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Search Results for " FKBP "

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カタログ番号	製品名	別名	ターゲット
T18610	PROTAC FKBP Degrader-3		Others
	PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader[1].		Others
T14298	Rimiducid		Apoptosis , Others , Fatty Acid Synthase
	Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affinity. Rimiducid is a dimerizer agent that acts by cross-link...		Apoptosis , Others , Fatty Acid Synthase
T13884	Shield-1		Others
	Shield-1 is a specific, high-affinity and cell-permeant ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused protein...		Others
T14299	AP20187	B/B Homodimerizer	Others
	AP20187 (B/B Homodimerizer) is a cell-permeable compound employed to dimerize FK506-binding protein (FKBP) fusion proteins, thereby initiating biological signaling cascades, gene expression, or disrupting protein-protein...		Others
T1784	Everolimus	RAD001,SDZ-RAD	Apoptosis , Others , mTOR , Autophagy
	Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors.		Apoptosis , Others , mTOR , Autophagy
T11451	GPI-1046		Others , HIV Protease
	GPI-1046 is an immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core.		Others , HIV Protease
T2567	Etonogestrel	3-Oxodesogestrel,3-keto-Desogestrel,Nexplanon,Implanon	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Progesterone Receptor , Endogenous Metabolite
	Etonogestrel (Implanon) is a steroidal progestin used as hormonal contraceptives.
T13694	FKBP12 PROTAC RC32	RC32	Others
	FKBP12 PROTAC RC32 contains conjugation of Rapamycin and a ligand for an E3 ubiquitin ligase.FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology.		Others
T11291	FKBP12 PROTAC dTAG-13	dTAG-13	Epigenetic Reader Domain
	FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) also is a selective degrader of BET bromodomain transcription...		Epigenetic Reader Domain
T11292	FKBP12 PROTAC dTAG-7	dTAG-7	Epigenetic Reader Domain
	FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by connecting BET bromodomains to the E3 ubiquitin ligase CRBN. Additionally,...		Epigenetic Reader Domain
T71840	FKBP12-IN-Q2
	FKBP12-IN-Q2 is an inhibitor of FKBP12.
T79184	FKBP51F67V-selective antagonist Ligand2		FKBP
	FKBP51F67V-selective antagonist Ligand2 (example 3-3), a potent ligand, selectively binds to the FKBP51 F67V variant, with no affinity for wild-type FKBP51 or FKBP52 [1]. It effectively reverses the anxiogenic phenotype ...		FKBP
T18597	DFKBP-1		Others
	dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker[1].		Others
T6033	Zotarolimus	ABT-578,A 179578	mTOR
	Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).		mTOR
T2648	Pimecrolimus	SDZ-ASM 981,ASM 981	Others
	Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineuri...		Others
T24788	Shield-2
	Shield-2 is a potent FKBP-derived destabilizing domain stabilizing ligand.
T13888	SLF		Others
	SLF is a synthetic ligand for FK506-binding protein (FKBP)( with an affinity of 3.1 μM for FKBP51 and an IC50 of 0.22 μM for FKBP12). SLF can be used in the synthesis of PROTAC.		Others
T76622	Suc-Ala-Leu-Pro-Phe-pNA
	Suc-Ala-Leu-Pro-Phe-pNA (Suc-ALPF-pNA), a substrate for FK-506 binding protein (FKBP) [1], showcases the intricate interactions necessary for specific biochemical assays.
T13914	SLF-amido-C2-COOH	PROTAC FKBP12-binding moiety 1	Others
	SLF-amido-C2-COOH is a synthetic ligand for FKBP (SLF), and can be used in the synthesis of PROTACs.		Others
T13549	AP1867-3-(aminoethoxy)		Others
	AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.		Others
T80928	TSPO ligand-3		AUTACs
	TSPO ligand-3, functioning as an AUTAC2 ligand, incorporates both a p-fluorobenzylguanine (FBnG) and a synthetic ligand of FKBP (SLF) moiety, leading to the substantial inhibition of FKBP12 in HeLa cells [1].		AUTACs
T74026	AUTAC2
	AUTAC2, an autophagy-mediated degrader (AUTAC) targeting FKBP12, comprises an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. The SLF component binds non-covalently to FKBP12 [1].
T73817	SLF TFA
	SLF TFA, a synthetic ligand for FK506-binding protein (FKBP), exhibits affinity toward FKBP51 with a value of 3.1 μM and demonstrates an IC50 of 2.6 μM for FKBP12. This compound is utilized in the synthesis of PROTAC [1]...

Compounds

PROTAC FKBP Degrader-3

Target: Apoptosis, Others, Fatty Acid Synthase

Synonym: B/B Homodimerizer

Target: Others

Everolimus

T1784

Synonym: RAD001,SDZ-RAD

Target: Apoptosis, Others, mTOR, Autophagy

GPI-1046

T11451

Synonym:

Target: Others, HIV Protease

Etonogestrel

T2567

Synonym: 3-Oxodesogestrel,3-keto-Desogestrel,Nexplanon,Implanon

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Progesterone Receptor, Endogenous Metabolite

FKBP12 PROTAC dTAG-13

T11291

Synonym: dTAG-13

Target: Epigenetic Reader Domain

FKBP12 PROTAC dTAG-7

T11292

Synonym: dTAG-7

Target: Epigenetic Reader Domain

FKBP51F67V-selective antagonist Ligand2

Synonym: ABT-578,A 179578

Target: mTOR

Pimecrolimus

T2648

Synonym: SDZ-ASM 981,ASM 981

Suc-Ala-Leu-Pro-Phe-pNA

Synonym: PROTAC FKBP12-binding moiety 1

Target: Others

AP1867-3-(aminoethoxy)

カタログ番号	製品名	別名	ターゲット
T2144	Tacrolimus	Fujimycin,FK506,FR900506	Phosphatase , Others , Antibacterial , Antibiotic , mTOR , Autophagy
	Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium/calmodulin-dependent protein phosphatase.
T1537	Rapamycin	Sirolimus,AY 22989,NSC-2260804	Others , Endogenous Metabolite , Antibiotic , mTOR , Autophagy , Antifungal
	Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy.
T2481	Ascomycin	FK520,Immunomycin,FR-900520	Phosphatase , Others , Antibiotic , Parasite , Antifungal
	Ascomycin (Immunomycin)(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.		Phosphatase , Others , Antibiotic , Parasite , Antifungal
T20879	Tacrolimus monohydrate	FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,FK 506	Phosphatase , Others , Antibacterial , Antibiotic , Autophagy
	Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, whi...

天然物製品

Tacrolimus

T2144

Synonym: Fujimycin,FK506,FR900506

Target: Phosphatase, Others, Antibacterial, Antibiotic, mTOR, Autophagy

Rapamycin

T1537

Synonym: Sirolimus,AY 22989,NSC-2260804

Target: Others, Endogenous Metabolite, Antibiotic, mTOR, Autophagy, Antifungal

Ascomycin

T2481

Synonym: FK520,Immunomycin,FR-900520

Target: Phosphatase, Others, Antibiotic, Parasite, Antifungal

Tacrolimus monohydrate

T20879

Synonym: FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,FK 506

Target: Phosphatase, Others, Antibacterial, Antibiotic, Autophagy

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-02259	FKBP25/FKBP3 Protein, Human, Recombinant (GST)	Human	E. coli
	FKBP3 is a member of FK506-binding proteins (FKBPs). miR-145-5p overexpression suppressed cell proliferation of NSCLC cells which was abrogated by FKBP3 overexpression, that FKBP3/Sp1/HDAC2/p27 control cell proliferation...
TMPY-00808	FKBP12 Protein, Human, Recombinant (His)	Human	E. coli
	FKBP12 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.9 kDa and the accession number is P62942.
TMPY-01662	FKBP12 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	FKBP12 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.7 kDa and the accession number is P26883.
TMPJ-01068	FKBP25/FKBP3 Protein, Human, Recombinant (His)	Human	E. coli
	FKBP25 contains 1 PPIase FKBP-type domain, belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell prolif...
TMPY-03148	FKBP7 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	FKBP7 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.8 kDa and the accession number is Q9Y680-2.
TMPY-02962	FKBP7 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	FKBP7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.4 kDa and the accession number is Q9Y680-2.
TMPY-00510	FKBP11 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	FKBP11 serve as biomarker and/or therapeutic target for Acute aortic dissection (AAD). FKBP11 during the development of HCC and FKBP11 has the potential to be an early marker for HCC.
TMPJ-01076	FKBP4 Protein, Human, Recombinant (His)	Human	E. coli
	FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone recepto...
TMPY-03385	FKBP14 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	FKBP14 belongs to the FK506-binding protein family. It contains 2 EF-hand domains and one PPIase FKBP-type domain. FKBP14 can be detected in the lumen of the endoplasmic reticulum where it is thought to accelerate the fo...
TMPJ-00919	FKBP2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Peptidyl-prolyl cis-trans isomerase FKBP2(FKBP2 for short), also named 13 kDa FK506-binding protein, FK506-binding protein 2, Immunophilin FKBP13, Rotamase, is a endoplasmic reticulum peripheral membrane protein. It cont...