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Search Results for " pathology "

ターゲット

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リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T7100	PLX5622	PLX-5622	c-Fms , CSF-1R
	PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor.		c-Fms , CSF-1R
T6111	Selisistat	EX-527,SEN0014196	Sirtuin
	Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM). Selisistat can be used in the study of neurological disorders such as Huntington's chorea.		Sirtuin
T7530	PD146176	NSC168807	Ferroptosis , Lipoxygenase , Autophagy
	PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology...		Ferroptosis , Lipoxygenase , Autophagy
T23709	AlphaSYN-IN-NAB2	alphaSYN inhibitor NAB2,alphaSYNINNAB2,alphaSYN-IN-NAB2,NAB2,alphaSYN inhibitor-NAB2
	alphaSYN-IN-NAB2, a neuron-protective agent, is a protein encoded by the NAB2 gene. NAB2 effectively and selectively protects a variety of cells from alpha-SYN toxicity. NAB2 promotes endosomal transport dependent on E3 ...
T30437	BF 126	BF-126,BF126
	BF 126 has potential applications in vivo imaging of tau pathology in Alzheimer's disease
T25525	IDT
	IDT is an orally active TNFα modulator. It acts by altering neutrophil infiltration, improving cognition and diminishing tau and amyloid pathology in the 3xTgAD mouse model.
T26879	BNC-1	BNC 1
	BNC-1 is a modulator of amyloid pathology. BNC-1 significantly decreases amyloid burden and improves markers of synaptic integrity in well-established mouse models of amyloid deposition by promoting phosphorylation and a...
T39607	NLRP3 modulators 1	NLRP3 modulators 1
	NLRP3 modulators 1 (WO2017184746A1, compound 107) is a potent modulator of NLRP3, capable of agonizing or partially agonizing the activity of NLRP3. This compound proves valuable in investigating conditions, diseases, or...
T26223	SR1555 HCl	SR-1555,SR1555,SR 1555
	SR1555 is a selective RORγ inverse agonist that inhibits the development and function of TH17 cells, a subset of T cells that have been involved in the pathology of several autoimmune diseases such as rheumatoid arthriti...
T60042	NPT200-11		Others
	NPT200-11 is an orally bioavailable and brain penetrating inhibitor of accumulation of alpha-synuclein (ASYN) misfolding and aggregation. NPT200-11 can be used in studies about the underlying pathology of synucleinopathi...		Others
T75827	UFP-803 TFA
	UFP-803 TFA, a potent ligand for the urotensin-II receptor (UT), exhibits minimal residual agonist activity, rendering it a valuable asset for exploring the UT system's function in physiology and pathology [1].
T60543	THK-523
	THK-523 has shown selectivity and high affinity for tau pathology both in vitro and in vivo. 18 F-THK523 is a potent tau imaging radiotracer which is a potent in vivo tau imaging ligand for Alzheimer's disease [1].
T78774	MMP13-IN-4		MMP
	MMP13-IN-4 (compound 13) is a potent, selective MMP-13 inhibitor with an IC50 of 14.6 μM, implicated in the pathology of osteoarthritis (OA) [1].		MMP
T61130	SSTR4 agonist 3
	SSTR4 agonist 3 is a potent compound that activates the SSTR4 receptor. The SSTR4 receptor is highly expressed in the hippocampus and neocortex, which are regions associated with memory, learning, and Alzheimer's disease...
T40355	IL-17A modulator-2
	IL-17A modulator-2, exhibits inhibitory properties towards IL-17A, with a pIC50 of 8.3. Its effectiveness lies in attenuating the biological effects associated with IL-17A activity. IL-17A modulator-2 finds utility in th...
T78775	MMP13-IN-5		MMP
	MMP13-IN-5 (compound 13m) is a potent, selective MMP-2/MMP-13 inhibitor with IC50 values of 3.6 μM for MMP-2 and 14.6 μM for MMP-13, implicated in the pathology of osteoarthritis (OA) [1].		MMP
T12505	PLX5622 hemifumarate		c-Fms
	PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor with an IC 50 of 0.016 μM and Ki of 5.9 nM. PLX5622 hemifumarate allows for extended and specific microglial elimination, prece...		c-Fms
TP2301	Type II collagen fragment		Others
	Type II collagen is composed of a triple helix of three identical α chains. These molecules associate to form a fibril that is stabilized by intermolecular crosslinks1. Damage to the fibrillar meshwork, made up of primar...		Others
T75779	β-Amyloid (12-28) (TFA)
	β-Amyloid (12-28) (TFA), a peptide fragment of the β-amyloid protein (β1-42)—a 42 amino acid protein primarily found in senile plaque cores—exhibits aggregation properties. This compound holds significance for research i...
T60911	SSTR4 agonist 4
	SSTR4 agonist 4 is a potent SSTR4 agonist that has the potential for the pain research. SSTR4 agonists are effective in rodent models of pain associated with acute and chronic associated anti-peripheral nociceptive and a...
T36947	Pyrithiamine (hydrobromide)
	Pyrithiamine is the pyridine analog of thiamine that prevents growth of organisms that require intact thiamine. [1] It inhibits the growth of bacterial and fungal species at a pyrithiamine:thiamine ratio of 10:1 in growt...
T37697L	D-GsMTx4 TFA		TRP/TRPV Channel , Piezo Channel
	D-GsMTx4 TFA, a selective spider venom peptide, is a TRPC1/6 and Piezo2 inhibitor that inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families, blocks cation-selective s...		TRP/TRPV Channel , Piezo Channel
T35507	12-HETE
	(±)12-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The biological activity of (±)12-HETE is similar to that of its constituent enantiomers . It aggregates ne...
T35639	Sulfatides (bovine) (sodium salt)
	Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system. They are produced from the combination of ceramide and UDP-galacto...
T35892	Q134R	Q134R
	Q134R, a neuroprotective derivative of hydroxyquinoline, effectively inhibits nuclear factor of activated T-cell (NFAT) signaling and possesses the ability to cross the blood-brain barrier. This compound shows promise fo...
T35836	PMX-205 (trifluoroacetate salt)
	PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50= 31 nM).1It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma.2,3...
T35890	Pentosidine
	Advanced glycation end products (AGEs) are compounds formed by non-enzymatic chemical reactions following the bonding of sugars to proteins or lipids during diabetes, uremia, aging, rheumatic arthritis, and other conditi...
T35799	MBX-8025 (sodium salt)
	MBX-8025 is an agonist of peroxisome proliferator-activated receptor δ (PPARδ).1 It is greater than 750- and 2,500-fold selective for PPARδ over PPARα and PPARγ. MBX-8025 (10 mg/kg per day for eight weeks) reduces increa...
T36903	Rasagiline-13C3 (mesylate)	Rasagiline-13C3 (mesylate)
	Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is se...

Compounds

PLX5622

T7100

Synonym: PLX-5622

Target: c-Fms, CSF-1R

Selisistat

T6111

Synonym: EX-527,SEN0014196

Target: Ferroptosis, Lipoxygenase, Autophagy

alphaSYN-IN-NAB2

T23709

Synonym: alphaSYN inhibitor NAB2,alphaSYNINNAB2,alphaSYN-IN-NAB2,NAB2,alphaSYN inhibitor-NAB2

Target:

BF 126

T30437

Synonym: BF-126,BF126

Synonym: NLRP3 modulators 1

Target:

SR1555 HCl

T26223

Synonym: SR-1555,SR1555,SR 1555

type II collagen fragment

TP2301

Synonym:

Target: Others

β-Amyloid (12-28) (TFA)

Pyrithiamine (hydrobromide)

Target: TRP/TRPV Channel, Piezo Channel

Sulfatides (bovine) (sodium salt)

PMX-205 (trifluoroacetate salt)

MBX-8025 (sodium salt)

T35799

Synonym:

Target:

Rasagiline-13C3 (mesylate)

T36903

Synonym: Rasagiline-13C3 (mesylate)

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-04778	Prolactin Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Prolactin (PRL) is a hormone with multiple actions in the central nervous system (CNS) spanning from physiology to pathology. PRL exerts different actions through its receptors that can be found in both neurons and glial...
TMPY-02424	Prolactin Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	Prolactin (PRL) is a hormone with multiple actions in the central nervous system (CNS) spanning from physiology to pathology. PRL exerts different actions through its receptors that can be found in both neurons and glial...
TMPY-02956	Apolipoprotein L/APOL1 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	APOL1, also known as apolipoprotein L1, is a minor apoprotein component of HDL (High-density lipoprotein) or 'good cholesterol' which is synthesized in the liver and also in many other tissues, including pancreas, kidney...
TMPY-01727	GLA/alpha-Galactosidase A Protein, Human, Recombinant (His)	Human	HEK293
	Alpha-galactosidase A, also known as Alpha-D-galactoside galactohydrolase, Alpha-D-galactosidase A, Melibiase and GLA, is a member of the glycosyl hydrolase 27 family. GLA is used as a long-term enzyme replacement therap...
TMPY-02751	Cathepsin S Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Cathepsin S (CTSS), one of the lysosomal proteinases, has many important physiological functions in the nervous system, especially in process of extracellular matrix degradation and endocellular antigen presentation. CTS...
TMPY-00735	Cathepsin S Protein, Human, Recombinant (His)	Human	HEK293
	Cathepsin S (CTSS), one of the lysosomal proteinases, has many important physiological functions in the nervous system, especially in process of extracellular matrix degradation and endocellular antigen presentation. CTS...
TMPY-05094	Tissue Factor Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemost...
TMPY-02530	Tissue Factor Protein, Human, Recombinant (His)	Human	HEK293
	Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemost...
TMPK-00191	PILRA Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive decline in cognitive performance; Mild Cognitive Impairment (MCI) is instead an objective decline in cognitive performance that does ...
TMPK-01205	MDL-1/CLEC5A Protein, Human, Recombinant (hFc)	Human	HEK293
	In C. elegans, increased lifespan in daf-2 insulin/IGF-1 receptor mutants is accompanied by up-regulation of the MDL-1 Mad basic helix-loop-helix leucine zipper transcription factor.MDL-1, like its mammalian orthologs, i...
TMPK-01218	MDL-1/CLEC5A Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	In C. elegans, increased lifespan in daf-2 insulin/IGF-1 receptor mutants is accompanied by up-regulation of the MDL-1 Mad basic helix-loop-helix leucine zipper transcription factor.MDL-1, like its mammalian orthologs, i...
TMPY-02393	Thimet Oligopeptidase/THOP1 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	THOP1, also known as Thimet oligopeptidase 1, Thimet oligopeptidase, EC 3.4.24.15, or EP24.15, is a zinc(II) endopeptidase implicated in the processing of numerous physiological peptides. As an intracellular enzyme, high...
TMPJ-00028	CCL2 Protein, Mouse, Recombinant	Mouse	E. coli
	C-C motif chemokine 2 (CCL2) is a member of the C-C or β chemokine family. Mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence, and 58%, 56%, 55%, 53% and 53% aa identity with human, equ...
TMPJ-00920	CD40 Ligand Protein, Mouse, Recombinant (aa 112-260, His)	Mouse	Human Cells
	CD40 Ligand, also known as TNFSF5, CD154, is a type II transmembrane glycoprotein member of the TNF superfamily. Mature mouse CD40 Ligand consists of a 22 amino acid (aa) cytoplasmic domain, a transmembrane segment, and ...
TMPY-01290	CHIT1 Protein, Human, Recombinant (His)	Human	HEK293
	Chitotriosidase, also known as Chitinase-1 and CHIT1, is a member of the glycosyl hydrolase 18 family and Chitinase class II subfamily. It is a member of the mammalian chitinase family, structurally homologous to chitina...
TMPY-02857	GLA/alpha-Galactosidase A Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Alpha-galactosidase A, also known as Alpha-D-galactoside galactohydrolase, Alpha-D-galactosidase A, Melibiase and GLA, is a member of the glycosyl hydrolase 27 family. GLA is used as a long-term enzyme replacement therap...
TMPY-02045	SECTM1 Protein, Human, Recombinant (His)	Human	HEK293
	Secreted and transmembrane 1 (SECTM1), also known as K12, is a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein of SECTM family. It is found in a perinuclear Golgi-like pattern a...
TMPJ-01312	TWEAKR/TNFRSF12A Protein, Mouse, Recombinant (hFc)	Mouse	Human Cells
	Tumor necrosis factor receptor superfamily member 12A(Tnfrsf12a) is a single-pass type I membrane protein and contains 1 TNFR-Cys repeat. It is weak inducer of apoptosis in some cell types.It promotes angiogenesis and it...
TMPY-00362	Cathepsin S Protein, Rat, Recombinant (His)	Rat	HEK293
	Cathepsin S (CTSS), one of the lysosomal proteinases, has many important physiological functions in the nervous system, especially in process of extracellular matrix degradation and endocellular antigen presentation. CTS...
TMPY-02537	Tissue Factor Protein, Human, Recombinant (hFc)	Human	HEK293
	Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemost...
TMPY-06957	Tissue Factor Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	HEK293
	Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemost...
TMPY-01325	Tissue Factor Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemost...
TMPY-05083	Tissue Factor Protein, Human, Recombinant (aa 1-295, His)	Human	Baculovirus-Insect Cells
	Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemost...
TMPY-02318	Tissue Factor Protein, Rabbit, Recombinant (His)	Rabbit	HEK293
	Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemost...
TMPY-03209	Tissue Factor Protein, Rat, Recombinant (His)	Rat	HEK293
	Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemost...
TMPH-01066	CCR6 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is its major ligand it can also act as a receptor for non-...
TMPH-03500	IL-6 Protein, Sheep, Recombinant (GST)	Sheep	E. coli
	Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-sign...
TMPH-03208	IL-6 Protein, Rabbit, Recombinant (His)	Rabbit	Yeast
	Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-sign...