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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T14767 | BP 897 hydrochloride | Dopamine Receptor | |
BP 897 is a potent and selective agonist of dopamine D3 receptor and it is a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 and D2 receptors. Which shows low affinities at D1 and D4 receptors ... | |||
T9100 | BP 897 | 2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]- | Dopamine Receptor |
BP 897 (2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-) is a potent and selective dopamine D3 receptor agonist, and a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 ... | |||
T21380 | Pravadoline | WIN 48098-6,WIN48098-6,WIN-48098-6 | Cannabinoid Receptor |
Pravadoline (WIN48098-6) is a cannabinoid receptor agonist. Pravadoline inhibited the PGs synthesis in mouse brain and displayed antinociceptive activity in rodents subjected to a variety of thermal, chemical, and mechan... | |||
T36310 | AKT-IN-6 | INCB-047775 | Akt |
AKT-IN-6 (INCB-047775) has an inhibitory effect on ATK. Akt is an important component of cellular signaling for growth factors, cytokines, and other cell stimuli. Abnormal Akt activation has been associated with the deve... | |||
T29968 | AMG-0347 | UNII-CD7L9290QR | TRP/TRPV Channel |
AMG-0347 (UNII-CD7L9290QR) is a small molecule inhibitor targeting TRPA1(transient receptor potential ankyrin 1) ion channels, a receptor found in sensory neurons and involved in the detection of pain and environmental s... | |||
T1627 | Famotidine | MK-208 | Histamine Receptor |
Famotidine (MK-208) is a propanimidamide and histamine H2-receptor antagonist with antacid activity. As a competitive inhibitor of histamine H2-receptors located on the basolateral membrane of the parietal cell, famotidi... | |||
T14198 | ALX-1393 | GlyT | |
ALX-1393 is a selective GlyT2 inhibitor that effectively reduces neuronal action potential activity in a concentration-dependent manner and inhibits the activity of spontaneous networks by inducing glycinergic tetanic cu... | |||
T35105 | Way 100252 | Way-100252,Way100252 | |
Way 100252 inhibits evoked [3H]GABA release when tested against a number of release-inducing stimuli. | |||
T35082 | VU6010608 | VU-6010608,VU 6010608 | |
VU6010608 is an effective mGlu7 NAM with excellent CNS permeability and is powerful in electrophysiological studies in blocking long-term enhancement of high-frequency stimuli. | |||
TP1608 | PTD-p65-P1 Peptide | ||
PTD-p65-P1 Peptide, a selective inhibitor of the nuclear transcription factor NF-kappaB, consists of a conjugation between a membrane-translocating peptide derived from antennapedia (PTD) and p65-P1. This composition eff... | |||
TP1395 | PTD-p65-P1 Peptide TFA | ||
Ptd-p65-p1 Peptide TFA is a nuclear transcription factor nf-kappab inhibitor, consisting of a membrane transport Peptide sequence derived from antennapedia linked to p65-p1, selectively inhibiting nf-kappab activity indu... | |||
T70581 | CY208-243 Mandelate | ||
CY208-243 is a D1 agonist. CY208-243 attenuates the pattern electroretinogram to low spatial frequency stimuli in the monkey. CY208-243 stimulates adenylate cyclase in rat striatal homogenates with an EC50 of 125 nM. CY... | |||
T67212 | Ligustrazine HCl | ||
Ligustrazine Hydrochloride, is a natural substance discovered in the plant Ligusticum chuanxiong Hort. It inhibits platelet aggregation, improves atherosclerosis situation, protects endothelium injury, and has antithromb... | |||
T26807 | Bifeprunox Mesylate | Bifeprunox,DU 127090,DU-127090,DU127090 | |
Bifeprunox is a partial dopamine and serotonin agonist potentially for the treatment of schizophrenia. Bifeprunox suppresses in vivo VTA dopaminergic neuronal activity via D2 and not D3 dopamine autoreceptor activation. ... | |||
TP2176 | Amyloid A protein fragment [Homo sapiens] | Others | |
Amyloid A proteins (H2N-Ala-Gly-Leu-Pro-Glu-Lys-Tyr-OH) are a family of apolipoproteins associated with high-density lipoprotein in plasma. Different isoforms of SAA are expressed constitutively at different levels or in... | |||
T74779 | JNJ-28583113 | ||
JNJ-28583113, a TRPM2 antagonist with brain permeability, inhibits the phosphorylation of GSK3α and β subunits, thereby protecting cells from oxidative stress-induced cell death. Additionally, it suppresses cytokine rele... | |||
T36838 | (R)-Bromoenol lactone | ||
The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily... | |||
T21750 | A 784168 | ||
A-784168, a potent and orally active inhibitor of vanilloid receptor type 1 (TRPV1), acts on a ligand-gated nonselective cation channel pivotal in integrating pain stimuli including endogenous lipids, capsaicin, heat, an... | |||
T79556 | NDBM | Autophagy | |
NDBM, a tumor-specific probe that targets Pim-1 kinase, exhibits heightened fluorescence upon binding and induces cytotoxicity, facilitating both cell screening and killing. It possesses targeted action on lysosomes and ... | |||
T82771 | CB2-H | ||
CB2-H is a dual-channel fluorescent probe designed for the concurrent detection of HOCl and ONOO- with two separate channels that avoid spectral cross-interference. It facilitates dual-channel fluorescence imaging to mon... | |||
T83749 | Tertiapin LQ TFA | TPNLQ | |
Tertiapin LQ, a peptide derivative of honeybee venom peptide tertiapin, acts as an inhibitor of inwardly rectifying potassium (Kir) channels. Specifically, it targets and inhibits heteromultimeric potassium channels, inc... | |||
T38193 | β-Endorphin (1-27) (human) (trifluoroacetate salt) | ||
β-Endorphin (1-27) is an endogenous peptide that binds to μ-, δ-, and κ-opioid receptors (Kis = 5.31, 6.17, and 39.82 nM, respectively, in COS-1 cells expressing rat receptors). It binds to rat and mouse brain membrane p... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T2P2870 | Damascenone | trans-damascenone,Beta-Damascenone | Others , NF-κB , Endogenous Metabolite |
Damascenone (trans-damascenone) is a norisoprenoid ketone mainly found in red wines. It occurs naturally in tomato and grapes. | |||
TN3460 | Asebogenin | Antifungal | |
Asebogenin is a compound fractionated from Salvia miltiorrhiza with antifungal activity, inhibition of GPVI-induced platelet reactions, and inhibition of NET formation induced by pro-inflammatory stimuli. | |||
TN5131 | Tetrahydrocannabivarin | THCV,delta9-Tetrahydrocannabivarin,CRM,Tetrahydrocannavarin | Cannabinoid Receptor |
Tetrahydrocannabivarin (CRM) is a neutral cannabis receptor subtype (CB1) receptor antagonist, it can increases neural responding to rewarding and aversive stimuli, this effect profile suggests therapeutic activity in ob... | |||
T32614 | L-Clausenamide | (-)-Clausenamide | Microtubule Associated |
L-Clausenamide is an alkaloid extracted from the leaves of the yellow bark (Clausena lansium (Lour) skeels) and can be used to improve cognitive function. L-Clausenamide inhibits beta-amyloid (Aβ) toxicity and prevents t... | |||
T10109 | 3-Carene | Delta-3-Carene | COX , Antifungal |
カタログ番号 | 製品名 | Species | Expression System |
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TMPJ-00603 | TL1A/TNFSF15 Protein, Mouse, Recombinant | Mouse | E. coli |
Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor ... | |||
TMPJ-01465 | GM-CSF/CSF2 Protein, Human, Recombinant (E. coli) | Human | E. coli |
Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of... | |||
TMPY-04572 | MKK4 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is... | |||
TMPY-06981 | IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli) | Human | E. coli |
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proli... | |||
TMPY-04396 | C-ABL/ABL1 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy... | |||
TMPH-02856 | SAAL1 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Plays a role in promoting the proliferation of synovial fibroblasts in response to proinflammatory stimuli. | |||
TMPH-02693 | GNAI2 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhi... | |||
TMPK-00696 | PRAK/MAPKAPK5 Protein, Human, Recombinant (Strep-II) | Human | Baculovirus Insect Cells |
The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in cellular responses to inflammatory stimuli and environmental stress. p38 regulated/activated protein kinase (PRAK, also known as mitogen-... | |||
TMPJ-00839 | ODC1 Protein, Human, Recombinant (His) | Human | E. coli |
Ornithine decarboxylase (ODC1) is an enzyme which belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC1 is the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. ... | |||
TMPH-03390 | TRPV2 Protein, Rat, Recombinant (His) | Rat | E. coli |
Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce phys... | |||
TMPH-01665 | TIMP3 Protein, Human, Recombinant (His) | Human | E. coli |
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to ac... | |||
TMPY-00924 | SMAC Protein, Human, Recombinant (His) | Human | E. coli |
Apoptosis is an essential processes required for normal development and homeostasis of all metazoan organisms. Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric p... | |||
TMPK-01387 | EPhA3 Protein, Canine, Recombinant (His) | Canine | HEK293 Cells |
Erythropoietin‑producing hepatocellular carcinoma cell surface type‑A receptor 3 (EPHA3) has been found to promote the proliferation and survival of prostate cancer (PCa) cell lines and prostate tumor development in nude... | |||
TMPJ-01109 | EIF4EBP2 Protein, Human, Recombinant (His) | Human | E. coli |
Eukaryotic Translation Initiation Factor 4E-Binding Protein 2 (EIF4EBP2) is a member of the Eukaryotic Translation Initiation Factor 4E Binding Protein Family. EIF4EBP2 regulates eIF4E activity by preventing its assembly... | |||
TMPH-02118 | SCN1A Protein, Human, Recombinant (His) | Human | E. coli |
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective chann... | |||
TMPY-03058 | SLITL2/VASN Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Vasorin is a typical type I membrane protein. It contains 1 EGF-like domain, 1 fibronectin type-III domain, 10 LRR (leucine-rich) repeats, 1 LRRCT domain and 1 LRRNT domain. Vasorin is predominantly expressed in vascular... | |||
TMPJ-00661 | PDCD5 Protein, Human, Recombinant (His) | Human | E. coli |
Programmed Cell Death Protein 5 (PDCD5) is a member of the PDCD5 family. PDCD5 is expressed in tumor cells during apoptosis, independent of apoptosis-inducing stimuli. This protein may function in the process of apoptosi... | |||
TMPJ-00887 | NFKB1 Protein, Human, Recombinant (His) | Human | E. coli |
The 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radica... | |||
TMPH-02669 | GJA1 Protein, Mouse, Recombinant (His & Myc) | Mouse | Baculovirus Insect Cells |
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one... | |||
TMPJ-00402 | CD117 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to ... | |||
TMPJ-00177 | BAFF/TNFSF13B Protein, Human, Recombinant (Avi & hFc), Biotinylated | Human | HEK293 Cells |
B-cell activating factor (BAFF), also known as BLyS, TALL-1, THANK, and TNFSF13B, is a transmembrane glycoprotein in the TNF ligand superfamily. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), T... | |||
TMPJ-01385 | CLEC4E Protein, Human, Recombinant (His) | Human | HEK293 Cells |
C-Type Lectin Domain Family 4 Member E (CLEC4E) is a 219 amino acid single-pass type II membrane protein that contains one C-type Lectin domain. It is expressed in monocytes, CLEC4E functions as a downstream target of C/... | |||
TMPY-01824 | Caspase-14 Protein, Human, Recombinant (His) | Human | E. coli |
Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses... | |||
TMPY-04540 | S6K1/RPS6KB1 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
PS6K, also known as RPS6KB1, is a serine/threonine-protein kinase. It belongs to the RSK (ribosomal s6 kinase) family. Members of this family function in signal transduction. PS6K is an isoform of p70 ribosomal S6 kinase... | |||
TMPY-01769 | 4EBP1 Protein, Human, Recombinant (His) | Human | E. coli |
The translational suppressor eIF4E binding protein-1, 4E-BP1 functions as a key regulator in cellular growth, differentiation, apoptosis and survival. The Eif4ebp1 gene, encoding 4E-BP1, is a direct target of a transcrip... | |||
TMPH-01532 | IKBKB Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. A... | |||
TMPH-01531 | IKBKB Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. A... | |||
TMPY-04542 | CDK2 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinas... |
カタログ番号 | 製品名 | ||
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L1400 | MAPK Inhibitor Library | 365 compounds | |
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases; | |||
L6710 | Anti-Inflammatory Traditional Chinese Medicine Compound Library | 1246 compounds | |
A collection of 1246 TCM monomers with anti-inflammatory activity or targeting molecular therapeutic targets in inflammation, a powerful tool for drug discovery and mechanism study; |