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T9685 |
DS-1971a
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Sodium Channel
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DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects. |
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T23498 |
UNC3230
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UNC 3230 |
Others
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UNC3230 is a potent, selective and ATP-competitive PIP5K1C inhibitor with an IC50 of ~41 nM. UNC3230(UNC 3230) also inhibits PIP4K2C. |
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T3146 |
BMS-202
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PD1-PDL1 inhibitor 2,PD-1/PD-L1 inhibitor 2 |
Apoptosis
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PD-1/PD-L1
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BMS-202 (PD1-PDL1 inhibitor 2) is an inhibitor of the PD-1 (Programmed death- 1) /PD-Ll (Programmed death-ligand 1) protein/protein interaction. |
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T22447 |
Tri-Salicylic Acid
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Others
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Tri-Salicylic Acid, a product of the thermal decomposition of aspirin, is a compound for proteomics research. |
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T28973 |
TIBI
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Others
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TIBI is an ATP-competitive Rio1 inhibitor that acts in a similar manner to fungamycin and enhances the thermal stability of the enzyme. |
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T15192 |
Eact
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Chloride channel
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Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception and thermal hypersensitivity. |
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T21380 |
Pravadoline
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WIN 48098-6,WIN48098-6,WIN-48098-6 |
Cannabinoid Receptor
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Pravadoline (WIN48098-6) is a cannabinoid receptor agonist. Pravadoline inhibited the PGs synthesis in mouse brain and displayed antinociceptive activity in rodents subjected to a variety of thermal, chemical, and mechan... |
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T7363 |
Ibuprofen Piconol
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U75630 |
Others
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Ibuprofen Piconol (U75630) is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns.Ibuprofen piconol is a Pyridyl ester of ibuprofen. |
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T12632 |
(R)-Mirtazapine
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(R)-Org3770,(R)-6-Azamianserin |
5-HT Receptor
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(R)-Mirtazapine ((R)-Org3770) is the R(-)-enantiomer of Mirtazapine, which has anti-injury sensory properties in an animal model of acute thermal hyperalgesia. (R)-Mirtazapine is an antagonist of 5-HT3 receptors and a po... |
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T65641 |
TAPS
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Others
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TAPS, a biochemical buffer, safeguards the integrity of lysozyme structures against thermal denaturation at high temperatures. At a pKa of 8.1, TAPS achieves half-maximal activity of conjugated protein channels. |
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T19820 |
MOPS sodium salt
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MOPS-Na,3-(N-morpholino)propanesulfonic acid sodium salt,Sodium 3-Morpholinopropanesulfonate,4-Morpholinepropanesulfonic acid, sodium salt |
Others
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MOPS sodium salt (MOPS-Na) is a novel stabilizer maintaining the pH of mammalian cell culture media. It used as a buffer for the native structure of BSA against thermal denaturation.MOPS sodium salt(3-(N-morpholino)propa... |
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T14198 |
ALX-1393
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GlyT
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ALX-1393 is a selective GlyT2 inhibitor that effectively reduces neuronal action potential activity in a concentration-dependent manner and inhibits the activity of spontaneous networks by inducing glycinergic tetanic cu... |
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T37610 |
AT-121
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Opioid Receptor
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AT-121 is a dual μ-opioid and neuropeptide receptor partial agonist (Kis 16.49 and 3.67 nM, respectively). It stimulates [35S]GTPγS binding to cell membranes expressing either μ-opioid receptors or neuropeptide receptors... |
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T23642L |
ADR-851 HCl
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Adr-851,Adr 851,Adr851 |
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ADR-851 HCl is an HT3 receptor antagonist. It works against mechanical, acute thermal, and formalin-induced inflammatory pain. |
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T39339 |
Ochratoxin α
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Ochratoxin α is a less toxic photolytic and thermal degradation product of Ochratoxin A. |
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T68409 |
SHP244
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SHP244 is an allosteric inhibitor of SHP2 with modest thermal stabilization of the enzyme. |
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T80501 |
Myr-TAT-CBD3
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Calcium Channel
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Myr-TAT-CBD3, a CRMP2-CaV2.2 interaction inhibitor, has been shown to significantly attenuate carrageenan-induced thermal hypersensitivity and reverse thermal hypersensitivity in a rat model of postoperative pain, making... |
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T38437 |
NMTCA
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N-Nitroso-2-methylthiazolidine4-carboxylicacid,NMTPRO,N-nitrosomethylthioproline |
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NMTCA (NMTPRO) is a sulfur-containing N-nitrosamino acid utilized as an endogenous nitrosation indicator in gas chromatography-thermal energy analysis. |
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T21393 |
Ethopropazine Hydrochloride
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Lysivane,Parphezein,Dibutil,Parfezin,Profenamine HCl,Pardisol |
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Ethoproprazine hydrochloride is an butyrylcholinesterase inhibitor. It reduces extrapyramidal motor effects and used as an antidyskinetic, characteristic of Parkinson′s disease. It also alleviates thermal hyperalgesia in... |
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T32217 |
Isomaltol
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Isomaltol is a natural furan obtained by the enzymatic degradation of starch used as also a flavor component in bread crust produced by thermal degradation of sugars. |
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T35788 |
Orlistat Degradation Product (sodium salt)
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Orlistat degradation product is a degradation product of the digestive lipase inhibitor orlistat . It is formed via hydrolytic and thermal degradation as well as digestion by human carboxyl ester lipase. |
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T60563 |
NLRP3/AIM2-IN-1
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NLRP3/AIM2-IN-1 is an inhibitor of thermal sepsis (IC50 = 3.136 ± 0.7667 μM). |
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T61858 |
HDAC8-IN-3
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HDAC8-IN-3 (compound P19) is a highly potent inhibitor of HDAC8, displaying an IC50 value of 9.3 μM and producing thermal stabilization. Moreover, HDAC8-IN-3 exhibits cytotoxicity and induces apoptosis specifically in le... |
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T37704 |
Olanzapine Lactam Impurity
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Olanzapine lactam impurity is a potential impurity found in commercial preparations of olanzapine.1It is a degradation product formed by exposure to thermal or oxidative stress.
1.Baertschi, S.W., Brunner, H., Bunnell, C... |
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T19386 |
ITIC
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CXCR
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ITIC, a non-fullerene acceptor, demonstrates exceptional thermal stability and exhibits a glass-crystal transition at a significantly lower temperature than its high glass transition temperature (Tg) of 180 °C. Furthermo... |
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T72098 |
Eleven-Nineteen-Leukemia Protein IN-3
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Epigenetic Reader Domain
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Eleven-Nineteen-Leukemia Protein IN-3, an orally active ENL YEATS domain inhibitor, exhibits potent activity with an IC50 of 15.4 nM. It downregulates MYC expression via ENL in cells and enhances ENL protein's thermal st... |
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T78457 |
Pyrromethene 597
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Pyrromethene 597, a BODIPY laser dye, exhibits a wide tuning range of lasing wavelengths along with high photostability, and can serve as a thermal probe [1] [2]. |
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T15167 |
Draflazine
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R-75231 |
Others
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Draflazine is an ENT1 inhibitor. It completely reverses the hypersensitivity in the complete Freund’s adjuvant (CFA) model of mechanical hyperalgesia. Draflazine also completely reverses the hypersensitivity of the carra... |
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T82470 |
Endokinin C
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Endokinin C, a peptide constituent of endokinin, functions as a neurotransmitter or modulator within the pain pathway. Pretreatment with this compound impedes the onset of scratching behavior and thermal hyperalgesia ind... |
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T72096 |
Eleven-Nineteen-Leukemia Protein IN-1
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Epigenetic Reader Domain
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Eleven-Nineteen-Leukemia Protein IN-1 is a potent inhibitor of the ENL YEATS domain, exhibiting an IC50 of 14.5 nM. It binds to the ENL protein, consequently increasing its thermal stability in vitro [1]. |
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T41148 |
Phototrexate
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Phototrexate is a photoswitchable potent inhibitor of human dihydrofolate reductase (DHFR). Phototrexate is a photochromic analog of Methotrexate. Antifolate activity is switched on (cis-Phototrexate) by UVA (375 nm) lig... |
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T78354 |
Subtilisin
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EC 3.4.21.14 |
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Subtilisin, also known as rubinase, is a serine protease of bacterial origin. This enzyme exhibits thermal stability, pH tolerance, and calcium-dependent stability, characteristics that make it suitable for use as an add... |
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T82451 |
Epsilon-polylysine
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ε-Polylysine,ε-PL |
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Epsilon-polylysine is a natural antimicrobial peptide synthesized by specific bacteria, commonly utilized as a preservative in food and beverage products to thwart the proliferation of a broad range of microorganisms, in... |
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T38193 |
β-Endorphin (1-27) (human) (trifluoroacetate salt)
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β-Endorphin (1-27) is an endogenous peptide that binds to μ-, δ-, and κ-opioid receptors (Kis = 5.31, 6.17, and 39.82 nM, respectively, in COS-1 cells expressing rat receptors). It binds to rat and mouse brain membrane p... |
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T61723 |
SS-RJW100
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SS-RJW100 is an enantiomer of RJW100, known as a racemic agonist that targets two nuclear receptors: liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1). In vitro experiments reveal that SS-RJW100 promotes... |
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T63549 |
MRGPRX1 agonist 4
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MRGPRX1 agonist 4 is a potent and orally active Mas-related G protein-coupled receptor X1 (MRGPRX1) positive conformation modulator (EC50: 0.1 μM). MRGPRX1 agonist 4 ameliorated the behavioral thermal allergic response i... |
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T80446 |
ω-Conotoxin FVIA
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Calcium Channel
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ω-Conotoxin FVIA is an inhibitor of N-type Ca²⁺ channels (Caᵥ2.2), shown to alleviate mechanical and thermal pain abnormalities in a rat model of caudal nerve injury. This compound has potential utility in the research o... |
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T82939 |
ATTO 425 NHS ester
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ATTO 425 NHS ester, a Rhodamine-structure-based fluorescent marker, exhibits strong absorption, high fluorescence quantum yield, and robust thermal and photochemical stability. This compound is ideal for applications in ... |
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T38147 |
(S)-AM1241
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(S)-AM1241 |
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(S)-AM1241 binds to cannabinoid (CB) receptors and is selective for the CB2 over the CB1 receptor (Kis = 658 and >10,000 nM, respectively, in a membrane assay using human receptors). (S)-1241 acts as an agonist at human,... |
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T38030 |
(R)-AM1241
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(R)-AM1241 |
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(R)-AM1241 binds to cannabinoid (CB) receptors and has greater than 100-fold selectivity for the CB2 over the CB1 receptor (Kis = 15 and 5,000 nM, respectively, in a membrane assay using human receptors). (R)-AM1241 acts... |
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T37182 |
AX 048
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The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid from membrane phospholipids, playing a central role in initiating the synthesis of prostagla... |
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T61891 |
SHP2-IN-8
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SHP2-IN-8 is a reversible, noncompetitive, selective and efficient allosteric SHP2 inhibitor (IC50=23 nM, Ki=22 nM), which also has effects in cells. SHP2-IN-8 can cause significant thermal displacement（ Δ Tm = 7.01 ℃）。 ... |
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T80385 |
K11
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K11, an antimicrobial peptide, demonstrates activity against MDR/XDR K. pneumoniae isolates (MIC: 8-512 μg/mL) and inhibits bacterial biofilm formation. It also acts synergistically with various antibiotics (Chlorampheni... |
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T83731 |
Tat-CBD3 TFA
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Tat-CBD3 is a chemical compound inhibiting the interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2), as well as the interaction between CRMP2 and the NMDA ... |
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T36722 |
Deltorphin II (trifluoroacetate salt)
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Deltorphin II is a peptide agonist of δ2-opioid receptors.1,2It is selective for δ-opioid receptors over μ- and κ-opioid receptors in radioligand bindings assays (Kis = 0.0033, >1, and >1 μM, respectively) and induces [3... |
