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カタログ番号 | 製品名 | 別名 | ターゲット |
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T26712 | AZD-1656 | AZD 1656 | Glucokinase |
AZD-1656 is a glucokinase activator (GKA) that can cause dose-limiting hypoglycemia in normal animals used in embryofetal development studies and type 2 diabetes. | |||
T0334 | Rosiglitazone | BRL49653 | Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy |
Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer. | |||
T1502 | Vildagliptin | NVP-LAF 237,LAF237 | Apoptosis , Ferroptosis , Proteasome , DPP-4 |
Vildagliptin (LAF237) is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiety undergoes hydrolysis and this inactive metabolit... | |||
T6646 | Rosiglitazone hydrochloride | BRL-49653 HCl,Rosiglitazone HCl | Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy |
Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells. | |||
T1453 | Phenformin hydrochloride | Phenformin HCl,Phenethylbiguanide hydrochloride | Potassium Channel , AMPK , Autophagy |
Phenformin hydrochloride (Phenformin HCl) is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity. | |||
T8493 | Ingliforib | GPi 296,CP 368296 | Phosphorylase |
Ingliforib (CP 368296) is a novel glycogen phosphorylase inhibitor,has antihyperglycemic and cardioprotective properties. | |||
T21764 | MCC-555 | Isaglitazone,Netoglitazone | PPAR |
MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects. | |||
T3547 | Sotagliflozin | LX-4211,LP-802034 | SGLT |
Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity. | |||
T1527 | Gliclazide | S1702,SE1702 | Potassium Channel |
Gliclazide (SE1702), an oral antihyperglycemic agent, belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating beta-cells of the pancreas to release insulin. | |||
T2389 | Dapagliflozin | BMS-512148 | SGLT , HIF |
Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity. | |||
T0371 | Gliquidone | AR-DF 26,Glurenorm | Potassium Channel |
Gliquidone (AR-DF 26) is a potent, second-generation sulfonylurea with antihyperglycemic activity. Like other second-generation compounds, gliquidone exerts greater binding affinity to SUR1 and increased potency compared... | |||
T28560 | Ro 16-8714 | Ro-16-8714,Ro16-8714 | |
Ro 16-8714 is an agonist of beta-adrenoreceptor with antihyperglycemic and thermogenic properties. | |||
T68561 | ASP-4000 free base | ||
ASP-4000 free base is a dipeptidyl peptidase 4 (DPP) inhibitor with antihyperglycemic activity. | |||
T15386 | Glisoxepide | Others | |
Glisoxepide is a sulphonamide derivative and is an orally available nonselective K(ATP) channel blocker. It has antihyperglycemic activity and cardiovascular regulation effect. | |||
T69015 | THR-0921 | ||
THR-0921 is a peroxisome proliferator-activated gamma (PPAR gamma) agonist that has antihyperglycemic activity with low adipogenic potential. | |||
T31960 | Glymidine | Glycodiazin,Glymidinum,Glycodiazine,Glidiazine | |
Glycodiazine is a sulfadiazine derivative with antihyperglycemic activity. Glycanamidine can lower blood sugar levels by increasing insulin release from pancreatic beta cells and increasing peripheral tissue sensitivity ... | |||
T24164 | Indanorex | JL-11698,Dietor,JL11698,Indanorexum,JL 11698 | |
Indanorex is a stimulant drug. It has appetite suppressant effects and also has antihyperglycemic effects. | |||
T61076 | Vildagliptin dihydrate | ||
Vildagliptin dihydrate (LAF237 dihydrate) is a powerful and stable dipeptidyl peptidase IV (DPP-IV) inhibitor, demonstrating selectivity with an IC50 of 3.5 nM in human Caco-2 cells. This compound exhibits exceptional or... | |||
T15505 | HSK0935 | HSK 0935,HSK-0935 | SGLT |
T73779 | 5β-Androstan-3β-ol-17-one | ||
5β-Androstan-3β-ol-17-one (3β-Etiocholanolone; 5β-Epiandrosterone), a 5β-reduced steroid and a significant metabolic derivative of dehydroepiandrosterone (DHEA), demonstrates potent antihyperglycemic actions in C57BL/KsJ... | |||
T76310 | Acetyl Gastric Inhibitory Peptide (human) | ||
Acetyl Gastric Inhibitory Peptide (human), a fatty acid-derivatized analog of glucose-dependent insulinotropic polypeptide, exhibits enhanced antihyperglycemic and insulinotropic characteristics. This compound is utilize... | |||
T78543 | Acetyl Gastric Inhibitory Peptide (human) TFA | Human N-acetyl GIP TFA | |
Acetyl Gastric Inhibitory Peptide (human) TFA, a fatty acid-derivatized analog of the glucose-dependent insulinotropic polypeptide, exhibits enhanced antihyperglycemic and insulinotropic properties. It is utilized in the... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T0247 | Acarbose | BAY g 5421 | Glucosidase |
Acarbose (BAY g 5421) is an inhibitor of α-Glucosidases with antihyperglycemic activity. | |||
T3675 | 1-Deoxynojirimycin | Duvoglustat,Moranoline,moranolin | PI3K , Glucosidase |
1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus. | |||
T21344 | 1-Deoxynojirimycin hydrochloride | Moranoline,AT2220,Duvoglustat hydrochloride,1-Deoxynojirimycin,DNJ,deoxynojirimycin | PI3K , Antibacterial , Antibiotic , Glucosidase |
1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves. Duvoglustat is used to suppress the elevation of postprandial hyperglycemia. | |||
TN1026 | Vomicine | Others | |
Vomicine is a natural product from Strychnos nux-vomica, the S. nux-vomica extracts show antihyperglycemic activity in experimental animals. | |||
T1529 | Miglitol | BAY1099,BAY-m1099 | Others |
Miglitol (BAY1099) is an alpha-Glucosidase Inhibitor with antihyperglycemic activity. | |||
T5743 | Gymnemagenin | Liver X Receptor | |
Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity. | |||
T7846 | Aegeline | Others , Antifungal | |
Aegeline is an alkaloidal-amide, isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus. | |||
T6S1371 | Isovitexin | Homovitexin,Saponaretin,Apigenin-6-C-Glucoside | NF-κB , JNK , Glucosidase |
1. Isovitexin (Apigenin-6-C-Glucoside) exhibits a potential antioxidant activity. 2. Isovitexin shows a strong antihyperglycemic action, inhibits α-glucosidase in vivo. | |||
T7448 | 4-Hydroxyisoleucine | 4-Hydroxy-L-isoleucine | Others |
4-Hydroxyisoleucine (4-Hydroxy-L-isoleucine) has antidepressant-like, antidyslipidemic, and antihyperglycemic effects. It displays an insulinotropic activity. | |||
TN2247 | Swertisin | Adenosine Receptor | |
Swertisin, a novel herbal biomolecule, shows a strong antihyperglycemic action. Swertisin is an adenosine A1 receptor antagonist, is known to have antidiabetic, anti-inflammatory and antioxidant effects. | |||
TN1334 | 7-Methoxyrosmanol | 7-O-Methylrosmanol | cAMP |
7-Methoxyrosmanol (7-O-Methylrosmanol) can effectively suppress FSK-induced luciferase expression under the control of the CRE, PEPCK-C and G6Pase gene promoters, it may contribute to its antihyperglycemic activity. | |||
T3S2072 | 3-Butylidenephthalide | Butylidene phthalide,n-Butylidenephthalide | Parasite , Glucosidase |
1. 3-Butylidenephthalide (Butylidene phthalide) has antihyperglycemic effect is due to inhibition of α-glucosidase at the intestinal level, inhibited the activity of yeast-α-glucosidase (IC(5) 2.35 mM) in a noncompetitiv... | |||
T3415 | Secoisolariciresinol diglucoside | LGM2605 | ROS |
Secoisolariciresinol diglucoside (LGM2605) was cytoprotective in an in vitro model of iron overload-induced redox-inflammatory damage. Secoisolariciresinol diglucoside (25 mg/kg b.w.) exerts the antihyperglycemic effect ... | |||
T2909 | Fraxetin | 7,8-dihydroxy-6-methoxy coumarin | Apoptosis , Others |
Fraxetin (7,8-dihydroxy-6-methoxy coumarin) has dual-antioxidative ,hepatoprotective and antihyperglycemic functions, it shows potent protective effects against CCl4 induced oxidative stress and hepatic fibrosis, has a m... | |||
TN4584 | Morolic acid | IL Receptor , COX , HIV Protease | |
Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent changes of glucose, cholesterol and triglycerides, in part mediat... | |||
T75493 | Ellipyrone B | ||
Ellipyrone B, a γ-pyrone-based macrocyclic polyketide with antihyperglycemic properties, demonstrates inhibitory activity against dipeptidyl peptidase-4 (IC 50 =0.48 mM) [1]. | |||
TN4585 | Moronic acid | HIV Protease , Antifection , HSV | |
Moronic acid shows oral therapeutic efficacy in HSV-infected mice and possessed novel anti-HSV activity. It also shows significant anti-HIV activity (EC(50) 186) and was modified to develop more potent anti-AIDS agents. ... | |||
T60692 | Masoprocol | ||
Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active inhibitor of lipoxygenase. Masoprocol exhibits antihyperglycemic activity that has the potential for the type II diabetes research. In vivo, Masop... |
カタログ番号 | 製品名 | ||
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L6110 | Alkaloid Natural Product Library | 464 compounds | |
A unique collection of 464 natural alkaloids can be used for high throughput and high content screening; |