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阻害剤

天然化合物

220

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T38332	Complement factor D-IN-2		Complement System
	Complement factor D-IN-2 is an inhibitor of Complement factor D and reduces the excessive activation of complement factor D.		Complement System
T10863	Complement C5-IN-1		Complement System
	Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5).		Complement System
T7497L	C3a 70-77 2TFA(63555-63-5(free base))	Complement 3a (70-77)	Complement System
	C3a 70-77 2TFA(63555-63-5(free base)) (Complement 3a (70-77)) is an octapeptide corresponding to the COOH terminus of C3a.		Complement System
T16898	Complement factor D-IN-1		Others
	Complement factor D-IN-1 is an effective and selective small-molecule reversible factor d inhibitor (IC50s: 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively).		Others
T38287	C3a Receptor Agonist	C3a receptor agonist 1,Complement 3a Receptor Agonist	Complement System
	C3a Receptor Agonist (C3a receptor agonist 1) binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR prevents neutrophils from being mobilized in a model of intestin...		Complement System
T80059	Complement factor I		Endogenous Metabolite
	Complement factor I, a serine protease, attenuates complement activity both in the fluid phase and on cell surfaces, working alongside cofactors such as factor H (FH), complement receptor 1 (CR1/CD35), C4 binding protein...		Endogenous Metabolite
T74816	Complement C1s-IN-1
	Complement C1s-IN-1 is a potent and selective C1s inhibitor that is orally active and capable of crossing the blood-brain barrier, demonstrating an IC50 value of 36 nM [1].
T9915	Eculizumab		Complement System
	Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5		Complement System
TP1304	Compstatin		Complement System
	Compstatin, a cyclic tridecapeptide, which was originally discovered from phage-display libraries, is a highly potent and selective C3 inhibitor.		Complement System
T7497	C3a (70-77)	Complement 3a (70-77),C3a 70-77	Complement System
	C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a.		Complement System
T9316	JR14a	5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride	Complement System
	JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) is a potent antagonist of human complement C3a receptor.		Complement System
T9189	Iptacopan hydrochloride	Iptacopan HCl,LNP023 hydrochloride	Complement System
	Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. Iptacopan hydrochloride shows direct, reversible, and high-affinity b...		Complement System
T8509	Danicopan	ACH-4471	Complement System
	Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the ...		Complement System
TP1193	C3a (70-77) TFA (63555-63-5 free base)	C3a (70-77) TFA,Complement 3a (70-77) (TFA)
	C3a (70-77) TFA (Complement 3a (70-77) TFA) is a COOH-terminal fragment of the C3a anaphylatoxin peptide.
T3638	Leukadherin-1		Integrin , Complement System
	Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendothelial migration; reduces inflammation.		Integrin , Complement System
T12851	SB290157 trifluoroacetate		Complement System
	SB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor(IC50 of 200 nM).		Complement System
T17250	W-54011		ROS , Complement System
	W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki: 2.2 nM). W-54011 inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and g...		ROS , Complement System
T7776	ADH-503	GB1275	Complement System
	ADH-503 (GB1275) is a potent agonist of the integrin CD11b to mitigate myeloid cell immunosuppression.		Complement System
T1076	Dexamethasone	MK 125,Prednisolone F,NSC 34521,Hexadecadrol	Glucocorticoid Receptor , Mitophagy , IL Receptor , SARS-CoV , Antibacterial , Antibiotic , Autophagy , Complement System
	Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activity and induces autophagy. Dexamethasone inhibits LPS-induced...
T13379	(Z)-Leukadherin-1	ADH-503 free base	Complement System
	(Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b.		Complement System
TP2180L	Compstatin control peptide acetate		Complement System
	Compstatin control peptide acetate is an inhibitor of complement protein C3 by binding and inhibiting the cleavage of complement C3.		Complement System
T76867	Ravulizumab	ALXN1210	Complement System
	Ravulizumab (ALXN1210) is a humanized monoclonal antibody targeting complement factor 5 that specifically binds to human complement protein C5 with high affinity to block complement activation. Ravulizumab can be used fo...		Complement System
T64388	3-Phenoxybenzaldehyde		Complement System
	3-Phenoxybenzaldehyde is a complement (classical pathway) inhibitor with IC50 of 1388μM.		Complement System
T12506L1	PMX 205 acetate(514814-49-4 free base)		Complement System
	PMX 205 acetate is an antagonist of complement C5a receptor (C5aR; CD88).		Complement System
T76702	Sutimlimab		Complement System
	Sutimlimab is a novel monoclonal antibody targeting complement protein C1. Sutimlimab is commonly used as a C1 inhibitor to treat cold agglutina-associated hemolysis.		Complement System
TP2296L	TLQP 21 acetate		Complement System
	TLQP 21 acetate is a potent agonist of G-protein-coupled receptor complement-3a receptor 1 (C3aR1). The EC50 values are 10.3 μM for mouse and 68.8 μM for human. TLQP 21 acetate is a VGF-derived peptide with endocrine a...		Complement System
T38951	Isatuximab	SAR-650984,hu38SB19,Isatuximab-irfc	Apoptosis , CD38
	Isatuximab is a monoclonal antibody targeting the transmembrane receptor and extracellular enzyme CD38 in malignant cells of the hematological system and is a highly expressed protein in multiple myeloma. Isatuximab has ...		Apoptosis , CD38
T12506L	PMX 205		Others
	PMX 205 is an effective complement antagonist of the C5a receptor.		Others
T39493	Vemircopan	ACH0145228,ACH-5228,ALXN2050
	Vemircopan is a complement factor D inhibitor.
T32353	K 76 Carboxylic acid	K76 Carboxylic acid,K-76 Carboxylic acid
	K 76 Carboxylic acid effectively blocks human complement from forming tumor cell chemokines.
T77107	Olendalizumab
	Olendalizumab (ALXN1007), a humanized IgG2-G4-κ antibody derived from mice, specifically targets Complement protein C5a with a binding affinity (K i) of 60 pM. This compound is designed to inhibit the complement inflamma...
T69393	SID-7977382
	SID-7977382 is a complement factor C1 inhibitor.
T74431	Cemdisiran
	Cemdisiran, a conjugated siRNA with N-acetylgalactosamine (GalNAc), targets the liver to inhibit the production of complement 5 (C5) protein, serving as a potential therapeutic agent for the study of complement-mediated ...
T12506	PMX 205 Trifluoroacetate (514814-49-4 free base)	PMX 205 Trifluoroacetate	Others
	PMX 205 Trifluoroacetate is a potent complement antagonist of C5a receptor.		Others
T75966	C3a (70-77) (TFA)
	Complement 3a (70-77) TFA is an octapeptide that corresponds to the COOH terminus of C3a and exhibits the specificity and 1 to 2% biological activities of C3a [1] [2].
T62276	Factor B-IN-3
	Factor B-IN-3 is a potent inhibitor of complement factor B. Factor B-IN-3 can be used to study inflammatory and immune-related diseases.
T11269	FD-IN-1		Others
	FD-IN-1 is a factor D (FD) inhibitor with an IC50 of 12 nM.FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5μM, respectively. Complement FD, a highly specific S1 serine protease, plays a...		Others
T62689	Factor B-IN-5
	Factor B-IN-5 is a potent inhibitor (IC50: 1.2 μM) of complement factor B. Factor B-IN-4 can be used to study inflammatory and immune-related diseases.
T73710	PMX 205 Trifluoroacetate
	PMX 205 Trifluoroacetate is a potent complement C5a receptor ( C5aR ; CD88 ) antagonist.
T76913	Avdoralimab
	Avdoralimab (IPH 5401), a fully human IgGκ monoclonal antibody, specifically inhibits the complement C5a receptor 1 (C5aR1) by preventing its interaction with C5a. This compound is utilized in research concerning complem...
T75775	Compstatin TFA
	Compstatin TFA, a potent inhibitor of the complement system C3 characterized by species specificity, is a 13-residue cyclic peptide. It selectively binds to baboon C3 and demonstrates resistance to proteolytic cleavage i...
T9695L	POT-4 acetate	POT-4 acetate (934461-40-2 free base)	Complement System
	POT-4 acetate inhibits Complement C3 activation. POT-4 acetate can be used for studies about age-related macular degeneration.		Complement System
T77121	Pozelimab
	Pozelimab (REGN3918), a fully human IgG4 monoclonal antibody, is designed to target and bind with high affinity to both C5 and its variants, effectively inhibiting complement-mediated hemolysis. It holds potential for re...
TP2139	AMY-101	Cp40	Others
	AMY-101 is a peptidic inhibitor of the central complement component C3 (KD: 0.5 nM). AMY-101 shows a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation.		Others
TP2139L	AMY-101 TFA	Cp40 TFA	Others
	AMY-101 TFA (Cp40 TFA) is a peptidic inhibitor of the central complement component C3 (KD: 0.5 nM). AMY-101 TFA shows a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper in...		Others
T75106	ARC186
	ARC186 is a highly potent aptamer that serves as a complement inhibitor by blocking the convertase-catalyzed activation of C5.
T76814	Lampalizumab
	Lampalizumab (RG 7417), a humanized monoclonal antibody, selectively inhibits complement Factor D in the alternative complement pathway by binding to an exosite and sterically hindering Factor B's access to the active si...
T62688	Factor B-IN-4
	Factor B-IN-4 is a potent inhibitor (IC50: 1 μM) of complement factor B. Factor B-IN-4 can be used to study inflammatory and immune-related diseases.
T62292	Factor B-IN-2
	Factor B-IN-2 is a potent inhibitor (IC50: 1.5 μM) of complement factor B. Factor B-IN-2 can be used to study inflammatory and immune-related diseases.
T76276	Zilucoplan
	Zilucoplan (RA101495), a 15-amino acid macrocyclic peptide and potent complement component 5 (C5) inhibitor, is utilized in the study of immune-mediated necrotising myopathy (IMNM) [1] [2].

Compounds

Complement factor D-IN-2

T38332

Synonym:

Target: Complement System

Complement C5-IN-1

T10863

Synonym:

Target: Complement System

C3a 70-77 2TFA(63555-63-5(free base))

T7497L

Synonym: Complement 3a (70-77)

Target: Complement System

Complement factor D-IN-1

Synonym: C3a receptor agonist 1,Complement 3a Receptor Agonist

Target: Complement System

Complement factor I

T80059

Synonym:

Target: Endogenous Metabolite

Complement C1s-IN-1

Target: Complement System

Compstatin

TP1304

Synonym:

Target: Complement System

C3a (70-77)

T7497

Synonym: Complement 3a (70-77),C3a 70-77

Target: Complement System

JR14a

T9316

Synonym: 5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride

Target: Complement System

Iptacopan hydrochloride

T9189

Synonym: Iptacopan HCl,LNP023 hydrochloride

Target: Complement System

Danicopan

T8509

Synonym: ACH-4471

Target: Complement System

C3a (70-77) TFA (63555-63-5 free base)

TP1193

Synonym: C3a (70-77) TFA,Complement 3a (70-77) (TFA)

Target: Integrin, Complement System

SB290157 trifluoroacetate

T12851

Synonym:

Target: Complement System

W-54011

T17250

Synonym:

Target: ROS, Complement System

ADH-503

T7776

Synonym: GB1275

Target: Complement System

Dexamethasone

T1076

Synonym: MK 125,Prednisolone F,NSC 34521,Hexadecadrol

Target: Glucocorticoid Receptor, Mitophagy, IL Receptor, SARS-CoV, Antibacterial, Antibiotic, Autophagy, Complement System

(Z)-Leukadherin-1

T13379

Synonym: ADH-503 free base

Target: Complement System

Compstatin control peptide acetate

TP2180L

Synonym:

Target: Complement System

Ravulizumab

T76867

Synonym: ALXN1210

Target: Complement System

3-Phenoxybenzaldehyde

T64388

Synonym:

Target: Complement System

PMX 205 acetate(514814-49-4 free base)

T12506L1

Synonym:

Target: Complement System

Sutimlimab

T76702

Synonym:

Target: Complement System

TLQP 21 acetate

TP2296L

Synonym:

Target: Complement System

Isatuximab

T38951

Synonym: SAR-650984,hu38SB19,Isatuximab-irfc

Target: Apoptosis, CD38

Synonym: ACH0145228,ACH-5228,ALXN2050

Target:

K 76 Carboxylic acid

T32353

Synonym: K76 Carboxylic acid,K-76 Carboxylic acid

PMX 205 Trifluoroacetate (514814-49-4 free base)

T12506

Synonym: PMX 205 Trifluoroacetate

PMX 205 Trifluoroacetate

Synonym: POT-4 acetate (934461-40-2 free base)

Target: Complement System

カタログ番号	製品名	別名	ターゲット
T0945	Cyclosporin A	Cyclosporine A,Ciclosporin,Cyclosporine	Phosphatase , Antibiotic , Complement System
	Cyclosporin A is a naturally occurring cyclic polypeptide that is the active metabolite of a fungus. Cyclosporin A is an immunosuppressant that binds to procyclins and inhibits calcineurin (IC50=7 nM).		Phosphatase , Antibiotic , Complement System
T40646	Lipoteichoic acid		Complement System
	Lipoteichoic acid, a polymer of Staphylococcus aureus cell wall, activates the complement system by inducing C3 and inhibiting CD55, and reduces fat deposition via the IGF-1 pathway.		Complement System
T83339	3β-(Acetyloxy)stigmast-5-en-7-one
	3β-(Acetyloxy)stigmast-5-en-7-one exhibits anti-complement activity [1].
TN3430	Apigenin 4'-O-rhamnoside		Others
	Apigenin-4'-O-rhamnosylglucoside can strongly inhibit the classical pathway of the complement system.		Others
T80869	Versicolactone B
	Versicolactone B, a sesquiterpene extracted from Viola yedoensis, exhibits anti-complement activity affecting both the classical and alternative pathways [1].
T82786	Campneoside II
	Campneoside II, a compound extracted from the wood of Paulownia tomentosa var. tomentosa, demonstrates remarkable anti-complement activity [1].
T3S0964	Thermopsoside	Chrysoeriol-7-O-glucoside	Others
	Chrysoeriol-7-O-glucoside can strongly inhibit the classical pathway of the complement system.Chrysoeriol-7-O-d-glucoside and luteolin-7-O-d-glucoside can inhibit palmitic acid uptake into small intestinal brush border m...		Others

天然物製品

Cyclosporin A

T0945

Synonym: Cyclosporine A,Ciclosporin,Cyclosporine

Target: Phosphatase, Antibiotic, Complement System

Lipoteichoic acid

T40646

Synonym:

Target: Complement System

3β-(Acetyloxy)stigmast-5-en-7-one

T83339

Synonym:

Target:

Apigenin 4'-O-rhamnoside

Synonym: Chrysoeriol-7-O-glucoside

Target: Others

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-00653	Complement C5 Protein, Human, Recombinant (Complement C5a)	Human	E. coli
	C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPY-05732	Complement C3 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Complement C3 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 186.40 kDa. Accession number: XP_005587776.1
TMPY-04902	Complement C5a Protein, Mouse, Recombinant	Mouse	E. coli
	C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPY-05057	Complement C5 Protein, Human, Recombinant (His & FLAG)	Human	HEK293
	C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPY-00686	Complement C2 Protein, Human, Recombinant (His)	Human	HEK293
	Complement component C2 is part of the classical complement pathway which plays a major role in innate immunity against infection. C2 is a glycoprotein synthesized in liver hepatocytes and several other cell types in ext...
TMPY-05731	Complement C3 Protein, Human, Recombinant (His)	Human	HEK293
	Complement C3 Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 186.43 kDa. Accession number: P01024
TMPY-04921	Complement factor B/CFB Protein, Human, Recombinant (His)	Human	HEK293
	Complement factor B/CFB Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 84.5 kDa. Accession number: AAH04143.1
TMPY-03012	Complement C7 Protein, Human, Recombinant (hFc)	Human	HEK293
	Complement component 7 is a component of the complement system. It belongs to the complement C6/C7/C8/C9 family. It contains 1 EGF-like domain, 1 LDL-receptor class A domain, 1 MACPF domain, 2 Sushi (CCP/SCR) domains and...
TMPY-02892	Complement C7 Protein, Human, Recombinant (His)	Human	HEK293
	Complement component 7 is a component of the complement system. It belongs to the complement C6/C7/C8/C9 family. It contains 1 EGF-like domain, 1 LDL-receptor class A domain, 1 MACPF domain, 2 Sushi (CCP/SCR) domains and...
TMPJ-00417	Complement C3a Protein, Human, Recombinant	Human	E. coli
	Complement is defined as key part of innate immunity and as the first line of defense in the fight against invading pathogens. Complement 3 (C3) is the most abundant component of the complement cascade and the convergent...
TMPJ-00416	Complement C3a Protein, Mouse, Recombinant	Mouse	E. coli
	Complement is defined as key part of innate immunity and as the first line of defense in the fight against invading pathogens. Complement 3 (C3) is the most abundant component of the complement cascade and the convergent...
TMPY-06538	Complement C5 Protein, Cynomolgus, Recombinant	Cynomolgus	HEK293
	C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPY-03447	Complement C2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Complement component C2 is part of the classical complement pathway which plays a major role in innate immunity against infection. C2 is a glycoprotein synthesized in liver hepatocytes and several other cell types in ext...
TMPY-05459	Complement C5a Protein, Mouse, Recombinant, Biotinylated	Mouse	E. coli
	C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPY-02641	Complement C6 Protein, Human, Recombinant (His)	Human	HEK293
	Complement C6 Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 104 kDa. Accession number: AAA59668.1
TMPY-06137	Complement C5 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPY-06814	Complement C5 Protein, Human, Recombinant (Flag)	Human	HEK293
	C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPH-01133	Complement C8b Protein, Human, Recombinant (His)	Human	E. coli
	Complement C8b Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-01132	Complement C8a Protein, Human, Recombinant (His)	Human	E. coli
	Complement C8a Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-00231	Complement C3 Protein, Bovine, Recombinant (His & SUMO)	Bovine	E. coli
	C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently,...
TMPH-02604	Complement C3 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently,...
TMPH-03107	Complement C5a Protein, Pig, Recombinant (His)	Sus scrofa (Pig)	Yeast
	Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, ...
TMPH-03270	Complement C5 Protein, Rat, Recombinant (His & Myc)	Rat	E. coli
	Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the founda...
TMPY-00687	Complement C2 Protein, Human, Recombinant (hFc)	Human	HEK293
	Complement component C2 is part of the classical complement pathway which plays a major role in innate immunity against infection. C2 is a glycoprotein synthesized in liver hepatocytes and several other cell types in ext...
TMPJ-00585	Complement C8 gamma Protein, Human, Recombinant (His)	Human	E. coli
	Complement component C8 is a constituent of the membrane attack complex, C8 alpha, C8 beta and C8G. C8G is a secreted protein and comsists a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 ...
TMPY-02167	Complement Factor D/CFD Protein, Mouse, Recombinant (His,HEK293)	Mouse	HEK293
	Complement factor D, also known as Adipsin, C3 convertase activator, Properdin factor D and CFD is a secreted protein which belongs to thepeptidase S1 family. CFD / Adipsin contains onepeptidase S1 domain. Complement ...
TMPH-01134	Complement C8g Protein, Human, Recombinant (His)	Human	E. coli
	Complement C8g Protein, Human, Recombinant (His) is expressed in E. coli.
TMPY-06767	Complement C3 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Complement C3 Protein, Mouse, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 36.34 kDa. Accession number: NP_033908.2
TMPK-01268	Complement C2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Single nucleotide polymorphism (SNP) of complement component 2 (C2) has been found to be significantly associated with hepatocellular carcinoma (HCC). Significantly lower C2 expression was found at HCC compared to health...
TMPH-02607	Complement factor B Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convert...
TMPH-03273	Complement factor I Protein, Rat, Recombinant (His & Myc)	Rat	Baculovirus
	Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and tw...
TMPH-02605	Complement C4-B Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of imm...
TMPY-04141	Complement factor H/CFH Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defens...
TMPY-04129	Complement factor H/CFH Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defens...
TMPJ-00980	Complement Factor MASP3 Protein, Human, Recombinant (His)	Human	Human Cells
	MASP3 is a member of the MASPs involved in mannan-binding lectin (MBL) complement pathway. The MBL pathway is initiated by the binding of MBL to specific carbohydrate structures found on the surface of a variety of micro...
TMPH-01131	Complement C4-B Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Complement C4-B Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPY-02183	Complement Factor D/CFD Protein, Human, Recombinant (His)	Human	HEK293
	Complement factor D, also known as Adipsin, C3 convertase activator, Properdin factor D and CFD is a secreted protein which belongs to thepeptidase S1 family. CFD / Adipsin contains onepeptidase S1 domain. Complement ...
TMPK-01023	Complement factor I Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible for controlling the complement-mediated processes.
TMPK-00776	Complement factor I Protein, Human, Recombinant (His)	Human	HEK293
	Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible for controlling the complement-mediated processes.
TMPJ-00149	Complement Factor D/CFD Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Complement factor D, also known as adipsin, is a member of the chymotrypsin family of serine proteases, which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement a...
TMPH-03272	Complement factor D Protein, Rat, Recombinant (His)	Rat	Yeast
	Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classi...
TMPK-00790	Complement factor H/CFH Protein, Human, Recombinant (His)	Human	HEK293
	Factor H is the major soluble inhibitor of complement, where its binding to self markers (i.e., particular glycan structures) prevents complement activation and amplification on host surfaces. Not surprisingly, mutations...
TMPH-03271	Complement factor D Protein, Rat, Recombinant (His & Myc)	Rat	HEK293
	Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classi...
TMPK-00151	Complement Factor D/CFD Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli sugge...
TMPK-00755	Complement Factor D/CFD Protein, Human, Recombinant (hFc)	Human	HEK293
	Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli sugge...
TMPK-00671	Complement Factor D/CFD Protein, Rhesus macaque, Recombinant (His)	Rhesus macaque	HEK293
	Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli sugge...
TMPJ-00809	CFH Protein, Human, Recombinant (His)	Human	Human Cells
	Complement Factor H (CFH) is a secreted protein which is a member of the regulators of complement activation family and is a complement control protein. It is expressed by the liver and secreted in plasma. Its principal ...
TMPH-02603	C1SB Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
TMPH-02602	C1RA Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
TMPY-06585	C1s Protein, Human, Recombinant (His)	Human	HEK293
	Complement is an integral component of the adaptive and innate immune systems and represents one of the major effector systems for the immune responses. The classical complement pathway is triggered by C1, a complex comp...
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