|
T1476 |
Pramipexole
|
SND 919 |
Dopamine Receptor
|
|
Pramipexole (SND 919) is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment but has not... |
|
T6951 |
Pramipexole dihydrochloride hydrate
|
Pramipexole 2HCl Monohydrate,Mirapex |
Dopamine Receptor
|
|
Pramipexole dihydrochloride hydrate (Mirapex) is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and su... |
|
T70470 |
CM-352
|
|
MMP
|
|
CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage. |
|
T12269 |
NUCC-390
|
|
CXCR
|
|
NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100. This compound facilitates nerve functional recovery following neurodeg... |
|
T8860 |
DSRM-3716
|
|
Androgen Receptor
|
|
Isoquinoline, 5-iodo- (9CI) is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons. |
|
T8887 |
2'MeO6MF
|
|
GABA Receptor
|
|
2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors.It offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response... |
|
T50050 |
2,3-dihydroxy-3-methylbutanoic acid
|
|
Others
|
|
2,3-dihydroxy-3-methylbutanoic acid is a natural metabolite of the branched-chain amino acid leucine. It acts by activating the mTOR signaling pathway to promote the synthesis of new muscle proteins and reduce the breakd... |
|
T28866 |
Stemazole
|
|
Apoptosis
|
|
Stemazole is a novel small molecule human stem/progenitor cell proliferation activator that promotes the survival of human embryonic stem cells and maintains stemness, and promotes the survival of oligodendrocyte precurs... |
|
T33019 |
LY-79771 free base
|
LY 79771,LY79771,LY-79771 |
|
|
LY-79771 is a phenylethanolamine anti-obesity agent, which can effectively prevent fat recovery after energy deprivation. |
|
T21185 |
CEP03
|
CEP 03,CEP-03 |
|
|
CEP03 enhances EC/EPC proliferation, tubelike formation, and wound-healing efficiency, leading to promote angiogenesis and significantly improve blood flow perfusion recovery in the ischemic hind limbs of mice. |
|
T71601 |
CU-2010
|
|
|
|
CU-2010 is a synthetic serine protease inhibitor with antifibrinolytic and anticoagulant properties. CU-2010 dose-dependently reduces postoperative blood loss and improves postischemic recovery after cardiac surgery in a... |
|
T39890 |
8-Bromo-AMP
|
8-Bromoadenosine 5'-monophosphate,8-Bromo-AMP,8-Bromoadenylicacid |
|
|
8-Bromo-AMP, also known as 8-Bromoadenosine 5'-monophosphate, is a membrane permeable cAMP analogue. It enhances cardiac recovery from ischemia and reperfusion by elevating ATP, ADP, and total adenine nucleotide concentr... |
|
T25312 |
Detajmium
|
Tachmalcor |
|
|
Detajmium is an anti-arrhythmia compound. It is an Na(+)-channel-blocking drug with an extremely long recovery from use-dependent sodium channel block. |
|
T82798 |
C3bot(154-182) TFA
|
|
|
|
C3bot(154-182) TFA, a C3 peptide, facilitates spinal cord injury recovery by promoting regenerative growth of descending fiber tracts. It serves as a potential therapeutic agent to support axonal protection and/or repair... |
|
T71398 |
RO5126946
|
|
|
|
RO5126946 is a Novel α7 nicotinic acetylcholine receptor-positive allosteric modulator. RO5126946 allosterically modulates α7nAChR activity. RO5126946 increased acetylcholine-evoked peak current and delayed current decay... |
|
T60792 |
NMDA receptor antagonist-3
|
|
|
|
NMDA receptor antagonist-3 is a NMDA receptor antagonist with a significan recovery rate (40.0%, at 100 μM) and safe toxicological characteristics in SH-SY5Y and human adipose mesenchymal stem cells. |
|
T62137 |
ANKRD22-IN-1
|
|
|
|
ANKRD22-IN-1 is a potent inhibitor of ANKRD22, which promotes the expansion of gastrointestinal mucosal epithelial stem cells and thus indirectly activates the Wnt classical pathway, which is beneficial for the recovery ... |
|
T71559 |
Melanotan II acetate
|
|
|
|
Melanotan II acetate is an agonist of melanocortin receptor 1 (MC1R), MC3R, MC4R, and MC5R. It has been shown to improve recovery of sciatic nerve function after mechanical injury and increase cisplatin-induced decreases... |
|
T63004 |
NUCC-390 dihydrochloride
|
|
|
|
NUCC-390 dihydrochloride, a novel and selective CXCR4 receptor agonist, effectively induces the internalization of CXCR4 receptors and acts antagonistically to AMD3100 [1]. This small-molecule compound has demonstrated t... |
|
T69589 |
PX-316
|
|
|
|
PX-316 is a AKT inhibior. PX-316, when administered intraperitoneally to mice at 150 mg/kg, inhibits Akt activation in HT-29 human tumor xenografts up to 78% at 10 h with recovery to 34% at 48 h. PX-316 has antitumor act... |
|
T80420 |
TAT-NEP1-40 acetate
|
|
Apoptosis
|
|
TAT-NEP1-40 acetate, a potential therapeutic for axonal regeneration and functional recovery post-stroke, safeguards PC12 cells from oxygen and glucose deprivation (OGD) and encourages neurite outgrowth. This compound al... |
|
T83963 |
Z-DEVD-FMK Caspase-3 Inhibitor
|
|
|
|
Z-DEVD-FMK, a Caspase-3 Inhibitor, is an irreversible, cell-permeable inhibitor of caspase-3/CPP32 that impedes tumor cell apoptosis. In vivo studies show it offers neuroprotection in rat hippocampi post-seizures and con... |
|
T71228 |
Adaprolol maleate
|
|
|
|
Adaprolol maleate is a beta-blocker and opthalmic which may be used in the treatment of Glaucoma or other ailments of the eye. Adaprolol has marked electrophysiologic effects. Its major action was on sinus node; it prolo... |
|
T38282 |
C22 Glucosylceramide (d18:1/22:0)
|
|
|
|
C22 Glucosylceramide (d18:1/22:0) is an endogenous glucosylceramide. Glucosylceramides are major constituents of skin lipid membranes where they play a role in maintaining the water permeability barrier. They are precurs... |
|
TP1989 |
NEP(1-40)
|
Nogo-66 (1-40) |
|
|
Peptide fragment corresponding to residues 1 - 40 of Nogo-66, the domain of the myelin protein Nogo that inhibits axonal outgrowth. Acts as a competitive antagonist at the Nogo-66 receptor (NgR); blocks Nogo-66- and CNS ... |
|
T80544 |
PTPσ Inhibitor, ISP
|
|
Phosphatase
|
|
PTPσ Inhibitor ISP is a compound that binds to recombinant human PTPs, thereby inhibiting PTPσ signaling. It has the capability to penetrate membranes and counteract the inhibitory effects of chondroitin sulfate proteogl... |
|
T80418 |
TAT-NEP1-40
|
|
Apoptosis
|
|
TAT-NEP1-40, a blood-brain barrier (BBB) permeable peptide, confers protection to PC12 cells against oxygen and glucose deprivation (OGD) while promoting neurite outgrowth. Furthermore, it enhances neurologic outcomes po... |
|
T35494 |
(±)11(12)-EET
|
|
|
|
(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.[1][2][3[]A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms C... |
|
T71966 |
PD-128763
|
|
|
|
PD-128763 is a selective inhibitor of poly(ADP-ribose) polymerase. PD-128763 has an IC50 value against the purified enzyme approximately 50X lower than 3-aminobenzamide (3-AB), a widely used specific inhibitor of the enz... |
|
T37297 |
Ru360
|
|
|
|
Ru360, an oxygen-bridged dinuclear ruthenium amine complex, is a selective mitochondrial calcium uptake inhibitor. Ru360 potently inhibits Ca2+ uptake into mitochondria with an IC50 of 0.184 nM. Ru360 binds to mitochondr... |
|
T23800 |
BI-9627 hydrochloride
|
BIX Hydrochloride,BIX HCl |
|
|
BIX HCl is a sodium-hydrogen exchange type 1 inhibitor. |
