|
T38359 |
Dup-721
|
|
Antibacterial
|
|
DuP-721 is a broad spectrum and orally active antibacterial agent. DuP-721 inhibits a variety of clinically susceptible and resistant bacteria, especially M. tuberculosis. |
|
T8694 |
ML406
|
|
Antibacterial
,
Antibiotic
|
|
ML406 shows anti-tubercular activity via MtbbioA (DAPA synthase) enzyme inhibition(IC50 : 30 nM) |
|
T22365 |
Methyl α-D-mannopyranoside
|
Methyl α-D-mannopyranoside |
Antibacterial
|
|
Methyl α-D-mannopyranoside (Methyl α-D-mannopyranoside) can be used as an intermediate for chemical sythesis and can target macrophages in anti-tuberculosis inhalation therapy[1]. |
|
T5400 |
Q203
|
IAP6,Telacebec |
Antibacterial
,
Antibiotic
|
|
Q203 (Telacebec) is a novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB and inhibits M. tuberculosis H37Rv (MIC50: 2.7 nM). |
|
T3642 |
TBA-354
|
TBA 354 |
Antibacterial
,
Antibiotic
|
|
TBA-354 is anti-tuberculous and active against Mycobacterium tuberculosis strain H37Rv. |
|
T4531 |
GSK2200150A
|
|
Antibacterial
|
|
GSK2200150A is an anti-tuberculosis (TB) agent identified by high-throughput screening (HTS) campaign. |
|
T10329 |
anti-TB agent 1
|
|
Antibiotic
|
|
anti-TB agent 1 is a potent and orally active anti-tuberculosis agent (MICs: < 2 nM against the Mtb strains H37Rv, rRMP and rINH). |
|
T2585 |
Bedaquiline
|
R207910,TMC207 |
Antibacterial
,
Antibiotic
|
|
Bedaquiline (R207910) is an anti-tuberculosis drug which selectively inhibit the mycobacterial energy metabolism i.e. ATP synthesis and found to be effective against all states of Mycobacterium tuberculosis. |
|
T6096 |
Pretomanid
|
(S)-PA 824,PA-824 |
Antibacterial
,
Antibiotic
|
|
Pretomanid ((S)-PA 824) , a nitroimidazole, is used as an anti-tuberculosis drug for tuberculosis with MIC less than 2.8 μM. |
|
T5997 |
TBAJ-587
|
|
Antibacterial
,
Antibiotic
|
|
TBAJ-587 is a potent anti-tuberculosis agent. TBAJ-587 inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and <0.02 µg/mL in MABA and LORA assay, respectively. BAJ-587 has more potent activity against M. tuberculosis... |
|
T38345 |
SQ609
|
|
|
|
SQ609 is a potential anti-tuberculosis drug selected from a library of dipiperidine derivatives. SQ609 showed significant anti-tuberculous activity in mouse macrophages in vitro[1]. |
|
T4202 |
Delamanid
|
OPC-67683 |
Anti-infection
,
Antibacterial
,
Antibiotic
|
|
Delamanid (OPC-67683) is an anti-tuberculosis agent derived from the nitro-dihydro-imidazooxazole class of compounds that inhibits mycolic acid synthesis of bacterial cell wall. |
|
T12231 |
NITD-349
|
|
Others
,
Antibacterial
|
|
NITD-349 is an inhibitor of MmpL3. It shows highly potent anti-mycobacterial activity with MIC50 of 23 nM against virulent Mycobacterium tuberculosis H37Rv. |
|
T9085 |
JFD01307SC
|
[(1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)AMINO] |
Antibacterial
|
|
JFD01307SC ([(1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)AMINO]) is a glutamine synthetase inhibitor. It is anti-tuberculosis agent and acts as a mimic of L-Glutamate and thus target enzymes involved in glutamine biosynthesis. |
|
T11449L |
Golotimod
|
Gamma-D-glutamyl-L-tryptophan,SCV 07 |
Antibiotic
|
|
Golotimod (SCV 07) is an antimicrobial dipeptide with immunomodulatory activity that significantly improves the efficacy of anti-tuberculosis therapy, induces thymic and splenic cell proliferation, modulates macrophage f... |
|
T23621 |
Aconiazide
|
Aconiazida |
|
|
Aconiazide is a prodrug of anti-tuberculosis. |
|
T27978 |
Maritinone
|
|
|
|
Maritinone is a novel anti-tuberculosis (anti-TB) agent. |
|
T28120 |
MTC420
|
MTC-420,MTC 420 |
|
|
MTC420 is a anti-tuberculosis agent with acceptable anti-tuberculosis activity (Mtb IC50 =525 nM, Mtb Wayne IC50 = 76 nM and MDR Mtb patient isolates IC50 = 140 nM). |
|
T39091 |
Spectinamide 1599
|
|
|
|
Spectinamide-1599 is a combination partner for anti-tuberculosis therapy. |
|
T30604 |
BTZ-N3
|
BTZ N3 |
|
|
BTZ-N3 is an effective and selective anti-tuberculosis drug candidate. |
|
T11259 |
FadD32 Inhibitor-1
|
|
Others
|
|
FadD32 inhibitor -1 has anti-tuberculosis activity and is an effective FadD32 inhibitor. |
|
T10171 |
5-Hydroxypyrazine-2-Carboxylic Acid
|
|
Others
|
|
5-Hydroxypyrazine-2-Carboxylic Acid is a metabolite of anti-tuberculosis drug pyrazinamide. |
|
T33683 |
NITD-304
|
NITD304 |
|
|
NITD-304 is an anti-tuberculosis drug candidate for the treatment of multidrug-resistant tuberculosis (MDR-TB), showing effective activity against both MTB drug-sensitive and multidrug-resistant clinical isolates. |
|
T27477 |
GSK366A
|
|
|
|
GSK366A is an anti-TB agent against Mycobacterium bovis BCG and Mycobacterium tuberculosis, targeting MmpL3 and inhibiting EchA6. |
|
T10563 |
BM635
|
|
Others
|
|
BM635 is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv). |
|
T62086 |
Tuberculosis inhibitor 5
|
|
|
|
Tuberculosis inhibitor 5 (Compound 11i) is a potent anti-tuberculosis agent with no apparent cytotoxicity. tuberculosis inhibitor 5 is an antimycobacterial biphenyl analogue. |
|
T61676 |
4-Piperidinecarboxamide
|
|
|
|
4-Piperidinecarboxamide is a mycobacterial aspartyl-tRNA synthetase (AspS) inhibitor and a potential anti-tuberculosis (TB) agent [1]. |
|
T63525 |
Antitubercular agent-23
|
|
|
|
Antitubercular agent-23 is an effective anti-Candida and anti-tuberculosis agent against Candida albicans MTCC 3017 (MIC: 1.1 μg/ml) and M. tuberculosis (H37Rv) (MIC: 1 μg/ml). |
|
T63755 |
Antitubercular agent-22
|
|
|
|
Antitubercular agent-22 (Compound 2) is an effective anti-Candida and anti-tuberculosis agent against Candida albicans MTCC 3017 (MIC: 2.34 μg/ml) and M. tuberculosis (H37Rv) (MIC: 2 μg/ml). |
|
T10887 |
CRS400393
|
|
Antibacterial
|
|
CRS400393 is an effective anti-mycobacterial drug , with MIC of 0.03, 2, and ≤ 0.12 µg/mL against M. abs., M. avium, M. intracellulare, and M. tuberculosis, respectively. |
|
T16419 |
Oxyphenbutazone
|
|
COX
|
|
Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is a phenylbutazone derivative. It has an anti-inflammatory effect. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis. |
|
T38298 |
Tuberculosis inhibitor 3
|
|
|
|
Tuberculosis inhibitor 3 (compound 2i) exhibits potent anti-TB properties (MIC < 0.016 μg/mL) against both drug-sensitive and resistant MTB strains, along with acceptable pharmacokinetic profiles and oral bioavailability... |
|
T61303 |
MmpL3-IN-1
|
|
|
|
MmpL3-IN-1, also known as compound 32, is a highly effective inhibitor of Mycobacterial membrane protein large 3 (MmpL3). With an anti-tuberculosis activity exhibiting a minimum inhibitory concentration (MIC) of less tha... |
|
T11497 |
Ganfeborole HCl
|
GSK3036656 HCl,GSK656 HCl |
Antibacterial
|
|
Ganfeborole HCl (GSK3036656 HCl) is a small molecule compound with anti-tuberculosis activity and is an inhibitor of Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (LeuRS; IC50: 0.2 μM). |
|
T10513 |
Benzothiohydrazide
|
|
Antibacterial
|
|
Benzothiohydrazide is an analog of isoniazid with anti-tuberculosis activity and can be used to isolate fungi and bacteria. |
|
T61149 |
Antibacterial agent 121
|
|
|
|
Antibacterial agent 121 (Compound 10) demonstrates antibacterial properties and exhibits efficacy against mycobacterial strains while also possessing anti-inflammatory activity. This compound finds potential applications... |
|
T61520 |
Antitubercular agent-24
|
|
|
|
Antitubercular agent-24 (Compound 1) exhibits anti-tubercular properties against M. tuberculosis H37Rv. It demonstrates an extracellular IC50 of 0.83 μM and an intracellular IC50 of 0.17 μM [1]. |
|
T110951 |
Compound F0447-0245
|
|
|
|
Antitubercular agent-33 is a 2-aminothiazole derivative with potent anti-tubercular activity against Mycobacterium tuberculosis ( Mtb ) [1]. |
|
T10563L |
BM635 hydrochloride (1493762-74-5 free base)
|
BM635 hydrochloride |
Others
|
|
BM635 hydrochloride is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv). |
|
T40520 |
Thiophene-2
|
Thiophene-2,TP2 |
|
|
Thiophene-2 (TP2) is a targeted inhibitor of polyketide synthase 13 (Pks13), specifically designed to disrupt mycolic acid biosynthesis. By doing so, it effectively induces rapid cell death in mycobacteria. Thiophene-2 d... |
|
T10563L2 |
BM635 mesylate (1493762-74-5 free base)
|
BM635 mesylate |
Others
|
|
BM635 mesylate is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv). |
|
T73329 |
MMV676584
|
|
|
|
MMV676584 has anti-tuberculosis avtivity. MMV676584 is a novel drug candidate for eumycetoma . |
|
T78602 |
Chaetoglobosin C
|
|
|
|
Chaetoglobosin C (Compound 4), an anthraquinone-chromone derivative of Chaetomium globosum KMITL-N0802, exhibits anti-tuberculosis activity [1]. |
|
T21778 |
10-DEBC hydrochloride
|
|
|
|
10-DEBC hydrochloride, a selective Akt inhibitor demonstrating an IC50 value of 1.28 μM, is identified as a novel anti-tuberculosis compound [1] [2]. |
|
T11817 |
Lansoprazole Sulfide D4
|
|
Proton pump
|
|
Lansoprazole Sulfide D4 is a deuterium labeled Lansoprazole Sulfide. Lansoprazole Sulfide is an orally active anti-TB (Mycobacterium tuberculosis) agent with IC50 values of 0.59 μM intracellularly and 0.46 μM in broth.La... |
|
T38073 |
Thiocarlide
|
Isoxyl |
|
|
Thiocarlide (isoxyl) is a thiourea derivative that was used in the 1960s to successfully treat tuberculosis (TB). It has considerable antimycobacterial activity in vitro and is effective against multi-drug resistant stra... |
|
T73441 |
TBI-166
|
|
|
|
TBI-166, an orally active riminophenazine analogue, serves as an anti-tuberculosis agent and exhibits fewer adverse reactions compared to its lead compound, Clofazimine [1] [2] [3]. |
|
T72177 |
Oxyphenbutazone monohydrate
|
|
|
|
Oxyphenbutazone monohydrate, a metabolite of Phenylbutazone, exhibits anti-inflammatory properties and acts as a non-selective COX inhibitor when taken orally. It also selectively targets and kills non-replicating Mycoba... |
|
T63786 |
WX-081
|
|
|
|
WX-081 is an anti-tuberculosis agent that exhibits significant anti-mycobacterial effects against M. tuberculosisH37Rv and is able to act on drug-susceptible (DS-TB) mycobacteria (MIC: 0.083 μg/ml) and multidrug-resistan... |
|
T73271 |
MMV688845
|
(R)-GSK1729177A |
|
|
MMV688845 is a bactericidal nontuberculous mycobacteria (NTM) RNA polymerase inhibitor that exhibits anti-tuberculosis efficacy and is effective against Mycobacterium abscessus. |
