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阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T72306	Mycobacterial Zmp1-IN-1
	Mycobacterial Zmp1-IN-1, a zinc metalloprotease-1 (Zmp1) inhibitor, demonstrates dose-dependent anti-mycobacterial activity against Mtb H37Ra, making it suitable for tuberculosis (TB) research.
T16339	Norverapamil hydrochloride	(±)-Norverapamil hydrochloride,D591 hydrochloride	Calcium Channel , P-gp , Drug Metabolite
	Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.		Calcium Channel , P-gp , Drug Metabolite
T60073	Antimycobacterial agent-4	4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide	Antibacterial
	Antimycobacterial agent-4 (4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide) has antibacterial activity against Mycobacterium tuberculosis.		Antibacterial
T63420	Antimycobacterial agent-2
	Antimycobacterial agent-2 is an effective anti-mycobacterial agent with a MIC99 of 0.8 μM against Mycobacterium tuberculosis (M.tb) H37Rv. Antimycobacterial agent-2 is cytotoxic, acting on CHO cells (IC50: 48.1 μM).
T61853	Antimycobacterial agent-1
	Antimycobacterial agent-1 (compound 33) demonstrates potent antimycobacterial activity against Mycobacterium tuberculosis H37Ra, with a minimal inhibitory concentration (MIC) value of 1 μg/ml. Notably, antimycobacterial ...
T79281	Antimycobacterial agent-6
	Antimycobacterial agent-6 (compound 25) effectively inhibits Mycobacterium tuberculosis, including wild-type and fluoroquinolone-resistant strains, by targeting the Mtb DprE1-C387S mutant. It displays minimal inhibitory ...
T63865	Antimycobacterial agent-3
	Antimycobacterial agent-3 is an antimycobacterial agent with low cytotoxicity. antimycobacterial agent-3 is effective against sensitive MTB strain H37Rv and resistant clinical isolates (MIC < 0.029-0.110 μ M).
T12231	NITD-349		Others , Antibacterial
	NITD-349 is an inhibitor of MmpL3. It shows highly potent anti-mycobacterial activity with MIC50 of 23 nM against virulent Mycobacterium tuberculosis H37Rv.		Others , Antibacterial
T78748	MtUng-IN-1		Antibacterial
	MtUng-IN-1 (Compound 18a) inhibits mycobacterial uracil DNA glycosylase (MtUng) with an IC50 value of 300 μM. MtUng-IN-1 is suitable for use in cancer and infectious disease research.		Antibacterial
T8411	C-215		Others
	C-215 is a novel inhibitor of mycobacterial membrane protein large 3 (MmpL3).		Others
T0377	Clofazimine	NSC-141046	DNA , Antibacterial , Antibiotic
	Clofazimine (NSC-141046) is a phenazine dye with anti-mycobacterial and anti-inflammatory activities. Clofazimine has a slow bactericidal effect on Mycobacterium leprae and is active against various other Mycobacteria.		DNA , Antibacterial , Antibiotic
T2585	Bedaquiline	R207910,TMC207	Antibacterial , Antibiotic
	Bedaquiline (R207910)(TMC207; R207910) is an anti-tuberculosis drug which selectively inhibit the mycobacterial energy metabolism i.e. ATP synthesis and found to be effective against all states of Mycobacterium tuberculo...		Antibacterial , Antibiotic
T29249	(+)-Xylariamide A	Xylariamide-A,ent Xylariamide A,ent-Xylariamide A,Xylariamide A
	(+)-Xylariamide A is a probe used for mycobacterial and fungal carbonic anhydrase.
T10563	BM635		Others
	BM635 is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).		Others
T61676	4-Piperidinecarboxamide
	4-Piperidinecarboxamide is a mycobacterial aspartyl-tRNA synthetase (AspS) inhibitor and a potential anti-tuberculosis (TB) agent [1].
T10887	CRS400393		Antibacterial
	CRS400393 is an effective anti-mycobacterial drug , with MIC of 0.03, 2, and ≤ 0.12 µg/mL against M. abs., M. avium, M. intracellulare, and M. tuberculosis, respectively.		Antibacterial
T10563L2	BM635 mesylate (1493762-74-5 free base)	BM635 mesylate	Others
	BM635 mesylate is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).		Others
T61149	Antibacterial agent 121
	Antibacterial agent 121 (Compound 10) demonstrates antibacterial properties and exhibits efficacy against mycobacterial strains while also possessing anti-inflammatory activity. This compound finds potential applications...
T10563L	BM635 hydrochloride (1493762-74-5 free base)	BM635 hydrochloride	Others
	BM635 hydrochloride is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).		Others
T36357	Dimethyldioctadecylammonium (bromide)
	Dimethyldioctadecylammonium (DDA) is a cationic amphipathic lipid. DDA liposomes containing an Ag85B-ESAT-6 antigen induce antigen deposition at an intramuscular or subcutaneous injection site in mice, increasing immune ...
T10992	Delamanid D4	OPC-67683 D4	Others
	Delamanid D4 is deuterium-labeled Delamanid. Delamanid is a newer mycobacterial cell wall synthesis inhibitor that inhibits the synthesis of mucus acid.		Others
T61772	PknB-IN-1
	PknB-IN-1 (Compound 2) is an inhibitor of protein kinase B (PknB) with a concentration causing 50% inhibition (IC50) of 14.4 μM. This compound demonstrates anti-mycobacterial activity by effectively suppressing the growt...
T60690	Antibacterial agent 122
	Antibacterial agent 122 (compound 15) is a thiourea derivative that can be used in the studies of tuberculosis. Antibacterial agent 122 shows low cytotoxicity as well as anti-mycobacterial activity [1].
T61303	MmpL3-IN-1
	MmpL3-IN-1, also known as compound 32, is a highly effective inhibitor of Mycobacterial membrane protein large 3 (MmpL3). With an anti-tuberculosis activity exhibiting a minimum inhibitory concentration (MIC) of less tha...
T61665	Antibacterial agent 118
	Antibacterial agent 118 (also known as compound 20) is a potent antimycobacterial compound with activity against various mycobacterial strains, including Mtb H37Ra, M. aurum, M. smegmatis, Mtb H37Rv, and M. avium. The mi...
T61143	Antitubercular agent-18
	Antitubercular agent-18 (Compound 9a) is an antitubercular agent that exhibits highly selective antimycobacterial effects, with minimum inhibitory concentration (MIC) values of 2 μg/ml against M. tuberculosis H37Rv, Spec...
T79441	DprE1-IN-6
	DprE1-IN-6 (Compound 56) is a DprE1 inhibitor with demonstrated anti-TB activity, exhibiting a minimum inhibitory concentration (MIC) of 1 μM against the Mtb H37Rv strain, along with efficacy against drug-resistant mycob...
T63786	WX-081
	WX-081 is an anti-tuberculosis agent that exhibits significant anti-mycobacterial effects against M. tuberculosisH37Rv and is able to act on drug-susceptible (DS-TB) mycobacteria (MIC: 0.083 μg/ml) and multidrug-resistan...
T73986	ONX-0914 TFA
	ONX-0914 (PR-957) TFA is a selective, noncompetitive, irreversible inhibitor targeting the chymotrypsin-like subunit (LMP7) of the immunoproteasome, effectively blocking cytokine production and mitigating the progression...

Compounds

Mycobacterial Zmp1-IN-1

T72306

Synonym:

Target:

Norverapamil hydrochloride

T16339

Synonym: (±)-Norverapamil hydrochloride,D591 hydrochloride

Target: Calcium Channel, P-gp, Drug Metabolite

Antimycobacterial agent-4

T60073

Synonym: 4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide

Target: Antibacterial

Antimycobacterial agent-2

T63420

Synonym:

Target:

Antimycobacterial agent-1

T61853

Synonym:

Target:

Antimycobacterial agent-6

T79281

Synonym:

Target:

Antimycobacterial agent-3

Target: Others, Antibacterial

MtUng-IN-1

T78748

Synonym:

Target: Antibacterial

Target: DNA, Antibacterial, Antibiotic

Bedaquiline

T2585

Synonym: R207910,TMC207

Target: Antibacterial, Antibiotic

(+)-Xylariamide A

T29249

Synonym: Xylariamide-A,ent Xylariamide A,ent-Xylariamide A,Xylariamide A

4-Piperidinecarboxamide

Target: Antibacterial

BM635 mesylate (1493762-74-5 free base)

T10563L2

Synonym: BM635 mesylate

Target: Others

Antibacterial agent 121

T61149

Synonym:

Target:

BM635 hydrochloride (1493762-74-5 free base)

T10563L

Synonym: BM635 hydrochloride

Target: Others

Dimethyldioctadecylammonium (bromide)

Synonym: OPC-67683 D4

Antibacterial agent 122

Antibacterial agent 118

T61665

Synonym:

Target:

Antitubercular agent-18

カタログ番号	製品名	別名	ターゲット
TN1040	Skullcapflavone II		COX , Antibacterial , TGF-beta/Smad
	Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy. Skullcapflavone II may have therapeutic potential for the treatment of al...		COX , Antibacterial , TGF-beta/Smad
T10662L	Calcimycin	Antibiotic A-23187,A-23187	Apoptosis , Antibacterial , Antibiotic , Autophagy , Antifungal

T4S1545	Licarin B	(-)-Licarin B,Licarine B	transporter , Antibacterial , PPAR
	1.(-)-Licarin B (Licarine B) has anti-mycobacterial activity.		transporter , Antibacterial , PPAR
T8229	5,7,3',4'-Tetramethoxyflavone		Antibacterial , Parasite , Antifungal
	5,7,3',4'-Tetramethoxyflavone (TMF), a prominent polymethoxyflavone (PMF) derived from M. exotica, displays a range of notable bioactivities. These include anti-malarial, anti-fungal, anti-mycobacterial, and anti-inflamm...		Antibacterial , Parasite , Antifungal
TN1594	DL-Syringaresinol	(±)-Syringaresinol	Antioxidant , Antifungal
	DL-Syringaresinol ( (±)-Syringaresinol) is a lignan from ginseng berries with anti-inflammatory, antioxidant, analgesic and weak anti-mycobacterial activities.DL-Syringaresinol can delay oxidative stress-induced skin agi...		Antioxidant , Antifungal
TN3691	Communic acid		MMP , MAPK , Akt , PI3K , DNA/RNA Synthesis , Antifection
	Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic ingredients, as they suppress UVB-induced MMP-1 expression...		MMP , MAPK , Akt , PI3K , DNA/RNA Synthesis , Antifection
TN1556	Decarine		Antifection
	Decarine has high antibacterial activity against mycobacterial, gram-positive and gram-negative bacteria, and low cytotoxicity towards human macrophages.Decarine inhibits fMLP/CB-induced elastase release with IC(50) valu...		Antifection
T72742	(-)-Pinocembrin
	(-)-Pinocembrin demonstrates anti-mycobacterial activity against Mycobacterium tuberculosis H37Ra, presenting IC 50 values of 1.11 mg/mL in the dormant phase and 1.21 mg/mL in the active phase. Additionally, this compoun...

天然物製品

Skullcapflavone II

TN1040

Synonym:

Target: COX, Antibacterial, TGF-beta/Smad

Calcimycin

T10662L

Synonym: Antibiotic A-23187,A-23187

Target: Apoptosis, Antibacterial, Antibiotic, Autophagy, Antifungal

Licarin B

T4S1545

Synonym: (-)-Licarin B,Licarine B

Target: transporter, Antibacterial, PPAR

5,7,3',4'-Tetramethoxyflavone

T8229

Synonym:

Target: Antibacterial, Parasite, Antifungal

DL-Syringaresinol

TN1594

Synonym: (±)-Syringaresinol

Target: Antioxidant, Antifungal

Communic acid

TN3691

Synonym:

Target: MMP, MAPK, Akt, PI3K, DNA/RNA Synthesis, Antifection

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-01701	IL-12RB1 Protein, Human, Recombinant (His)	Human	HEK293
	Interleukin 12 receptor, beta 1 is also known as IL-12 receptor beta component, IL-12R subunit beta-1, and CD212 antigen (CD212). IL12RB1(CD212) is a subunit of the interleukin 12 receptor. IL12RB1(CD212) is a type I tra...
TMPH-03008	ENR Protein, Mycobacterium tuberculosis, Recombinant (His)	Mycobacterium tuberculosis	E. coli
	Enoyl-ACP reductase of the type II fatty acid syntase (FAS-II) system, which is involved in the biosynthesis of mycolic acids, a major component of mycobacterial cell walls. Catalyzes the NADH-dependent reduction of the ...
TMPY-02122	IFNGR2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Interferon-gamma receptor beta chain (IFNgammaR2), also known as IFNGR2, belongs to the type II cytokine receptor family, whose deficiency is a cause of autosomal recessive mendelian susceptibility to mycobacterial disea...
TMPY-04013	Dectin-1 Protein, Human, Recombinant	Human	HEK293
	Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system...
TMPY-00016	Dectin-1 Protein, Human, Recombinant (mFc)	Human	HEK293
	Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system...
TMPY-01387	Dectin-1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system...
TMPY-06662	IL-12RB1 Protein, Human, Recombinant	Human	HEK293
	Interleukin 12 receptor, beta 1 is also known as IL-12 receptor beta component, IL-12R subunit beta-1, and CD212 antigen (CD212). IL12RB1(CD212) is a subunit of the interleukin 12 receptor. IL12RB1(CD212) is a type I tra...
TMPY-06427	IL-12RB1 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Interleukin 12 receptor, beta 1 is also known as IL-12 receptor beta component, IL-12R subunit beta-1, and CD212 antigen (CD212). IL12RB1(CD212) is a subunit of the interleukin 12 receptor. IL12RB1(CD212) is a type I tra...
TMPY-03726	Dectin-1 Protein, Human, Recombinant (hFc)	Human	HEK293
	Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system...
TMPH-01792	RORC Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunit...