|
T9966 |
GSK-1520489A
|
|
Wee1
|
|
GSK-1520489A is an active PKMYT1 inhibitor. |
|
T6255 |
Bromosporine
|
|
Epigenetic Reader Domain
,
CDK
|
|
Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively. |
|
T6967 |
RHPS4
|
RHPS 4 methosulfate,NSC714187 |
Apoptosis
,
Telomerase
|
|
RHPS4 (RHPS 4 methosulfate) is a potent inhibitor of Telomerase at submicromolar. |
|
T2617 |
SNS-314 Mesylate
|
SNS-314 |
Aurora Kinase
|
|
SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor (IC50: 9/31/3 nM). It is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2. |
|
T16961 |
Supinoxin
|
RX-5902 |
Apoptosis
,
DNA/RNA Synthesis
|
|
Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase and a potent first-in-class anti-cancer agent. Supinoxin induces cell apoptosis and inhibits the growth of TNBC cancer cell lines (IC50... |
|
T13009 |
STAT3-IN-1
|
|
Apoptosis
,
STAT
|
|
STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor apoptosis. |
|
T78156 |
MC4033
|
|
Apoptosis
|
|
MC4033 exhibits inhibitory concentration 50 (IC50) values of 39.4 µM in HCT116, 52.1 µM in H1299, 41 µM in A549, and 30.1 µM in U937 [1]. Additionally, treatment with MC4033 at concentrations of 25, 50, 100, and 200 µM f... |
|
T68896 |
Daniquidone
|
NSC 320846,BAY-H 2049 |
Topoisomerase
|
|
Daniquidone (Batracylin) is a potent dual inhibitor of DNA topoisomerase I and DNA topoisomerase II with cytotoxic and antiproliferative activity that induces DNA fragmentation for the study of neoplasms, immune disorder... |
|
T20882 |
4-Nitrobenzoic acid
|
Kyselina p-nitrobenzoova,4Nitrobenzoic acid,Nitrodracylic acid,4 Nitrobenzoic acid |
|
|
4-Nitrobenzoic acid (4Nitrobenzoic acid) is a pharmaceutical intermediate often found in the production of folic acid, DABA, PABA and dyes. |
|
T11369 |
GB-110
|
|
Others
|
|
GB-110 selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM. GB-110 is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist. |
|
T2283 |
PX-12
|
IV-2,PX12 |
Thioredoxin
|
|
PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits tumor gr... |
|
T73854 |
GB-110 hydrochloride
|
|
|
|
GB-110 hydrochloride, a potent and orally active nonpeptidic agonist of the protease-activated receptor 2 (PAR2), selectively triggers PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM [1]. |
|
T12259 |
NSC 601980
|
|
Others
|
|
NSC601980 demonstrates antitumor potency, as evidenced by its ability to inhibit cell proliferation in the COLO 205 and HT29 cancer cell lines, achieving Log GI 50 values of -6.6 and -6.9, respectively, in yeast screenin... |
|
T72524 |
Antitumor agent-47
|
|
|
|
Antitumor agent-47 is a silibinin derivative with an antitumor activity. Antitumor agent-47 shows cytotoxic activity against NCI-H1299 and HT29 cells with IC 50 values of 8.07 µM and 6.27 µM, respectively . |
|
T62922 |
Tubulin inhibitor 25
|
|
|
|
Tubulin inhibitor 25 is a potent inhibitor of tubulin (IC50: 0.98 μM) and significantly inhibits HT29 cells. tubulin inhibitor 25 inhibits cell migration and microtubule formation and contributes to anti-angiogenesis. |
|
T41189 |
AY 254
|
|
|
|
AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50= 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+release). Reduces cytoKi ne-induced caspase 3/8 activation, promotes scratch-woun... |
|
T11369L |
GB-110 hydrochloride (1252806-70-4 free base)
|
GB-110 hydrochloride |
Others
|
|
GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM. GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR... |
|
T72525 |
Antitumor agent-48
|
|
|
|
Antitumor agent-48 is a 2,3-dehydrosilybin derivative with an antitumor activity. Antitumor agent-48 shows cytotoxic activity against MCF-7, NCI-H1299, HepG2 and HT29 cells with IC 50 values of 8.06 µM, 13.1 µM, 16.51 µM... |
|
T21749 |
4-iodo-SAHA
|
|
|
|
4-Iodo-SAHA (1k), an orally active inhibitor of both class I and class II histone deacetylase (HDAC), exhibits EC50 values of 1.1, 0.95, 0.12, 0.24, 0.85, and 1.3 μM for Skbr3, HT29, U937, JA16, and HL60 cell lines, resp... |
|
T61532 |
Tubulin polymerization-IN-6
|
|
|
|
Tubulin polymerization-IN-6 (compound 5f) is a potent inhibitor of tubulin polymerization, with an IC50 of 1.09 μM. It not only inhibits cell migration and tube formation but also has anti-angiogenic properties. Addition... |
|
T3437 |
Lys05
|
Lys01 trihydrochloride |
lysosomal autophagy
,
Autophagy
|
|
Lys05, or Lys01 trihydrochloride, is a potent, water soluble lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compa... |
|
T36704 |
CCT241533 dihydrochloride
|
CCT 241533 dihydrochloride |
|
|
Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radi... |
|
T79353 |
P-gp/BCRP-IN-2
|
|
|
|
P-gp/BCRP-IN-2 (compound 15), an oxadiazole derivative, functions as a dual inhibitor targeting both the ABC transporter P-glycoprotein (IC50: 1.6 nM) and BCRP (IC50: 600 nM). Additionally, it bolsters the anti-prolifera... |
|
T79388 |
Anticancer agent 154
|
|
Reactive Oxygen Species
|
|
Anticancer agent 154 (Compound 8h) enhances reactive oxygen species production, causing mitochondrial damage, and promotes cell apoptosis and DNA damage. It triggers ferroptosis by depleting GSH, diminishing GPX4 express... |
|
T60793 |
Tubulin inhibitor 26
|
|
|
|
Tubulin inhibitor 26 (compound 3c) is an indazole derivative which is a potent tubulin inhibitor with noteworthy low nanomolar potency against HepG2, HCT116, SW620, HT29 and A549 cancer cell lines. Tubulin inhibitor 26 i... |
|
T79598 |
Anti-inflammatory agent 52
|
|
COX
|
|
Anti-inflammatory agent 52 (compound 7j) is an orally active, selective COX-2 inhibitor with the capability to induce G2/M phase arrest and exhibit anti-HT29 transfer activity. It demonstrates moderate anti-inflammatory ... |
|
T79599 |
Anti-inflammatory agent 53
|
|
COX
|
|
Anti-inflammatory agent 52 (compound 7c) is an orally active, selective COX-2 inhibitor with demonstrated anti-HT29 metastatic activity, causing periodic arrest in the S phase and G2/M phase. This agent exhibits moderate... |
|
T78855 |
Anticancer agent 157
|
|
NO Synthase
|
|
Anticancer Agent 157 (compound 15) is a nitric oxide (NO) inhibitor with IC50 values of 0.62 μg/mL, exhibiting both anti-inflammatory and anticancer effects. It interacts with inducible NO synthase (iNOS) and caspase 8, ... |
|
T71382 |
KRC-108
|
|
|
|
KRC-108 is a multiple kinase inhibitor. KRC-108 is a potent inhibitor of Ron, Flt3 and TrkA as well as c-Met. KRC-108 inhibited oncogenic c-Met M1250T and Y1230D more strongly than wild type c-Met. The anti-proliferative... |
|
T41070 |
LP-184
|
|
|
|
LP-184 (Compound 6), referred to as an acylfulvene analog, demonstrates the ability to inhibit tumor growth with noteworthy anti-cancer efficacy observed across multiple cell lines, including ovarian, colon, prostate, an... |
|
T13782 |
MS432
|
|
MEK
|
|
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2. |
