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T9564 |
IRE1α kinase-IN-1
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IRE1
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IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. It displays 100-fold selectivity for IRE1α over the IRE1β isoform. It inhibits ER stress-induced IRE1α oligomerization and autophosph... |
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T30479 |
Bis-T-23
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Bis T-23,Bis-T 23,AG1717 |
HIV Protease
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Bis-T-23 is a promoter of actin-dependent dynamin oligomerization, an HIV-I integrase inhibitor, and a Telstar derivative. Bis-T-23 promotes actin-dependent dynamin oligomerization. Bis-T-23 can be used in studies of HIV... |
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T3587 |
NOD-IN-1
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Compound 4 |
NOD-like Receptor (NLR)
,
NOD
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NOD-IN-1 (Compound 4) is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors. |
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T38361 |
GSK717
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IL Receptor
,
NOD
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GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretio... |
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T13287 |
VBIT-4
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VDAC
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VBIT-4 is a voltage-dependent anion channel 1 (VDAC1) oligomerization inhibitor (Kd: 17 μM). VBIT-4 can be used for therapeutic purposes in apoptosis-associated disorders (such as neurodegenerative and cardiovascular dis... |
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T14884 |
CBR-5884
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Others
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Dehydrogenase
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CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with h... |
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T60442 |
NLRP3/AIM2-IN-3
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NOD
,
AIM2
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NLRP3/AIM2-IN-3 is a unique molecule that inhibits NLRP3 and AIM2 inflammasome activation in a species-specific manner. It has an IC50 value for cell lysis of 0.077 ± 0.008 μ M. NLRP3/AIM2-IN-3 is a potent inhibitor of N... |
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T35841 |
5-Benzyloxygramine
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Dopamine Receptor
,
5-HT Receptor
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5-Benzyloxygramine is a N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities[1].
5-benzyloxygramine stabilizes the N-NTD dimers through simultaneous hydrophobic inter... |
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T28117 |
MSN-50
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MSN50,MSN 50 |
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MSN-50, an inhibitor of Bax and Bak oligomerization, inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection. |
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T28224 |
OB-2
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OB-2 is an inhibitor of stomatin-like protein-3 (STOML3) oligomerization. OB-2 reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo. |
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T78689 |
HAChE-IN-1
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hAChE-IN-1 (Compound 24) is a potent inhibitor of human acetylcholinesterase (hAChE), exhibiting an inhibition concentration half-maximum (IC50) of 1.09 μM. Additionally, it inhibits tau-oligomerization with an effective... |
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T14150 |
AKOS-22
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Others
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AKOS-22 is a potent mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor (Kd=15.4 μM). AKOS-22 protects against mitochondrial dysfunction[1]. AKOS-22 interacts with VDAC1 and inhibiting both VDAC1 ol... |
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T71527 |
NSC145366
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NSC145366 is an inhibitor of Hsp90 activities which targets the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation. NSC145366 increases Hsp90 oligomerization resulting in alloster... |
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T28223 |
OB-1
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OB-1 is an inhibitor of stomatin-like protein-3 (STOML3) oligomerization. OB-1 reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo. |
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T16155 |
MSN-125
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Akt
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MSN-125 effectively inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons protect primary neurons against glutamate excitotoxicity. MSN-125 is an effective Bax and Bak oligomerization in... |
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T13286 |
VBIT-3
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Others
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VBIT-3 is a voltage-dependent anion channel 1 (VDAC1) oligomerization inhibitor (Kd: 31.3 μM). VBIT-3 also is an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders (such as neurod... |
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T79752 |
DDC 2′,3′-O-disulfate
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DDC 2′,3′-O-disulfate (compound 4) inhibits the fibrillization and oligomerization of Aβ42, showing promise for Alzheimer's disease (AD) research [1]. |
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T78692 |
HAChE-IN-2
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hAChE-IN-2, a potent inhibitor of human acetylcholinesterase (hAChE), exhibits an inhibitory concentration 50 (IC50) of 0.71 μM and additionally impedes tau-oligomerization with an effective concentration 50 (EC50) of 2.... |
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T78894 |
NLRP3-IN-21
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NOD-like Receptor (NLR)
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NLRP3-IN-21 (compound L38) is an inhibitor of the NLRP3 inflammasome that possesses anti-inflammatory properties. It suppresses the activation of the NLRP3 inflammasome and pyroptosis by inhibiting gasdermin D cleavage, ... |
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T63717 |
CAM833
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CAM833 is a potent orthosteric inhibitor of the interaction between BRCA2 and RAD51 and also inhibits RAD51 oligomerization and is able to act on the ChimRAD51 protein (Kd: 366 nM). |
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T11207 |
Entacapone sodium salt
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Others
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Entacapone sodium salt inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. Entacapo... |
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T82599 |
DDC 3′-O-β-D glucuronide
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Drug Metabolite
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Compound 5, DDC 3′-O-β-D-glucuronide, is a drug metabolite with properties that inhibit the fibrillization and oligomerization of Aβ42, suggesting its potential utility in Alzheimer's disease research [1]. |
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T78784 |
RIPK3-IN-3
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RIPK3-IN-3 (compound 20) is a selective RIPK3 inhibitor that demonstrates potent activity with an IC50 value of 10 nM. This compound effectively blocks RIPK3-mediated phosphorylation of MLKL, preventing its oligomerizati... |
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T83751 |
PUMA BH3 (human) TFA
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PUMA BH3, a peptide that includes the BH3 domain from the p53-upregulated modulator of apoptosis (PUMA) and activates the pro-apoptotic protein Bak, demonstrates binding affinity to Bak with dissociation constants (Kds) ... |
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T82621 |
D359-0396
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NOD-like Receptor (NLR)
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D359-0396 is an orally active NLRP3 inflammasome inhibitor that mitigates pyroptosis and reduces IL-1β release in macrophages by inhibiting the oligomerization of NLRP3, ASC, and the cleavage of GSDMD. This compound is e... |
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T72473 |
NOD1/2 antagonist-1
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NOD1/2 Antagonist-1 is a potent dual inhibitor of nucleotide-binding oligomerization domain-like receptors 1 and 2 (NOD1/2), displaying inhibitory concentrations (IC50) of 1.13 μM for NOD1 and 0.77 μM for NOD2. It exhibi... |
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T62506 |
3,6-DMAD dihydrochloride
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3,6-DMAD dihydrochloride is an acridine derivative and a potent inhibitor of the IRE1α-XBP1s pathway. 3,6-DMAD dihydrochloride can induce IL-6 secretion by exploiting the IRE1α-XBP1s pathway. 3,6-DMAD dihydrochloride is ... |
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T83509 |
[Arg6]-β-Amyloid (1-40), england mutation
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β-Amyloid (1-40), England mutation, is a biologically active peptide with a histidine (His) to arginine (Arg) substitution at position 6, known to enhance oligomerization kinetics that serve as fibril seeds and increase ... |
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T79731 |
MLKL-IN-6
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Necroptosis
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MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein. It effectively prevents MLKL phosphorylation and oligomerization, which are crit... |
