|
T8452 |
Dantrolene
|
|
Others
|
|
Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. |
|
T9998 |
MIND4-19
|
|
Sirtuin
|
|
MIND4-19 is an inhibitor of SIRT2 with antitumor activity. |
|
T0412 |
Idebenone
|
CV-2619 |
Apoptosis
,
Antioxidant
,
Mitochondrial Metabolism
|
|
Idebenone (CV-2619) is a synthetic analogue of ubiquinone (Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC). |
|
T6111 |
Selisistat
|
EX-527,SEN0014196 |
Sirtuin
|
|
Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM). Selisistat can be used in the study of neurological disorders such as Huntington's chorea. |
|
T3206 |
NKL 22
|
Histone Deacetylase Inhibitor IV,PAOA |
HDAC
|
|
NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor. |
|
T9159 |
PBT-1033
|
PB 1033,PBT1033,PBT-2,PBT 2,PBT2 |
Others
|
|
PBT-1033 (PBT-2) is a potential neuroprotective agent for the treatment of Alzheimer's disease and Huntington's disease. |
|
TP2417 |
Tidembersat
|
|
Others
|
|
Tidembersat is a small molecule compound used to treat and/or prevent degenerative diseases such as Huntington's chorea, schizophrenia, neurological. |
|
T62839 |
Dalzanemdor
|
SAGE-718 |
NMDAR
,
iGluR
|
|
Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dysfunction. |
|
T15035 |
Cystamine
|
2,2'-Disulfanediyldiethanamine |
Caspase
|
|
Cystamine (2,2'-Disulfanediyldiethanamine) is an inhibitor of transglutaminase and inhibits caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used in studies about Huntington's diseases. |
|
T61859 |
MK-28
|
|
Antiviral
,
PERK
|
|
MK-28 is a selective PERK agonist that reduces toxicity and prolongs survival in a Huntington's disease model.MK-28 has a significant killing effect on MK28 gastric cancer cells. |
|
T22595 |
B2
|
Linazolamide intermediate B impurity 2,CPNQ,5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline |
Others
,
Sirtuin
|
|
B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease |
|
T23331 |
SC 51089
|
SC 51089 free base |
Prostaglandin Receptor
|
|
SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's... |
|
T38605 |
NCT-504
|
|
Others
|
|
NCT-504, a selective allosteric inhibitor of PIP4Kγ, exhibits an IC50 value of 15.8 μM. It holds promise for the investigation of Huntington's disease. |
|
T2075 |
Pyrazolo[1,5-a]pyrimidine 4h
|
|
Others
|
|
Pyrazolo[1,5-a]pyrimidine 4h is a morpholine derivative that is a selective antagonist of the adenosine A2A receptor. It has been shown to be neuroprotective in animal models of Parkinson's disease and Huntington's chore... |
|
T9340 |
1-phenyl-3,4-dihydroisochinoline
|
3,4-Dihydro-1-phenylisoquinoline |
Others
|
|
1-phenyl-3,4-dihydroisochinoline (3,4-Dihydro-1-phenylisoquinoline) is a structural analog of the neurotransmitter dopamine that interacts with dopamine receptors in the central nervous system. It has been studied as a p... |
|
T13133 |
Tetrabenazine Metabolite
|
(-)-β-Dihydrotetrabenazine,(-)-β-HTBZ |
Monoamine Transporter
|
|
Tetrabenazine Metabolite ((-)-β-HTBZ), a vesicles monoamine transporter 2 (VMAT2) inhibitor, is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite has a high affinity for VMAT2 with a Ki of 13.4 nM. Tetraben... |
|
T40652 |
Meclizine
|
Meclozine |
Histamine Receptor
|
|
Meclizine, also known as Meclozine, is a piperazine class H1 antagonist with antihistamine properties that inhibits the interaction of histamine at H1 receptors reversibly. It serves as an effective anti-motion sickness ... |
|
T28363 |
PF-02545920
|
|
|
|
PF-02545920, a PDE10 inhibitor, is used potentially for the treatment of Huntington's Disease. |
|
T39480 |
Lexanersen
|
WVE-120102,Lexanersen |
|
|
Lexanersen (WVE-120102), an antisense oligonucleotide, is utilized in Huntington's disease research. |
|
T33895 |
PBT-1033 hydrochloride
|
PBT 1033,PBT2,PBT 2,PBT-2,PBT1033,PBT-1033 |
|
|
PBT-1033 hydrochloride is a potential neuroprotective agent for the treatment of Alzheimer's disease and Huntington's disease. |
|
T40843 |
1-(Anilinocarbonyl)proline
|
|
|
|
1-(Anilinocarbonyl)proline is a compound utilized for identifying dual-action probes within a cell model of Huntington's disease. |
|
T69441 |
NSC66098
|
|
|
|
NSC66098 is a novel potent inhibitor of Huntington's disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein. |
|
T26683 |
AUTEN-67
|
Autophagy enhancer 67,MTMR14 inhibitor,AUTEN67 |
|
|
AUTEN-67 is a specific inhibitor of MTMR14 and autophagy enhancer with potent antiaging and neuroprotective effects. AUTEN-67 also delays the onset and decreases the severity of Huntington's disease. |
|
T34662 |
SMER10
|
SMER-10,SMER 10 |
|
|
SMER10 is an enhancer of the clearance of mutant aggregate-prone proteins by autophagy in mammalian cell models of Huntington's and Parkinson's disease, independent of rapamycin. |
|
T71969 |
Remacemide
|
|
|
|
Remacemide is a low-affinity NMDA antagonist with sodium channel blocking properties. It has been studied for the treatment of acute ischemic stroke, epilepsy, Huntington's disease, and Parkinson's disease. |
|
T80813 |
WAY-354574
|
|
Sirtuin
|
|
WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1]. |
|
T38146 |
Chloroguanabenz (acetate)
|
|
|
|
Chloroguanabenz is an antiprion agent and a derivative of the α2-adrenergic receptor agonist guanabenz . It inhibits prion formation in yeast and mammalian cell-based assays. Chloroguanabenz reduces the levels of both so... |
|
T61497 |
Rho-Kinase-IN-2
|
|
|
|
Rho-Kinase-IN-2 (Compound 23) is an orally active and selective inhibitor of Rho Kinase (ROCK), which can penetrate the central nervous system (CNS). It exhibits a high affinity for ROCK2 with an inhibition constant (IC5... |
|
T79865 |
Votoplam
|
|
DNA/RNA Synthesis
|
|
Votoplam functions as a gene splicing modulator, employed in the inhibition of Huntington's disease [1]. |
|
T7352L |
Pridopidine hydrochloride
|
ASP2314 HCl,Pridopidine HCl,FR310826,ASP-2314 hydrochloride |
|
|
Pridopidine Hydrochloride is a dopaminergic stabilizer that has been shown to improve a variety of neurological and psychiatric disorders, including Huntington's disease. Pridopidine Hydrochloride stabilizes psychomotor ... |
|
T38279 |
C2-8
|
C2-8 |
|
|
C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isola... |
|
T79038 |
Tau protein aggregation-IN-1
|
|
|
|
Tau Protein Aggregation-IN-1 (Compound 0c) serves as an inhibitor of Tau protein aggregation, applicable in research related to protein folding disorders including Alzheimer's disease, dementia, Parkinson's disease, Hunt... |
|
T61991 |
HTT-D3
|
|
|
|
HTT-D3 is a potent and orally active huntingtin (HTT) splicing modulator. HTT-D3 can lead to HTT mRNA degradation and reduction of HTT levels. HTT-D3 reduces p-glycoprotein (P-gp) efflux, and has research value in Huntin... |
|
T73289 |
MHTT-IN-1
|
|
|
|
mHTT-IN-1 (Example 1) is a potent inhibitor of the mutant huntingtin protein (mHTT), which is toxic and primarily responsible for Huntington's disease (HD), an inherited autosomal dominant neurodegenerative disorder. Thi... |
|
T74247 |
TPE-MI
|
|
|
|
Tetraphenylethene maleimide (TPE-MI) serves as a thiol probe to assess unfolded protein levels and proteostasis within cells. It is particularly effective in identifying proteostasis imbalances in both induced pluripoten... |
|
T83947 |
HDAC4 CHDI Degrader 11
|
|
|
|
HDAC4 CHDI Degrader 11 is a potent, selective degrader of HDAC4 (PROTAC) with DC_50 values of 4 nM and 6 nM in Jurkat E6-1 and Jurkat cells, respectively. This compound integrates the class IIa HDAC inhibitor trifluorome... |
