|
T6311 |
Bafetinib
|
NS-187,INNO-406 |
Bcr-Abl
,
Src
,
Autophagy
|
|
Bafetinib (INNO-406) (INNO-406) is an effective and specific dual Bcr-Abl/Lyn inhibitor (IC50: 5.8/19 nM), and no inhibition of the phosphorylation of the T315I mutant and less effective to c-Kit and PDGFR. |
|
T21503 |
(E/Z)-Zotiraciclib
|
(E/Z)-TG02,(E/Z)-SB1317 |
FLT
,
JAK
,
CDK
|
|
(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively. |
|
T0707L |
Cyclophosphamide
|
|
DNA Alkylator/Crosslinker
,
DNA
,
MRP
|
|
Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer. |
|
T3099 |
Pinometostat
|
EPZ-5676 |
Histone Methyltransferase
|
|
Pinometostat (EPZ-5676) has been used in trials studying the treatment of Leukemia, Acute Leukemias, Acute Myeloid Leukemia, Myelodysplastic Syndrome, and Acute Lymphocytic Leukemia, among others. |
|
T3078 |
SGI-1776
|
SGI-1776 free base,Pim-Kinase Inhibitor IX |
Apoptosis
,
FLT
,
Pim
,
Autophagy
|
|
SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias. |
|
T12943 |
SNDX-5613
|
|
Epigenetic Reader Domain
,
Histone Methyltransferase
|
|
SNDX-5613 is a potent and specific inhibitor of Menin-MLL(Ki of 0.149 nM and a cell based IC50 of 10-20 nM). SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias. |
|
T26754 |
BC-23
|
NSC 45382,BC 23,BC23,NSC-45382,NSC45382 |
Proteasome
|
|
BC-23 (NSC 45382) is a potent proteasome inhibitor with antitumor and antimicrobial activity.BC-23 inhibits the CT-L activity of the proteasome and is used in the study of leukemias, lymphomas, gliomas, breast cancer, an... |
|
T77339 |
BRD4-IN-4
|
|
Epigenetic Reader Domain
|
|
BRD4-IN-4 is a selective BRD4 inhibitor with an IC50 value of 6.83 μM for BRD4.BRD4-IN-4 selectively inhibits the proliferation of the MV4-11 cell line and arrests the cells in G1 phase.BRD4-IN-4 can be used to study MLL... |
|
T70563 |
KC-11404
|
|
|
|
KC-11404 is an LTB4 inhibitor for the treatment of b-cell leukemias and lymphomas, potently inhibiting histamine, platelet activating factor and 5-lipoxygenase. |
|
T74096 |
Prednimustine
|
|
|
|
Prednimustine (Leo 1031;NSC 134087) is the ester formed from Prednisolone and Chlorambucil . Prednimustine can be used for leukemias and lymphomas research [1] . |
|
T69130 |
Zorubicin
|
Rubidazon ; Rubidazone,Rubidazone,Rubidazon |
|
|
Zorubicin (Rubidazon), a Daunorubicin derivative, inhibits DNA polymerases and interacts with topoisomerase II. It is utilized in the research of acute leukemias and sarcomas [1] [2] [3] [4] [5]. |
|
T33737 |
NSC 109555
|
NSC-109555,DDUG dimethanesulfonate,NSC109555,DDUG diMS |
|
|
NSC 109555 is a selective, reversible, ATP-competitive Chk2 inhibitor (IC50 = 0.2 μM) that displays no effect on a range of other kinases including Chk1 (IC50 > 10 μM). Inhibits histone H1 phosphorylation (IC50 = 0.24 μM... |
|
T68502 |
Dibrospidium Free Base
|
|
|
|
Dibrospidium Free Base is a dispirotripiperazine derivative and alkylating agent with potential antineoplastic and anti-inflammatory activities. The duration of DNA synthesis inhibition in tumor cells was found to correl... |
