|
T10335 |
Antihistamine-1
|
|
P450
|
|
Antihistamine-1 is an H1-antihistamine (Ki: 6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel (IC50s: 5.4 and 0.8 μM). |
|
T25180 |
Bromodiphenhydramine hydrochloride
|
|
Others
|
|
Bromodiphenhydramine hydrochloride is a new antihistaminic in the control of cutaneous. |
|
T9353 |
OXOMEMAZINE
|
|
AChR
,
Histamine Receptor
|
|
Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic activity. Oxomemazine is a selective antagonist of mycotoxins M1 receptors, showing high (Ki=84 nM, M1 receptors) and low ... |
|
T0211 |
Azelastine
|
Azelastina,Astelin,Azelastinum |
SARS-CoV
,
Histamine Receptor
|
|
|
|
T1278 |
Astemizole
|
Laridal,Histaminos,Paralergin |
Potassium Channel
,
Histamine Receptor
|
|
Astemizole (Laridal) is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors, with less anticholinergic effects compared to re... |
|
T0118 |
Mizolastine
|
SL 850324 |
Histamine Receptor
|
|
Mizolastine (SL 850324) (IC50= 47 nM) is a histamine H1-receptor antagonist.It is used in the treatment of allergic reactions such as hay fever (seasonal allergic rhinitis), hives. |
|
T1030 |
Triprolidine hydrochloride monohydrate
|
Triprolidine hydrochloride |
Histamine Receptor
|
|
Triprolidine hydrochloride monohydrate is a histamine H1 antagonist used in allergic rhinitis, asthma. |
|
T0211L |
Azelastine hydrochloride
|
Optivar,Azelastine HCl,Allergodil,Astelin |
SARS-CoV
,
Histamine Receptor
|
|
Azelastine hydrochloride (Astelin) is a phthalazinone derivative with antihistaminergic activity. |
|
T6488 |
Epinastine hydrochloride
|
Alesion,Epinastine HCl,WAL-801CL HCl,Elestat |
5-HT Receptor
,
Histamine Receptor
|
|
Epinastine hydrochloride (WAL-801CL HCl) is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. |
|
T6426 |
Buclizine dihydrochloride
|
Longifene,Buclina,Buclizine HCl,UCB-4445 |
5-HT Receptor
,
AChR
,
Histamine Receptor
|
|
Buclizine dihydrochloride (Buclina) is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine dihydrochloride binds to and ... |
|
T6814 |
Cyproheptadine hydrochloride
|
Periactin hydrochloride,Anarexol,Cyproheptadine HCl,Nuran |
5-HT Receptor
|
|
Cyproheptadine hydrochloride (Periactin hydrochloride) is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist. |
|
T1110 |
Meclizine dihydrochloride
|
Meclozine dihydrochloride,NSC28728,Meclizine 2HCl |
Apoptosis
,
Histamine Receptor
|
|
Meclizine dihydrochloride (NSC28728) is a histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness. |
|
T2335 |
Ebastine
|
Ebastel,LAS-W 090,Ebastin,Kestine,RP64305 |
Histamine Receptor
|
|
Ebastine (Kestine) (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine. It does not penetrate the blood-brain barrier and thus allows an effective block of the H1 receptor in peripheral tiss... |
|
T0205 |
Brompheniramine maleate
|
Dimotane,Rolabromophen,Brompheniramine hydrogen maleate,Dimetane |
5-HT Receptor
,
Histamine Receptor
|
|
Brompheniramine maleate (Dimotane) is an antagonist against histamine H1 receptors. |
|
T0147 |
Clemastine fumarate
|
HS-592 (fumarate),Meclastine fumarate,Meclastine (fumarate) |
Autophagy
,
Histamine Receptor
|
|
Clemastine fumarate (Meclastine (fumarate)) is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties. |
|
T3609 |
Dioxopromethazine
|
Prothanon,Dioxoprothazine |
Others
|
|
Dioxopromethazine (Dioxoprothazine) is a drug for the treatment of a cough and expectoration. It also can be used in local anesthesia. |
|
T0174 |
Cyproheptadine hydrochloride sesquihydrate
|
Peritol,Periactin hydrochloride,Cyproheptadine hydrochloride |
5-HT Receptor
,
Histone Methyltransferase
,
Histamine Receptor
|
|
Cyproheptadine hydrochloride sesquihydrate (Peritol), an antihistamine, is an antagonist of serotonin and histamine2. |
|
T4526 |
Piperoxan hydrochloride
|
dl-Piperoxan hydrochloride,Benodaine hydrochloride |
Adrenergic Receptor
|
|
Piperoxan hydrochloride (Benodaine hydrochloride) is an α2 adrenoceptor antagonist. Piperoxan (benodaine) is a drug which was the very first antihistamine to be discovered. |
|
T25875 |
Noberastine
|
R64947,T25875,R-64947,R 64947 |
Histamine Receptor
|
|
Noberastine (R 64947) is a novel histamine H1 antagonist with potent and specific peripheral antihistamine activity. |
|
T68150 |
Talastine
|
|
Histamine Receptor
|
|
Talastine is an antihistamine compound that can induce an allergic rash. |
|
T4250 |
Bilastine
|
Bilaxten |
Histamine Receptor
|
|
Bilastine (Bilaxten) is a novel new-generation antihistamine that is highly selective for the H1 histamine receptor, has a rapid onset and prolonged duration of action. |
|
T21014 |
Thonzylamine hydrochloride
|
Resistab,Thonzylamine HCl,Novohetramin,Neohetramine hydrochloride,Anahist |
AChR
,
Histamine Receptor
|
|
Thonzylamine hydrochloride (Resistab) is an anticholinergic and antihistamine used as an antipruritic. |
|
T7477 |
Antazoline
|
|
Others
|
|
Antazoline has antihistamine and anticholinergic effects.It used to treat a variety of arrhythmias. |
|
T7564 |
Chlorphenoxamine
|
Contristamine |
Histamine Receptor
|
|
Chlorphenoxamine (Contristamine) is an antihistamine and anticholinergic used as an antipruritic and antiparkinsonian agent. |
|
T29096L |
Vapitadine
|
R 129160 |
Histamine Receptor
|
|
Vapitadine is a non-sedative antihistamine compound that relieves itching caused by atopic dermatitis. |
|
T6562 |
Latrepirdine dihydrochloride
|
Dimebolin dihydrochloride,Latrepirdine,Latrepirdine 2HCl,Dimebolin |
Beta Amyloid
,
5-HT Receptor
,
Adrenergic Receptor
,
GluR
,
Autophagy
,
Histamine Receptor
|
|
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug. |
|
T31488 |
Dimethindene
|
Dimetindeno,Z 2001,Dimetindene,Z-2001,Z2001 |
Potassium Channel
,
Endogenous Metabolite
,
AChR
,
Histamine Receptor
|
|
Dimethindene (Dimetindeno) is a selective antagonist of H1 receptor and blocks K+ current. Dimethindene exhibits antihistamine and anticholinergic effects. |
|
T0113 |
Mebhydrolin napadisylate
|
Incidal,Diazolin,Mebhydroline 1,5-naphthalenedisulfonate salt,Omeril,Diazoline |
5-HT Receptor
,
AChR
,
Histamine Receptor
|
|
Mebhydrolin napadisylate (Incidal) is an antihistamine used to relieve allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis. |
|
T1170 |
Olopatadine hydrochloride
|
Olopatadine HCl,KW4679,ALO4943A |
5-HT Receptor
,
Histamine Receptor
|
|
Olopatadine hydrochloride (ALO4943A) is an antihistamine with mast-cell stabilizing properties used as eye drops in the treatment of ALLERGIC CONJUNCTIVITIS. |
|
T1470 |
Fexofenadine hydrochloride
|
Terfenidine carboxylate hydrochloride,MDL-16455 hydrochloride,Telfast,Fexofenadine HCl,Allegra,MDL 16455A |
Histamine Receptor
|
|
Fexofenadine hydrochloride (Terfenidine carboxylate hydrochloride) is a second generation antihistamine that is used for the treatment of allergic rhinitis, angioedema and chronic urticaria. |
|
T0092 |
Antazoline hydrochloride
|
Phenazocine HCl,Phenazoline hydrochloride,Antazoline HCl |
Histamine Receptor
|
|
Antazoline hydrochloride (Phenazoline hydrochloride), a first-generation antihistamine, can bind to the histamine H1 receptor and block the action of endogenous histamine. |
|
T21419 |
Diphenhydramine
|
Debendrin,PM 255,PM255,Dabylen,Syntedril,PM-255 |
Histamine Receptor
|
|
Diphenhydramine (Syntedril), a first-generation antihistamine possessing antiemetic, antitussive, anticholinergic, and sedative properties, is mainly used in the treatment of allergies. Diphenhydramine is also used in th... |
|
T0785 |
Dexchlorpheniramine Maleate
|
S-(+)-Chlorpheniramine maleate salt |
Dopamine Receptor
,
5-HT Receptor
,
Norepinephrine
,
Histamine Receptor
|
|
Dexchlorpheniramine Maleate (S-(+)-Chlorpheniramine maleate salt) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active d... |
|
T4563 |
Thonzylamine
|
neohetramine |
Histamine Receptor
|
|
Thonzylamine (neohetramine) is an antihistamine and anticholinergic drug. It is available as combination products with Clofedanol or Phenylephrine for temporary relief of symptoms of common cold, hay fever (allergic rhin... |
|
T0445L |
Promethazine hydrochloride
|
Promethazine HCl,Phenergan |
Adrenergic Receptor
,
Histamine Receptor
|
|
Promethazine hydrochloride (Promethazine HCl) , the first-generation antihistamine, is a strong antagonist of the H1 receptor and a moderate antagonist of the mACh receptor, moderate affinity for 5-HT2A, 5-HT2C, D2 and α... |
|
T21390 |
Fexofenadine
|
Carboxyterfenadine,Telfast,MDL 16.455,Allegra |
Histamine Receptor
|
|
Fexofenadine (Carboxyterfenadine), an antihistamine pharmaceutical drug, is used to treat allergy symptoms, such as nasal congestion, hay fever, and urticaria. Compared to first-generation antihistamines, Fexofenadine is... |
|
T0059 |
Diphenylpyraline hydrochloride
|
4-Diphenylmethoxy-1-methylpiperidine hydrochloride |
Histamine Receptor
|
|
Diphenylpyraline hydrochloride (4-Diphenylmethoxy-1-methylpiperidine hydrochloride) is used in the treatment of Parkinsonism.It is a first-generation antihistamine with anticholinergic effects, functions as a dopamine re... |
|
T9084 |
Cetirizine Impurity B dihydrochloride
|
De(carboxymethoxy) Cetirizine Acetic Acid Dihydrochloride |
Histamine Receptor
|
|
Cetirizine Impurity B dihydrochloride (De(carboxymethoxy) Cetirizine Acetic Acid Dihydrochloride) is an impurity of Cetirizine dihydrochloride. Cetirizine is a second-generation antihistamine. Cetirizine is a specific, o... |
|
T21428 |
Mianserin
|
Lantanon,Lumin,Norval,Lerivon,Depnon |
Histamine Receptor
|
|
Mianserin, an H1 receptor reverse agonist, is a psychoactive compound in the tetracyclic antidepressant (TeCA) treatment family. Mianserin has antidepressant, antianxiety, antiemetic, hypotrophic, hypnotic and antihistam... |
|
T19839 |
Oxatomide
|
Oxatomida |
P2X Receptor
,
Calcium Channel
,
5-HT Receptor
,
Histamine Receptor
|
|
Oxatomide (Oxatomida) is a potent and orally active dual H1 histamine receptor and P2X7 receptor antagonist with antihistamine and antiallergic activity.Oxatomide can be used to block ATP-induced currents in the human P2... |
|
T40652 |
Meclizine
|
Meclozine |
Histamine Receptor
|
|
Meclizine, also known as Meclozine, is a piperazine class H1 antagonist with antihistamine properties that inhibits the interaction of histamine at H1 receptors reversibly. It serves as an effective anti-motion sickness ... |
|
T23851 |
Captodiame
|
BRN 2625367 |
|
|
Captodiame is an antihistamine agent. |
|
T23608 |
Acequinoline
|
CB 4985,CB4985,CB-4985 |
|
|
Acequinoline is an analgesic with certain antihistamine properties. |
|
T24575 |
Oxetorone fumarate
|
L-6257,L6257,L 6257,Nocertone |
|
|
Oxetorone fumarate is a serotonin antagonist, antihistamine, and alpha-blocker. It was used as an antimigraine drug. |
|
T36949 |
Niaprazine
|
|
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Niaprazine is a histamine H1-receptor antagonist with marked sedative properties. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research[1][2].
Niaprazine exhibits a low aff... |
|
T24851 |
Talastine HCl
|
HL-2186,Talastine hydrochloride,HL2186,Ahanon,HL 2186 |
|
|
Talastine is an antihistamine drug. |
|
T27836 |
Linadryl hydrochloride
|
A 446,A446,A-446 |
|
|
Linadryl hydrochloride may have antihistamine activity. |
|
T21247 |
Carbinoxamine
|
Allergefon,(+-)-Carbinoxamine,Paracarbinoxamine |
|
|
Carbinoxamine, an anticholinergic and antihistamine agent, is used for hay fever, angioedema, vasomotor rhinitis, mild urticaria, dermatographism and allergic conjunctivitis. It is a histamine antagonist, specifically an... |
|
T25320 |
Diafen NN
|
NSC3410,NSC 3410,NSC-3410 |
|
|
Diafen NN is an antihistamine agent. |
|
T21372 |
Chlophedianol Hydrochloride
|
clofedanol hydrochloride,clofedanol,chlophedianol |
|
|
Chlophedianol hydrochloride, a centrally acting cough suppressant, is used in the treatment of dry cough. It has antihistamine and local anesthetic properties, and may have anticholinergic effects at high doses. |
