|
T12670 |
(Rac)-MGV354
|
MGV354 |
Others
|
|
(Rac)-MGV354 (MGV354) is the racemate of MGV354. MGV354 is a soluble activator of guanylate cyclase (sGC)(EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively). |
|
T6424 |
Bromfenac Sodium
|
AHR 10282B,Bronuck,AHR 10282R |
COX
|
|
Bromfenac Sodium (AHR 10282R) is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2. |
|
T2403 |
Bromfenac sodium hydrate
|
Bromfenac sodium,Bromfenac monosodium salt sesquihydrate |
COX
|
|
Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophthalmic admi... |
|
T26923 |
Bunazosin Hydrochloride
|
E 1015,E643,E-1015,E-643,E 643 |
Adrenergic Receptor
|
|
Bunazosin Hydrochloride (E 1015) is an alpha(1)-adrenoceptor antagonist used as a systemic antihypertensive and an ocular hypotensive drug. |
|
T20157 |
Brimonidine
|
AGN190342,Bromoxidine,AGN 190342,AGN-190342 |
Adrenergic Receptor
|
|
Brimonidine (Bromoxidine) is a drug used as eye drops under the brand names Alphagan and Alphagan-P. It is used to treat open-angle glaucoma or ocular hypertension |
|
T68120L |
Ot-730 HCl
|
Ot-730 HCl(870809-51-1 Free base) |
Others
|
|
ot-730 HCl is a novel selective beta blocker prodrug for the study of ocular diseases. |
|
T6472 |
Difluprednate
|
Myser,Epitopic,CM 9155 |
Others
|
|
Difluprednate (Myser)(Durezol) is a corticosteroid, approved for the treatment of post-operative ocular inflammation and pain. |
|
T6422 |
Brimonidine Tartrate
|
AGN190342 tartrate,304 tartrate,AGN190342 (tartrate),UK 14304 (tartrate),UK14304 tartrate |
Adrenergic Receptor
|
|
Brimonidine Tartrate (AGN190342 tartrate) is a quinoxaline derivative and adrenergic α-2 receptor agonist (EC50: 0.45 nM) that is used to manage intraocular pressure associated with open-angle glaucoma or ocular hyperten... |
|
T2538 |
Bimatoprost
|
AGN 192024 |
Prostaglandin Receptor
|
|
Bimatoprost (AGN 192024) is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertension. |
|
T2528 |
Latanoprost
|
Xalatan,PHXA41 |
GPR
,
Prostaglandin Receptor
,
RAR/RXR
|
|
Latanoprost (Xalatan) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. |
|
T3174 |
Taprenepag
|
CP-544326 |
Prostaglandin Receptor
|
|
Taprenepag (CP-544326) (CP-544326) is a potent and selective prostaglandin E2 receptor agonist (EC50 = 2.8 nM). Taprenepag has been used in trials studying the treatment of Ocular Hypertension and Glaucoma, Open-Angle. |
|
T5841 |
Travoprost
|
Flu-Ipr,Fluprostenol isopropyl ester,AL6221 |
Prostaglandin Receptor
|
|
Travoprost (Fluprostenol isopropyl ester) is used to treat glaucoma and ocular hypertension,is a potent and selective FP prostaglandin receptor agonist. |
|
T7423 |
Diquafosol tetrasodium
|
INS365 |
P2Y Receptor
|
|
Diquafosol Tetrasodium is a P2Y2 receptor agonist that stimulates the secretion of mucins from ocular tissues Diquafosol tetrasodium (INS365) improves tear film stability and visual function, as a topical treatment of dr... |
|
T0397 |
Tetrahydrozoline
|
Tetryzolin,Tetryzoline |
Adrenergic Receptor
|
|
Tetrahydrozoline (Tetryzoline), an alpha agonist, have an effect on the constriction of conjunctival blood vessels. This contributes to relieve the redness of the eye resulted from minor ocular irritants. |
|
T15719 |
Latanoprostene bunod
|
LBN,NCX116 |
Others
|
|
Latanoprostene bunod (LBN) is nitric oxide (NO)-donating prostaglandin F2a analog and is a topical ophthalmic therapeutic. It is used for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma o... |
|
T77194L |
D-Ribose 5-phosphate disodium dihydrate
|
|
Endogenous Metabolite
|
|
D-Ribose 5-phosphate disodium dihydrate participates in the pentose phosphate pathway and is an intermediate in the pentose phosphate pathway, and is used in studies of ocular diseases and endocrine and metabolic disorde... |
|
T73400L |
PG-11047 2HCl
|
PG-11047 2HCl(949933-50-0 Free base),CGC-11047 2HCl |
Apoptosis
|
|
PG-11047 2HCl is an apoptosis-stimulating agent used in the treatment of genitourinary disorders, immune system disorders, genetic disorders and malformations, ocular disorders, and disorders of the blood and lymphatic s... |
|
T77600 |
Methyl-4-oxoretinoate
|
|
Apoptosis
|
|
Methyl-4-oxoretinoate is a synthetic retinoid compound with anticancer compounds that can induce differentiation and apoptosis in cancer cells.Methyl-4-oxoretinoate is used in the treatment of acne, psoriasis, and other ... |
|
T1281 |
Tropicamide
|
Ro 1-7683 |
AChR
|
|
Tropicamide (Ro 1-7683) is a synthetic muscarinic antagonist with actions similar to atropine and with an anticholinergic property. Upon ocular administration, tropicamide binds to and blocks the muscarinic receptors in ... |
|
T3979 |
Emedastine
|
LY188695,Emadine |
Histamine Receptor
|
|
Emedastine (LY188695) is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its... |
|
T34644 |
Simenepag isopropyl
|
AGN210669,AGN-210669,AGN 210669 |
Others
|
|
Simenepag isopropyl can be used for the treatment of Glaucoma, Ocular Hypertension. |
|
T26586 |
AL-37350A
|
|
Others
|
|
AL-37350A is a 5-HT2 receptor-selective agonist with ocular hypotensive activity. |
|
T32458 |
L 653328
|
L 653,328,L653328,L653,328,L-653,328,L-653328 |
Others
|
|
L 653328 is an ocular hypotensive agent that has modest beta-receptor blocking activity. |
|
T10001 |
(E)-Alprenoxime
|
CDDD-1815 |
Others
|
|
(E)-Alprenoxime is the isomer of the Alprenoxime which is a site-activated ocular β-blocker. |
|
T11294 |
Flavanone hydrazone
|
|
Others
|
|
Flavanone hydrazine is a potent non-steroidal anti-inflammatory agent that effectively inhibits lens protein-induced ocular inflammation. |
|
T27739 |
KR-31378
|
MSH1001,DNB 001,DNB-001,DNB001,MSH-1001,KR31378 |
Others
|
|
KR-31378, a K(ATP) channel activator, is used potentially for the treatment of ocular hypertension and glaucoma. |
|
T31054 |
CP-432
|
CP432,CP734432,CP 734432,CP-734432 |
Others
|
|
CP-432 (CP-734432) is an EP4 prostaglandin agonist for the treatment of glaucoma and ocular hypertension. |
|
T29749 |
AHR-16329
|
AHR16329 |
Others
|
|
AHR-16329 can be used in ocular pharmacology. |
|
T13955 |
Unoprostone
|
|
Others
|
|
Unoprostone is a prostaglandin F2α analogs (PGAs), and reduces intraocular pressure and is used topically for glaucoma or ocular hypertension. |
|
T20644 |
Unoprostone isopropyl
|
UF021,Rescula,UF-021,UF 021 |
Others
|
|
Unoprostone isopropyl, a prostanoid and synthetic docosanoid, is approved for the treatment of ocular hypertension and open-angle glaucoma. |
|
T29811 |
AL-16049
|
AL 16049,AL16049 |
Others
|
|
AL-16049 is an FP-Class prostaglandin analog which may be useful in the treatment of glaucoma and ocular hypertension. |
|
T68269 |
Aminozolamide
|
|
Others
|
|
Aminozolamide is a carbonic anhydrase inhibitor that may be useful in the treatment of ocular hypertension. |
|
T0446L |
Naphazoline nitrate
|
Benil,Sanorin Spofa,Rhinon,Rinazina,Clera |
Others
|
|
Naphazoline nitrate is an α1-Adrenergic receptor agonist. It also induces autophagy and necrotic cell death in erythroleukemia cells and inhibits erythroid differentiation. It used to treat congestion and ocular patholog... |
|
T19682 |
Levobetaxolol
|
(S)-(-)-Betaxolol,(S)-Betaxolol |
Others
|
|
Levobetaxolol, also known as AL-1577A and Betaxon, is a cardioselective β-adrenergic receptor inhibitor. It has been demonstrated to reduce intraocular pressure in patients affected by ocular hypertension and primary ope... |
|
T21388 |
Emedastine Difumarate
|
Rapimine,DSSTox_CID_26911,AL-3432A,KB-2413,Emedastine fumarate,KB 2413 |
Others
|
|
Emedastine Difumarate is a selective histamine H1 receptor antagonist with anti-allergic activity, prescribed for allergic conjunctivitis. Upon ocular administration, emedastine causes a dose-dependent inhibition of hist... |
|
T28487 |
Quininib
|
|
Others
|
|
Quininib is a regulator of Ocular Angiogenesis. Quininib significantly inhibits angiogenic tubule formation in HMEC-1 cells, angiogenic sprouting in aortic ring explants and retinal revascularisation in OIR mice. |
|
T70346 |
TOP1362
|
|
Others
|
|
TOP1362 is a Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders. TOP1362 strongly inhibited the kinase targets p38α, Syk, Src, and Lck, bloc... |
|
T83169 |
Adenylyl cyclase-IN-1
|
|
Others
|
|
Adenylyl cyclase-IN-1 is a potential adenylyl cyclase inhibitor for ocular hypotonia research [1]. |
|
T36908 |
Bimatoprost grenod
|
15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α |
Others
|
|
Bimatoprost grenod(15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2α) is a nitric oxide-donating derivative of 17-phenyl trinor PGF2α.1It increases cGMP levels in rabbit aqueous humor and iris ciliary body when topically adm... |
|
T75084 |
Foslevcromakalim
|
|
Others
|
|
Foslevcromakalim (QLS-101), an ATP-sensitive potassium channel opener, serves as a proagent for ocular hypotensive effects [1] [2]. |
|
T37813 |
Fluprostenol methyl ester
|
|
Others
|
|
Fluprostenol is an F-series prostaglandin analog which has been approved for many years as a luteolytic in veterinary animals. The isopropyl ester of fluprostenol (travoprost) is an effective ocular hypotensive drug. CAY... |
|
T84569 |
Thromboxane B3
|
Δ17-TXB2 |
Others
|
|
Thromboxane B3 (TXB3), the stable hydrolysis product of TXA3, is synthesized from eicosapentaenoic acid (EPA) through the action of COX and thromboxane synthase enzymes. This compound is biosynthesized in several tissues... |
|
T9819 |
Bunazosin
|
|
Others
|
|
Bunazosin is a potent and selective α1-adrenoceptor antagonist that can be used for antihypertensive and ocular hypotensive research [1]. |
|
T69357 |
AL-34662
|
|
Others
|
|
AL-34662 is a serotonin-2 receptor agonist with antihypertensive action. AL-34662 has a high-affinity for the 5-HT2 receptor and may potentially lead mobilization of [Ca2+]i in h-CM and h-TM cells leading to a decrease ... |
|
T84652 |
Prostaglandin F2α ethyl amide
|
Dinoprost ethyl amide |
Others
|
|
Prostaglandin F2αethyl amide (PGF2α-NEt), a PGF2α analog featuring an N-ethyl amide modification at the C-1 carboxyl group, possesses ocular hypotensive activity similar to PG esters. Introduced as alternative prostaglan... |
|
T29725 |
AGN-191129
|
AGN191129,Prostaglandin F2α alcohol methyl ether,PGF2α-OMe,UNII-NK1168QB5T |
Others
|
|
AGN-191129, also known as Prostaglandin F2α alcohol methyl ether (PGF2α-OMe), is an analog of PGF2α in which the C-1 carboxyl group has been replaced by an O-methyl ether. The compound is reported to retain ocular hypote... |
|
T79080 |
ROCK-IN-7
|
|
ROCK
|
|
ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1]. |
|
T71988 |
Moxaverine hydrochloride
|
|
Others
|
|
Moxaverine hydrochloride is a derivative of papaverine, a phosphodiesterase inhibitor. Moxaverine has been studied in phase III of a clinical trial for the treatment of ocular blood flow in patients with age- related mac... |
|
T64299 |
Valacyclovir hydrochloride hydrate
|
|
Others
|
|
Valacyclovir hydrochloride hydrate is a potent antiviral agent, a prodrug that is rapidly converted to acyclovir in vivo. valacyclovir hydrochloride hydrate can be used to formulate ocular inserts for the treatment of oc... |
|
T73250 |
JAK-IN-17
|
|
Others
|
|
JAK-IN-17 is a potent inhibitor of JAK . JAK-IN-17 is useful for the research of multiple diseases, particularly ocular, skin, and respiratory diseases. |
