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T19277 |
Dexamethasone 9,11-epoxide
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Others
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Dexamethasone 9,11-epoxide is a compound obtained by extraction and is an intermediate in the preparation of dexamethasone. |
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T37149 |
Carbamazepine 10,11-epoxide
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Others
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Carbamazepine 10,11-epoxide is an active metabolite of the anticonvulsant carbamazepine.1,2It is formed from carbamazepine by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C8 in microsomes prepared from HepG2 cells e... |
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TQ0300 |
Conduritol B epoxide
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Glucosidase
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Conduritol B epoxide is an irreversible inhibitor of β-glucosidase (GCase). |
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T35973 |
Cholesterol-5α,6α-epoxide
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Epoxycholesterol,5α,6α-epoxy Cholestanol,NSC 18176 |
Others
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Cholesterol-5α,6α-epoxide (Epoxycholesterol) is the metabolite of cholesterol produced by oxidation. Cholesterol-5α,6α-epoxide induces triacylglycerol biosynthesis by binding to LXRβ following tamoxifen and PBPE applicat... |
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T36730 |
Vitamin K1 2,3-epoxide
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Vitamin K1 epoxide,Phylloquinone oxide,Vitamin K1 2,3-epoxide |
Others
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Vitamin K1 2,3-epoxide (Phylloquinone oxide) is reduced to vitamin k and is involved in the vitamin k cycle. |
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T83857 |
Soluble Epoxide Hydrolase PROTAC 1a
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sEH Proteolysis-targeting Chimera 1a,Soluble Epoxide Hydrolase Proteolysis-targeting Chimera 1a,sEH PROTAC 1a |
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Soluble epoxide hydrolase (sEH) PROTAC 1a is a proteolysis-targeting chimera (PROTAC) comprising a cereblon ligand linked to the sEH inhibitor t-TUCB via a linker, promoting selective sEH degradation and inhibiting its h... |
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T29690 |
Aflatoxin G1 9,10-epoxide
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Aflatoxin G1 9,10-epoxide is a biochemical. |
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T12974 |
Soluble epoxide hydrolase inhibitor
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Others
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Soluble epoxide hydrolase inhibitor is a soluble epoxide hydrolase inhibitor (human soluble epoxide hydrolase (h-sEH) with pIC50 of 8.4). |
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T32059 |
Hepaxanthin
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Vitamin A epoxide |
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Hepaxanthin is a carotenoid. |
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T34627 |
SFO
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Safrole epoxide,Safrole oxide |
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SFO is an endothelial-to-mesenchymal transition (EndoMT) inducer. |
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T7898 |
AUDA
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Epoxide Hydrolase
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AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively) |
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T7199 |
TPPU
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Epoxide Hydrolase
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TPPU is a potent inhibitor of both human and mouse sEH (IC50 of 3.7 and 2.8 nM, respectively) |
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T34070 |
Piperitenone oxide
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Rotundifolone,Lippione,cis-Piperitenone epoxide,Piperitenone oxide, (+-)- |
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Piperitenone oxide is a major chemical constituent of the carvone pathway MS essential oil. |
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T14557 |
BI-1935
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Epoxide Hydrolase
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BI-1935 is an inhibitor of soluble epoxide hydrolase (sEH). For diseases related to cardiovascular disease. |
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T130051 |
Detigloylswietenine, 2-Hydroxy, 8?,30?-epoxide, 3-
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Detigloylswietenine, 2-Hydroxy, 8?,30?-epoxide, 3- is a useful organic compound for research related to life sciences and the catalog number is T130051. |
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T10900 |
CUDA
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PPAR
,
Epoxide Hydrolase
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CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR... |
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T14315 |
AR-9281
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APAU |
Epoxide Hydrolase
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AR-9281 (APAU) is a potent and selective inhibitor of soluble epoxide hydrolase (s-EH) potentially for the treatment of hypertension and type 2 diabetes |
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T17158 |
Trans-AUCB
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t-AUCB |
Epoxide Hydrolase
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trans-AUCB (t-AUCB) is an effective and selective soluble epoxide hydrolase inhibitor (IC50s: 1.3 nM, 8 nM, 8 nM for hsEH, mouse sEH and rat sEH, respectively). |
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T11147 |
EC5026
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BPN-19186 |
Epoxide Hydrolase
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EC5026 (BPN-19186) has the potential to relieve pain by stabilizing natural analgesic and anti-inflammatory mediators. |
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T8844 |
Diflapolin
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Others
,
FLAP
,
Epoxide Hydrolase
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Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. |
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T17196 |
UC-1728
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t-TUCB |
Epoxide Hydrolase
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UC-1728 (t-TUCB) is an effective rabbit soluble epoxide hydrolase inhibitor (IC50: 2 nM on rabbit liver). |
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T21859 |
ARM1
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Aminopeptidase
,
Epoxide Hydrolase
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ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase. |
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T15430 |
GSK2256294A
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GSK 2256294 |
Others
,
Epoxide Hydrolase
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GSK2256294A (GSK 2256294) is potent, selective inhibitor of recombinant human, rat and mouse sEH with IC50 of 27 pM, 61 pM and 189 pM, respectively. |
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T0355 |
Valpromide
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Depamide,Valpramide,Dipropylacetamide,2-propylpentanamide |
Epoxide Hydrolase
,
HSV
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Valpromide (Dipropylacetamide) is a carboxamide derivative of valproic acid, used in the treatment of epilepsy and some affective disorders. |
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T8315 |
1-Cyclohexyl-3-dodecyl urea
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CDU,N-Cyclohexyl-N-dodecyl urea,NCND |
Epoxide Hydrolase
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1-Cyclohexyl-3-dodecyl urea (NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. |
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T23044 |
N,N'-Dicyclohexylurea
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DCU,1,3-Dicyclohexylurea,NSC 17013,Dicyclohexylurea,Dicyclohexylcarbodiamide,AURORA KA-3582 |
Epoxide Hydrolase
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N,N'-Dicyclohexylurea (AURORA KA-3582) is a soluble epoxide hydrolase (sEH) inhibitor. |
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T131605 |
Crotepoxide (Futoxide)
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Crotepoxide (Futoxide) is a useful organic compound for research related to life sciences and the catalog number is T131605. |
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T2716 |
1,3-Diphenylurea
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Epoxide Hydrolase
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1, 3-Diphenylurea is involved with Epoxide hydrolase activity. |
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T17025 |
Tecarfarin
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ATI-5000,ATI-5923 |
Others
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Tecarfarin (ATI-5923) is an orally active and potent vitamin K epoxide reductase (VKOR) antagonist and cannabinoid-1 receptor inverse agonist with antithrombotic activity that attenuates abdominal pain and increases inte... |
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T60358 |
SEH inhibitor-7
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Epoxide Hydrolase
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sEH inhibitor-7 is a soluble epoxide hydrolase (sEH) inhibitor that inhibits sEH in human and mouse with IC 50 s of 6.2 μM and 0.15 μM, respectively. sEH inhibitor-7 is associated with anti-inflammatory active molecules. |
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T38367 |
CAY10640
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sEH inhibitor-1 |
Epoxide Hydrolase
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CAY10640 (sEH inhibitor-1) is a potent, orally active, water-soluble epoxide hydrolase (sEH) inhibitor that inhibits sEH in humans and mice with IC50s of 0.4 and 5.3 nM, respectively. |
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T9832 |
(Rac)-EC5026
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Urea, N-[3-fluoro-4-(trifluoromethoxy)phenyl]-N'-[1-(2-methyl-1-oxobutyl)-4-piperidinyl]- |
Epoxide Hydrolase
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(Rac)-EC5026 ((Rac)-BPN-19186) is a potent piperidine inhibitor of soluble epoxide hydrolase (sEH) with Ki of 0.06 nM. (Rac)-EC5026 can be used for the research of Parkinson's disease and dementia with Lewy Bodies (DLB) ... |
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T63536 |
Dual FAAH/sEH-IN-1
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FAAH
,
Epoxide Hydrolase
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Dual FAAH/sEH-IN-1 is a dual inhibitor of sEH (soluble epoxide hydrolase) (IC50: 9.6 nM) and FAAH (fatty acid amide hydrolase) (IC50: 7 nM) with high affinity and anti-inflammatory activity. |
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T36696 |
DMBA
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7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzy... |
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T68786 |
Orniplabin
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Orniplabin, also known as SMTP-7 is a dual inhibitor of thrombolysis and soluble epoxide hydrolase. SMTP-7 promotes thrombolysis and inhibits soluble epoxide hydrolase. |
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T24778 |
SEH-IN-12
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sEH inhibitor 12,sEH-inhibitor-12 |
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sEH-IN-12 is an effective inhibitor of the enzyme soluble epoxide hydrolase (sEH). |
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T32310 |
Johnstonol
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Johnstonol is an specifically halogenated epoxide obtained from the red alga. |
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T70626 |
MS 347a
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MS 347a is a myosin light chain kinase (MLCK) inhibitor; an epoxide analog of sydowinin B (MS-347b). |
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T32385 |
Keto-anhydrokinamycin
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Keto-anhydrokinamycin, as a keto-epoxide kinamycin intermediate, is isolated from Streptomyces murayamaensis. |
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T37334 |
(±)11,12-DiHETE
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(±)11,12-DiHETE is a dihydroxy metabolite of EPA produced by cytochrome P450-mediated epoxide formation and subsequent hydrolysis by epoxide hydrolase. Plasma levels of (±)11,12-DiHETE are increased over baseline after a... |
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T17024 |
Tecarfarin sodium
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ATI-5923 sodium |
Others
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Tecarfarin sodium is a novel orally active non-competitive vitamin K epoxide reductase antagonist. Tecarfarin sodium has the antithrombotic activity. |
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T68259 |
TUPS
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TUPS is a selective soluble epoxide hydrolase inhibitor which protects against isoprenaline-induced cardiac hypertrophy. |
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T61541 |
SEH inhibitor-6
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sEH inhibitor-6 (Compound 3g) is a highly potent soluble epoxide hydrolase (sEH) inhibitor, exhibiting an IC 50 value of 0.5 nM [1]. |
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T13042 |
SWE101
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Others
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SWE101 is a potent human and rat soluble epoxide hydrolase (sEH)-P inhibitor(IC50s of 4 μM and 2.8 μM, respectively). |
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T61690 |
MEH-IN-1
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mEH-IN-1 (Compound 62) is a potent inhibitor of microsomal epoxide hydrolase (mEH), with an IC50 value of 2.2 nM. mEH is an α/β-fold hydrolase enzyme that is widely expressed in various mammalian tissues, responsible for... |
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T37226 |
(±)7(8)-EpDTE
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(±)7(8)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid . It is formed via cytochrome P450 (CYP) metabolism of DPA, and can be further metabolized to (±)7(8)-DiHDTE by epoxide hydrolase. |
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T37239 |
(±)19(20)-EpDTE
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(±)19(20)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid . It is formed via cytochrome P450 (CYP) metabolism of DPA and can be further metabolized to (±)19(20)-DiHDTE by epoxide hydrolase. |
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T64136 |
SEH inhibitor-5
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sEH inhibitor-5 is a potent inhibitor of sEH (soluble epoxide hydrolase) (IC50: 0.1 nM). |
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T35493 |
(±)10(11)-EpDPA
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Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)10(11)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 10,11-double bo... |
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T72698 |
SEH inhibitor-14
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sEH inhibitor-14, a benzoxazolone-5-urea analogue, acts as an efficient soluble Epoxide Hydrolase (sEH) inhibitor, demonstrating significant activity with an IC50 value of 0.39 nM. |
