|
T8959 |
OS-3-106
|
|
Dopamine Receptor
|
|
OS-3-106 is a novel arylamide phenylpiperazines, as partial agonists at the D3R in the adenylyl cyclase inhibition assay. |
|
T5345 |
V-9302
|
|
Others
|
|
V-9302 (V9302) is a competitive antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (IC50: 9.6 uM). |
|
T50005 |
Sertaconazole
|
|
Antifungal
|
|
Sertaconazole is a broad-spectrum antifungal. |
|
T8528 |
AC1903
|
|
TRP/TRPV Channel
|
|
AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss. |
|
T0031L2 |
Ziprasidone
|
Geodon,Zeldox,CP-88059 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Norepinephrine
,
Histamine Receptor
|
|
Ziprasidone (Geodon) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity. |
|
T3520 |
Setipiprant
|
KYTH-105,ACT-129968 |
GPR
,
Prostaglandin Receptor
|
|
Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in vari... |
|
T6665 |
Sertaconazole nitrate
|
FI-7045,Ginedermofix,FI7056,Ertaczo |
Antibiotic
,
Antifungal
|
|
Sertaconazole nitrate (FI-7045), a topical broad-spectrum antifungal, is developed to supply an additional agent for the treatment of superficial cutaneous and mucosal infections. |
|
T0031 |
Ziprasidone hydrochloride monohydrate
|
CP 88059 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Norepinephrine
,
Histamine Receptor
|
|
Ziprasidone hydrochloride monohydrate (CP 88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity. |
|
T16569 |
Praliciguat
|
IW-1973 |
Others
,
Guanylate cyclase
|
|
Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances NO signaling and acts as a vasodilator. |
|
T6934 |
Pexmetinib
|
ARRY-614 |
Tie-2
,
p38 MAPK
,
Autophagy
|
|
Pexmetinib (ARRY-614) (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1. |
|
T11076 |
Dooku1
|
|
Others
|
|
Dooku1 is an analog of Yoda1 and a selective antagonist of endogenous Piezo1 channels. Dooku1 inhibits Ca2+ entry induced by 2μMYoda1 with IC50 values of 1.3μM (in HEK 293 cells) and 1.5μM (in HUVEC). Dooku1 inhibits Yod... |
|
T9018 |
JHU37160
|
JHU 37160 |
AChR
|
|
JHU37160 (JHU 37160) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. ... |
|
T9019 |
JHU37152
|
JHU 37152 |
AChR
|
|
JHU37152 (JHU 37152) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. ... |
|
T4967 |
NPS-2143 hydrochloride
|
NPS-2143 HCL |
CaSR
|
|
NPS-2143 hydrochloride (NPS-2143 HCL) is a selective potent calcium ion-sensing receptor antagonist. |
|
T1730 |
NPS-2143
|
SB262470,NPS 2143,SB 262470A |
Calcium Channel
,
CaSR
|
|
|
|
T2092 |
Amitifadine hydrochloride
|
DOV-21947 hydrochloride,EB-1010 hydrochloride |
Dopamine Receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Norepinephrine
|
|
Amitifadine hydrochloride (EB-1010 hydrochloride) is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). |
|
T14190 |
Alniditan
|
Alnitidan |
5-HT Receptor
|
|
Alniditan is a receptors agonist of 5-HT1B/1D in HEK 293 cells (IC50: 1.7 and 1.3 nM). For 5-HT1B/1D receptors, the pKi values are 8.96 and 9.40, respectively. |
|
T15398 |
GNE-0946
|
|
Others
|
|
GNE-0946 is a potent and selective agonist of RORγ (EC50: 4 nM for HEK-293 cell). |
|
T15404 |
GNE-6468
|
|
Others
|
|
GNE-6468 is a potent and selective agonist of RORγ(RORc) (EC50: 13 nM for HEK-293 cell). |
|
T25109 |
ARN-6039
|
ARN 6039,ARN6039 |
|
|
ARN-6039 is an orally available inverse agonist of RORγ for Autoimmune Neuroinflammatory Demyelinating Disease. The activity of ARN-6039 against RORγ was demonstrated in a RORγ-activated IL-17A Prom/LUCPorter assay in HE... |
|
T38984 |
Z-Ala-Ala-Asn-AMC
|
Cbz-Ala-Ala-Asn-AMC,Z-Ala-Ala-Asn-AMC |
|
|
Z-Ala-Ala-Asn-AMC, also known as Cbz-Ala-Ala-Asn-AMC, serves as a substrate for legumain. The overexpression of legumain in 293 HEK-Leg cells results in efficient cleavage of Cbz-Ala-Ala-Asn-AMC. |
|
T40064 |
V-9302 hydrochloride
|
|
|
|
V-9302 hydrochloride is a potent and selective competitive antagonist that inhibits transmembrane glutamine flux by specifically targeting the amino acid transporter ASCT2 (SLC1A5), and not ASCT1. In HEK-293 cells, V-930... |
|
TP2093 |
Apelin-36(human)
|
Apelin-36 (human) |
|
|
Endogenous APJ receptor agonist (EC50 = 20 nM) that is secreted by adipocytes. Binds with high affinity to human APJ receptors expressed in HEK 293 cells (pIC50= 8.61). Involved in regulation of cardiovascular function, ... |
|
T74917 |
KPC-2-IN-1
|
|
|
|
KPC-2-IN-1, a boronic acid derivative, serves as an effective KPC-2 inhibitor with a K i of 0.032 μM, augmenting cefotaxime's efficacy against KPC-2 expressing E. coli. It demonstrates good tolerance in human HEK-293 cel... |
|
T75785 |
Apelin-17(human, bovine) TFA
|
|
|
|
Apelin-17(human, bovine) TFA is an endogenous agonist of the orphan G protein-coupled receptor APJ. This compound demonstrates affinity for human APJ receptors on HEK 293 cells, evidenced by a pIC50 value of 9.02. Additi... |
|
T63456 |
Antimalarial agent 12
|
|
|
|
Antimalarial agent 12 is an effective antimalarial agent that inhibits the growth of Plasmodium falciparum strains Dd2 and 3D7 with EC50 values of 155 nM and 136 nM, respectively. antimalarial agent 12 has a MIC >250,000... |
|
T75783 |
Apelin-36(human) TFA
|
|
|
|
Apelin-36(human) TFA, an endogenous agonist of the orphan G protein-coupled receptor APJ, exhibits a potent EC50 of 20 nM and high affinity (pIC5 50 = 8.61) for human APJ receptors in HEK 293 cells. It is involved in sig... |
|
T6202 |
DAPT
|
LY-374973,GSI-IX |
Apoptosis
,
Beta Amyloid
,
Gamma-secretase
,
Autophagy
|
|
DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces cell differentiation, autophagy and apoptosis. |
