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T24539 |
nNOS-IN-25
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nNOS inhibitor 25,nNOS inhibitor-25,nNOSIN25 |
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nNOS-IN-25 is an effective, selective, and cell-permeable inhibitor of neuronal nitric oxide synthase. |
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T37696 |
NOS1-IN-1
|
nNOS Inhibitor I |
NOS
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NOS1-IN-1（nNOS Inhibitor I） is a potent, selective and cell permeable nNOS inhibitor (Ki: 120 nM).NOS1-IN-1 has a Ki value of 39 μM for eNOS and 325 μM for iNOS.NOS1-IN-1 can be used for the study of neurological disorde... |
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T22724 |
Dimaprit dihydrochloride
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|
NOS
,
NO Synthase
,
Histamine Receptor
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Dimaprit dihydrochloride is a selective histamine H2 receptor agonist. Dimaprit dihydrochloride also inhibits nNOS with an IC50 of 49 μM. It can stimulate gastric acid secretion. |
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T21700 |
NOS-IN-1
|
2-Imino-4-methylpiperidine (acetate) |
NOS
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NOS-IN-1 (2-Imino-4-methylpiperidine acetate) is a potent and orally active inhibitor of NO synthase (NOS) isoforms. NOS-IN-1 exhibits IC50s of 0.1 μM, 0.2 μM, and 1.1μM for human iNOS (hiNOS), hnNOS and heNOS, respectiv... |
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T19916 |
TRIM
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1-(2-Trifluoromethylphenyl)imidazole |
NOS
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TRIM (1-(2-Trifluoromethylphenyl)imidazole) is an inhibitor of nNOS. |
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T37986 |
D-Mannose-6-Phosphate sodium salt hydrate
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Others
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D-Mannose-6-Phosphate sodium salt hydrate is a multifunctional monosaccharide used in the study of metabolism, lysosomal delivery and cancer. |
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T19655 |
N-Acetyl-D-mannosamine
|
DEXM74,ManNAc,DEX M 74,DEX M-74,N-Acetylmannosamine hydrate,DEX-M-74,N-Acetylmannosamine |
Antibacterial
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N-Acetyl-D-mannosamine (ManNAc) is a drug potentially for the treatment of hereditary inclusion body myopathy. |
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T124434 |
Sennoside A1
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Sennoside A1 is a useful organic compound for research related to life sciences and the catalog number is T124434. |
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T11382 |
GDP-α-D-mannose disodium
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Others
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GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM).GDP-α-D-mannose disodium is the donor substrate for mannosy... |
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T75247 |
Mannose 1-phosphate
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Mannose 1-phosphate, an endogenous metabolite, serves as a substrate for the enzyme GDP-mannose pyrophosphorylase to synthesize GDP-Man [1]. |
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T34944 |
Trimannosyldilysine
|
Man(3)lys(2) |
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Trimannosyldilysine is a bioactive chemical. |
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T79928 |
Phosphomannose isomerase
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Phosphomannose isomerase, the initial enzyme in GDP-Man biosynthesis, catalytically facilitates the interconversion of fructose-6-phosphate (Fru6P) and mannose-6-phosphate (Man6P), playing a crucial role in cell wall syn... |
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T14439 |
Azido-PEG4-alpha-D-mannose
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Others
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Azido-PEG4-alpha-D-mannose is a PEG-based PROTAC linker employed for PROTACs synthesis[1]. |
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T78738 |
HnNOS-IN-2
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|
NO Synthase
|
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Compound 17, also known as hnNOS-IN-2, is an inhibitor of human neuronal nitric oxide synthase (hnNOS) that exhibits good metabolic stability. It is potentially useful for research into neurodegenerative diseases [1]. |
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T81537 |
Paucimannose
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Paucimannose, a prevalent mannosidic N-glycoepitope found in invertebrates and plants, is also expressed in cancers [1]. |
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T7543 |
S-(2-aminoethyl) Isothiourea (dihydrobromide)
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NOS
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S-(2-aminoethyl) Isothiourea (dihydrobromide) is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the Ki values are 1.8, 2.1, and 0.59 µM, respectively |
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T6570 |
L-NAME hydrochloride
|
L-NAME HCl,N(G)-Nitro-L-arginine methyl ester,NG-Nitroarginine methyl ester hydrochloride |
NOS
,
NO Synthase
|
|
L-NAME hydrochloride (L-NAME HCl), a cell-permeable NO synthase inhibitor, displays Ki values of 4.4 μM, 15 nM, and 39 nM, for iNOS (mouse) , nNOS (bovine) , and eNOS (human), respectively. |
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T17293 |
ZL006
|
|
NMDAR
,
iGluR
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ZL006 is an effective inhibitor of nNOS/PSD-95 interaction. ZL006 also inhibits NMDA receptor-mediated NO synthesis. |
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T7206L |
2-Iminobiotin hydrobromide
|
Guanidinobiotin |
NOS
,
NO Synthase
|
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2-Iminobiotin hydrobromide (Guanidinobiotin) is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of 21.8 and 37.5 μM for mouse i... |
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T7355 |
IC87201
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Others
,
iGluR
|
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IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain. |
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T15697 |
L-NMMA acetate
|
Tilarginine acetate,Methylarginine acetate |
NOS
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T83625 |
INOS-IN-14
|
3-bromo-1H-indazole-7-carbonitrile |
NOS
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iNOS-IN-14 (3-bromo-1H-indazole-7-carbonitrile) is a potent nitric oxide synthase (NOS) inhibitor that inhibits the NADPH oxidase activity of nNOS. |
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T9955 |
EX-A5758
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NOS
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EX-A5758 is a novel putative small molecule nNOS-NOS1AP inhibitor, suppressing inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability. |
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T11518L |
GW274150
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NOS
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T10107 |
3-Bromo-7-nitroindazole
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NOS
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T64317 |
ZZL-7
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Serotonin Transporter
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ZZL-7 is a fast-onset antidepressant agent. ZZL-7 disrupts the interaction between the neuronal nitric oxide synthase (nNOS) and serotonin transporter (SERT) in the dorsal raphe nucleus (DRN). ZZL-7 can easily cross the ... |
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T13112L1 |
Tat-NR2B9c acetate
|
Tat-NR2B9c acetate (500992-11-0 Free base),NA-1 acetate |
Others
|
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Tat-NR2B9c acetate (NA-1 acetate) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c acetate disrupts the PSD-... |
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T7474 |
7-Nitroindazole
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|
NOS
|
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7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS. |
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T7206 |
2-Iminobiotin
|
2-IMINOBIOTIN HYDROBROMIDE,Guanidinobiotin |
NOS
,
NO Synthase
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2-Iminobiotin (Guanidinobiotin) is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of 21.8 and 37.5 μM for mouse iNOS and rat n... |
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T38786 |
Nω-Propyl-L-arginine
|
N-omega-Propyl-L-arginine,Nω-Propyl-L-arginine |
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Nω-Propyl-L-arginine, a powerful and specific inhibitor of neuronal nitric oxide synthase (nNOS), effectively inhibits nNOS with a Ki of 57 nM. It exhibits a remarkable 149-fold selectivity for nNOS over endothelial NOS ... |
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T38819 |
Nω-allyl-L-arginine
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Nω-allyl-L-arginine is a competitive and reversible inhibitor of bovine brain nitric oxide synthase (nNOS), efficiently inactivating nNOS in a time-dependent manner. Additionally, Nω-allyl-L-arginine acts as a substrate,... |
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T28736 |
SCR-4026
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SCR-4026 is an inhibitor of the nNOS-PSD-95 interaction with neuroprotective activities. SCR-4026 also promotes neural stem cells to differentiate into neurons-like cells. |
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T81899 |
LY836
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|
iGluR
|
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LY836 is an orally active, neuroprotective compound that effectively inhibits the PSD95-nNOS association in cortical neurons. It has potential applications in the study of ischemic stroke [1]. |
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T11806 |
L-NIO dihydrochloride
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|
NOS
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L-NIO dihydrochloride, a potent and non-selective NADPH-dependent nitric oxide synthase (NOS) inhibitor, consistently induces focal ischemic infarct in rats. It exhibits inhibitory constants (Kis) of 1.7, 3.9, and 3.9 μM... |
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T60305 |
ZLc-002
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|
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ZLc-002 is a selective small-molecule inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain. ZLc-002 can be used in anxiety disorder and inflammation rese... |
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T38017 |
Nω-Propyl-L-arginine hydrochloride
|
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|
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Highly selective and potent inhibitor of nNOS (Ki = 57 nM). Displays 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo.
Kakoki et al (2001) The influence of nitric oxide synthase 1 o... |
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T72866 |
(Rac)-ZLc-002
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(Rac)-ZLc-002 is a compound that inhibits the interaction between neuronal nitric oxide synthase (nNOS) and the nitric oxide synthase 1 adaptor protein (NOS1AP), effectively reducing inflammatory pain and chemotherapy-in... |
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T25749 |
L-NIL dihydrochloride
|
L-NIL HCl,N-Iminoethyl-L-lysine dihydrochloride |
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L-NIL HCl is a relatively selective iNOS inhibitor (IC50s: 0.4-3.3, 8-38, and 17-92 µM for iNOS, eNOS, and nNOS). L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical r... |
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T3491 |
1400W dihydrochloride
|
1400W 2HCl,N-(3-(Aminomethyl)benzyl)acetamidine |
NOS
,
NO Synthase
|
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1400W dihydrochloride (N-(3-(Aminomethyl)benzyl)acetamidine) is a highly effective and specific inhibitor of inducible NOS2 (iNOS). |
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T82251 |
GW274150 dihydrochloride
|
|
NO Synthase
|
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GW274150 (dihydrochloride) is a potent, selective inhibitor of human and rat inducible nitric oxide synthase (iNOS), exhibiting oral activity and NADPH-dependence with an IC50 of 2.19 μM and Kd of 40 nM for human iNOS, a... |
