleamine 2,3-Dioxygenase (IDO), AChR, AChE, Aurora Kinase
Coptisine chloride
T5S0056
Synonym: Q-100696,NSC-119754
Target: Indoleamine 2,3-Dioxygenase (IDO), Influenza Virus, Antibacterial
Kushenol E
T8214
Synonym: Flemiphilippinin D
Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)
5-Methoxytryptophol
T13515
Synonym: 2-(5-Methoxy-1H-indol-3-yl)ethanol,Methoxytryptophol
Target: Endogenous Metabolite
Palmatine hydroxide
T72508
Synonym:
Target:

Recombinant Proteins

Species：
Human (3)
Mouse (1)
Expression System：
E. coli (4)
Tag：
C-His (1)
His (1)
N-His (1)
Tag Free (1)
カタログ番号 製品名 Species Expression System
TMPY-02928 IDO Protein, Human, Recombinant Human E. coli
IDO Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 45.2 kDa and the accession number is A0A348GSI3.
TMPY-01821 IDO Protein, Human, Recombinant (His) Human E. coli
IDO Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 46 kDa and the accession number is P14902-1.
TMPY-06772 IDO Protein, Mouse, Recombinant (His) Mouse E. coli
IDO Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 46.47 kDa and the accession number is P28776.
TMPY-02803 IDO2 Protein, Human, Recombinant (His) Human E. coli
IDO2 belongs to the indoleamine 2,3-dioxygenase family. Indoleamine 2,3-dioxgyenase (IDO), is a cytosolic haem protein which, together with the hepatic enzyme tryptophan 2,3-dioxygenase, catalyzes the conversion of trypt...
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