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T9704 |
1-Ethynylpyrene
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|
P450
|
|
1-Ethynylpyrene is an aryl acetylenic inhibitor of CYTP450 1A1(IC50=0.18 μM), 1A2(IC50 = 0.32 μM), and 2B1(IC50 = 0.04 μM). |
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T39675 |
ALDH1A2-IN-1
|
ALDH1A2-IN-1 |
|
|
ALDH1A2-IN-1 is a reversible inhibitor of the active site of ALDH1A2, showing a significant affinity for the enzyme with an IC50 value of 0.91 μM and a Kd value of 0.26 μM. This compound interacts hydrophobically with th... |
|
T29468 |
61A2
|
61-A-2,61 A 2 |
|
|
61A2, known as a stabilizer of the active LPL dimer can prevents LPL inactivation. |
|
T7410 |
Furafylline
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|
P450
|
|
Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 : 0.07 µM), |
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T23533 |
WIN 18446
|
|
Dehydrogenase
|
|
inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) |
|
T2753 |
Avasimibe
|
PD-148515,CI-1011 |
P450
,
Acyltransferase
|
|
Avasimibe (PD-148515) is an orally bioavailable inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT, IC50: 3.3 μM) that prevents cholesterol deposition in the arterial wall. It also inhibits human P450 isoenz... |
|
T3215 |
JNJ-42165279
|
JNJ42165279 |
FAAH
,
Autophagy
|
|
JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 (10 μM) exhibits high selectivity against a panel of 50 re... |
|
T1540 |
Doxepin hydrochloride
|
Toruan,Doxepin HCl,Aponal,Novoxapin |
P450
,
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
AChR
,
Norepinephrine
,
Histamine Receptor
|
|
Doxepin hydrochloride (Aponal) is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it ap... |
|
T1415 |
Gemfibrozil
|
CI-719,Jezil,Decrelip,Lopid |
P450
,
Adrenergic Receptor
,
PPAR
|
|
Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfi... |
|
T24988 |
7ETMC
|
7 ETMC,7-ETMC |
|
|
7ETMC is a selective Human Cytochrome P450s 1A1 and 1A2 inhibitor. 7ETMC showed IC50s of 0.46 μM and 0.50 μM for P450s 1A1 and 1A2 in the first six minutes, respectively, and did not show any inhibition activity for P450... |
|
T39371 |
LKY-047
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|
|
|
LKY-047, a derivative of Decursin, is a highly effective and specific reversible competitive inhibitor of cytochrome P45022J2 (CYP2J2), with an IC 50 value of 1.7 μM. LKY-047 does not display inhibitory activity against ... |
|
T70782 |
PF-05139962
|
|
|
|
PF-05139962 is a novel potent mTOR inhibitor with excellent mTOR biochemical inhibition, cellular potency, kinase selectivity and in vitro ADME properties. PF-05139962 has pS473 and pS6 cellular IC50 = 48 and 6 nM respec... |
|
T11088 |
Doxepin D3 Hydrochloride
|
|
Histamine Receptor
|
|
Doxepin D3 Hydrochloride is a deuterium-labeled doxepin hydrochloride.Doxepin hydrochloride is an oral active tricyclic antidepressant used as a sedative.Doxepin hydrochloride is also an effective CYP450 inhibitor, signi... |
