ホーム 計算ツール
代理店ログイン
製品 阻害剤 ライブラリー リコンビナントタンパク質 キット サービス お問い合わせ
ペプチド 抗体 色素試薬 PROTAC バーチャルスクリーニング TargetMolキット Cell Counting Kit-8 (CCK-8) Inhibitor Cocktails 天然化合物 フェノール類 アルカロイド類 フラボノイド類
阻害剤 血管新生 アポトーシス オートファジー 細胞周期・チェックポイント クロマチン・エピジェネティック 細胞骨格シグナル DNA損傷・DNA修復 内分泌・ホルモン GPCR/Gタンパク質 免疫・炎症 JAK・STATシグナル MAPK
膜輸送体・イオンチャネル 代謝 微生物学・ウィルス学 神経科学 NF-Κb 酸化還元 PI3K/Akt/mTORシグナル プロテアーゼ・プロテアソーム 幹細胞 チロシンキナーゼ・アダプター ユビキチン PROTAC
化合物ライブラリー 生物活性化合物ライブラリー ゼネラルバイオウアクティヴライブラリー 承認/再開発 医薬品ライブラリー 疾患別 化合物ライブラリー 標的/経路別 化合物ライブラリー 特徴的な生物活性化合物ライブラリー 天然化合物ライブラリー HTS用天然物ライブラリー 分野別 天然化合物ライブラリー 天然物誘導体ライブラリー CADD用天然物ライブラリー ドラッグライク 化合物ライブラリー フラグメントライブラリー カスタム化合物ライブラリー
シグナル伝達経路 血管新生 アポトーシス オートファジー 細胞周期・チェックポイント クロマチン・エピジェネティック 細胞骨格シグナル
DNA損傷・DNA修復 内分泌・ホルモン GPCR/Gタンパク質 免疫・炎症 JAK・STATシグナル MAPK 膜輸送体・イオンチャネル
代謝 微生物学・ウィルス学 神経科学 NF-Κb 酸化還元 PI3K/Akt/mTORシグナル プロテアーゼ・プロテアソーム
幹細胞 チロシンキナーゼ・アダプター ユビキチン その他 PROTAC
生物活性化合物ライブラリー ゼネラルバイオウアクティヴライブラリー 承認/再開発 医薬品ライブラリー 疾患別 化合物ライブラリー 標的/経路別 化合物ライブラリー 特徴的な生物活性化合物ライブラリー
天然化合物ライブラリー HTS用天然物ライブラリー 分野別 天然化合物ライブラリー 天然物誘導体ライブラリー CADD用天然物ライブラリー
ドラッグライク 化合物ライブラリー ドラッグライクライブラリー
フラグメントライブラリー ゼネラルフラグメントライブラリー 特徴的なフラグメントライブラリー カスタム化合物ライブラリー
Cytokines and Growth Factors •   Cytokines •   Growth Factors Receptor Proteins •   Fc Receptors •   Cytokines and Growth Factor Receptors
CD Proteins •   T Cell CD Proteins •   B Cell CD Proteins Immune Checkpoint Proteins •   Co-inhibitory Immune Checkpoint Proteins •   Co-stimulatory Immune Checkpoint Proteins
CAR-T Therapy Target Proteins •   Hematologic Malignancies Target Proteins •   Solid Tumors Target Proteins Enzymes •   Oxidoreductases,EC 1 •   Transferases,EC 2
Viral Proteins •   Coronavirus (CoV) Proteins •   Influenza Proteins Fluorescent Proteins Others

検索結果

Search Results for " HMGCR "

ターゲット

HMG-CoA Reductase

17

阻害剤

10

天然化合物

6

リコンビナントタンパク質

1

ライブラリー

カタログ番号 製品名 別名 ターゲット
T14342 Atorvastatin lactone HMG-CoA Reductase
Atorvastatin lactone is a prodrug form of atorvastatin. Which is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.
T20765 Atorvastatin HMG-CoA Reductase , Autophagy
Atorvastatin is an orally active HMG-CoA reductase inhibitor that has the ability to effectively lower blood lipids by activating liver cytochrome p450 to accelerate metabolism. Atorvastatin inhibited proliferation and i...
T6450 Clinofibrate S-8527,Lipoclin HMG-CoA Reductase , Autophagy
Clinofibrate (Lipoclin)(IC50 of 0.47 mM), a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cholesterol and triacylglyceride levels in the blood.
T6994 SR12813 SR-12813,SR 12813,GW 485801 HMG-CoA Reductase , Autophagy
SR12813 (GW 485801) is a pregnane X receptor (PXR) agonist.
T12092 Monacolin J Antibiotic MB 530A,Lovastatin diol lactone HMG-CoA Reductase , Autophagy
Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor.
T2250 DY131 DY 131,GSK 9089,DY-131 Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Smo
DY131 (DY-131) is a novel selective agonist of ERRβ and ERRγ.
T1676 Rosuvastatin ZD 4522 Potassium Channel , HMG-CoA Reductase , Autophagy
Rosuvastatin (ZD 4522) is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting...
T3116 Atorvastatin hemicalcium salt Lipitor,Atorvastatin hemicalcium,Atorvastatin Calcium,CI-981,Sortis Ferroptosis , HMG-CoA Reductase , Autophagy
Atorvastatin hemicalcium salt (Atorvastatin Calcium), an effective HMG-CoA reductase inhibitor (IC50 = 8 nM), is utilized as a cholesterol-lowering medication.
T2534 Pitavastatin calcium P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,NK-104 Apoptosis , Mitophagy , Endogenous Metabolite , HMG-CoA Reductase , Autophagy
Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cyt...
T1487 Fluvastatin sodium XU 62320 sodium,XU-62-320,Fluvastatin sodium salt Ferroptosis , HMG-CoA Reductase , Autophagy
Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent.
T1510 Rosuvastatin calcium ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium Potassium Channel , HMG-CoA Reductase , Autophagy
Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.
T21080 (3S,5S)-Atorvastatin ent-Atorvastatin,3S,5S-Atorvastatin
ent-Atorvastatin is a selective and competitive inhibitor of HMGCR (HMG-CoA reductase).
T69006 Atorvastatin lysine
Atorvastatin lysine is a selective and competitive HMGCR (HMG-CoA reductase) inhibitor.
T11572 HMG499 HMG-CoA Reductase
HMG499 is a potent and selective HMG-CoA reductase inhibitor with an IC 50 of 0.41 μM. HMG499 can eliminate statins-induced accumulation of HMGCR, lower serum cholesterol levels and decrease atherosclerosis [1].
T64292 Simvastatin acid calcium hydrate
Simvastatin acid (Tenivastatin) calcium hydrate is an orally active inhibitor of HMG-CoA reductase (HMGCR). Simvastatin acid calcium hydrate also inhibits indoxyl sulfate mediated reactive oxygen species (ROS) production...
T63777 QH536
QH536 is an effective degrader of HMGCR (EC50: 0.22 μM).QH536 exhibits anti-inflammatory effects and does not have the side effect of inducing intracellular accumulation of cholesterol.QH536 can be used to study cardiova...
T63430 Rosuvastatin Sodium
Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor (IC50: 11 nM) that effectively blocks hERG currents (IC50: 195 nM). Rosuvastatin Sodium reduces the expression of mature hERG and inhibits the inte...

Compounds

Atorvastatin lactone
T14342
Synonym:
Target: HMG-CoA Reductase
Atorvastatin
T20765
Synonym:
Target: HMG-CoA Reductase, Autophagy
Clinofibrate
T6450
Synonym: S-8527,Lipoclin
Target: HMG-CoA Reductase, Autophagy
SR12813
T6994
Synonym: SR-12813,SR 12813,GW 485801
Target: HMG-CoA Reductase, Autophagy
Monacolin J
T12092
Synonym: Antibiotic MB 530A,Lovastatin diol lactone
Target: HMG-CoA Reductase, Autophagy
DY131
T2250
Synonym: DY 131,GSK 9089,DY-131
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Smo
Rosuvastatin
T1676
Synonym: ZD 4522
Target: Potassium Channel, HMG-CoA Reductase, Autophagy
Atorvastatin hemicalcium salt
T3116
Synonym: Lipitor,Atorvastatin hemicalcium,Atorvastatin Calcium,CI-981,Sortis
Target: Ferroptosis, HMG-CoA Reductase, Autophagy
Pitavastatin calcium
T2534
Synonym: P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,NK-104
Target: Apoptosis, Mitophagy, Endogenous Metabolite, HMG-CoA Reductase, Autophagy
Fluvastatin sodium
T1487
Synonym: XU 62320 sodium,XU-62-320,Fluvastatin sodium salt
Target: Ferroptosis, HMG-CoA Reductase, Autophagy
Rosuvastatin calcium
T1510
Synonym: ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium
Target: Potassium Channel, HMG-CoA Reductase, Autophagy
(3S,5S)-Atorvastatin
T21080
Synonym: ent-Atorvastatin,3S,5S-Atorvastatin
Target:
Atorvastatin lysine
T69006
Synonym:
Target:
HMG499
T11572
Synonym:
Target: HMG-CoA Reductase
Simvastatin acid calcium hydrate
T64292
Synonym:
Target:
QH536
T63777
Synonym:
Target:
Rosuvastatin Sodium
T63430
Synonym:
Target:
カタログ番号 製品名 別名 ターゲット
TN1733 Hesperetin 7-O-glucoside Anti-infection , Antibacterial , HMG-CoA Reductase
Hesperetin 7-O-glucoside and prunin are direct precursors of naringin and neohesperidin, respectively, in C. aurantium. Hesperetin 7-O-glucoside shows inhibition of human HMG-CoA reductase, it also exhibits effective inh...
T5S0246 Pseudoprotodioscin Others , Fatty Acid Synthase
1. Pseudoprotodioscin has moderate cytotoxicity.
T1207 Lovastatin MK-803,Mevinolin Ferroptosis , HMG-CoA Reductase , Autophagy
Lovastatin (MK-803) is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.
T1664 Meglutol Dicrotalic acid,3-Hydroxy-3-methylglutaric acid Endogenous Metabolite , HMG-CoA Reductase , Autophagy
Meglutol (3-Hydroxy-3-methylglutaric acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conve...
T0683 Mevastatin Compactin,ML236B Apoptosis , Antibacterial , Antibiotic , HMG-CoA Reductase , Autophagy , Lipid
Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.
TN1438 Beta-Amyrin acetate Antioxidant , HMG-CoA Reductase , Epoxide Hydrolase , Antifungal
beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 μM. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, and anti-hyperlipidemic activities.
T0672 Pravastatin sodium CS-514 Sodium,CS-514 (sodium) Ferroptosis , HMG-CoA Reductase , Autophagy
Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.
T0687 Simvastatin MK-0733,MK 733 Apoptosis , Mitophagy , Ferroptosis , HMG-CoA Reductase , Autophagy
Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cholesterol, and is also used for the prevention of cardiovasc...
T5S0053 Coptisine Coptisin Indoleamine 2,3-Dioxygenase (IDO)
1. Coptisine (Coptisin) treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myocardial I/R likely through suppressing myocardial ...
T75626 Ganoderenic acid K
Ganoderenic Acid K, isolated from the fruiting bodies of Ganoderma lucidum, exhibits potent inhibitory activity against HMG-CoA reductase (HMGCR), demonstrating an IC50 of 16.5 μM [1].

天然物製品

Hesperetin 7-O-glucoside
TN1733
Synonym:
Target: Anti-infection, Antibacterial, HMG-CoA Reductase
Pseudoprotodioscin
T5S0246
Synonym:
Target: Others, Fatty Acid Synthase
Lovastatin
T1207
Synonym: MK-803,Mevinolin
Target: Ferroptosis, HMG-CoA Reductase, Autophagy
Meglutol
T1664
Synonym: Dicrotalic acid,3-Hydroxy-3-methylglutaric acid
Target: Endogenous Metabolite, HMG-CoA Reductase, Autophagy
Mevastatin
T0683
Synonym: Compactin,ML236B
Target: Apoptosis, Antibacterial, Antibiotic, HMG-CoA Reductase, Autophagy, Lipid
beta-Amyrin acetate
TN1438
Synonym:
Target: Antioxidant, HMG-CoA Reductase, Epoxide Hydrolase, Antifungal
Pravastatin sodium
T0672
Synonym: CS-514 Sodium,CS-514 (sodium)
Target: Ferroptosis, HMG-CoA Reductase, Autophagy
Simvastatin
T0687
Synonym: MK-0733,MK 733
Target: Apoptosis, Mitophagy, Ferroptosis, HMG-CoA Reductase, Autophagy
Coptisine
T5S0053
Synonym: Coptisin
Target: Indoleamine 2,3-Dioxygenase (IDO)
Ganoderenic acid K
T75626
Synonym:
Target:

Recombinant Proteins

Species：
Human (4)
Mouse (2)
Expression System：
E. coli (5)
HEK293 Cells (1)
Tag：
N-6xHis (3)
C-hFc (1)
N-10xHis, C-Myc (1)
N-6xHis-SUMO (1)
カタログ番号 製品名 Species Expression System
TMPH-00007 HMGCR Protein, Human, Recombinant (His) Human E. coli
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol ...
TMPH-02476 HMGCR Protein, Mouse, Recombinant (His) Mouse E. coli
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol ...
TMPH-01259 AMFR Protein, Human, Recombinant (His) Human E. coli
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
TMPH-01260 AMFR Protein, Human, Recombinant (hFc) Human HEK293 Cells
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
TMPH-01535 INSIG2 Protein, Human, Recombinant (His & Myc) Human E. coli
Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol...
TMPH-02717 HMGCS1 Protein, Mouse, Recombinant (His & SUMO) Mouse E. coli
Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. HMGCS1 Protein, Mouse, Recombinant (H...
カタログ番号 製品名
L2510 Lipid Metabolism Compound Library

492 compounds
A unique collection of 492 compounds targeting lipid metabolism, can be used for high-throughput screening (HTS) and high-content screening (HCS).

ライブラリー

Lipid Metabolism Compound Library
L2510
Compounds: 492
TARGETMOLについて
会社情報 プライバシー保護について イベント＆ニュース 利用規約
サポート
お問い合わせ 代理店情報 品質管理 技術サポート
技術資料
製品カタログ 引用文献 シグナル伝達経路 溶解計算
ニュースレター登録
ニュースレターで最新の製品情報やお得な情報をお届けします。
ニュースレターで最新の製品情報やお得な情報をお届けします。
TargetMolについて
サポート
技術資料
本ウェブサイトに掲載されている製品は全て研究用試薬です。研究目的以外の用途にはご使用できません。
Copyright © 2015-2023 TargetMol Chemicals Inc. All rights reserved.