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T1180 |
Blonanserin
|
AD-5423 |
Dopamine Receptor
,
Sigma receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Blonanserin (AD-5423) is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability profile, lacking side effects such as extrapyramidal ... |
|
T8171 |
Glycyl-glutamine
|
Glycyl-L-glutamine monohydrate,Glycyl-L-glutamine,Glycylglutamine |
Others
|
|
Glycyl-glutamine (Glycyl-L-glutamine monohydrate) is an inhibitory neuropeptide derived from beta-endorphin. |
|
T2150 |
Guanfacine hydrochloride
|
Tenex,Intuniv,Guanfacine |
Adrenergic Receptor
|
|
Guanfacine hydrochloride (Intuniv) is a centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS. |
|
T2547 |
Droxidopa
|
SM5688,DOPS,L-DOPS |
Adrenergic Receptor
|
|
Droxidopa (L-DOPS) is an orally available prodrug of norepinephrine that is used in the treatment of symptomatic orthostatic hypotension due to neurogenic causes of autonomic failure. |
|
T22419 |
S-Methylisothiourea sulfate
|
(S)-Methylisothiourea sulfate |
NOS
,
NO Synthase
,
HSV
|
|
S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock[1]. |
|
T0045 |
Heptaminol hydrochloride
|
RP-2831 hydrochloride |
Others
|
|
Heptaminol hydrochloride (RP-2831 hydrochloride), a vasoconstrictor, is used in the therapy of hypotension, especially orthostatic hypotension. |
|
T13142L |
Theodrenaline hydrochloride
|
Theodrenaline hydrochloride(13460-98-5 Free base) |
SARS-CoV
|
|
Theodrenaline hydrochloride is an inhibitor targeting SARS-CoV-2 for the study of hypotension induced by spinal anesthesia. |
|
T70722 |
N 0861
|
|
Adenosine Receptor
|
|
N 0861 is a selective adenosine A1 receptor antagonist that attenuates renal insufficiency during adenosine-controlled hypotension in rats. |
|
T0279 |
Metaraminol tartrate
|
Metaradrine tartrate,Metaraminol bitartrate |
Adrenergic Receptor
|
|
Metaraminol tartrate (Metaradrine tartrate) is a sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors. It has been used primarily as a vasoconstrictor in the treatment of HYPOTENSION. |
|
TP1898 |
HS024
|
HS 024 |
Melanocortin Receptor
|
|
HS024 is a highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-... |
|
T3126 |
Bethanechol chloride
|
(±)-Bethanechol,Urecholine,Myocholine,Carbamyl-β-methylcholine chloride |
AChR
|
|
Bethanechol chloride (Carbamyl-β-methylcholine chloride) is a slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following ab... |
|
T33384 |
Midodrine (R-isomer HCl)
|
ProAmatine,Midodrine,ST-1085,Gutron,Amatine |
|
|
Midodrine is a vasopressor/antihypertensive agent for the treatment of symptomatic postural hypotension. |
|
T0279L2 |
Metaraminol hydrochloride
|
Metaraminol HCl |
|
|
Metaraminol hydrochloride, used primarily as a vasoconstrictor in the treatment of HYPOTENSION, is a sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors. |
|
T34072 |
Pipotiazine
|
19366 RP,Pipotiazina,Pipotiazinum,Piportil L4,Pipothiazine |
|
|
Pipotiazine has less sedating and a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics among the different phenothiazine derivatives. However, it produces a high incide... |
|
T38945 |
Carboxy-PTIO
|
|
|
|
Carboxy-PTIO is a highly effective nitric oxide (NO) scavenger known for its rapid reaction rate with NO, resulting in the formation of nitric dioxide (NO2). Its direct scavenging action against NO plays a crucial role i... |
|
T69000 |
Prenalterol hydrochloride
|
|
|
|
Prenalterol hydrochloride is a partial adrenergic agonist with functional beta 1-receptor specificity and inotropic effect. It is effective in the treatment of acute cardiac failure, postmyocardial infarction low-output ... |
|
T40850 |
[D-Trp11]-Neurotensin
|
[D-Trp11]-Neurotensin |
|
|
[D-Trp11]-Neurotensin is a compound that functions as a selective antagonist of Neurotensin (NT) in perfused rat hearts, while exhibiting full agonist properties in guinea pig atria and rat stomach strips. Additionally, ... |
|
T60369 |
Droxidopa hydrochloride
|
|
|
|
Droxidopa (L-DOPS) hydrochloride is a potent, orally active precursor to norepinephrine that elevates standing blood pressure, mitigates orthostatic hypotension symptoms, and enhances standing capability. It holds promis... |
|
TP1999 |
MEN 11270
|
|
|
|
Peptide antagonist of the B2 bradykinin receptor (pKi = 10.3); conformationally constrained cyclized analog of HOE 140. Blocks hypotension and bronchoconstriction in vivo. Displays selectivity for B2 over 29 other recept... |
|
T25912 |
Oxypyrronium bromide
|
L.D. 3055,Immetropan,LD 3055,LD3055,LD-3055 |
|
|
Oxypyrronium bromide is an anticholinergic and spasmolytic agent containing quaternary ammonium. In animal models it inhibited gastric motility, hypotension induced by vagus stimulation or intravenation of acetylcholine;... |
|
T78027 |
PAMP-12 (unmodified)
|
|
|
|
PAMP-12 (unmodified), an endogenous peptide and potent MRGPRX2 (MrgX2) agonist (EC50=20-50 nM), induces hypotension by inhibiting catecholamine release from sympathetic nerve endings and adrenal chromaffin cells [1]. |
|
T68639 |
Ciprostene (free base)
|
|
|
|
Ciprostene (free base) is a synthetic, chemically stable analog of prostacyclin (PGI2). In animal models, administration of ciprostene resulted in dose-dependent hypotension, tachycardia, and inhibition of ex vivo ADP-in... |
|
T80080 |
PAMP-12 (unmodified) (TFA)
|
|
|
|
PAMP-12 (unmodified) TFA, an endogenous peptide and potent MRGPRX2 (MrgX2) agonist (EC50=20-50 nM), induces hypotension by inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells [1... |
|
T36732 |
Ciprostene (calcium salt)
|
|
|
|
Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI2. Ciprostene exhibits biological activity similar to PGI2, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension a... |
|
T36545 |
Prostaglandin D2 methyl ester
|
Prostaglandin D2 methyl ester |
|
|
Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis. It causes vasodilation, flushing, hypoten... |
|
TP2009 |
K41498
|
K 41498 |
|
|
Potent and highly selective CRF2 receptor antagonist (Ki values are 0.66, 0.62 and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-exp... |
|
T75804 |
K41498 TFA
|
|
|
|
K41498 TFA, an analog of antisauvagine-30 (aSvg-30), is a potent and highly selective antagonist of CRF2 receptors, exhibiting K i values of 0.66 nM, 0.62 nM, and 425 nM for human CRF 2α, CRF 2β, and CRF 1 receptors, res... |
|
T83121 |
Anatumomab mafenatox
|
ABR-214936 |
|
|
Anatumomab mafenatox (ABR-214936), a 73 KDa recombinant protein, targets the tumor-associated antigen 5T4 commonly expressed in malignancies. It is a conjugate comprising a modified form of SEA linked to a murine Fab. Th... |
|
T83905 |
Brain Natriuretic Peptide-32 (rat) acetate
|
BNP (14-45),B-type Natriuretic Peptide-32,Brain Natriuretic Polypeptide-32,BNP-32 |
|
|
Brain natriuretic peptide-32 (BNP-32), a fragment of the proBNP cardiovascular hormone precursor, exhibits affinity for natriuretic peptide receptors in rat vascular smooth muscle cells (IC50 = 7.3 nM) and promotes cGMP ... |
|
T70456 |
Nolpitantium Free Base
|
|
|
|
Nolpitantium Free Base is a highly selective nonpeptide antagonist of neurokinin-1 (NK1) receptor. Nolpitantium potently, selectively and competitively inhibited substance P binding to NK1 receptors from various animal s... |
|
T83674 |
K 41498 TFA
|
|
|
|
K 41498 is a selective peptide antagonist targeting both corticotropin-releasing factor receptor 2α (CRF2α) and CRF2β, demonstrating high affinity with Kis of 0.66 and 0.62 nM, respectively, in HEK293 cells expressing th... |
|
T83697 |
PAMP-12 (human, mouse, rat, porcine, bovine) TFA
|
Proadrenomedullin N-terminal 12 Peptide,PAMP (9-20) |
|
|
Proadrenomedullin N-terminal 12 peptide (PAMP-12), an endogenous fragment originating from the adrenal medulla and spanning amino acids 9-20 of human PAMP-20, plays a role in causing hypotension. It functions as an agoni... |
|
T36618 |
Rupatadine
|
|
|
|
Rupatadine (UR-12592) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM(rabbit platelet membranes/guinea pig cerebellum membranes).IC50 value:Target: PAF/H1 antagonistin vitro: Rupatadine competitively inhibited ... |
