|
T0488 |
Finasteride
|
MK-906 |
Reductase
|
|
Finasteride (MK-906) is an oral inhibitor of active testosterone 5-alpha-reductase and Ki value is 10 nM. |
|
T0696 |
Naftopidil
|
KT-611,BM-15275 |
Adrenergic Receptor
|
|
Naftopidil (KT-611) (INN, marketed under the brand name Flivas), an antihypertensive medicine, is used as a selective α1-adrenergic receptor antagonist or α-blocker. |
|
T0197 |
Terazosin hydrochloride
|
Terazosin HCl,Terazosine,Blavin,Hytrin,Zayasel,Fosfomic |
Adrenergic Receptor
|
|
Terazosin hydrochloride (Hytrin) , a selective alpha1-antagonist, can treat the benign prostatic hyperplasia (BPH). It also can lower blood pressure, so it is a drug of choice for patients with prostate enlargement and h... |
|
T1504 |
Silodosin
|
KAD 3213,KMD 3213 |
Adrenergic Receptor
|
|
Silodosin (KAD 3213) is an alpha-Adrenergic Blocker. The mechanism of action of silodosin is as an Adrenergic alpha-Antagonist. |
|
T6600 |
Naftopidil dihydrochloride
|
KT-611,KT-611 2HCl,Naftopidil DiHCl |
5-HT Receptor
,
Adrenergic Receptor
|
|
Naftopidil dihydrochloride (KT-611 2HCl) is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively. |
|
T6461 |
Dapoxetine hydrochloride
|
LY-210448,LY-210448 hydrochloride,Dapoxetine HCl,Priligy |
5-HT Receptor
,
Serotonin Transporter
|
|
Dapoxetine hydrochloride (LY-210448 hydrochloride) is a selectivity short-acting serotonin reuptake inhibitor, used for the therapy of premature ejaculation. |
|
T6701 |
Terazosin hydrochloride dihydrate
|
Flotrin dihydrate,Terazosin HCl Dihydrate,Dysalfa dihydrate,Heitrin dihydrate |
Adrenergic Receptor
|
|
Terazosin hydrochloride dihydrate (Heitrin dihydrate) is a selective α1-adrenoceptor antagonist, used for treatment of symptoms of an enlarged prostate (BPH). |
|
T9220 |
Naftopidil hydrochloride
|
1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-,KT-611 hydrochloride,BM-15275 hydrochloride |
Adrenergic Receptor
|
|
Naftopidil hydrochloride (BM-15275 hydrochloride) is a selective alpha1-adrenoceptor antagonist with Ki of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, respective... |
|
T0039 |
Dapoxetine
|
Dapoxetina,Dapoxetinum |
Others
,
5-HT Receptor
|
|
Dapoxetine (Dapoxetina) is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. |
|
T13703 |
Gestonorone Capronate
|
|
Prostaglandin Receptor
|
|
Gestonorone Capronate is a progesterone used to treat benign prostatic hyperplasia and endometrial cancer. |
|
T28922 |
Taprizosin
|
Taprizosin Mesylate,UK-338003,UK-338,003,UK338003,UK 338003 |
Adrenergic Receptor
|
|
Taprizosin（UK-338003） is a selective and orally active α1-adrenoceptor antagonist for vasodilatation in the treatment of benign prostatic hyperplasia. |
|
T26278 |
Tildacerfont
|
|
CRFR
|
|
Tildacerfont is an antagonist of CRF1 and reduces the levels of adrenocorticotropic hormone and adrenal androgen. Tildacerfont can be used in studies about congenital adrenal hyperplasia. |
|
T76978 |
Siltuximab
|
CNTO-328 |
IL Receptor
|
|
Siltuximab（CNTO-328） is a monoclonal antibody with anti-tumor activity targeting IL-6 for the study of giant lymph node hyperplasia (MCD) and COVID-19. |
|
T27798 |
Lapisteride
|
CS891B,CS-891,CS-891B,CS891 |
Others
|
|
Lapisteride (CS-891) a steroidal 5α-reductase inhibitor is used to treat benign prostatic hyperplasia (BPH) and androgenetic alopecia and may be effective in preventing or treating AGA . |
|
T14843 |
Bifluranol
|
BX341 |
Androgen Receptor
|
|
Bifluranol (BX341) has anti-androgenic activity and has shown significant anti-prostatic activity in in vivo studies for the treatment of benign prostatic hyperplasia (BPH). |
|
T31095 |
Crinecerfont
|
SSR125543,SSR 125543,SSR-125543,SSR125543A,SSR 125543A,SSR-125543A |
CRFR
|
|
Crinecerfont (SSR-125543) is a selective antagonist of corticotropin-releasing factor 1 receptor (CRF1) and can be used in studies about Classic congenital adrenal hyperplasia. |
|
T0091 |
Alfuzosin hydrochloride
|
SL 77499-10,Alfuzosin HCl |
Adrenergic Receptor
|
|
Alfuzosin hydrochloride (Alfuzosin HCl) is an α1 adrenergic receptor antagonist. It applies to treat benign prostatic hyperplasia (BPH). |
|
T35182 |
Xinidamine
|
BRN 0891979,Xinidaminum,Xinidamino |
|
|
Xinidamine (BRN 0891979) has antitumor activity and can be used to study benign prostatic hyperplasia, macular degeneration and prostatic intraepithelial neoplasia .Xinidamine inhibits the proliferation of PWR-1E cells w... |
|
T22316 |
Doxazosin
|
UK 33274 |
Adrenergic Receptor
|
|
Doxazosin (UK 33274) is a long-lasting inhibitor of α1-adrenoceptors that is widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms. |
|
T15688 |
L-771688
|
SNAP 6383 |
Adrenergic Receptor
|
|
L-771688 (SNAP 6383) is a novel potent and selective α1A-adrenoceptor antagonist with a Ki value of 0.43±0.02 nM.L-771688 KE is used for the treatment of benign prostatic hyperplasia. |
|
T1499 |
Dutasteride
|
GG 745,Avodart,GI 198745 |
Apoptosis
,
Reductase
|
|
Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostatic hyperplasia. |
|
T11286 |
Fiduxosin
|
A 185980.1,ABT 980 |
Adrenergic Receptor
|
|
|
|
T68123 |
Oxodipine
|
|
Calcium Channel
|
|
Oxodipine, a dihydropyridine-type calcium antagonist , inhibited KCl-induced aortic contraction in rabbits and reduced cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventri... |
|
T0210L |
Tamsulosin
|
LY253351 free base,HSDB7744,(R)-(-)-YM12617 free base,Harnal-D,Flowmax,HSDB 7744,HSDB-7744 |
Adrenergic Receptor
|
|
Tamsulosin ((R)-(-)-YM12617 free base) is an alpha1A adrenergic receptor antagonist for the symptomatic treatment of benign prostatic hyperplasia (BPH). Tamsulosin is used to treat difficulty urinating, a common symptom ... |
|
T32029 |
GYKI-16084
|
GYKI 16084 |
|
|
GYKI-16084 is a postsynaptic alpha2 receptor blocker with potential efficacy in the treatment of benign prostatic hyperplasia. |
|
T28956 |
TF-505
|
FR-146687,FK-687,TF 505,FK687 |
|
|
TF-505, a steroid 5α-reductase inhibitor, is used potentially for the treatment of benign prostatic hyperplasia. |
|
T69927 |
Fiduxosin hydrochloride
|
|
|
|
Fiduxosin hydrochloride is an alpha 1a-adrenoceptor antagonist that may be useful in the treatment of Benign Prostatic Hyperplasia. |
|
TP1224 |
[Sar1, Ile8]-Angiotensin II TFA
|
Angiotensin 2 TFA,AngiotensinII TFA |
|
|
[Sar1, Ile8]-Angiotensin II (TFA) is a peptide compound that exerts various effects on vascular smooth muscle. These effects include the contraction of normal arteries as well as the hypertrophy or hyperplasia of culture... |
|
T20024 |
Tadalafil, (6R ,12aS)-
|
Tadalafil (6R ,12aS)- Lilly,Tadalafil specified impurity A,(-)-Tadalafil (6R ,12aS) diastereomer |
|
|
Tadalafil is a carboline derivative and Phosphodiesterase 5 Inhibitor. It is used primarily to treat Erectile dysfunction, Benign Prostatic Hyperplasia, and Primary Pulmonary Hypertension. |
|
T33826 |
Osaterone
|
|
|
|
Osaterone is effective against prostatic hyperplasia in dogs. |
|
T40398 |
Crinecerfont hydrochloride
|
SSR-125543A,SSR-125543 hydrochloride |
|
|
Crinecerfont hydrochloride (SSR-125543) is a highly potent, orally active, non-peptide antagonist of the CRF1 receptor. It has demonstrated efficacy in the context of Classic congenital adrenal hyperplasia (CAH) research... |
|
T24378 |
L-771688 dihydrochloride
|
L 771688 dihydrochloride |
|
|
L-771688 is an α1A-adrenoceptor antagonist potentially for the treatment of benign prostatic hyperplasia. |
|
T3290L |
Pikamilone Sodium
|
GABA-NG,Nicotinoyl-GABA sodium salt,GABA NG,GABANG,Pikamilone Na |
|
|
Pikamilone Sodium is a prodrug of GABA used for therapy of neurogenic bladder in spinal and benign prostatic hyperplasia. |
|
T70396 |
Fexapotide triflutate
|
|
|
|
Fexapotide triflutate is a caspase and TNF signaling pathway activator used to treat benign prostatic hyperplasia (BPH). |
|
T79793 |
CRF1 receptor antagonist-1
|
|
CFTR
|
|
CRF1 Receptor Antagonist-1 (Compound 2), a CRF1 receptor antagonist, is utilized in research pertaining to congenital adrenal hyperplasia (CAH) [1]. |
|
T71793 |
CDMG1
|
|
|
|
CDMG1 is a novel Wnt inhibitor, promoting heart regeneration, injury repair, and myocardial hyperplasia through expansion of the cardiac progenitor cell population |
|
T83428 |
1-Myristoyl-3-chloropropanediol
|
|
|
|
1-Myristoyl-3-chloropropanediol, a 3-monochloropropanediol (3-MCPD) fatty acid ester, induces nephropathy, tubular hyperplasia, and adenomas through chronic oral administration. It also diminishes fertility or leads to i... |
|
T28245 |
ONO-0300302
|
ONO 0300302 |
|
|
ONO-0300302 is a slow tight binding LPA1 antagonist (IC50: 0.16 nM) used to treat Benign Prostatic Hyperplasia. ONO-0300302 inhibits significantly an LPA-induced increase of intraurethral pressure (IUP) in rat (3 mg/kg, ... |
|
T38697 |
[Tyr(P)4] Angiotensin II
|
|
|
|
[Tyr(P)4] Angiotensin II is a peptide that exerts a multitude of effects on vascular smooth muscle. These effects include the contraction of normal arteries, as well as the induction of hypertrophy or hyperplasia in cult... |
|
T61729 |
Terazosin
|
|
|
|
Terazosin, a quinazoline derivative, is an orally active and competitive antagonist of α1-adrenoceptors. Its mechanism of action involves relaxing blood vessels and promoting bladder opening. Terazosin exhibits therapeut... |
|
T35665 |
Pregnanetriol
|
|
|
|
Pregnanetriol is a metabolite of 17α-hydroxyprogesterone .1,2It is formed from 17α-hydroxyprogesterone by reduction of the C-20 ketone.2Urinary levels of pregnanetriol are elevated in patients with 21-hydroxylase deficie... |
|
T37983 |
GM 1489
|
|
|
|
GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. It reduces 5-aza-2'-deoxycytidine-induc... |
|
T21814 |
ONO 4817
|
|
|
|
ONO-4817 is a broad-spectrum matrix metalloproteinase (MMP) inhibitor that potentially mitigates atherosclerotic neointimal proliferation and atheromatous plaque progression by suppressing matrix metalloproteinases (MMPs... |
|
T76242 |
MMI-0100
|
|
|
|
MMI-0100, a cell-permeant peptide inhibitor of mitogen-activated protein kinase activated protein kinase II (MK2), effectively reduces intimal hyperplasia ex vivo and in vivo. It specifically suppresses IL-6 expression w... |
|
T76275 |
Fexapotide
|
|
|
|
Fexapotide (NX-1207 free acid) selectively induces apoptosis, effectively reducing prostate volume at the cellular level. This compound is applicable in the research of lower urinary tract symptoms (LUTS) and benign pros... |
|
T35519 |
Aflatoxin B2-13C17
|
Aflatoxin B2-13C17 |
|
|
Aflatoxin B2-13C17(AFB2-13C17) is intended for use as an internal standard for the quantification of AFB2by GC- or LC-MS. AFB2is a mycotoxin that has been found inA. terricola.1It induces hepatic autophagy and apoptosis ... |
|
T21668 |
Finasteride acetate
|
|
|
|
Finasteride (MK-906) acetate is a potent and competitive 5α-reductase inhibitor, with an IC 50 of 4.2 nM for type II 5α-reductase. The affinity of Finasteride acetate for type II 5α-reductase enzyme was approximately 100... |
|
T36380 |
GLP-1 (1-36) amide (human, rat) (trifluoroacetate salt)
|
|
|
|
GLP-1 amide is a peptide hormone cleaved from proglucagon in the pancreas.1,2 Mice lacking the glucagon receptor (Gcgr-/-) have approximately nine-fold higher levels of total GLP-1 amide, including GLP-1 (1-36) amide and... |
|
T35579 |
PKSI-527
|
|
|
|
PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM). It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 μM, respect... |
