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カタログ番号 | 製品名 | 別名 | ターゲット |
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T7832 | Ibrolipim | NO-1886 | LPL Receptor |
Ibrolipim (NO-1886) attenuates high glucose-induced endothelial dysfunction in cultured human umbilical vein endothelial cells via PI3K/Akt pathway. | |||
T6690 | T0901317 | Apoptosis , FXR , Liver X Receptor , ROR | |
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB). | |||
T15427 | GSK2033 | Liver X Receptor | |
GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively). | |||
T3970 | BMS-779788 | XL652,EXEL04286652,XL 652,XL-652,BMS-788 | Liver X Receptor |
BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM). | |||
T16930 | SR9238 | Liver X Receptor | |
SR9238 is a synthetic agonist of liver X receptor inverse (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively). | |||
T63896 | BE1218 | Liver X Receptor | |
BE1218 is a liver X receptor (LXR) inverse agonist active on LXRα and LXRβ with an IC50 of 9 nM and 7 nM, respectively. | |||
T1783 | LXR-623 | LXR623,WAY 252623 | Liver X Receptor |
LXR-623 (WAY 252623) is an orally bioavailable and highly specifical synthetic modulator of LXR. | |||
T7796 | TUG-1375 | GPR | |
TUG-1375 is an Agonist of Thiazolidine Free Fatty Acid Receptor 2 | |||
T27478 | GSK3987 | Liver X Receptor | |
GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM. | |||
T7621 | 6-Thioinosine | 6-Mercaptopurine riboside,6TI | Nucleoside Antimetabolite/Analog |
6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent. | |||
T5178 | AZ876 | Liver X Receptor | |
AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively. | |||
T68696 | AZ-2 | ||
AZ-2 is an inducer of ABCA1 and apoE. It enhances ABCA1 activity and decreases P2X7 receptor activity. AZ-2 activates endogenous LXR signaling but shows no direct LXRα or LXRβ agonist activity. | |||
T25528 | IMB-808 | ||
IMB-808 is an effective partial dual agonist of liver X receptor α and β (LXRα/β) that promotes the expression of genes related to reverse cholesterol transport (including ABCA1 and ABCG1). | |||
T68668 | AZ-1 | ||
AZ-1 is an inducer of ABCA1 and apoE. It enhances ABCA1 activity and decreases P2X7 receptor activity. AZ-1 activates endogenous LXR signaling but shows no direct LXRα or LXRβ agonist activity. | |||
T6310 | GW3965 hydrochloride | GW3965 HCl | Liver X Receptor |
GW3965 hydrochloride (GW3965 HCl) is an effective and specific LXR agonist for hLXRα/β (EC50: 190/30 nM). | |||
T64171 | LXR antagonist 2 | ||
LXR antagonist 2 (compound 10rr) is a potent LXR (liver X receptor) inverse agonist, acting on LXRβ (IC50: 0.36 μM) and LXRα (IC50: 2.25 μM). LXR antagonist 2 is an adipogenesis inhibitor that downregulates LXR target ge... | |||
T37414 | CAY10771 | ||
CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 μM, respectively)... | |||
T37408 | Bischloroanthrabenzoxocinone | ||
Bacterial type II fatty acid synthesis (FAS-II) is mediated by a series of enzymes, each of which may be targeted by potential antibiotics. Bischloroanthrabenzoxocinone (BABX) is an inhibitor of FAS-II, blocking fatty ac... | |||
T83765 | Dendrogenin A | DDA | |
Dendrogenin A (DDA) is a compound acting as a selective liver X receptor (LXR) modulator, cholesterol epoxide hydrolase inhibitor (Ki = 120 nM), and a metabolic product of cholesterol, originating from 5,6α-epoxy cholest... | |||
T36130 | 22(S)-hydroxy Cholesterol | 22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol | |
22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatoc... | |||
T11899 | LXRβ agonist-2 | Others | |
LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM. |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T2810 | (20S)-Protopanaxatriol | 20(S)-APPT,g-PPT | Apoptosis , Estrogen Receptor/ERR , Glucocorticoid Receptor , Estrogen/progestogen Receptor , Liver X Receptor |
(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor. | |||
T2768 | Saikosaponin A | NF-κB , Antibacterial , Liver X Receptor | |
Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropath... | |||
TN1719 | Gymnestrogenin | Liver X Receptor | |
Gymnestrogenin has a dual LXRα±/α2 antagonistic profile. |