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T7057 |
Methylstat
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Histone Demethylase
,
Others
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Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of methylstat inhibits JMJD2A, JMJD2C, JMJD2E, PHF8, and JMJD... |
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T7791 |
Iberdomide
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CC-220 |
Apoptosis
,
Ligand for E3 Ligase
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Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay). |
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T8616 |
Fasentin
|
N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide |
transporter
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Fasentin (N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide) is an inhibitor of GluT1. |
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T1862 |
PR-619
|
PR 619,2,6-Diamino-3,5-dithiocyanopyridine |
Apoptosis
,
DUB
,
Autophagy
|
|
PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs). |
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T61884 |
C6 Ceramide
|
N-hexanoylsphingosine,N-(hexanoyl)sphing-4-enine |
Apoptosis
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C6 Ceramide (N-hexanoylsphingosine) is an activator of the ceramide pathway that arrests cells in the G0/G1 phase by activating ERK. It can act in a variety of cancer cell lines. |
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T83641 |
HNPMI
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Apoptosis
,
EGFR
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HNPMI is an EGFR inhibitor that induces G0/G1 phase arrest of CRC cells in colorectal cancer, regulates enzymes associated with apoptosis, and can promote apoptosis, and can be used for the study of colorectal cancer. |
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T11158 |
EGFR-IN-11
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EGFR
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EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R/T790M/C797S with an IC50 of 18 nM and arrests cell cycle at G0/G1. |
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T8494 |
NS-3-008 hydrochloride
|
NS-3-008 HCl |
Others
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NS-3-008 hydrochloride (NS-3-008 HCl) is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM). |
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T35900 |
JAK2-IN-7
|
JAK2-IN-7 |
JAK
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JAK2-IN-7, a selective inhibitor targeting Janus Kinase 2 (JAK2), exhibits inhibitory concentrations (IC50) of 3 nM for JAK2, 11.7 nM for SET-2 cells, and 41 nM for Ba/F3 V617F cells, indicative of its potency and select... |
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T9244 |
σ1 Receptor antagonist-1
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Sigma receptor
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σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist. |
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T30214 |
Austrocortirubin
|
NSC626307,(+)-Austrocortirubin,NSC 626307,NSC-626307 |
|
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Austrocortirubin is a DNA damage inducer at the G0/G1, S, and G2 cell cycle stages distinct from other DNA damage agents. |
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T26194 |
SKLB70326
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SKLB 70326,SKLB-70326 |
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SKLB70326 is a cell-cycle progression inhibitor that acts by inducing G0/G1 phase arrest and apoptosis in human hepatic carcinoma cells. |
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T63594 |
Topoisomerase IIα-IN-3
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|
|
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Topoisomerase IIα-IN-3 is a DNA-inserting topoisomerase-Iiα inhibitor that blocks the cell cycle in G0/G1 phase and induces apoptosis. |
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T79474 |
GSPT1 degrader-1
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|
Apoptosis
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GSPT1 Degrader-1 (Compound 9q) effectively facilitates the degradation of G1 to S phase transition 1 (GSPT1) through the ubiquitin-proteasome system and induces G0/G1 phase arrest and apoptosis in cells [1]. |
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T72722 |
Physachenolide C
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|
Epigenetic Reader Domain
|
|
Physachenolide C, a selective BET inhibitor, induces apoptosis and arrests the cell cycle at the G0-G1 phase, exhibiting antitumor activity [1]. |
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T63352 |
BRD4 Inhibitor-18
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|
|
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BRD4 Inhibitor-18 is a potent BRD4 inhibitor (IC50: 110 nM) with a hydrophobic acetylcyclopentane side chain. BRD4 Inhibitor-18 significantly reduces the proliferation of MV-4-11 cells with high BRD4 levels, inhibits G0/... |
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T64034 |
Antitumor agent-45
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|
|
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Antitumor agent-45 has an inhibitory effect on c-Met expression and is able to block A549 cells in the G0/G1 and G2/M phases and induce apoptosis. |
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T74768 |
Antitumor agent-92
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|
Apoptosis
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Antitumor Agent-92, an Icaritin derivative, induces G0/G1 phase cell cycle arrest and promotes apoptosis. This compound shows promise for hepatocellular carcinoma (HCC) research [1]. |
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T64026 |
ERα antagonist 1
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|
|
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ERα antagonist 1 is a selective, potent, covalent estrogen receptor alpha (ERα) antagonist that blocks the cell cycle of MCF-7 cells in G0/G1 phase and induces apoptosis. |
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T61412 |
Anticancer agent 47
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|
|
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Anticancer agent 47 (compound 4j) exhibits potent anticancer properties, demonstrating antiproliferative activities and inducing apoptosis as well as cell cycle arrest at G0/G1 phase. Moreover, Anticancer agent 47 has ex... |
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T74440 |
YM281
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|
|
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YM281, a potent EZH2 inhibitor, promotes cell apoptosis and induces cell cycle arrest at the G0/G1 phase, demonstrating antitumor effects in vivo. This compound holds promise for lymphoma research [1]. |
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T63767 |
P300 bromodomain-IN-1
|
|
|
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P300 bromodomain-IN-1 is a potent inhibitor of p300 (EP300) bromodomain (IC50: 49 nM). p300 bromodomain-IN-1 blocks c-Myc expression and induces cell cycle arrest at G1/G0 phase and apoptosis in OPM-2 cells. apoptosis). |
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T61299 |
PAK4-IN-2
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|
|
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PAK4-IN-2 is an exceptionally effective inhibitor of PAK4, exhibiting an IC 50 value of 2.7 nM. This compound is capable of arresting MV4-11 cells at the G0/G1 phase and inducing cell apoptosis. It holds significant pote... |
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T36963 |
CAY10503
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|
|
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CAY10503 is a proapoptotic, antiproliferative compound that is able to arrest cell cycle progression in the G0-G1 phase. CAY10503 inhibits the growth of HL60, multidrug resistant HL60R, and K562 cells with IC50 values of... |
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T63693 |
EGFR-IN-55
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|
|
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EGFR-IN-55 is a potent inhibitor of EGFR, acting on EGFRWT (IC50: 70 nM) and EGFRL858R/T790M (IC50: 3.9 nM). EGFR-IN-55 was able to block the cell cycle of NCI-H1975 cells in G0/G1 phase, exhibiting anticancer effects. |
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T79434 |
Antitumor agent-103
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|
Apoptosis
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Antitumor Agent-103 (compound 24l) induces apoptosis and possesses antiproliferative and anti-colony formation properties. This compound halts the cell cycle at the G0/G1 phase, augments nitric oxide (NO) production, and... |
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T78549 |
Ethylene glycol dimethacrylate
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Reactive Oxygen Species
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Ethylene glycol dimethacrylate, a methacrylate monomer, demonstrates cytotoxic and genotoxic impacts on human gingival fibroblasts (HGFs), elevating intracellular reactive oxygen species (ROS) levels, inducing DNA damage... |
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T79466 |
Antitumor agent-111
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c-Met/HGFR
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Antitumor Agent-111 (Compound 46), a c-Met kinase inhibitor (IC50 = 46 nM), exhibits both antitumor and antiproliferative effects. It impedes the cell cycle at the G0/G1 phase and induces apoptosis [1]. |
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T63105 |
Topotecan hydrochloride hydrate
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|
|
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Topotecan hydrochloride hydrate is an orally active Topoisomerase I inhibitor with anticancer properties. topotecan hydrochloride hydrate is capable of blocking the cell cycle in G0/G1 and S phases and inducing apoptosis... |
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T63448 |
BRAF V600E/CRAF-IN-1
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|
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BRAF V600E/CRAF-IN-1 is a potent inhibitor of BRAFV600E/CRAF. BRAF V600E/CRAF-IN-1 acts in the G0/G1 phase of HCT-116 colon cancer cells to arrest the cell cycle and cause apoptosis. BRAF V600E/CRAF-IN-1 shows potential ... |
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T63599 |
Anticancer agent 54
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|
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Anticancer agent 54 is an effective anticancer agent whose anticancer activity depends on DNA embedding and ROS generation. Anticancer agent 54 has an anti-proliferative effect by blocking the cell cycle in G0/G1 phase a... |
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T61097 |
Anticancer agent 70
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|
|
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Anticancer agent 70 (Compound 21) is a potent anticancer compound that demonstrates remarkable cytotoxicity against multiple human cancer cell lines. It induces G0/G1-cell cycle arrest and concurrently elevates the level... |
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T81569 |
PAK4-IN-3
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PAK
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PAK4-IN-3 (compound 27e) is a PAK4 inhibitor exhibiting an IC50 of 10 nM and demonstrates antiproliferative effects on A549 cells with an IC50 of 0.61μM. It also induces concentration-dependent apoptosis in A549 cells an... |
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T78942 |
HSP90-IN-23
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|
HSP
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HSP90-IN-23 (Comp 12-1), a heat shock protein 90 (HSP90) inhibitor, exhibits potent activity with an IC50 of 9nM. It promotes apoptosis in tumor cells and arrests their cell cycle at the G0/G1 phase, making it applicable... |
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T63123 |
FAK inhibitor 6
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|
|
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Compound 26F effectively optimizes enzyme inhibition (IC50 = 28.2 nM) while demonstrating relatively low cytotoxicity (IC50 = 3.32 μM). It induces apoptosis in MDA-MB-231 cells in a dose-dependent manner and efficiently ... |
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T83433 |
1D228
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c-Met/HGFR
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1D228, a c-Met/TRK inhibitor with antitumor properties, suppresses cyclin D1 to precipitate G0/G1 arrest, thereby inhibiting proliferation and migration of cancer cells. This compound is applicable in researching gastric... |
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T61695 |
GLUT4-IN-2
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|
|
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GLUT4-IN-2, a selective inhibitor specifically targeting GLUT4, demonstrates potent antitumor activity with IC50 values of 6.8 μM for GLUT4 and 11.4 μM for GLUT1. It effectively induces cell apoptosis and arrests the cel... |
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T79701 |
PI3K-IN-48
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|
Akt
|
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PI3K-IN-48, a PI3K inhibitor, exhibits an IC50 of 1.55 ± 0.18 μM in A549 cells, demonstrating its potency in this context. It induces G0/G1 phase arrest and cell apoptosis, while also down-regulating the expression of p-... |
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T79393 |
ALK/EGFR-IN-2
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|
|
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ALK/EGFR-IN-2 is a potent dual inhibitor targeting ALK and EGFR, promoting apoptosis and G0/G1 cell cycle arrest in cancer cells. It effectively suppresses proliferation in H1975, PC9, and Baf3-EML4-ALK cancer cell lines... |
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T63882 |
BRAF V600E/CRAF-IN-2
|
|
|
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BRAF V600E/CRAF-IN-2 is a potent inhibitor of BRAFV600E/CRAF with IC50 values of 0.888 and 0.229 μM, respectively.BRAF V600E/CRAF-IN-2 induces cell cycle arrest at G0/G1 phase and apoptosis in HCT-116 colon cancer cells.... |
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T73257 |
USP7-IN-9
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|
|
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USP7-IN-9, a potent inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 40.8 nM, effectively induces apoptosis and arrests cell progression at the G0/G1 and S phases in RS4;11 cells. It decreases the protei... |
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T80748 |
YS-363
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|
EGFR
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YS-363 is a potent, selective, and orally active inhibitor of the epidermal growth factor receptor (EGFR), exhibiting half-maximal inhibitory concentrations (IC50) of 0.96 nM for the wild-type EGFR and 0.67 nM for the ... |
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T63648 |
EGFR kinase inhibitor 1
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|
|
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EGFR kinase inhibitor 1 is a potent inhibitor of EGFR that acts on WT (IC50: 37 nM), l885R/T790M (IC50: 1.7 nM), and L858R/T790M/C797S (IC50>300 nM). EGFR kinase inhibitor 1 is capable of blocking the cell cycle in G0/G1... |
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T82439 |
Estrogen receptor modulator 10
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Estrogen Receptor/ERR
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Compound G-5b, an estrogen receptor modulator 10, functions as an estrogen receptor (ER) antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM). It has the capability to induce apoptosis and block cells at the G1/G0 phase, ... |
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T63895 |
EGFR-IN-62
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|
|
|
EGFR-IN-62 is a potent inhibitor of EGFR kinase with IC50 values of 10 nM for L858R/T790 M, 29 nM for WT and 2 42 nM for L858R/T790 M/C797S. EGFR-IN-62 blocks the cell cycle of A549 and/or H1975 cells in G1/G0 phase and ... |
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T73028 |
HCAIX-IN-16
|
|
Carbonic Anhydrase
|
|
hCAIX-IN-16 (Compound 12d), an inhibitor of hCA IX, exhibits inhibition constants (K i) of 190.0 nM for hCA IX and 187.9 nM for hCA XII. It can arrest the cell cycle in the G0-G1 and S phases and induce apoptosis in MDA-... |
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T72836 |
SHP2/CDK4-IN-1
|
|
|
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SHP2/CDK4-IN-1 (compound 10) is a dual inhibitor targeting SHP2 and CDK4, exhibiting oral activity and high potency with IC50 values of 4.3 nM for SHP2 and 18.2 nM for CDK4. It effectively induces G0/G1 arrest, inhibitin... |
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T64187 |
HDAC1/6-IN-1
|
|
|
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HDAC1/6-IN-1 is a potent multi-target inhibitor of GLP (IC50: 1.3 nM), HDAC6 (IC50: 13 nM) and HDAC1 (IC50: 89 nM). HDAC1/6-IN-1 inhibits the methylation and deacetylation of H3K9 at the protein level. HDAC1/6-IN-1 can b... |
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T61005 |
K783-0308
|
|
|
|
K783-0308 is a potent and selective MNK2 and FLT3 dual inhibitor with IC 50 values of 406 and 680 nM, respectively. K783-0308 promotes the apoptosis and cell cycle arrests in the G0/G1 phase of acute myeloid leukemia (AM... |
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T37056 |
D-erythro-MAPP
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|
|
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D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 μM; IC50 = 1-5 μM). It is selective for alkaline ceramidase over acid ceramidase (IC50 = >500 μM) as well as the serine/threon... |
