HDAC6 | TargetMol

カタログ番号	製品名	別名	ターゲット
T69753	HDAC6 degrader 9c		HDAC
	HDAC6 degrader 9c is a small molecule histone deacetylase 6 (HDAC6) degrader that can be used to study cancer or other diseases.		HDAC
T36625	LSD1/HDAC6-IN-1	LSD1/HDAC6-IN-1
	LSD1/HDAC6-IN-1 is an orally active compound that functions as a dual inhibitor, targeting lysine specific demethylase 1 (LSD1) and histone deacetylase 6 (HDAC6). This compound demonstrates promising anti-tumor activity ...
T1983	CAY10603	HDAC6 Inhibitor,BML-281	HDAC
	CAY10603 (BML-281) is a potent and selective inhibitor of HDAC6.		HDAC
T22159	TCS HDAC6 20b
	TCS HDAC6 20b is a HDAC6 -selective inhibitor that blocks the growth of estrogen receptor α-positive breast cancer MCF-7 cells [1].
T79769	HDAC6-IN-23		HDAC
	HDAC6-IN-23 (compound 9), an orally active inhibitor of HDAC6 [1], displays selective enzymatic inhibition.		HDAC
T82224	HDAC6-IN-25		HDAC
	HDAC6-IN-25 (compound 8) is a potent and selective HDAC6 inhibitor, exhibiting an IC50 value of 0.6 nM [1].		HDAC
T73043	HDAC6-IN-15
	HDAC6-IN-15, a selective histone deacetylase 6 (HDAC6) inhibitor, exhibits potent inhibitory activity with an IC50 value of 38.2 nM, making it valuable for research in cancer and neurodegenerative diseases.
T78839	HDAC6-IN-19		HDAC
	HDAC6-IN-19 (Compound 14g), an HDAC6 inhibitor with an IC50 of 2.68 nM, additionally inhibits HDAC1, HDAC2, and HDAC3, with IC50 values of 61.6 nM, 98.7 nM, and 103 nM, respectively. This compound effectively suppresses ...		HDAC
T74617	HDAC6-IN-8		HDAC
	Compound 12C, modified by altering cap groups, exhibits broad-spectrum enzyme inhibitory activity, as demonstrated in enzyme inhibition assays. Conversely, compounds 9m and 9q display a predilection towards HDAC6 inhibit...		HDAC
T82225	HDAC6-IN-24		HDAC
	HDAC6-IN-24 (compound N1) is an inhibitor of histone deacetylase 6 (HDAC6) [1].		HDAC
T61792	HDAC6-IN-10
	HDAC6-IN-10 is a potent and specific HDAC6 inhibitor, exhibiting an IC50 value of 0.73 nM. It demonstrates remarkable selectivity towards HDAC6, with a selectivity range of 144 to 10,941-fold over other HDAC isoforms. Fu...
T82226	HDAC6-IN-21		HDAC
	HDAC6-IN-21 (compound 13) is an irreversible inhibitor of histone deacetylase 6 (HDAC6) [1].		HDAC
T63472	HDAC6-IN-4
	HDAC6-IN-4 (C10) is an orally active, highly selective, potent and non-significantly toxic HDAC6 inhibitor (IC50: 23 nM). HDAC6-IN-4 induces apoptosis and exhibits potent anti-tumor effects.
T60954	HDAC6-IN-6
	HDAC6-IN-6 (compound 6a) is a potent inhibitor of HDAC6 that can penetrate BBB with an IC50 value of 0.025 μM. HDAC6-IN-6 has potent inhibitory activity against AChE and Aβ 1-42 self-aggregation with IC50 values of 0.72 ...
T77922	HDAC6 degrader-1		PROTACs
	HDAC6 degrader-1, a proteolysis-targeting chimeric molecule (PROTAC), incorporates the selective HDAC6 inhibitor Nexturastat A (Nex A) for HDAC6 binding, a linker, and an E3 ligase recruiting ligand. This compound effect...		PROTACs
T63247	HDAC6-IN-12
	HDAC6-IN-12 is a potent inhibitor of HDAC6 that binds in the DNA chain, causing DNA damage and exhibiting anticancer effects that can be used in cancer research.
T79523	HDAC6-IN-18		HDAC
	HDAC6-IN-18 (Compound 4), an irreversible and selective HDAC6 isoform inhibitor, exhibits potent anti-multiple myeloma effects. It demonstrates HDAC6 inhibitory activity with IC50 values of 0.17, 0.7, and 0.42 μM in RPMI...		HDAC
T61474	HDAC6-IN-13
	HDAC6-IN-13 (Compound 35m) is a potent and highly selective orally active inhibitor of HDAC6, with an IC50 of 0.019 μM. It also demonstrates inhibitory activity against HDAC1, HDAC2, and HDAC3, with IC50 values of 1.53 μ...
T75018	HDAC6 degrader-3		PROTACs
	HDAC6 degrader-3, a selective and potent degrader of HDAC6 through ternary complex formation and the ubiquitin-proteasome pathway, exhibits a DC50 value of 19.4 nM. With IC50 values of 4.54 nM for HDAC6 and 0.647 μM for ...		PROTACs
T78769	HDAC6-IN-17		HDAC
	HDAC6-IN-17 (compound 5b) is a potent inhibitor of HDAC6, exhibiting IC50 values of 150 nM for HDAC6, 1400 nM for HDAC8, and 2300 nM for HDAC4. It demonstrates cytotoxic activity against human cancer cell lines and is ut...		HDAC
T60856	HDAC6-IN-9
	HDAC6-IN-9 (compound 12c) is a potent and selective inhibitor of HDAC6 with anti-proliferative activities. The IC 50 values of HDAC6-IN-9 for HDAC6, HDAC1,HDAC3, HDAC8, and HDAC10 is 4.2, 11.8, 15.2, 139.6, and 21.3 nM, ...
T61044	HDAC6-IN-11
	HDAC6-IN-11 (Compound 9) has anti-proliferative activities against cancer cells. HDAC6-IN-11 is a selective inhibitor of HDAC6 with the IC50 value of 20.7 nM. The selectivity of HDAC6-IN-11 is more than 300-fold over HDA...
T61139	HDAC6-IN-3
	HDAC6-IN-3 (Compound 14) is a potent anti-prostate cancer agent that acts as an orally active inhibitor of HDAC6. It has IC50 values ranging from 0.02-1.54 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10. Additional...
T62046	HDAC6-IN-5
	HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated inhibitor of HDAC6 (IC50= 0.025 μM). HDAC6-IN-5 inhibits Aβ 1-42 self-aggregation and AChE, with IC 50s of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowt...
T73031	HDAC6-IN-14
	HDAC6-IN-14, an inhibitor of HDAC6 (HDAC), exhibits high selectivity with an IC50 value of 42 nM, demonstrating over 100-fold selectivity compared to HDAC1, HDAC2, HDAC3, and HDAC4.
T79771	HDAC6-IN-22		HDAC
	HDAC6-IN-22 (compound 30), an HDAC6 inhibitor, exhibits an IC50 of 4.63 nM and demonstrates antiproliferative effects against multiple myeloma both in vitro and in vivo. It induces cell cycle arrest in the G2 phase and p...		HDAC
T78768	HDAC6-IN-16		HDAC
	HDAC6-IN-16 (compound 5c), a quinazolin-4(3H)-one-based inhibitor of histone deacetylase 6 (HDAC6), demonstrates an anticancer effect by inhibiting colony formation, arresting the cell cycle at the G2 phase, and inducing...		HDAC
T61315	HDAC6/HSP90-IN-2
	HDAC6/HSP90-IN-2 (compound 6e) is a dual inhibitor targeting HDAC6 and Hsp90, exhibiting IC50 values of 105.7 nM and 61 nM, respectively. It is primarily utilized in cancer research [1].
T63531	HDAC6/HSP90-IN-1
	HDAC6/HSP90-IN-1 is a potent and selective dual inhibitor of HDAC6 (IC50: 4.3 nM) and HSP90 (IC50: 46.8 nM).HDAC6/HSP90-IN-1 downregulates PD-L1 expression in INF-γ-treated H1975 lung cancer cells.HDAC6/HSP90-IN-1 exhibi...
T61888	MTOR/HDAC6-IN-1
	mTOR/HDAC6-IN-1 is an effective dual inhibitor of histone deacetylase (HDAC6) and mammalian rapamycin (mTOR). The IC50 values for HDAC6 and mTOR are 56 nM and 133.7 nM respectively. MTOR/HDAC6-IN-1 can significantly indu...
T78799	BChE/HDAC6-IN-1		HDAC
	BChE/HDAC6-IN-1 is a dual BChE/HDAC6 inhibitor that exhibits potent and selective inhibition with IC50 values of 4 nM for BChE and 8.9 nM for HDAC6. It demonstrates efficacy in alleviating cognitive deficits in an Aβ1–42...		HDAC
T79710	PI3Kα/HDAC6-IN-1		HDAC
	PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively. It effectively hinders AKT(Ser473) phosphorylation and promotes the build-up of acetylated...		HDAC
T75017	PROTAC HDAC6 degrader 1
	Compound A6, a potent and selective PROTAC HDAC6 degrader, exhibits a DC50 of 3.5 nM. It demonstrates notable antiproliferative activity by inducing apoptosis in myeloid leukemia cell lines [1].
T61727	HDAC6/8/BRPF1-IN-1
	HDAC6/8/BRPF1-IN-1 is a dual inhibitor that targets HDAC6, HDAC8, and the bromodomain and PHD finger containing protein 1 (BRPF1). It exhibits inhibitory activity against HDAC1, HDAC6, and HDAC8 with IC50 values of 797 n...
T6327	Tubacin		Virus Protease , HDAC
	Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.		Virus Protease , HDAC
T10255	AES-135		HDAC
	AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity.		HDAC
T3661	Citarinostat	ACY241,HDAC-IN-2	HDAC
	ACY-241, also known as Citarinostat (ACY241), is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, ACY-241 inhibits the activ...		HDAC
T6481	Droxinostat	NS 41080	Apoptosis , HDAC
	Droxinostat (NS 41080) is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10.		Apoptosis , HDAC
T7385	WT-161		Apoptosis , HDAC
	WT161 is a potent and selective inhibitor of HDAC6 (IC50:0.40 nM).		Apoptosis , HDAC
T1819	Nexturastat A		HDAC
	Nexturastat A is an effective and specific HDAC6 inhibitor (IC50: 5 nM). Its selectivity is >190-fold than other HDACs.		HDAC
T3509	ACY-738	ACY 738	HDAC
	ACY-738 demonstrates inhibitory activity against recombinant HDAC6 (IC50: 1.7 nM), with respective average selectivity over class I HDACs being 100-fold.		HDAC
T16129	MPI_5a		HDAC
	MPI_5a is an effective and selective inhibitor of HDAC6 (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms and it also inhibits acyl-tubulin accumulation in cells (IC50: 210 nM).		HDAC
T6161	Tubastatin A Hydrochloride	TSA HCl,Tubastatin A HCl	Apoptosis , HDAC , Autophagy
	Tubastatin A Hydrochloride (TSA HCl) is an effective and specific HDAC6 inhibitor (IC50: 15 nM). It has selectivity (>1000-fold) against all other isozymes except HDAC8 (>57-fold).		Apoptosis , HDAC , Autophagy
T9148	KA2507		HDAC
	KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM.		HDAC
T2430	HPOB		Apoptosis , HDAC
			Apoptosis , HDAC
T10244	ACY-1083		HDAC
	ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor (IC50: 3 nM) and effectively reverses chemotherapy-induced peripheral neuropathy.		HDAC
T2489	Ricolinostat	ACY-1215,Rocilinostat	Apoptosis , HDAC
	Ricolinostat (Rocilinostat) is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity.		Apoptosis , HDAC
T1966	Tubastatin A	Tubastatin A BASE	Apoptosis , HDAC , Autophagy
	Tubastatin A (Tubastatin A BASE) is an effective and specific HDAC6 inhibitor (IC50: 15 nM, in a cell-free assay). Its selectivity is 1000-fold against all the other isozymes except HDAC8.		Apoptosis , HDAC , Autophagy
T5830	SKLB-23bb		HDAC
	SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor and also has microtubule-disrupting ability.		HDAC
T60616	MPT0G211		HDAC
	MPT0G211 is a highly selective and orally active HDAC6 inhibitor (IC50=0.291 nM) that has neuroprotective effects and has shown anti-metastatic activity in human breast cancer cells. MPT0G211 has 1,000 times more affinit...		HDAC

Compounds

HDAC6 degrader 9c

T69753

Synonym: LSD1/HDAC6-IN-1

Target:

CAY10603

T1983

Synonym: HDAC6 Inhibitor,BML-281

PROTAC HDAC6 degrader 1

Target: Virus Protease, HDAC

Synonym: ACY241,HDAC-IN-2

Target: Apoptosis, HDAC

WT-161

T7385

Synonym:

Target: Apoptosis, HDAC

Tubastatin A Hydrochloride

T6161

Synonym: TSA HCl,Tubastatin A HCl

Target: Apoptosis, HDAC, Autophagy

Target: Apoptosis, HDAC

Synonym: ACY-1215,Rocilinostat

Target: Apoptosis, HDAC

Tubastatin A

T1966

Synonym: Tubastatin A BASE

Target: Apoptosis, HDAC, Autophagy

カタログ番号	製品名	Species	Expression System
TMPH-01474	HDAC6 Protein, Human, Recombinant (His)	Human	E. coli
	HDAC6 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-01263	PRKN Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ...
TMPH-02631	PRKN Protein, Mouse, Recombinant (GST)	Mouse	E. coli
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ...

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Compounds

Recombinant Proteins