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Search Results for " signal-regulating "

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13

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2

天然化合物

16

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1

ライブラリー

カタログ番号 製品名 別名 ターゲット
T9377 ASK1-IN-2 Apoptosis , ASK , MAPK
ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can potentially be used as a therapeutic strategy for ulcerative colitis[1].
T3101 NQDI-1 NQDI1,NQDI 1 Apoptosis , ASK , MAPK
NQDI-1 (NQDI 1) is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50/Ki: 3 μM/500 nM).
T5190 GS-444217 GS 444217,GS444217 Apoptosis , ASK , MAPK
GS-444217 is a selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1, IC50: 2.87 nM).
T13099 TC ASK 10 ASK , MAPK
T3350 Selonsertib GS-4997 Apoptosis , ASK , MAPK
Selonsertib (GS-4997) is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.
T9697 ASK1-IN-1 ASK
ASK1-IN-1 is an inhibitor of apoptosis signal-regulating kinase 1 which is a key mediator in the apoptotic and inflammatory cellular stress response with an IC50 of 21 nM in biochemica assays.
T68430 BPyO-34
BPyO-34 is a novel apoptosis signal-regulating kinase 1 (ASK1) inhibitor with IC50 of 0.52μM in vitro in kinase assay.
T61247 TRK-IN-16
TRK-IN-16 (WO2012034091A1, compound X-21) is a highly effective TRK inhibitor, targeting protein kinases that are integral to regulating cell growth, differentiation, and various cellular signal transduction processes. ...
T70622 Selonsertib HCl
Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and b...
T74029 Cis-11-Methyl-2-dodecenoic acid
Cis-11-Methyl-2-dodecenoic acid functions as a quorum sensing (QS) signal and a diffusion signaling factor (DSF) within extracellular microbial and fungal communication systems. It plays a pivotal role in regulating viru...
T37737 N-cis-octadec-9Z-enoyl-L-Homoserine lactone
Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm form...
T37738 N-cis-tetradec-9Z-enoyl-L-Homoserine lactone
Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm form...
T37736 N-cis-hexadec-9Z-enoyl-L-Homoserine lactone N-(2-oxotetrahydrofuran-3S-yl) Palmitoleyl Amide,N-cis-hexadec-9Z-enoyl-L-Homoserine lactone
Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm f...
カタログ番号 製品名 別名 ターゲット
T6S1418 Praeruptorin C Antioxidant , Calcium Channel
1. Praeruptorin C has been widely used as an antioxidant and a calcium antagonist to treat diseases. 2. Praeruptorin C partially protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors ...
TN4635 Neoechinulin A NADPH-oxidase , Beta Amyloid , ASK , IκB/IKK , p38 MAPK , TNF , NOS , NF-κB , COX , Prostaglandin Receptor
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) ...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-05004 FGF-4 Protein, Human, Recombinant Human E. coli
FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specificati...
TMPJ-00387 IL-4R alpha Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions a...
TMPJ-01003 STAT5B Protein, Human, Recombinant (His) Human E. coli
Signal Transducer and Activator of Transcription 5b (STAT5B) is a member of the STAT family of transcription factors. They are responsible for an array of cellular activities including regulating growth, survival, differ...
TMPH-02575 PDE5A Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-gen...
TMPH-01539 ILK Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered ...
TMPJ-01197 CRELD2 Protein, Human, Recombinant (His) Human HEK293 Cells
Cysteine-Rich with EGF-Like Domain Protein 2 (CRELD2) is a secreted protein that is a member of the CRELD family. Human CRELD2 is synthesized as a 353 amino acid precursor protein with a signal peptide, a highly conserve...
TMPH-03116 IL-4R Protein, Pig, Recombinant (His) Sus scrofa (Pig) E. coli
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production a...
TMPJ-00713 GDF-11 Protein, Human, Recombinant Human HEK293 Cells
Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes. ...
TMPJ-00587 NRCAM Protein, Human, Recombinant (hFc) Human HEK293 Cells
Neuronal cell adhesion molecule(NRCAM) is a single-pass type I membrane protein ,containing 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily....
TMPY-03175 Claudin-11 Protein, Human, Recombinant (mFc) Human HEK293 Cells
Claudin-11, also known as CLDN11, belongs to the group of claudins. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands function as a physical barrier to prevent solut...
TMPH-02131 SKP2 Protein, Human, Recombinant (His & SUMO) Human E. coli
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle pr...
TMPJ-00052 Leptin Protein, Mouse, Recombinant Mouse E. coli
Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signaling pathways involving OB-R in hypothalamus. Animal models have ...
TMPJ-00082 NGAL/Lipocalin-2 Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
Lipocalin-2, also known as Neutrophil Gelatinase-Associated Lipocalin (NGAL), is a secretory protein of the lipocalin superfamily. Lipocalin-2 contains a signal peptide that enables it to be secreted and form complexes w...
TMPY-01140 ACOT13/THEM2 Protein, Human, Recombinant (His) Human E. coli
The metabolites of fatty acyl-Coenzyme A (CoA) and metabolic enzymes contribute to lipid biosynthesis, signal transduction, and gene transcription. Members of the acyl-CoA thioesterase (Acot) gene family hydrolyze fatty ...
TMPJ-00193 TREML1 Protein, Human, Recombinant (hFc) Human HEK293 Cells
Triggering Receptor Expressed on Myeloid Cells-Like Protein 1 (TREML1) is a single-pass type I membrane protein. TREML1 precursor contains a 15 amino acid signal peptide, a 147 amino acid extracellular domain with an Ig-...
TMPJ-00192 CD32B Protein, Human, Recombinant (His) Human HEK293 Cells
FcγRIIB is a low affinity receptor that recognizes the Fc portion of IgG. The human CD32 group consists of FcγRIIA, FcγRIIB, and FcγRIIC proteins that share 94-99% sequence identity in their extracellular domains but dif...
FGF-4 Protein, Human, Recombinant
TMPY-05004
Species: Human
Expression System: E. coli
IL-4R alpha Protein, Mouse, Recombinant (hFc)
TMPJ-00387
Species: Mouse
Expression System: HEK293 Cells
STAT5B Protein, Human, Recombinant (His)
TMPJ-01003
Species: Human
Expression System: E. coli
PDE5A Protein, Mouse, Recombinant (His & Myc)
TMPH-02575
Species: Mouse
Expression System: E. coli
ILK Protein, Human, Recombinant (His)
TMPH-01539
Species: Human
Expression System: Baculovirus Insect Cells
CRELD2 Protein, Human, Recombinant (His)
TMPJ-01197
Species: Human
Expression System: HEK293 Cells
IL-4R Protein, Pig, Recombinant (His)
TMPH-03116
Species: Sus scrofa (Pig)
Expression System: E. coli
GDF-11 Protein, Human, Recombinant
TMPJ-00713
Species: Human
Expression System: HEK293 Cells
NRCAM Protein, Human, Recombinant (hFc)
TMPJ-00587
Species: Human
Expression System: HEK293 Cells
Claudin-11 Protein, Human, Recombinant (mFc)
TMPY-03175
Species: Human
Expression System: HEK293 Cells
SKP2 Protein, Human, Recombinant (His & SUMO)
TMPH-02131
Species: Human
Expression System: E. coli
Leptin Protein, Mouse, Recombinant
TMPJ-00052
Species: Mouse
Expression System: E. coli
NGAL/Lipocalin-2 Protein, Mouse, Recombinant (hFc)
TMPJ-00082
Species: Mouse
Expression System: HEK293 Cells
ACOT13/THEM2 Protein, Human, Recombinant (His)
TMPY-01140
Species: Human
Expression System: E. coli
TREML1 Protein, Human, Recombinant (hFc)
TMPJ-00193
Species: Human
Expression System: HEK293 Cells
CD32B Protein, Human, Recombinant (His)
TMPJ-00192
Species: Human
Expression System: HEK293 Cells
カタログ番号 製品名
L7700 Neural Regeneration Compound Library

524 compounds
A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening;