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109

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T8391	Cesium chloride	CsCl	Potassium Channel
	Cesium chloride (CsCl) is considered to be the most toxic of the alkali chlorides, inhibiting fungal growth.		Potassium Channel
T5023	Propiverine hydrochloride		Others , Calcium Channel , AChR
	Propiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB).		Others , Calcium Channel , AChR
T19723	AMTB hydrochloride	AMTB	TRP/TRPV Channel
	AMTB hydrochloride (AMTB HCl) is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. AMTB can act on the bladder afferent pathway to attenuate the bladder micturition reflex and nociceptive refl...		TRP/TRPV Channel
T15017	CU-T12-9		TLR
	CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activat...		TLR
T9419	Fesoterodine	(R) Fesoterodine	AChR
	Fesoterodine ((R) Fesoterodine) is an orally active, competitive mAChR antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. It is used for the overactive bladder (OAB).		AChR
TQ0219	MK-8033		c-Met/HGFR
	MK-8033 is a new and selective dual ATP competitive c-Met/Ron inhibitor (IC50: 1 nM Wt c-Met).		c-Met/HGFR
T4612	NS309		EGFR , Potassium Channel , HER
	NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activat...		EGFR , Potassium Channel , HER
T6916	OICR-9429	OICR 9429	Histone Methyltransferase , JAK
	OICR-9429 is a potent antagonist of the interaction that WDR5 effect with peptide regions of MLL and Histone 3. It reduces the viability of acute myeloid leukemia cells in vitro.		Histone Methyltransferase , JAK
T21976	ONO-8130		Prostaglandin Receptor
	ONO-8130 is an orally available antagonist of EP1 receptor.		Prostaglandin Receptor
T1472	Trospium chloride	Spasmex,Sanctura	AChR
	Trospium chloride (Spasmex) is an antispasmodic and anticholinergic agent used to treat urinary incontinence and overactive bladder syndrome. Trospium chloride has not been implicated in causing liver enzyme elevations o...		AChR
T1006	Propantheline bromide	Neopepulsan,Pro-Banthine,Neometantyl	AChR
	Propantheline bromide (Pro-Banthine) competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gland cells. Propantheline Bromide is the bromid...		AChR
T0091	Alfuzosin hydrochloride	SL 77499-10,Alfuzosin HCl	Adrenergic Receptor
	Alfuzosin hydrochloride (Alfuzosin HCl) is an α1 adrenergic receptor antagonist. It applies to treat benign prostatic hyperplasia (BPH).		Adrenergic Receptor
T0099	Tolterodine tartrate	Detrol LA,PNU-200583E,Kabi-2234	AChR
	Tolterodine tartrate (PNU-200583E) is a potent antagonist for muscarinic receptor. It show selectivity for the urinary bladder and salivary glands in vivo.		AChR
T1475	Fesoterodine fumarate	Toviaz,SPM 907	AChR
	Fesoterodine fumarate (Toviaz) is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodine is rapidly hydrolyzed in vivo...		AChR
T0334	Rosiglitazone	BRL49653	Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
	Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer.		Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
T0197	Terazosin hydrochloride	Terazosin HCl,Terazosine,Blavin,Hytrin,Zayasel,Fosfomic	Adrenergic Receptor
	Terazosin hydrochloride (Hytrin) , a selective alpha1-antagonist, can treat the benign prostatic hyperplasia (BPH). It also can lower blood pressure, so it is a drug of choice for patients with prostate enlargement and h...		Adrenergic Receptor
T1824	TGR5 Receptor Agonist		GPCR19
	TGR5 is a potent TGR5(GPCR19) agonist.		GPCR19
T15477	Hexaminolevulinate hydrochloride	Hexyl 5-aminolevulinate hydrochloride,5-Aminolevulinic acid hexyl ester hydrochloride,P-1206	Others
	Hexaminolevulinate hydrochloride (P-1206) has approved for cystoscopic detection of papillary bladder cancer and it also is a fluorescent agent.		Others
T6646	Rosiglitazone hydrochloride	BRL-49653 HCl,Rosiglitazone HCl	Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
	Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.		Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
T6701	Terazosin hydrochloride dihydrate	Flotrin dihydrate,Terazosin HCl Dihydrate,Dysalfa dihydrate,Heitrin dihydrate	Adrenergic Receptor
	Terazosin hydrochloride dihydrate (Heitrin dihydrate) is a selective α1-adrenoceptor antagonist, used for treatment of symptoms of an enlarged prostate (BPH).		Adrenergic Receptor
T0703	Flavoxate hydrochloride	Flavoxate HCl,NSC-114649,DW61,Rec-7-0040	AChR
	Flavoxate hydrochloride (DW61) , a muscarinic AChR antagonist, is used in the therapy of various urinary syndromes and as an antispasmodic.		AChR
T72038	YM-58790	YM-58790 free base	AChR
	YM-58790 free base is a potent mAChR antagonist.YM-58790 free base inhibited M1 mAChR, M2 mAChR, and M3 mAChR with Ki values of 28 nM, 260 nM, and 15 nM, respectively.YM-58790 free base inhibits reflex rhythmic bladder c...		AChR
T15273	Fedovapagon	VA483,A106483	Vasopressin Receptor
	Fedovapagon (VA106483) is a selective and potent agonist of the vasopressin V2 receptor (V2R) that inhibits the growth of intersegmental vessels in zebrafish. Fedovapagon can be used to study overactive bladder, nocturia...		Vasopressin Receptor
T13905	Stilbamidine	Ba 2652,Stilbamidin	Antifungal
	Stilbamidine (Ba 2652) has antifungal and anticancer activity and can be used to study multiple myeloma and bladder migratory cell carcinoma.		Antifungal
T1671	Mirabegron	YM178	Adrenergic Receptor
	Mirabegron (YM178) is a beta-3 adrenergic agonist that is used for treatment of overactive bladder syndrome.		Adrenergic Receptor
T23563	ZM 226600		Potassium Channel
	ZM 226600 is an ATP-sensitive potassium channel opener with an EC50 value of 500 nM. ZM226600 has an inhibitory effect on spontaneous bladder activity.		Potassium Channel
T1534	Darifenacin hydrobromide	Darifenacin HBr,UK-88525	AChR
	Darifenacin hydrobromide (UK-88525) is a selective muscarinic receptor antagonist used to treat urinary incontinence and overactive bladder syndrome.		AChR
TP1819L	Substance P 1-9 aceate		Neurotensin Receptor
	Substance P 1-9 aceate is nonapeptide, which decreases the inactivation of substance P by the guinea-pig ileum and urinary bladder.		Neurotensin Receptor
T1049L	Oxybutynin	Oxytrol,Ditropan,Oxibutyninum	Potassium Channel , AChR
	Oxybutynin (Ditropan) is a synthetic anticholinergic agent that is used for treatment of urinary incontinence and overactive bladder syndrome.		Potassium Channel , AChR
T60536	Terodiline		Calcium Channel , AChR
	Terodiline is an orally available selective muscarinic M1 receptor and calcium channel antagonist for the study of diseases caused by abnormal bladder function.		Calcium Channel , AChR
T15558	GSK319347A		IκB/IKK
	GSK319347A is a selective and potent dual inhibitor of TBK1 and IKKε with potential anti-tumor activity and inhibition of IKK2 activity, which can be used in the study of bladder cancer and lung adenocarcinoma.		IκB/IKK
TP1883	[Lys5,MeLeu9,Nle10]-NKA(4-10)		Neurokinin receptor
	Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).		Neurokinin receptor
T12255	NS19504		Potassium Channel
	NS19504 is an activator of Ca2+-activated K+ channel with EC50 of 11.0 µM. NS19504 shows relaxing effect on bladder smooth muscle spontaneous phasic contractions[1].		Potassium Channel
T1049	Oxybutynin chloride	Oxybutynin hydrochloride,Oxybutynin HCl	Potassium Channel , AChR
	Oxybutynin chloride (Oxybutynin HCl) is an anticholinergic medication used to relieve urinary and bladder difficulties. It competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor.		Potassium Channel , AChR
T36898	Sandacanol	Sandranol,2-Ethyl-4-(2,2,3-trimethylcyclopent-3-en-yl)-but-2-en-1-ol	Apoptosis
	Sandacanol（Sandranol） is a selective olfactory receptor (OR10H1) agonist. Sandacanol can induce cell cycle arrest and partial apoptosis in bladder cancer cells, and can reduce cell migration rate and proliferation rate.		Apoptosis
T24051	Exisulind	Sulindac sulfone,CP248	Apoptosis , PKA
	Exisulind (CP248) induces apoptosis through the activation of protein kinase G (PKG). Exisulind exhibits antineoplastic activity in solid tumour and haematological cancer cell lines and is an inhibitor of tumour growth i...		Apoptosis , PKA
T11918L	Lysipressin acetate(50-57-7(fb_acetate))	Lysine vasopressin acetate,[Lys8]-Vasopressin acetate	Others
	Lysipressin acetate(50-57-7(fb_acetate)) ([Lys8]-Vasopressin acetate) , Induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase. Lysipressin is Antidiuretic hormone that have been foun...		Others
T60039	KSQ-4279	USP1-IN-1	PARP , DUB
	KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP.KSQ-4279 has anticancer activity and is used in the study of non-small cell lung cancer, osteosarcoma, ovarian, breast, glioblastoma, bladder, uterine and pancreatic ...		PARP , DUB
T12970	Solabegron	GW 427353	Adrenergic Receptor
	Solabegron (GW 427353) is a selective agonist of β3-adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR(EC50 : 22 nM). It is used for treatment of overactive bladd...		Adrenergic Receptor
T23888	CID-5056270		ROCK
	CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma, breast cancer and bone cancer. It can be used to study hype...		ROCK
T15713	Larotaxel	XRP9881	P-gp
	Larotaxel (XRP9881) is a taxane analogue that has anticancer activity, exerts its cytotoxic effects by promoting tubulin assembly and stabilizing microtubules, and ultimately induces cell death through apoptosis. Larotax...		P-gp
T0210L	Tamsulosin	LY253351 free base,HSDB7744,(R)-(-)-YM12617 free base,Harnal-D,Flowmax,HSDB 7744,HSDB-7744	Adrenergic Receptor
	Tamsulosin ((R)-(-)-YM12617 free base) is an alpha1A adrenergic receptor antagonist for the symptomatic treatment of benign prostatic hyperplasia (BPH). Tamsulosin is used to treat difficulty urinating, a common symptom ...		Adrenergic Receptor
T0976	Propoxur	Aprocarb,Propoxure,Baygon	AChR , Antifungal
	Propoxur (Propoxure) is an insecticide used to control cockroaches, flies, mosquitoes, and lawn and turf insects. Acute (short-term) exposure of humans to propoxur by ingestion leads to cholinesterase inhibition of red b...		AChR , Antifungal
T70632	DFL23448
	DFL23448 is a TRPM8-selective ion channel antagonist, modifying bladder function and reduces bladder overactivity in awake rats.
T71349	GRC-6211
	GRC-6211 is an oral specific TRPV1 antagonist which decreases bladder overactivity and noxious bladder input in cystitis animal models.
T11275	Fesoterodine L-mandelate		Others
	Fesoterodine L-mandelate is a efficacious antimuscarinic agent for the overactive bladder (OAB).		Others
T29208	ZD-0947	AZD0947,AZD-0947,ZD 0947,AZD 0947
	ZD-0947, a K(ATP) channel activator, is used potentially for the treatment of overactive bladder (OAB).
T29667	Adosopine	Adosupine
	Adosopine is a dibenzoazepine which affects urinary bladder hyperreflexia and may be suitable for treating urinary incontinence.
T61438	Propiverine
	Propiverine is a potent antimuscarinic agent that effectively inhibits cellular calcium influx, leading to the reduction of muscle spasm. It exhibits neurotropic and musculotropic effects specifically on the smooth muscl...
T3290L	Pikamilone Sodium	GABA-NG,Nicotinoyl-GABA sodium salt,GABA NG,GABANG,Pikamilone Na
	Pikamilone Sodium is a prodrug of GABA used for therapy of neurogenic bladder in spinal and benign prostatic hyperplasia.

Compounds

Cesium chloride

T8391

Synonym: CsCl

Target: Potassium Channel

Propiverine hydrochloride

T5023

Synonym:

Target: Others, Calcium Channel, AChR

AMTB hydrochloride

T19723

Synonym: AMTB

Target: TRP/TRPV Channel

Synonym: (R) Fesoterodine

Target: EGFR, Potassium Channel, HER

OICR-9429

T6916

Synonym: OICR 9429

Target: Histone Methyltransferase, JAK

ONO-8130

T21976

Synonym:

Target: Prostaglandin Receptor

Trospium chloride

T1472

Synonym: Spasmex,Sanctura

Target: AChR

Propantheline bromide

T1006

Synonym: Neopepulsan,Pro-Banthine,Neometantyl

Target: AChR

Alfuzosin hydrochloride

T0091

Synonym: SL 77499-10,Alfuzosin HCl

Target: Adrenergic Receptor

Tolterodine tartrate

T0099

Synonym: Detrol LA,PNU-200583E,Kabi-2234

Target: AChR

Fesoterodine fumarate

T1475

Synonym: Toviaz,SPM 907

Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy

Terazosin hydrochloride

T0197

Synonym: Terazosin HCl,Terazosine,Blavin,Hytrin,Zayasel,Fosfomic

Target: Adrenergic Receptor

TGR5 Receptor Agonist

T1824

Synonym:

Target: GPCR19

Hexaminolevulinate hydrochloride

T15477

Synonym: Hexyl 5-aminolevulinate hydrochloride,5-Aminolevulinic acid hexyl ester hydrochloride,P-1206

Target: Others

Rosiglitazone hydrochloride

T6646

Synonym: BRL-49653 HCl,Rosiglitazone HCl

Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy

Terazosin hydrochloride dihydrate

T6701

Synonym: Flotrin dihydrate,Terazosin HCl Dihydrate,Dysalfa dihydrate,Heitrin dihydrate

Target: Adrenergic Receptor

Flavoxate hydrochloride

T0703

Synonym: Flavoxate HCl,NSC-114649,DW61,Rec-7-0040

Target: AChR

YM-58790

T72038

Synonym: YM-58790 free base

Target: AChR

Fedovapagon

T15273

Synonym: VA483,A106483

Target: Vasopressin Receptor

Stilbamidine

T13905

Synonym: Ba 2652,Stilbamidin

Target: Adrenergic Receptor

ZM 226600

T23563

Synonym:

Target: Potassium Channel

Darifenacin hydrobromide

T1534

Synonym: Darifenacin HBr,UK-88525

Target: AChR

Substance P 1-9 aceate

TP1819L

Synonym:

Target: Neurotensin Receptor

Oxybutynin

T1049L

Synonym: Oxytrol,Ditropan,Oxibutyninum

Target: Potassium Channel, AChR

Terodiline

T60536

Synonym:

Target: Calcium Channel, AChR

[Lys5,MeLeu9,Nle10]-NKA(4-10)

TP1883

Synonym:

Target: Neurokinin receptor

NS19504

T12255

Synonym:

Target: Potassium Channel

Oxybutynin chloride

T1049

Synonym: Oxybutynin hydrochloride,Oxybutynin HCl

Target: Potassium Channel, AChR

Sandacanol

T36898

Synonym: Sandranol,2-Ethyl-4-(2,2,3-trimethylcyclopent-3-en-yl)-but-2-en-1-ol

Target: Apoptosis

Exisulind

T24051

Synonym: Sulindac sulfone,CP248

Target: Apoptosis, PKA

Lysipressin acetate(50-57-7(fb_acetate))

T11918L

Synonym: Lysine vasopressin acetate,[Lys8]-Vasopressin acetate

Target: Adrenergic Receptor

Synonym: LY253351 free base,HSDB7744,(R)-(-)-YM12617 free base,Harnal-D,Flowmax,HSDB 7744,HSDB-7744

Target: Adrenergic Receptor

Propoxur

T0976

Synonym: Aprocarb,Propoxure,Baygon

Target: AChR, Antifungal

Fesoterodine L-mandelate

Synonym: AZD0947,AZD-0947,ZD 0947,AZD 0947

Synonym: GABA-NG,Nicotinoyl-GABA sodium salt,GABA NG,GABANG,Pikamilone Na

Target:

カタログ番号	製品名	別名	ターゲット
T3S0737	Flavokawain A	Flavokavain A	Apoptosis , p38 MAPK
	NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significant...		Apoptosis , p38 MAPK
T3A2467	Allocryptopine	Thalictrimine,Fagarine I	Potassium Channel
	Allocryptopine (Thalictrimine) induces muscle contraction and relaxation in urinary bladder and ileum, respectively.		Potassium Channel
T4S0350	Licochalcone B		Beta Amyloid , Others
	1. Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (murine bladder cancer cell line) tumor model. 2. LCB and Licoc...		Beta Amyloid , Others
T4S1619	L-Hyoscyamine sulfate	Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate	AChR
	L-Hyoscyamine sulfate (Levsin Sulfate) is the sulfate salt of a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits ...		AChR
T0962	L-Hyoscyamine	Daturine,Hyoscyamine	AChR
	L-Hyoscyamine (Daturine) functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as w...		AChR
T5715	(E)-Flavokawain A	FLAVOKAVAIN A(P)	Apoptosis , P450
	(E)-Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice.		Apoptosis , P450
T1086	Vitamin D2	Calciferol,Ergocalciferol,Ercalciol	DNA/RNA Synthesis , Endogenous Metabolite
	Ergocalciferol (Vitamin D2 (Calciferol)) is a derivative of ergosterol formed by ultraviolet rays breaking of the C9-C10 bond with a strong inhibitory effect against bladder tumor promotion by sodium saccharin, and it in...		DNA/RNA Synthesis , Endogenous Metabolite
T7028	Licochalcone C	LICOCHALCONEC	Phosphatase , Antioxidant , Glucosidase
	Licochalcone C (LICOCHALCONEC) has potent antioxidant properties and inhibition of bacterial growth and cellular respiration. It has cardioprotection effect, via antioxidant, anti-inflammatory, and anti-apoptotic activit...		Phosphatase , Antioxidant , Glucosidase
T4707	3-Hydroxyanthranilic acid	3-HYDROXY-2-AMINOBENZOIC ACID	Others , Endogenous Metabolite
	3-Hydroxyanthranilic acid (3-HYDROXY-2-AMINOBENZOIC ACID), also known as 2-amino-3-hydroxy-benzoate or 3-ohaa, belongs to the class of organic compounds known as hydroxybenzoic acid derivatives. 3-Hydroxyanthranilic acid...		Others , Endogenous Metabolite
T4366	Quinovic acid		NF-κB , Caspase
	Quinovic acid shows some anti-tumour activities, quinovic acid glycosides have a potent inhibitory effect on the growth of human bladder cancer cell lines by inducing apoptosis through modulation of NF-ÎºB.		NF-κB , Caspase
T10020	1-Methyluric acid	1-Methyl-2,6,8-trihydroxypurine,1-Methylurate	Endogenous Metabolite
	1-Methyluric acid (1-Methylurate) acts on the bladder mucosa and increases the levels of insulin, triglycerides, cholesterol, and blood glucose.		Endogenous Metabolite
TN6028	Gardneramine
	Gardneramine has a mild central depressive effect. Gardneramine and hirsutine show a local anesthetic action, they also can inhibit the ganglionic transmission of the dog urinary bladder and that the blockade of the nico...
TN4382	Kazinol A		AMPK , mTOR
	Kazinol A shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation. It also exhibits potent inhibition with IC50 values ranging 0.6-164 M against XOD. Kazinol A may be a candidate for the development...		AMPK , mTOR
TN4342	Izalpinine		Others
	Izalpinin exhibits potent antioxidant activities in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Izalpinin exhibits inhibitory role of muscarinic receptor-related detrusor contractile activity, and it may be a promisi...		Others
TN3404	Altholactone		BCL , p38 MAPK , ROS , Akt , Caspase , Antifection , p53
	Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of various types of cancer cells through inducing apoptosis vi...		BCL , p38 MAPK , ROS , Akt , Caspase , Antifection , p53

天然物製品

Flavokawain A

T3S0737

Synonym: Flavokavain A

Target: Apoptosis, p38 MAPK

Allocryptopine

T3A2467

Synonym: Thalictrimine,Fagarine I

Target: Potassium Channel

Licochalcone B

T4S0350

Synonym:

Target: Beta Amyloid, Others

L-Hyoscyamine sulfate

T4S1619

Synonym: Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate

Target: AChR

L-Hyoscyamine

T0962

Synonym: Daturine,Hyoscyamine

Target: AChR

(E)-Flavokawain A

T5715

Synonym: FLAVOKAVAIN A(P)

Target: Apoptosis, P450

Vitamin D2

T1086

Synonym: Calciferol,Ergocalciferol,Ercalciol

Target: DNA/RNA Synthesis, Endogenous Metabolite

Licochalcone C

T7028

Synonym: LICOCHALCONEC

Target: Phosphatase, Antioxidant, Glucosidase

3-Hydroxyanthranilic acid

T4707

Synonym: 3-HYDROXY-2-AMINOBENZOIC ACID

Target: Others, Endogenous Metabolite

Quinovic acid

T4366

Synonym:

Target: NF-κB, Caspase

1-Methyluric acid

T10020

Synonym: 1-Methyl-2,6,8-trihydroxypurine,1-Methylurate

Target: Endogenous Metabolite

Target: BCL, p38 MAPK, ROS, Akt, Caspase, Antifection, p53

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-03747	CCDC112 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	CCDC112 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 61.0 kDa and the accession number is Q8NEF3.
TMPY-05030	PCDH7 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	PCDH7, a member of protocadherins family, functions as tumor suppressor in several human cancers. The human PCDH7 gene is localized in chromosome 4p15, which is often inactivated in human cancers, including bladder cance...
TMPY-02220	HRAS Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	HRas, also known as HRAS, belongs to the small GTPase superfamily, Ras family, and is widely expressed. It functions in signal transduction pathways. HRas can bind GTP and GDP, and they have intrinsic GTPase activity. It...
TMPH-02669	GJA1 Protein, Mouse, Recombinant (His & Myc)	Mouse	Baculovirus Insect Cells
	Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one...
TMPY-06762	PCDH7 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	Baculovirus Insect Cells
	PCDH7, a member of protocadherins family, functions as tumor suppressor in several human cancers. The human PCDH7 gene is localized in chromosome 4p15, which is often inactivated in human cancers, including bladder cance...
TMPY-04263	UBE2T Protein, Human, Recombinant (His)	Human	E. coli
	Ube2T is the E2 ubiquitin-conjugating enzyme of the Fanconi anemia DNA repair pathway and it is overexpressed in several cancers, representing an attractive target for the development of inhibitors. Notably, UBE2T locate...
TMPK-00931	CD164 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	CD164 was found to play a role in many malignant diseases. CD164 was associated with clinical and pathological features of patients. High level of CD164 was related to the distant metastasis and vascular invasion of blad...
TMPK-01220	CD164 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	CD164 was found to play a role in many malignant diseases. CD164 was associated with clinical and pathological features of patients. High level of CD164 was related to the distant metastasis and vascular invasion of blad...
TMPJ-01248	Cytoglobin/CYGB Protein, Human, Recombinant (His)	Human	E. coli
	Cytoglobin is a ubiquitously globin protein that belongs to the globin family. The highest expressed in heart, stomach, bladder and small intestine. CYGB acts a protector under conditions of oxidative stress. CYGB may be...
TMPJ-01381	ANXA10 Protein, Human, Recombinant	Human	E. coli
	Annexin A10 (ANXA10) contains four Annexin repeats and is a member of the Annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in sign...
TMPH-00721	YgiS Protein, E. coli, Recombinant (His & SUMO)	E. coli	E. coli
	Probably part of a deoxycholate transport system. Its expression in the presence of deoxycholate in a ygiS deletion mutant increases intracellular deoxycholate levels and decreases cell growth; higher expression in the p...
TMPY-00507	UNC5B Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium ...
TMPY-04003	UNC5B Protein, Rat, Recombinant (hFc)	Rat	HEK293 Cells
	The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium ...
TMPY-04133	UNC5B Protein, Human, Recombinant (His)	Human	HEK293 Cells
	The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium ...
TMPK-00728	PSCA Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Gastric cancer is a deadly malignancy and is a prognostically unfavorable entity with restricted therapeutic strategies available. Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored cell s...
TMPK-00906	PSCA Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Gastric cancer is a deadly malignancy and is a prognostically unfavorable entity with restricted therapeutic strategies available. Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored cell s...
TMPH-02126	SORBS2 Protein, Human, Recombinant (His)	Human	E. coli
	Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of AB...
TMPJ-00657	UPK2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Uroplakin-2 is a single-pass type I membrane protein that belongs to the uroplakin-2 family. Uroplakin-2 is a component of the asymmetric unit membrane (AUM) and expressed in the ureter, a highly specialized biomembrane ...
TMPJ-00160	EMMPRIN/CD147 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) belongs to the immunoglobulin superfamily, which has the homology to both the immunoglobulin V domain and MHC class II antigen β-chain. EMMPRIN is a transmembrane ...
TMPY-00648	UNC5A Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	The netrin-1 receptor Uncoordinated Phenotype-5A, or UNC5A, plays an important role in predicting response to DNA damage induced by chemotherapeutic drug and regulating cell death in bladder cancer. Moreover, UNC5A is cu...
TMPY-00999	UNC5A Protein, Human, Recombinant (His)	Human	HEK293 Cells
	The netrin-1 receptor Uncoordinated Phenotype-5A, or UNC5A, plays an important role in predicting response to DNA damage induced by chemotherapeutic drug and regulating cell death in bladder cancer. Moreover, UNC5A is cu...
TMPY-04899	OGN/Osteoglycin Protein, Human, Recombinant (His)	Human	HEK293 Cells
	OGN (Osteoglycin) is a Protein Coding gene. This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. It belongs to the small leucine-rich proteoglycan (SLRP) family. The encoded protei...
TMPY-04171	MFAP3 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	MFAP3 (Microfibril Associated Protein 3) is a Protein Coding gene. The human gene encoding MFAP3 has a very simple structure, containing only two translated exons encoding a protein of 362 amino acids. The gene was found...
TMPJ-00715	FGF-19 Protein, Human, Recombinant (His)	Human	E. coli
	Fibroblast growth factor 19 (FGF19) is a secreted protein which belongs to the FGFs family. FGF19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 dis...
TMPY-04930	Notch 2 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	NOTCH2 (Notch Receptor 2) is a Protein Coding gene. This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics and play a role in a variety of dev...
TMPY-02384	MTSS1 Protein, Human, Recombinant (aa1-250, His & MBP)	Human	E. coli
	MTSS1 (Metastasis suppressor 1), also known as Missing in metastasis (MIM), is a tissue-specific regulator of plasma membrane dynamics. MTSS1 is well described for its function as a metastasis suppressor gene and is expr...
TMPH-01248	ADAR Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translatio...