検索結果

Search Results for " trypsin-like "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T17011	TCH-165		Proteasome
	TCH-165 is a small molecule modulator of proteasome assembly, resulting in an increase in 20S levels. The increase in the level of free 20S corresponds to enhanced proteolysis of IDPs.		Proteasome
T8362	Benzamidine hydrochloride	Benzamidine HCl	Serine/threonin kinase , Serine Protease
	Benzamidine hydrochloride (Benzamidine HCl) is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 μM, respectively).		Serine/threonin kinase , Serine Protease
T7016	VR23		Apoptosis , Proteasome , Caspase
	VR23 is a potent proteasome inhibitor. Data shows IC50 =1 nM for trypsin-like proteasomes, IC50=50-100 nM for chymotrypsin-like proteasomes, and IC50=3 μM for caspase-like proteasomes.		Apoptosis , Proteasome , Caspase
T63321	20S Proteasome activator 1		Proteasome
	20S Proteasome activator 1 is a 20S proteasome activator with IC50 of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites and 1.8 μM for caspase sites. 20S Proteasome activator 1 prevents the accumulation o...		Proteasome
T2122	Ixazomib	MLN2238	Proteasome , Caspase , Autophagy
	Ixazomib (MLN2238) , a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (IC50/Ki: 3.4/0.93 nM, in cell-free assays), also i...		Proteasome , Caspase , Autophagy
T6941	PI-1840	PI 1840	PARP , Proteasome
	PI-1840（IC50 = 27 nM）is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L).		PARP , Proteasome
T16169	N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride	N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride	Others , Proteasome , COX
	N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride (N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride) is an inhibitor of trypsin-like protease. N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride exhib...		Others , Proteasome , COX
T78409L	Boc-Val-Pro-Arg-MCA TFA
	Boc-Val-Pro-Arg-MCA TFA is a sensitive fluorescent substrate that is a thrombin substrate for the determination of trypsin-like serine protease activity.
T2391	Camostat mesylate	FOY-S980,FOY305,Camostat mesilate	Serine/threonin kinase , SARS-CoV , Sodium Channel
	Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.		Serine/threonin kinase , SARS-CoV , Sodium Channel
T78409	Boc-Val-Pro-Arg-MCA hydrochloride	Boc-Val-Pro-Arg-MCA HCl
	Boc-Val-Pro-Arg-MCA hydrochloride (Boc-Val-Pro-Arg-MCA HCl) is a sensitive fluorescent substrate for the determination of trypsin-like serine proteases activity.
T19580	Thrombin (MW 37kDa)	Thrombin	Thrombin
	Thrombin (MW 37kDa) is a trypsin-like allosteric serine protease.		Thrombin
T37011	Boc-LRR-AMC
	Boc-LRR-AMC is a fluorogenic substrate for the trypsin-like activity of the 26S proteasome or 20S proteolytic core. Upon enzymatic cleavage by the 26S proteasome or 20S proteolytic core, amino-4-methylcoumarin (AMC) is r...
T77221	Benzenecarboximidamide, hydrochloride, hydrate (1:1:x)
	Benzenecarboximidamide, hydrochloride, hydrate (1:1:x) (Benzamidine hydrochloride hydrate) is a reversible competitive trypsin-like serine proteases inhibitor with K i s of 20, 21, 97, 110, 320 and 750 μM against Tryptas...
T39029	APC-6860
	APC-6860 is a trypsin-like serine proteases inhibitor with k i values of 0.21, 0.44, 1.5, 16.8, 20, 30 μM for uPA, trypsin, tryptase, tPA, thrombin and factor Xa, respectively. APC-6860 has a selectivity ratio for tPA ve...
T80211	Ac-KQL-AMC
	Ac-KQL-AMC is a fluorogenic substrate designed for the quantification of Trypsin-like activity, emitting detectable fluorescence upon proteasomal cleavage [1].
T78625	Z-Ala-Arg-Arg-AMC	Z-ARR-AMC,Fluorogenic Proteasome Substrate	Proteasome
	Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) serves as a fluorogenic substrate designed to assay the trypsin-like activity within the proteasome [1].		Proteasome
TP2234	Coagulation factor II (thrombin) B chain fragment [Homo sapiens]		Others
	Thrombin is a "trypsin-like" serine protease that is encoded by the F2 gene in humans. Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). Thrombin in turn acts as a ser...		Others
T38052	CRA-2059 TFA
	CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2]. Tryptase is a trypsin-like serine protease found as a major protein component in human ma...
T38051	CRA-2059 hydrochloride
	CRA-2059 hydrochloride is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2]. Tryptase is a trypsin-like serine protease found as a major protein compone...

Compounds

Benzamidine hydrochloride

T8362

Synonym: Benzamidine HCl

Target: Serine/threonin kinase, Serine Protease

VR23

T7016

Synonym:

Target: Apoptosis, Proteasome, Caspase

20S Proteasome activator 1

Target: Proteasome, Caspase, Autophagy

PI-1840

T6941

Synonym: PI 1840

Target: PARP, Proteasome

N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride

T16169

Synonym: N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride

Target: Others, Proteasome, COX

Boc-Val-Pro-Arg-MCA TFA

Synonym: FOY-S980,FOY305,Camostat mesilate

Target: Serine/threonin kinase, SARS-CoV, Sodium Channel

Boc-Val-Pro-Arg-MCA hydrochloride

T78409

Synonym: Boc-Val-Pro-Arg-MCA HCl

Benzenecarboximidamide, hydrochloride, hydrate (1:1:x)

Synonym: Z-ARR-AMC,Fluorogenic Proteasome Substrate

Target: Proteasome

coagulation factor II (thrombin) B chain fragment [Homo sapiens]

CRA-2059 hydrochloride

T38051

Synonym:

Target:

カタログ番号	製品名	別名	ターゲット
T16012	Marizomib	NPI-0052,Salinosporamide A,ML858	Proteasome
	Marizomib (ML858) is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L (β5), CT-T-laspase-like (C-L, β1), and trypsin-like (T-L, β2) 20S proteasomes with IC50s of 3.5, 28, and 430 nM, respectiv...		Proteasome
T6S0071	Fraxinellone		HIF/HIF Prolyl-Hydroxylase , STAT , PD-1/PD-L1
	1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhibited a variety of insecticidal activities including feeding...		HIF/HIF Prolyl-Hydroxylase , STAT , PD-1/PD-L1

天然物製品

Marizomib

T16012

Synonym: NPI-0052,Salinosporamide A,ML858

Target: HIF/HIF Prolyl-Hydroxylase, STAT, PD-1/PD-L1

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-01203	HATL5 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Transmembrane Protease Serine 11B (TMPRSS11B) is a single-pass type II membrane protein member of the peptidase S1 family. TMPRSS11B contains one peptidase S1 domain and one SEA domain. TMPRSS11B is a serine protease tha...
TMPJ-01204	TPSAB1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Tryptases are serine proteases with trypsin-like specificity. Together with chymases and Cathepsin G, tryptases are important players in mast cell mediation of inflammatory and allergic responses. Tryptase alpha/beta-1(T...
TMPH-02895	Serpin A3K Protein, Mouse, Recombinant (His)	Mouse	P. pastoris (Yeast)
	Contrapsin inhibits trypsin-like proteases. Serpin A3K Protein, Mouse, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 45.7 kDa and the accession number is P07759.
TMPH-02455	Acrosin Protein, Meleagris gallopavo, Recombinant (His & Myc)	Meleagris gallopavo	E. coli
	Serine protease of trypsin-like cleavage specificity. Synthesized in a zymogen form, proacrosin and stored in the acrosome. Acrosin Protein, Meleagris gallopavo, Recombinant (His & Myc) is expressed in E. coli expression...
TMPJ-00481	CELA3A Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Chymotrypsin-Like Elastase Family Member 3A (CELA3A) is an enzyme that contains one peptidase S1 domain. ELA3A belongs to the peptidase S1 family of the Elastase subfamily. ELA3A is secreted from the pancreas as a zymoge...
TMPJ-00542	TPSB2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Tryptases are Trypsin-like Serine Proteases. β-Tryptases are the main isoenzymes in mast cells. Βtryptases form active tetramers with heparin proteoglycan. In the tetramer, the unique arrangement of the active sites faci...
TMPY-00867	Kallikrein 13/KLK13 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Tissue kallikrein 13 (hK13), also known as KLK-L4 (kallikrein-like gene 4), is a member of the human tissue kallikrein family of serine proteases having diverse physiological functions in many tissues. The KLK13 gene res...