|
T22016 |
A-582941 dihydrochloride
|
A 582941 |
5-HT Receptor
,
AChR
|
|
A-582941 dihydrochloride (A 582941) is a Selective agonist of α7 nAChR partial |
|
T7706 |
LY-404187
|
|
GluR
,
iGluR
|
|
LY404187 is a positive allosteric modulator of AMPA receptors |
|
T28368 |
PF-04859989 HCl
|
PF 04859989,PF04859989,PF-04859989HCl,PF-04859989 |
Others
|
|
PF-04859989 HCl is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid. PF-04859989 HCl has been implicated in s... |
|
T0024 |
Primidone
|
Primaclone,Mysoline,NCI-C56360 |
GABA Receptor
,
Sodium Channel
,
GluR
,
AChR
|
|
Primidone (NCI-C56360) is a potent anticonvulsant agent. It is a neuronal voltage-gated sodium channel blocker and has value in the study of epilepsy, essential tremor, and psychiatric disorders. |
|
T24656 |
PQ-10
|
A844337,PQ 10,A-844337,A 844337 |
PDE
|
|
PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker. |
|
T7165 |
Basmisanil
|
RG1662,RO5186582 |
GABA Receptor
|
|
Basmisanil (RG1662) is a negative allosteric modulator/inverse agonist of GABAAα5 receptors.Formulations containing basmisanil are in clinical trials for the treatment of cognitive impairments associated with Down syndro... |
|
T0678 |
Amitriptyline hydrochloride
|
Amitriptyline HCl,Tryptizol,Domical,Annoyltin |
Trk receptor
,
Sigma receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Sodium Channel
,
Adrenergic Receptor
,
AChR
,
Norepinephrine
,
Histamine Receptor
|
|
Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities. |
|
T20324 |
Butyrophenone
|
NSC8463,NSC 8463,NSC-8463 |
Others
|
|
Butyrophenone (NSC-8463) is a chemical compound. Some of its derivatives are used to treat various psychiatric disorders. |
|
T5444 |
CLP290
|
CLP-290 |
Potassium Channel
|
|
CLP290 is an activator of the neuron-specific K+-Cl cotransporter KCC2 and displays potential for the treatment of a wide range of neurological and psychiatric indications. |
|
T31079 |
CP-810123
|
CP 810123,UNII-E6G4550EC4,CP810123 |
AChR
|
|
CP-810123 is a new alpha 7 nAChR agonist for the treatment of cognitive impairment associated with psychiatric or neurological disorders such as schizophrenia and Alzheimer's disease. |
|
T50061 |
[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methanamine
|
|
Others
|
|
[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methanamine is a piperazine derivative that is a partial agonist at serotonin and dopamine receptors, making it a candidate for the treatment of psychiatric disorders such as depressi... |
|
T50054 |
Opromazine hydrochloride
|
|
Others
|
|
Opromazine hydrochloride belongs to the phenothiazine class of antipsychotics and reduces the activity of dopaminergic pathways by blocking dopamine receptors in the brain. It is mainly used for the treatment of psychiat... |
|
T83974 |
OPC18750 HCl
|
|
PDE
|
|
OPC18750 HCl is a potential phosphodiesterase inhibitor with positive inotropic effects that can be used to study asthma, cancer, diabetes, and psychiatric disorders. |
|
T1292 |
Tiapride hydrochloride
|
|
Dopamine Receptor
|
|
Tiapride is a selective blocker of D2/3 dopamine receptors in the brain. It is used in the therapy of various psychiatric and neurological disorders containing dyskinesia, negative symptoms of psychosis, alcohol withdraw... |
|
T23066 |
NGD 94-1
|
|
Dopamine Receptor
|
|
NGD 94-1 is a selective D4 receptor antagonist with an affinity of 3 nM for the D4 receptor and greater than 2 pM for the D1, D2, D3, and D5 receptors.NGD 94-1 can be used in the study of cognitive disorders and other ps... |
|
T77597 |
SXC 2023
|
(S)-2-acetamido-3-(4-methylbenzoylthio)propanoic acid |
Others
|
|
SXC 2023 ((S)-2-acetamido-3-(4-methylbenzoylthio)propanoic acid) is a therapeutic prodrug of N-acetyl-L-cysteine for the treatment of CNS disorders and neurocognitive disorders, and can be used to treat glutamatergic dys... |
|
T67811 |
Tefludazine
|
|
|
|
Tefludazine, a novel neuroleptic with a benzindone structure, is a compound with good oral activity and antagonistic effects on dopamine and 5-hydroxytryptamine receptors. Tefludazine has shown potent dopamine (DA) antag... |
|
T50111 |
6-Fluorotryptamine hydrochloride
|
|
Others
|
|
6-Fluorotryptamine hydrochloride is a compound used as a molecular structural unit and is a derivative of the natural tryptamine alkaloid serotonin. It is an agonist at 5-HT2A and 5-HT2C serotonin receptors, making it a ... |
|
T63115 |
Perphenazine dihydrochloride
|
|
|
|
Perphenazine dihydrochloride is an orally active dopamine receptor and histamine-1 receptor antagonist that acts on D2 (Ki: 0.56 nM), D3 (Ki: 0.43 nM), 5-HT2A (Ki: 0.6 nM). Perphenazine dihydrochloride is also able to bi... |
|
T24766 |
SBI-0061869
|
SBI0061869 |
|
|
SBI-0061869 is a potentiator of metabotropic glutamate receptors. It was used against neurological and psychiatric disorders. |
|
T39218 |
(S)-CVN424
|
(S)-CVN424 |
|
|
(S)-CVN424 is a powerful modulator of G-Protein-Coupled Receptor 6 (GPR6), known for its involvement in neurological and psychiatric disorders research, such as Parkinson's disease. |
|
T24767 |
SBI-0069332
|
|
|
|
SBI-0069332 is a potentiator of metabotropic glutamate receptors. It was used against neurological and psychiatric disorders. |
|
T12318 |
Org-10490
|
|
Others
|
|
Org-10490 is an dopamine D1 receptor and dopamine D2 receptor antagonist, and treatment for psychiatric disease. |
|
T39940 |
Plazinemdor
|
|
|
|
Plazinemdor is an NMDA receptor positive allosteric modulator with potential applications in psychiatric, neurological, neurodevelopmental disorders, and diseases of the nervous system. |
|
T28085 |
Moperone Hydrochloride
|
EN1733A,EN 1733A,EN-1733A |
|
|
Moperone Hydrochloride, a dopamine D2-receptor antagonist, is used for the treatment of psychiatric disorders. |
|
T38828 |
Mesdopetam
|
IRL790 |
|
|
Mesdopetam (IRL790) is a dopamine D3 receptor antagonist with a Ki of 90 nM and an IC50 of 9.8 μM for the human recombinant D3 receptor. It exhibits psychomotor stabilizing properties and is utilized in the study of moto... |
|
T7352L |
Pridopidine hydrochloride
|
ASP2314 HCl,Pridopidine HCl,FR310826,ASP-2314 hydrochloride |
|
|
Pridopidine Hydrochloride is a dopaminergic stabilizer that has been shown to improve a variety of neurological and psychiatric disorders, including Huntington's disease. Pridopidine Hydrochloride stabilizes psychomotor ... |
|
T62975 |
Haloperidol lactate
|
|
|
|
Haloperidol lactate is a potent antipsychotic. haloperidol lactate has potential for studies in psychiatric disorders. haloperidol lactate can be used in acute and chronic schizophrenia and polyarousal syndrome. |
|
T79838 |
(S)-Bexicaserin
|
|
5-HT Receptor
|
|
(S)-Bexcaserin (compound 2) serves as a 5-HT2C receptor agonist, presenting research possibilities in obesity and psychiatric disorders [1]. |
|
T61578 |
BRD3731
|
|
|
|
BRD3731 is a selective inhibitor of GSK3β, demonstrating an IC50 value of 15 nM for GSK3β and 215 nM for GSK3α. Due to its inhibitory properties, BRD3731 holds promise for investigating various medical conditions, includ... |
|
T61207 |
5-HT6/5-HT2A receptor ligand-1
|
|
|
|
5-HT6/5-HT2A receptor ligand-1 (compound 33) is a dual antagonist for the 5-HT6 and 5-HT2A receptors. It exhibits a K i value of 2 nM and 11 nM for the respective receptors. This compound holds promise for research in ne... |
|
T82891 |
Bexicaserin
|
|
|
|
Bexicaserin (Compound 3), a 5-HT2C receptor agonist, has potential applications in research pertaining to obesity and psychiatric disorders [1]. |
|
T78920 |
HDAC-IN-58
|
|
HDAC
|
|
HDAC-IN-58, a selective HDAC6 inhibitor, exhibits potent inhibitory activity with an IC50 of 2.06 nM, rendering it suitable for research into chronic neurodegenerative and psychiatric disorders [1]. |
|
T60913 |
Aceprometazine
|
|
|
|
Aceprometazine (1664CB) is an antipsychotic which is orally active. Aceprometazine can be used in psychiatric disorders research, for example, depression [1]. |
|
T70787 |
AZD1446 tosylate
|
|
|
|
AZD1446 tosylate, also known as TC-6683, is a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. AZD1446 tosylate showed favorable pharmaceutical properties an... |
|
T60923 |
Zelquistinel
|
|
|
|
Zelquistinel can be used for the depression, anxiety and other related psychiatric disorders research which is an agonist of N-methyl-D-aspartate (NMDA) receptor [1]. |
|
T60611 |
Talaglumetad hydrochloride
|
|
|
|
Talaglumetad hydrochloride is a prodrug of Eglumegad which is the potent and selective agonist of the type II metabotropic glutamate receptor (mGluR2/3) to treat with psychiatric disorders. |
|
T80971 |
TNIK-IN-6
|
|
|
|
TNIK-IN-6 (Compound 9) acts as an inhibitor of Traf2 and Nck-interacting kinase (TNIK), exhibiting an inhibitory concentration (IC50) of 0.93 μM, a kinase implicated in various neurological and psychiatric disorders [1] ... |
|
T70196 |
AZD1446 HCl
|
|
|
|
AZD1446 HCl, also known as TC-6683, is a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. AZD1446 HCl showed favorable pharmaceutical properties and in vivo ... |
|
T16507 |
PF-5006739
|
|
Casein Kinase
|
|
PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency... |
|
T74668 |
Zicronapine fumarate
|
|
|
|
Zicronapine (Lu 31-130) fumarate, an antipsychotic medication, exhibits potent pro-cognitive effects in animal models and holds promise for treating various neurological and psychiatric conditions. It acts as a strong an... |
|
T62202 |
MGluR2 modulator 1
|
|
|
|
mGluR2 modulator 1 (compound 95) is a potent, blood-brain-barrier permeable modulator of mGluR2 (metabotropic glutamate receptor-2) positive transmutation (EC50: 0.03 μM). mGluR2 modulator 1 can be used in the study of p... |
|
T72246 |
Bicuculline methobromide
|
(+)-Bicuculline methobromide,d-Bicuculline methobromide,(+)-Bicuculline methobromide ; d-Bicuculline methobromide |
|
|
Bicuculline methobromide, a selective GABAA Receptor antagonist with an IC50 value of 3 μM, induces tonic-clonic convulsions in mammals and blocks Ca2+ activated potassium channels. It is applicable in researching epilep... |
|
T60578 |
Procyclidine
|
|
|
|
Procyclidine (Tricyclamol; (±)-Procyclidine) is an anticholinergic agent which is a muscarinic receptor antagonist as well as an N-methyl-D-aspartate ( NMDA ) antagonist. Procyclidine can be used in studies of Parkinson'... |
|
T74112 |
Bicuculline methochloride
|
|
|
|
Bicuculline methochloride ((+)-Bicuculline; d-Bicuculline), a selective GABAA receptor antagonist, exhibits an IC50 of 3 μM. It induces tonic-clonic convulsions in mammals and blocks Ca2+ activated potassium channels, ma... |
|
T73677 |
SR 142948 dihydrochloride
|
|
|
|
SR 142948 dihydrochloride is a selective, orally active, non-peptide neurotensin receptor (NT) antagonist, featuring IC50 values of 1.19 nM, 0.32 nM, and 3.96 nM in h-NTR1-CHO cells, HT-29 cells, and adult rat brain, res... |
|
T72034 |
LI-2242
|
|
Others
|
|
LI-2242 is a potent inositol hexakisphosphate kinase (IP6K) inhibitor with IC50s of 31 nM, 42 nM, 8.7 nM, and 1944 nM for IP6K1, IP6K2, IP6K3, and IPMK, respectively.LI-2242 ameliorated hepatic steatosis by reducing the ... |
|
T38131 |
(E)-10-Hydroxynortriptyline
|
|
|
|
(E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline . Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1... |
