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T5850 |
Benzamil
|
Benzamil (hydrochloride) |
Na+/Ca2+ Exchanger
,
Sodium Channel
|
|
Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles. |
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T0993 |
Methoxamine hydrochloride
|
Methoxamine HCl |
Adrenergic Receptor
|
|
Methoxamine hydrochloride (Methoxamine HCl) is an alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION. |
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T13920L |
Terlipressin Acetate
|
Terlipressin diacetate anhydrous,Terlipressin acetate anhydrous |
Vasopressin Receptor
|
|
Terlipressin Acetate, a highly selective vasopressin V1 receptor agonist, on oxygen and glucose deprivation/re-oxygenation (OGD/R)-induced damage in intestinal epithelial cells (IEC-6).Terlipressin acetate exerts anti-in... |
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T0446 |
Naphazoline hydrochloride
|
Albalon,Rhinantin,Naphazoline HCl |
Adrenergic Receptor
|
|
Naphazoline hydrochloride (Naphazoline HCl) is an adrenergic vasoconstrictor agent used as a decongestant. |
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T21445 |
Naphazoline
|
AK-Con,Naphcon-a,Clear Eyes,All Clear |
Adrenergic Receptor
|
|
Naphazoline (Naphcon-a) is a sympathomimetic compound with marked alpha adrenergic activity. Naphazoline can be used as a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane. |
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T1066L |
Ketanserin tartrate
|
KJK 945 tartrate,KJK-945 tartrate,KJK945 tartrate |
5-HT Receptor
,
Serotonin Transporter
,
Adrenergic Receptor
|
|
Ketanserin tartrate (KJK-945 tartrate) is a 5-HT2A receptor and α1-adrenergic receptor antagonist with antihypertensive activity, inhibits serotonin-induced vasoconstriction and platelet activation, and can be used in th... |
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TP2446L |
Angiotensin amide acetate
|
Angiotensin amide acetate(53-73-6 Free base) |
Others
|
|
Angiotensin amide acetate is a derivative of Angiotensin amide, an octapeptide amide that increases blood pressure through vasoconstriction. |
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T2400 |
Candesartan Cilexetil
|
TCV-116 |
Apoptosis
,
RAAS
|
|
Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist (IC50: 0.26 nM). After hydrolysis of candesartan cilexetil to candesartan during gastrointestinal absorption, candesartan selectively competes with... |
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T21447 |
Tolazoline
|
Priscol,Priscoline,Pridazole,Divascol,Vasimid,Benzalolin |
Adrenergic Receptor
|
|
Tolazoline (Benzalolin), a non-selective competitive α-adrenergic receptor antagonist, is used as a vasodilator to treat spasms of peripheral blood vessels. It has also been used successfully as an antidote to reverse th... |
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T21231 |
Almotriptan
|
LAS 31416 |
5-HT Receptor
|
|
Almotriptan (LAS 31416) is a 5-HT1B/1D-receptor agonist used to treat migraine.Almotriptan is a triptan drug for treatment of migraine headaches.Binding of the drug to the receptor leads to vasoconstriction of the crania... |
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T1066 |
Ketanserin
|
R41468,Ketanserin tartrate,Ketanserinum |
Potassium Channel
,
5-HT Receptor
,
Autophagy
|
|
Ketanserin (Ketanserinum) is a quinazoline derivative and serotonin (5-hydroxytryptamine, 5HT) receptor subtype 2 (5-HTR2) antagonist with potential antihypertensive and antiplatelet activities. Following administration,... |
|
T1484L |
Perindopril erbumine
|
S9490-3,Perindopril tert-butylamine salt |
Apoptosis
,
RAAS
,
MRP
|
|
Perindopril erbumine (S9490-3) is the tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, Perindopril er... |
|
TP1295 |
Angiotensin I (human, mouse, rat)
|
Angiotensin 1 Human |
Others
|
|
Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensin II, cleaved by the angiotensin-converting enzyme (ACE).Angiotensin is a peptide hormone that causes vasoconstriction and an in... |
|
T1158 |
Phenoxybenzamine hydrochloride
|
NCI-c01661,NSC 37448,Phenoxybenzamine HCl |
CaMK
,
Adrenergic Receptor
|
|
Phenoxybenzamine hydrochloride (NCI-c01661) is the hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non... |
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T6602 |
Naratriptan hydrochloride
|
Naratriptan HCl,Amerge,Naramig,GR-85548A hydrochloride |
5-HT Receptor
|
|
Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride (GR-85548A hydroc... |
|
TP2158 |
TRV-120027 TFA
|
TRV-120027 TFA (1234510-46-3 free base) |
RAAS
,
Arrestin
|
|
TRV120027 TFA is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R) and engages ß-arrestins while blocking G-protein signaling. |
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T25922 |
PD 142893
|
PD-142893,PD142893 |
|
|
PD 142893 is a functional endothelin-stimulated vasoconstriction antagonist. |
|
T19665 |
Amastatin hydrochloride
|
BIMI-1803,Amastatin HCl,ZX-AFC000547,ZXAFC000547,BIMI1803,J-000280,J000280 |
|
|
Amastatin HCl is an inhibitor of aminopeptidase. It also induces vasoconstriction. |
|
TP2446 |
Angiotensin amide
|
Angiotensinamide,Hypertensine,Angiotensin,NSC 107678,NSC-107678 |
|
|
Angiotensin amide, an octapeptide amide, can be used to increase blood pressure by vasoconstriction. |
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T34862 |
Thromboxane A2
|
Rabbit aorta contracting substance,TXA-2,TXA2,TXA 2 |
|
|
Thromboxane A2, as an unstable intermediate between the prostaglandin endoperoxides and thromboxane B2, is a potent inducer of platelet aggregation and causes vasoconstriction. |
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TP2158L |
TRV-120027
|
|
Others
|
|
TRV120027 is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1. TRV120027 inhibits angiotensin II-mediated vasoconstriction and increases cardiomyocyte contractility. |
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T31845 |
Forasartan
|
SC52458,SC 52458,SC-52458 |
|
|
Forasartan is a non - peptide angiotensin II receptor antagonist with antihypertensive activity. Forasartan and angiotensin II compete to bind AT1 receptor subtypes in vascular smooth muscle, thereby blocking angiotensin... |
|
TP1706 |
BQ-3020 TFA (143113-45-5 free base)
|
BQ-3020 TFA |
|
|
BQ-3020 (TFA) is a selective ETB receptor agonist that inhibits [125I] et-1 binding to the ETB receptor in the cerebellum with a 0.2nm IC50, causing vasoconstriction. |
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T36153 |
15(S)-15-methyl Prostaglandin D2
|
15(S)-15-methyl Prostaglandin D2 |
|
|
15(S)-15-methyl Prostaglandin D2 (15(S)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2 . In contrast to PGD2, 15(S)-15-methyl PGD2 induces vasoconstriction and increases systemic blood pressure with m... |
|
T75771 |
BQ-3020 TFA
|
|
|
|
BQ-3020 (TFA) is a selective ETB receptor agonist that obstructs [125I]ET-1 binding to the ETB receptor in the cerebellum, exhibiting an IC50 of 0.2 nM, and induces vasoconstriction [1]. |
|
T75772 |
[Ala1,3,11,15]-Endothelin (53-63) (TFA)
|
|
|
|
[Ala1,3,11,15]-Endothelin (53-63) (TFA) is a selective ET B agonist with IC50 values ranging from 0.33 nM to 0.61 nM, demonstrating its preference for ET B receptors. It is utilized in the study of vasoconstriction. |
|
T36209 |
15-keto Prostaglandin A1
|
15-keto Prostaglandin A1 |
|
|
Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen. 15-keto PGA1 is a metabolite of PGA1, produced by 15-hydroxy PG dehydrogenase. It can be produced from PGA1 ... |
|
T70837 |
Rimegepant sulfate hydrate
|
|
|
|
Rimegepant, also known as BMS-927711 and BHV-3000, is a potent, selective, competitive, and orally active calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraines. Rimegepant has shown ... |
|
T60425 |
Tetrahydrozoline nitrate
|
|
|
|
Tetrahydrozoline (Tetryzoline) nitrate is a derivative of imidazoline. It is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline is widely used for the nasal congestion and conjunctival congestion rese... |
|
T22573 |
Angiotensin 1/2 (2-7)
|
|
Others
|
|
Angiotensin I/II (2-7) is a peptide that contains the amino acids 2-7 and is converted from Angiotensin I/II peptide. Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood press... |
|
T35598 |
Neuromedin U-25 (human) (trifluoroacetate salt)
|
|
|
|
Neuromedin U (NMU) is a neuropeptide first demonstrated to drive smooth muscle contraction.1Translated as a 174 amino acid propeptide, NMU is cleaved to different lengths in different animals. It has diverse receptor-med... |
|
T35467 |
(±)18-HETE
|
|
|
|
(±)18-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid. When formed by the CYP2E1 isoform, 18-HETE is comprised 100% of the (R) isomer. 18(R)-HETE dose-dependently stimulates vasod... |
|
T82933 |
Auriculin A
|
|
|
|
Auriculin A, a synthetic atrial natriuretic factor (ANF), exhibits hemodynamic properties by antagonizing renal vasoconstriction in dogs and affects arterial baroreflex regulation of heart rate, systemic blood pressure, ... |
|
T36216 |
19(R)-HETE
|
|
|
|
19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% o... |
|
T78096 |
BQ-3020 ammonium
|
|
Endothelin Receptor
|
|
BQ-3020 ammonium, a selective endothelin receptor (ET B receptor) agonist, demonstrates inhibition of [125 I] ET-1 binding to ET B receptors with an IC50 of 0.2 nM and induces vasoconstriction in rabbit pulmonary arterie... |
|
T71211 |
Rizatriptan-d6 benzoate salt
|
|
|
|
Rizatriptan-d6 is intended for use as an internal standard for the quantification of rizatriptan by GC- or LC-MS. Rizatriptan is an agonist of the serotonin
receptor subtypes 5-HT1B and 5-HT1D. It is selective for 5-H... |
|
T33631 |
Neocuproine
|
Neocuproin |
|
|
Neocuproine is a copper(I) chelator that enhances the purinergic component of vasoconstriction induced by electric field stimulation, and is often used as a ligand reagent and copper ion detector.Neocuproine forms stable... |
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TP2194 |
Neuropeptide Y (scrambled)
|
|
Others
|
|
Neuropeptide Y (NPY) is a 36-amino acid neuropeptide that exerts its activity via G-protein-coupled receptors. NPY is widely distributed in the peripheral and central nervous systems. It modulates a variety of physiologi... |
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T37969 |
12(S)-HpETE
|
|
|
|
12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the sy... |
|
T83840 |
Uridine-5'-O-(3-thiotriphosphate) sodium
|
UTP-γ-S |
|
|
Uridine-5'-O-(3-thiotriphosphate) (UTP-γ-S) is a hydrolysis-resistant UTP derivative and an agonist of the purinergic P2Y2 receptor. It effectively induces inositol phosphate formation in 1321N1 astrocytoma cells harbori... |
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T36070 |
(±)5(6)-EET
|
|
|
|
5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-δ-lactone, which can be converted to 5... |
|
T83677 |
Neuropeptide Y (porcine, bovine) TFA
|
NPY (porcine, bovine) |
|
|
Neuropeptide Y (NPY), a neuropeptide, plays roles in regulating appetite, vasoconstriction, cardiac contractility, and intestinal secretion, acting as an agonist for NPY receptors Y1, Y2, and Y5. Expressed ubiquitously, ... |
