ホーム 計算ツール
代理店ログイン

検索結果

Search Results for " FKBP "

ターゲット

23

阻害剤

4

天然化合物

10

リコンビナントタンパク質

カタログ番号 製品名 別名 ターゲット
T18610 PROTAC FKBP Degrader-3 Others , PROTACs
PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader[1].
T14298 Rimiducid Apoptosis , Others , Fatty Acid Synthase
Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affinity. Rimiducid is a dimerizer agent that acts by cross-link...
T13884 Shield-1 Others
Shield-1 is a specific, high-affinity and cell-permeant ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused protein...
T14299 AP20187 B/B Homodimerizer Others
AP20187 (B/B Homodimerizer) is a cell-permeable compound employed to dimerize FK506-binding protein (FKBP) fusion proteins, thereby initiating biological signaling cascades, gene expression, or disrupting protein-protein...
T1784 Everolimus RAD001,SDZ-RAD Apoptosis , Others , mTOR , Autophagy
Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors.
T11451 GPI-1046 Others , HIV Protease
GPI-1046 is an immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core.
T2567 Etonogestrel 3-Oxodesogestrel,3-keto-Desogestrel,Nexplanon,Implanon Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Progesterone Receptor , Endogenous Metabolite
Etonogestrel (Implanon) is a steroidal progestin used as hormonal contraceptives.
T13694 FKBP12 PROTAC RC32 RC32 Others , PROTACs
FKBP12 PROTAC RC32 contains conjugation of Rapamycin and a ligand for an E3 ubiquitin ligase.FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology.
T11292 FKBP12 PROTAC dTAG-7 dTAG-7 Epigenetic Reader Domain , PROTACs
FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by connecting BET bromodomains to the E3 ubiquitin ligase CRBN. Additionally,...
T11291 FKBP12 PROTAC dTAG-13 dTAG-13 Epigenetic Reader Domain , PROTACs
FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) also is a selective degrader of BET bromodomain transcription...
T71840 FKBP12-IN-Q2
FKBP12-IN-Q2 is an inhibitor of FKBP12.
T79184 FKBP51F67V-selective antagonist Ligand2 FKBP
FKBP51F67V-selective antagonist Ligand2 (example 3-3), a potent ligand, selectively binds to the FKBP51 F67V variant, with no affinity for wild-type FKBP51 or FKBP52 [1]. It effectively reverses the anxiogenic phenotype ...
T18597 DFKBP-1 Others , PROTACs
dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker[1].
T6033 Zotarolimus ABT-578,A 179578 mTOR
Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).
T2648 Pimecrolimus SDZ-ASM 981,ASM 981 Others
Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineuri...
T24788 Shield-2
Shield-2 is a potent FKBP-derived destabilizing domain stabilizing ligand.
T13888 SLF Others
SLF is a synthetic ligand for FK506-binding protein (FKBP)( with an affinity of 3.1 μM for FKBP51 and an IC50 of 0.22 μM for FKBP12). SLF can be used in the synthesis of PROTAC.
T76622 Suc-Ala-Leu-Pro-Phe-pNA
Suc-Ala-Leu-Pro-Phe-pNA (Suc-ALPF-pNA), a substrate for FK-506 binding protein (FKBP) [1], showcases the intricate interactions necessary for specific biochemical assays.
T13914 SLF-amido-C2-COOH PROTAC FKBP12-binding moiety 1 Others
SLF-amido-C2-COOH is a synthetic ligand for FKBP (SLF), and can be used in the synthesis of PROTACs.
T13549 AP1867-3-(aminoethoxy) Others
AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.
T80928 TSPO ligand-3 AUTACs
TSPO ligand-3, functioning as an AUTAC2 ligand, incorporates both a p-fluorobenzylguanine (FBnG) and a synthetic ligand of FKBP (SLF) moiety, leading to the substantial inhibition of FKBP12 in HeLa cells [1].
T74026 AUTAC2
AUTAC2, an autophagy-mediated degrader (AUTAC) targeting FKBP12, comprises an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. The SLF component binds non-covalently to FKBP12 [1].
T73817 SLF TFA
SLF TFA, a synthetic ligand for FK506-binding protein (FKBP), exhibits affinity toward FKBP51 with a value of 3.1 μM and demonstrates an IC50 of 2.6 μM for FKBP12. This compound is utilized in the synthesis of PROTAC [1]...
カタログ番号 製品名 別名 ターゲット
T2144 Tacrolimus Fujimycin,FK506,FR900506 Phosphatase , Others , Antibacterial , Antibiotic , mTOR , Autophagy
Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium/calmodulin-dependent protein phosphatase.
T1537 Rapamycin Sirolimus,AY 22989,NSC-2260804 Others , Endogenous Metabolite , Antibiotic , mTOR , Autophagy , Antifungal
Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy.
T2481 Ascomycin FK520,Immunomycin,FR-900520 Phosphatase , Others , Antibiotic , Parasite , Antifungal
Ascomycin (Immunomycin)(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.
T20879 Tacrolimus monohydrate FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,FK 506 Phosphatase , Others , Antibacterial , Antibiotic , Autophagy
Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, whi...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-02259 FKBP25/FKBP3 Protein, Human, Recombinant (GST) Human E. coli
FKBP3 is a member of FK506-binding proteins (FKBPs). miR-145-5p overexpression suppressed cell proliferation of NSCLC cells which was abrogated by FKBP3 overexpression, that FKBP3/Sp1/HDAC2/p27 control cell proliferation...
TMPY-00808 FKBP12 Protein, Human, Recombinant (His) Human E. coli
FKBP12 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.9 kDa and the accession number is P62942.
TMPY-01662 FKBP12 Protein, Mouse, Recombinant (His) Mouse E. coli
FKBP12 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.7 kDa and the accession number is P26883.
TMPJ-01068 FKBP25/FKBP3 Protein, Human, Recombinant (His) Human E. coli
FKBP25 contains 1 PPIase FKBP-type domain, belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell prolif...
TMPY-03148 FKBP7 Protein, Human, Recombinant (His) Human HEK293 Cells
FKBP7 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.8 kDa and the accession number is Q9Y680-2.
TMPY-02962 FKBP7 Protein, Human, Recombinant (hFc) Human HEK293 Cells
FKBP7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.4 kDa and the accession number is Q9Y680-2.
TMPY-00510 FKBP11 Protein, Human, Recombinant (mFc) Human HEK293 Cells
FKBP11 serve as biomarker and/or therapeutic target for Acute aortic dissection (AAD). FKBP11 during the development of HCC and FKBP11 has the potential to be an early marker for HCC.
TMPJ-01076 FKBP4 Protein, Human, Recombinant (His) Human E. coli
FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone recepto...
TMPY-03385 FKBP14 Protein, Human, Recombinant (His) Human HEK293 Cells
FKBP14 belongs to the FK506-binding protein family. It contains 2 EF-hand domains and one PPIase FKBP-type domain. FKBP14 can be detected in the lumen of the endoplasmic reticulum where it is thought to accelerate the fo...
TMPJ-00919 FKBP2 Protein, Human, Recombinant (His) Human HEK293 Cells
Peptidyl-prolyl cis-trans isomerase FKBP2(FKBP2 for short), also named 13 kDa FK506-binding protein, FK506-binding protein 2, Immunophilin FKBP13, Rotamase, is a endoplasmic reticulum peripheral membrane protein. It cont...