|
T12137 |
N-(2-Hydroxypropyl)methacrylamide
|
|
Parasite
|
|
|
|
T5491 |
GSK3179106
|
|
c-RET
|
|
GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nM |
|
T2525 |
Alosetron hydrochloride
|
Lotronex,GR 68755C,GR 68755,GR 68755X |
5-HT Receptor
|
|
Alosetron hydrochloride (GR 68755) is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system,... |
|
T0033 |
Miltefosine
|
HePC,Hexadecyl phosphocholine |
Akt
,
HIV Protease
,
PKC
|
|
Miltefosine (HePC) is the treatment of visceral and cutaneous leishmaniasis drug , and is proceeding clinical trials for this in several countries. Several medical agents produce some potency against visceral or cutaneou... |
|
T33846 |
Oxyphenonium bromide
|
Spasmophen,Oxifenon,Oxyfenon,Atrenyl,Oxyphenon |
Others
|
|
Oxyphenonium bromide (Oxyfenon) shows anticholinergic activity and can be used for research on the treatment of gastric and duodenal ulcers and for the relief of visceral spasms. |
|
T39746 |
DNDI-6148
|
|
Parasite
|
|
DNDI-6148 has anti-experimental cutaneous leishmaniasis activity and can be used to study visceral leishmaniasis by inhibiting Leishmania protozoa cleavage and polyadenylation-specific factor (CPSF3) endonuclease. |
|
T37427 |
(2R/S)-6-PNG
|
6-Prenylnaringenin,(±)-6-Prenylnaringenin |
Calcium Channel
,
HDAC
|
|
(2R/S)-6-PNG (6-Prenylnaringenin) is a novel natural histone deacetylase inhibitor with anticancer and antitumor activity, and blocks T-type calcium channels to reduce neuropathic and visceral pain in mice. |
|
T16448 |
PD173212
|
|
Calcium Channel
|
|
PD 173212 is a blocker that blocks N-type voltage sensitive calcium channel (Cav2.2). PD173212 (0.0017-1.7 μmol/kg, Intraperitoneal Injection.) dose-dependently reduced DNBS-induced visceral hypersensitivity in mice. |
|
TP1057L |
Phe-Met-Arg-Phe Like Peptide acetate
|
Pqdpflrfamide acetate,Phe-Met-Arg-Phe Like Peptide acetate（98495-35-3 free base) |
Others
|
|
Phe-Met-Arg-Phe Like Peptide acetate (Pqdpflrfamide acetate) is a FMRF-like peptide from visceral and somatic muscles of the snail Helix aspersa. FMRF (Phe-Met-Arg-Phe) is a neuropeptide peptide consisting of 4 amino aci... |
|
T7295 |
Miridesap
|
Ro63-8695,CPHPC,GSK2315698 |
Others
|
|
Miridesap (GSK2315698) is a divalent crosslinker of SAP that causes rapid depletion of circulating SAP via hepatic clearance. It also produces significant reduction of SAP from cerebrospinal fluid and visceral amyloid de... |
|
T39214L |
LXE408 fumarate
|
LXE408 fumarate (1799330-15-6 Free base) |
Proteasome
|
|
LXE408 fumarate is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor. LXE408 fumarate has an IC50 of 0.04 μM for L. donovani proteasome and an EC50 of 0.04 μM for L. donovani. LXE408 fuma... |
|
T71716 |
Nav1.1-IN-B
|
|
|
|
Nav1.1-IN-B is a selective NaV1.1 inhibitor which reduces visceral hypersensitivity. |
|
T71308 |
DSP-6952
|
|
|
|
DSP-6952 is a 5-HT4 receptor partial agonist, inhibiting visceral hypersensitivity and ameliorating gastrointestinal dysfunction. |
|
T12970L |
Solabegron HCl
|
GW-427,353,GW427353,GW-427353,GW 427,353,GW427,353 |
|
|
Solabegron (GW-427,353), is a selective agonist of β3 adrenergic receptors. In addition, Solabegron has been shown to produce visceral analgesia by releasing somatostatin from fat cells. |
|
T33637 |
Neostibosan
|
Stibanilic acid,693B,Astaril,Ethylstibamine,p-Aminobenzenestibonic acid,Bayer 693 |
|
|
Neostibosan is an arsenic-containing parasitic agent. Due to the activity of arsenic on visceral L/Ashmaniasis, one of the pentvalent antimony, which is less toxic, is synthesized and has potential activity on tumor cell... |
|
T28346 |
PD-217014 HCl
|
PD 217014,PD217014,PD-217,014,PD-217014 |
|
|
PD-217014 is a GABA analog. It inhibits (3)H-gabapentin binding to alpha(2)delta subunit of voltage-gated calcium channels in a concentration-dependent manner (K(i) = 18 nmol/l). PD-217014 possesses visceral analgesic ac... |
|
TP1057 |
Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa
|
Phe-Met-Arg-Phe Like Peptide |
|
|
Phe-Met-Arg-Phe-like peptide, derived from the visceral and somatic muscles of the snail Helix aspersa, is a neuropeptide known as FMRF (Phe-Met-Arg-Phe). This peptide comprises four amino acid residues[1]. |
|
T35374L |
(Ala13)-Apelin-13 acetate
|
|
Apelin receptor
|
|
(Ala13)-Apelin-13 acetate, an APJ antagonist, modulates CRF-induced enhanced colonic motility, visceral sensation, and gut barrier. |
|
T11661 |
INT-767
|
|
FXR
,
GPCR19
|
|
INT-767 is a potent farnesoid X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral adipose brown lipogenesis and mitochondrial function for the study of non-alcoholic steatohepatitis. |
|
T41183 |
Helianorphin-19
|
|
|
|
Helianorphin-19 is a high affinity, potent and selective κ-opioid receptor (KOR) agonist (Ki = 25 nM; EC50= 45 nM). Helianorphin-19 exhibits approximately 200-fold selectivity for KOR over μ and δ-opioid receptors.In viv... |
|
T78559 |
PDE7-IN-3
|
|
|
|
PDE7-IN-3 (Example 2) serves as an inhibitor of phosphodiesterase PDE7 and exhibits potential analgesic properties. It is applicable in the research of various pain types including inflammatory, neuropathic, visceral, an... |
|
T39214 |
LXE408
|
LXE408 |
|
|
LXE408 is an orally active, kinetoplastid-selective proteasome inhibitor, exhibiting non-competitive inhibitory effects. It demonstrates an IC50 of 0.04 μM for L. donovani proteasome and an EC50 of 0.04 μM for L. donovan... |
|
T63186 |
Cav 3.2 inhibitor 1
|
|
|
|
Cav 3.2 inhibitor 1 is a T-type calcium channel inhibitor with low binding affinity for the dopamine receptor (D2 receptor.) Cav 3.2 inhibitor 1 can be used in studies of physical and visceral pain. |
|
T71476 |
Afegostat TFA
|
|
|
|
Afegostat, aslo known as Isofagomine, and AT2101, was an experimental drug for the treatment of certain forms of Gaucher's disease. Isofagomine (IFG) is an acid β-glucosidase (GCase) active site inhibitor that acts as a ... |
|
T63606 |
Cav 3.2 inhibitor 2
|
|
|
|
Cav 3.2 inhibitor 2 is an inhibitor of Cav3.2 T-type Ca2+channels with an IC50=0.09339 μM at a constant potential of -80 mV. Cav 3.2 inhibitor 2 exhibits potent inhibition of T-channel-dependent somatic and visceral pain... |
|
T76127 |
Urocortin II, mouse
|
|
|
|
Urocortin II, mouse, is a selective and potent endogenous peptide agonist for the type-2 corticotropin-releasing factor (CRF2) receptor, displaying K_i values of 0.66 nM for CRFR2 and >100 nM for CRFR1, signifying its hi... |
|
T65387 |
Paromomycin, sulfate (1:1)
|
|
|
|
Paromomycin (Sulfate Salt) is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin in combination with sodium stibogluconate has proven... |
|
T83802 |
TNP-ATP sodium
|
|
|
|
TNP-ATP, a derivative of ATP, acts as an antagonist to the purinergic P2Y1, P2X3, and P2X2/3 receptors, demonstrating selectivity by showing lower inhibitory concentrations (IC50 = 6, 0.9, 7 nM, respectively) compared to... |
|
T36373 |
Urocortin II (mouse) (trifluoroacetate salt)
|
|
|
|
Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin III , frog sauvagine, and piscine urotensin I.1 Mouse urocortin II... |
