|
T7318 |
Elimusertib
|
BAY-1895344 |
ATM/ATR
|
|
Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the target... |
|
T60026 |
KIF18A-IN-2
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|
Microtubule Associated
|
|
KIF18A-IN-2 is an inhibitor of mitotic kinesin Kif18A with IC50 of 28 nM and can be used in studies about chromosomal instability-associated vulnerabilities. |
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T8856 |
Ascorbyl Propyl Hyaluronate
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|
Others
|
|
Ascorbyl propyl hyaluronate is a perfect combination of hyaluronic acid and vitamin C, to overcome the instability of vitamin C, is to improve wrinkles, moisturize, calm the skin, whitening quality raw materials. |
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T60536 |
Terodiline
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|
Calcium Channel
,
HER
,
AChR
|
|
Terodiline is a seconal amine with anticholinergic and calcium antagonistic properties that blocks the hERG current (IC50: 375 nM).Terodiline is cardiotoxic and has been used in the study of disorders caused by urethral ... |
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T13884 |
Shield-1
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|
Others
|
|
Shield-1 is a specific, high-affinity and cell-permeant ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused protein... |
|
T3353 |
Niraparib hydrochloride
|
MK-4827 hydrochloride,MK-4827 (hydrochloride) |
Apoptosis
,
Others
,
PARP
|
|
Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Niraparib hydrochloride inhibits PARP activity, enhancing the accumulation of... |
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T9497 |
Niraparib tosylate monohyrate
|
|
PARP
|
|
Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting... |
|
T61305 |
LasR-IN-3
|
|
|
|
LasR-IN-3, a chemical compound, acts as an inhibitor of LasR in Pseudomonas aeruginosa. It induces structural instability in LasR and causes complete dissociation of its functioning dimeric form [1]. |
|
T9126 |
PIP-199
|
|
|
|
PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC 50 of 36 μM. PIP-199 can be used for the study of the mechanisms underlying DNA crosslink repair... |
|
T71483 |
Streptonigrin (racemate)
|
|
|
|
Streptonigrin is an aminoquinone antitumor and antibacterial antibiotic produced by Streptomyces flocculus. Streptonigrin inhibits β-Catenin/Tcf signaling and shows cytotoxicity in β-catenin-activated cells. Streptonigri... |
|
T68344 |
AGG-523
|
|
|
|
AGG-523 is an aggrecanase specific inhibitor that has been shown to attenuate increases in synovial fluid ARG-aggrecan levels following surgically-induced joint instability in the rat MT model. Pharmacologic inhibition o... |
|
T61471 |
Antitubercular agent-13
|
|
|
|
Antitubercular agent-13 (Compound 3d) is an antitubercular agent with MIC values of 0.007 μg/mL and 1.851 μg/mL against MTB H37Rv and MDR-MTB 16833, respectively. Antitubercular agent-13 shows metabolic instability [1]. |
|
T28293 |
Pamiparib maleate
|
BGB290,BGB 290,BGB-29 maleat 0 |
|
|
Pamiparib is a highly potent and selective PARP inhibitor. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the acc... |
|
T70115 |
Pamiparib hydrate
|
|
|
|
Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of sin... |
