|
T2301 |
SB 202190
|
FHPI,SB202190 |
Apoptosis
,
p38 MAPK
,
Autophagy
|
|
SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 (IC50=50/100 nM) selectively and cell-permeably. SB 202190 has antitumor activity and also induces the differentiation of human embryonic stem cells i... |
|
T9317 |
TAK-041
|
NBI-1065846 |
GPR
|
|
TAK-041 (NBI-1065846) is a potent and selective GPR139 agonist. |
|
T12165 |
NAChR agonist 1
|
DUN71755 |
AChR
|
|
nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator. |
|
T4576 |
Perospirone
|
Lullan |
Dopamine Receptor
,
5-HT Receptor
|
|
Perospirone (Lullan) is an antagonist of serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist. |
|
T22103 |
ML-193
|
CID 1261822 |
Cannabinoid Receptor
|
|
ML-193 (CID 1261822) is a potent and selective GPR55 antagonist( IC50 : 221 nM). It shows more than 27-fold selectivity for GPR55 over GPR35, CB1 and CB2, and can improve the motor and the sensorimotor deficits of Parkin... |
|
T4074 |
GSK-872
|
GSK872,GSK'872,GSK2399872A |
RIP kinase
|
|
GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM). |
|
T2306 |
Brexpiprazole
|
OPC-34712 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Brexpiprazole (OPC-34712) is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors. |
|
T22016 |
A-582941 dihydrochloride
|
A 582941 |
5-HT Receptor
,
AChR
|
|
A-582941 dihydrochloride (A 582941) is a Selective agonist of α7 nAChR partial |
|
T8690 |
Brexpiprazole HCl
|
OPC 34712 dihydrochloride |
Others
|
|
Brexpiprazole HCl (OPC 34712 dihydrochloride) is a new antipsychotic drug. |
|
T23145 |
PHA 543613
|
|
Others
,
AChR
|
|
PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia. |
|
T26174 |
SAK3
|
SAK 3,SAK-3 |
Calcium Channel
,
AChR
|
|
SAK3 is a novel modulator of nAChR activity that enhances T-type voltage-gated Ca2+ channel (T-VGCC) activity, and has potentiating effects on both Cav3.1 and Cav3.3 T-type Ca2+ channel currents.SAK3 is neuroprotective a... |
|
T23331 |
SC 51089
|
SC 51089 free base |
Prostaglandin Receptor
|
|
SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's... |
|
T22378 |
Nilotinib hydrochloride
|
AMN-107 HCl |
Bcr-Abl
,
Autophagy
|
|
Nilotinib hydrochloride(AMN-107 HCl) is an orally available Bcr-Abl tyrosine kinase inhibitor with antitumor activity for modulation of neuroinflammation and cognitive deficits, and may be used in studies of chronic myel... |
|
T8448 |
ZSET1446
|
ZSET-1446,ST-101 |
Calcium Channel
,
AChR
|
|
ZSET1446 (ST-101) is a T-type calcium channel activator potentially for the treatment of learning deficits in various types of Alzheimer disease (AD) models. |
|
T24184 |
Itasetron
|
DAU6215CL,UNII-00S0D0OEKR,U-98079A,U 98079A,DAU 6215CL |
5-HT Receptor
|
|
Itasetron (U 98079A) is a 5-hydroxytryptamine 3-receptor antagonist used to prevent age-related memory deficits in rats.Itasetron's antiemetic activity in animal models of cancer chemotherapy and radiation therapy may be... |
|
T61564 |
PF-03463275
|
PF-3463275 |
GlyT
|
|
PF-03463275 is an orally active and selective reversible inhibitor of competitive glycine transporter protein-1 (GlyT1) with a Ki of 11.6 nM.PF-03463275 has CNS permeability and may be used to ameliorate cognitive defici... |
|
T67828 |
Enerisant
|
TS-091 |
Histamine Receptor
|
|
Enerisant (TS-091) is an orally active, selective and potent histamine H3 receptor antagonist that modulates histamine H3 receptors in mice in a dose-dependent manner.Enerisant promotes pro-cognitive effects and reverses... |
|
T60739L |
Y13g dihydrochloride
|
Y13g 2HCl(T60739 Free base) |
IL Receptor
,
AChE
|
|
Y13g dihydrochloride is a potent inhibitor of interleukin 6 (IL-6) and acetylcholinesterase (AChE) (both targets of Alzheimer's disease (AD) progression are related). Y13g dihydrochloride reverses STZ-induced memory defi... |
|
T34081 |
Piromelatine
|
NEU-P-11,NEU-P 11,NEU-P11 |
P2X Receptor
,
5-HT Receptor
,
MT Receptor
,
Sodium Channel
,
TRP/TRPV Channel
|
|
Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibitory effects on P2X3, TRPV1, and Nav1.7 channels, and can be ... |
|
T4364 |
Aftin-4
|
Aftin 4,Aftin4 |
Beta Amyloid
,
Gamma-secretase
|
|
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus... |
|
T67913 |
(-)-GSK598809 hydrochloride
|
|
|
|
(-)-GSK598809 hydrochloride is the isomer of GSK598809. GSK598809 is a selective antagonist of the dopamine D3 receptor (DRD3), which is a neural response that selectively enhances reward anticipation in drug and alcohol... |
|
T12531 |
PQCA
|
|
Others
,
AChR
|
|
PQCA is a muscarinic M1 receptor-positive allosteric regulator, which is highly selective and effective. PQCA exhibited EC50 values of 49 nM in rhesus monkey and 135 nM in human M1 receptors, but showed no activity again... |
|
T1240 |
Flumazenil
|
Ro 15-1788 |
GABA Receptor
|
|
Flumazenil (Ro 15-1788) antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous system (CNS), thereby preventing the chloride channel openi... |
|
T60616 |
MPT0G211
|
|
HDAC
|
|
MPT0G211 is a highly selective and orally active HDAC6 inhibitor (IC50=0.291 nM) that has neuroprotective effects and has shown anti-metastatic activity in human breast cancer cells. MPT0G211 has 1,000 times more affinit... |
|
T38192 |
Unifiram
|
|
Others
|
|
Unifiram is a nootropic agent.1It increases acetylcholine (ACh) release in the rat cerebral cortexin vivoand induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the ra... |
|
T20821 |
EPPS
|
|
|
|
EPPS is a rescuer of A aggregation and behavioral deficits. It binds to A aggregates and converts them into monomers. |
|
T30167 |
ASP-5854
|
UNII-BJS8Y4IC5V,ASP 5854,C524699 |
|
|
ASP-5854 is an adenosine A(2A) receptor antagonist with the potential to improve motor deficits in Parkinson's disease. |
|
T39527 |
Se-DMC
|
|
|
|
Se-DMC effectively reduces the inflammatory response, nociception, and neurobehavioral deficits induced by complete Freund's adjuvant (CFA) in mice. |
|
T24779 |
SEN-1269
|
|
|
|
SEN-1269 is an amyloid-β (AB) aggregation inhibitor that acts by blocking Aβ(1-42) aggregation and protecting neuronal cell lines exposed to Aβ(1-42), reducing Aβ oligomer-induced LTP and memory deficits in vivo. |
|
T68066 |
Eptastigmine
|
|
|
|
Eptastigmine, a potent and long-lasting cholinesterase inhibitor on age-related memory deficits. |
|
T82266 |
GPR139 agonist-2
|
|
|
|
GPR139 agonist-2 (compound 20a), a potent GPR139 agonist with an EC50 of 24.7 nM, has demonstrated efficacy in rescuing social interaction deficits and alleviating cognitive deficits in murine schizophrenia models, indic... |
|
T70271 |
PD-149163
|
|
|
|
PD-149163 is a selective, brain penetrating Neurotensin NTR1 receptor agonist. Neurotensin agonists block the pre-pulse inhibition deficits produced by a 5-HT2A and an α1 agonist. As a result, PD-149163 shows pro-cogniti... |
|
T70420 |
PHA 543613 hydrochloride
|
|
|
|
PHA-543613 hydrochloride acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors, with a high level of brain penetration and good oral bioavailability. It is under developmen... |
|
T79784 |
VU6004909
|
|
|
|
VU6004909 is a positive allosteric modulator of the mGlu5 receptor (pEC50: 7.59), exhibiting antipsychotic-like effects. It has the capability to reverse MK801-induced cortical hyperactivity and cognitive deficits [1] [2... |
|
T16563 |
Pozanicline
|
ABT-089 |
AChR
|
|
Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction. Pozanicline selectively activate neuronal nicotinic acetylcholine... |
|
T70196 |
AZD1446 HCl
|
|
|
|
AZD1446 HCl, also known as TC-6683, is a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. AZD1446 HCl showed favorable pharmaceutical properties and in vivo ... |
|
T38090 |
3'-sulfo Galactosylsphingosine (ammonium salt)
|
|
|
|
3'-sulfo Galactosylsphingosine is a form of sulfatide that is lacking the fatty acyl group. It decreases migration and adhesion of B35 neuroblastoma cells and increases cell rounding when used at a concentration of 20 μM... |
|
T62670 |
Cemdomespib
|
|
|
|
Cemdomespib (KU-596) is a potent second-generation Hsp90 modulator. cemdomespib induces a heat shock response, induces Hsp70 levels and has neuroprotective effects. cemdomespib has been shown to improve sensory deficits ... |
|
T70787 |
AZD1446 tosylate
|
|
|
|
AZD1446 tosylate, also known as TC-6683, is a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. AZD1446 tosylate showed favorable pharmaceutical properties an... |
|
T68665 |
Yonkenafil
|
Tunodafil |
|
|
Yonkenafil (Tunodafil), a novel phosphodiesterase 5 (PDE5) inhibitor, effectively reduces cerebral infarction, neurological deficits, edema, and neuronal damage in the infarcted area. It potentially enhances cognitive fu... |
|
T79857 |
Risevistinel
|
NYX-783 |
iGluR
|
|
Risevistinel (NYX-783), a positive allosteric modulator of the N-methyl-D-aspartate (NMDA) receptor, may mitigate cognitive deficits in neurodegenerative conditions, including mild cognitive impairment, mild Alzheimer's ... |
|
T63069 |
Usmarapride
|
|
|
|
Usmarapride (SUVN-D4010) is a selective, orally active, potent 5-HT4 receptor partial agonist with blood-brain barrier permeability and an EC50 value of 44 nM. Usmarapride (SUVN-D4010) can be used to study cognitive defi... |
|
T64036 |
5-HT6R/MAO-B modulator 1
|
|
|
|
5-HT6R/MAO-B modulator 1 is an antagonist of 5-HT6R at Gs signaling and an irreversible inhibitor of MAO-B that exhibits glial protective activity. 5-HT6R/MAO-B modulator 1 exhibits induction of scopolamine-induced memor... |
|
T79011 |
TrkB-IN-1
|
|
Trk receptor
|
|
TrkB-IN-1 is a potent, orally active agonist of the TrkB receptor, with favorable pharmacokinetic (PK) properties. It has been shown to reverse cognitive deficits in an Alzheimer's disease (AD) mouse model, thus serving ... |
|
T24919 |
UBP714
|
UBP 714,UBP-714 |
|
|
UBP714 is a derivative of the NMDA receptor negative allosteric modulator UBP608. It also enhanced NMDAR mediated field EPSPs in the CA1 region of the hippocampus. UBP714 is a novel template for the development of potent... |
|
T79855 |
Nevadistinel
|
NYX-458,NYX-3054 |
iGluR
|
|
Nevadistinel (NYX-458; NYX-3054) is a positive allosteric modulator of the N-methyl-D-aspartate (NMDA) receptor, indicated for mitigating cognitive deficits related to neurodegenerative conditions, including mild cogniti... |
|
T78799 |
BChE/HDAC6-IN-1
|
|
HDAC
|
|
BChE/HDAC6-IN-1 is a dual BChE/HDAC6 inhibitor that exhibits potent and selective inhibition with IC50 values of 4 nM for BChE and 8.9 nM for HDAC6. It demonstrates efficacy in alleviating cognitive deficits in an Aβ1–42... |
|
T79484 |
Nrf2 activator-8
|
|
|
|
Nrf2 Activator-8 (Compound 10e), with an EC50 of 37.9 nM, is a potent Nrf2 activator that demonstrates significant antioxidant and anti-inflammatory properties in BV-2 microglial cells. Furthermore, this compound notably... |
|
T61753 |
MPT0G211 mesylate
|
|
|
|
MPT0G211 mesylate is a powerful and selective HDAC6 inhibitor (IC50 = 0.291 nM), with high oral bioavailability. It exhibits remarkable selectivity for HDAC6 over other HDAC isoforms (>1000-fold selectivity). Additionall... |
|
T36582 |
Glucocerebrosides (Gaucher's spleen)
|
|
|
|
Glucocerebrosides are formed by the tethering of glucose to a ceramide by glucosylceramide synthase. They are present in neuronal and non-neuronal mammalian tissues and are found at low quantities in a large number of pl... |
