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Search Results for " stimuli "

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22

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5

天然化合物

28

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2

ライブラリー

カタログ番号 製品名 別名 ターゲット
T14767 BP 897 hydrochloride Dopamine Receptor
BP 897 is a potent and selective agonist of dopamine D3 receptor and it is a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 and D2 receptors. Which shows low affinities at D1 and D4 receptors ...
T9100 BP 897 2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]- Dopamine Receptor
BP 897 (2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-) is a potent and selective dopamine D3 receptor agonist, and a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 ...
T21380 Pravadoline WIN 48098-6,WIN48098-6,WIN-48098-6 Cannabinoid Receptor
Pravadoline (WIN48098-6) is a cannabinoid receptor agonist. Pravadoline inhibited the PGs synthesis in mouse brain and displayed antinociceptive activity in rodents subjected to a variety of thermal, chemical, and mechan...
T36310 AKT-IN-6 INCB-047775 Akt
AKT-IN-6 (INCB-047775) has an inhibitory effect on ATK. Akt is an important component of cellular signaling for growth factors, cytokines, and other cell stimuli. Abnormal Akt activation has been associated with the deve...
T29968 AMG-0347 UNII-CD7L9290QR TRP/TRPV Channel
AMG-0347 (UNII-CD7L9290QR) is a small molecule inhibitor targeting TRPA1(transient receptor potential ankyrin 1) ion channels, a receptor found in sensory neurons and involved in the detection of pain and environmental s...
T1627 Famotidine MK-208 Histamine Receptor
Famotidine (MK-208) is a propanimidamide and histamine H2-receptor antagonist with antacid activity. As a competitive inhibitor of histamine H2-receptors located on the basolateral membrane of the parietal cell, famotidi...
T14198 ALX-1393 GlyT
ALX-1393 is a selective GlyT2 inhibitor that effectively reduces neuronal action potential activity in a concentration-dependent manner and inhibits the activity of spontaneous networks by inducing glycinergic tetanic cu...
T35105 Way 100252 Way-100252,Way100252
Way 100252 inhibits evoked [3H]GABA release when tested against a number of release-inducing stimuli.
T35082 VU6010608 VU-6010608,VU 6010608
VU6010608 is an effective mGlu7 NAM with excellent CNS permeability and is powerful in electrophysiological studies in blocking long-term enhancement of high-frequency stimuli.
TP1608 PTD-p65-P1 Peptide
PTD-p65-P1 Peptide, a selective inhibitor of the nuclear transcription factor NF-kappaB, consists of a conjugation between a membrane-translocating peptide derived from antennapedia (PTD) and p65-P1. This composition eff...
TP1395 PTD-p65-P1 Peptide TFA
Ptd-p65-p1 Peptide TFA is a nuclear transcription factor nf-kappab inhibitor, consisting of a membrane transport Peptide sequence derived from antennapedia linked to p65-p1, selectively inhibiting nf-kappab activity indu...
T70581 CY208-243 Mandelate
CY208-243 is a D1 agonist. CY208-243 attenuates the pattern electroretinogram to low spatial frequency stimuli in the monkey. CY208-243 stimulates adenylate cyclase in rat striatal homogenates with an EC50 of 125 nM. CY...
T67212 Ligustrazine HCl
Ligustrazine Hydrochloride, is a natural substance discovered in the plant Ligusticum chuanxiong Hort. It inhibits platelet aggregation, improves atherosclerosis situation, protects endothelium injury, and has antithromb...
T26807 Bifeprunox Mesylate Bifeprunox,DU 127090,DU-127090,DU127090
Bifeprunox is a partial dopamine and serotonin agonist potentially for the treatment of schizophrenia. Bifeprunox suppresses in vivo VTA dopaminergic neuronal activity via D2 and not D3 dopamine autoreceptor activation. ...
TP2176 Amyloid A protein fragment [Homo sapiens] Others
Amyloid A proteins (H2N-Ala-Gly-Leu-Pro-Glu-Lys-Tyr-OH) are a family of apolipoproteins associated with high-density lipoprotein in plasma. Different isoforms of SAA are expressed constitutively at different levels or in...
T74779 JNJ-28583113
JNJ-28583113, a TRPM2 antagonist with brain permeability, inhibits the phosphorylation of GSK3α and β subunits, thereby protecting cells from oxidative stress-induced cell death. Additionally, it suppresses cytokine rele...
T36838 (R)-Bromoenol lactone
The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily...
T21750 A 784168
A-784168, a potent and orally active inhibitor of vanilloid receptor type 1 (TRPV1), acts on a ligand-gated nonselective cation channel pivotal in integrating pain stimuli including endogenous lipids, capsaicin, heat, an...
T79556 NDBM Autophagy
NDBM, a tumor-specific probe that targets Pim-1 kinase, exhibits heightened fluorescence upon binding and induces cytotoxicity, facilitating both cell screening and killing. It possesses targeted action on lysosomes and ...
T82771 CB2-H
CB2-H is a dual-channel fluorescent probe designed for the concurrent detection of HOCl and ONOO- with two separate channels that avoid spectral cross-interference. It facilitates dual-channel fluorescence imaging to mon...
T83749 Tertiapin LQ TFA TPNLQ
Tertiapin LQ, a peptide derivative of honeybee venom peptide tertiapin, acts as an inhibitor of inwardly rectifying potassium (Kir) channels. Specifically, it targets and inhibits heteromultimeric potassium channels, inc...
T38193 β-Endorphin (1-27) (human) (trifluoroacetate salt)
β-Endorphin (1-27) is an endogenous peptide that binds to μ-, δ-, and κ-opioid receptors (Kis = 5.31, 6.17, and 39.82 nM, respectively, in COS-1 cells expressing rat receptors). It binds to rat and mouse brain membrane p...
カタログ番号 製品名 別名 ターゲット
T2P2870 Damascenone trans-damascenone,Beta-Damascenone Others , NF-κB , Endogenous Metabolite
Damascenone (trans-damascenone) is a norisoprenoid ketone mainly found in red wines. It occurs naturally in tomato and grapes.
TN3460 Asebogenin Antifungal
Asebogenin is a compound fractionated from Salvia miltiorrhiza with antifungal activity, inhibition of GPVI-induced platelet reactions, and inhibition of NET formation induced by pro-inflammatory stimuli.
TN5131 Tetrahydrocannabivarin THCV,delta9-Tetrahydrocannabivarin,CRM,Tetrahydrocannavarin Cannabinoid Receptor
Tetrahydrocannabivarin (CRM) is a neutral cannabis receptor subtype (CB1) receptor antagonist, it can increases neural responding to rewarding and aversive stimuli, this effect profile suggests therapeutic activity in ob...
T32614 L-Clausenamide (-)-Clausenamide Microtubule Associated
L-Clausenamide is an alkaloid extracted from the leaves of the yellow bark (Clausena lansium (Lour) skeels) and can be used to improve cognitive function. L-Clausenamide inhibits beta-amyloid (Aβ) toxicity and prevents t...
T10109 3-Carene Delta-3-Carene COX , Antifungal

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPJ-00603 TL1A/TNFSF15 Protein, Mouse, Recombinant Mouse E. coli
Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor ...
TMPJ-01465 GM-CSF/CSF2 Protein, Human, Recombinant (E. coli) Human E. coli
Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of...
TMPY-04572 MKK4 Protein, Mouse, Recombinant (His & GST) Mouse Baculovirus Insect Cells
Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is...
TMPY-06981 IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli) Human E. coli
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proli...
TMPY-04396 C-ABL/ABL1 Protein, Human, Recombinant (GST) Human Baculovirus Insect Cells
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy...
TMPH-02856 SAAL1 Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Plays a role in promoting the proliferation of synovial fibroblasts in response to proinflammatory stimuli.
TMPH-02693 GNAI2 Protein, Mouse, Recombinant (His) Mouse E. coli
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhi...
TMPK-00696 PRAK/MAPKAPK5 Protein, Human, Recombinant (Strep-II) Human Baculovirus Insect Cells
The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in cellular responses to inflammatory stimuli and environmental stress. p38 regulated/activated protein kinase (PRAK, also known as mitogen-...
TMPJ-00839 ODC1 Protein, Human, Recombinant (His) Human E. coli
Ornithine decarboxylase (ODC1) is an enzyme which belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC1 is the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. ...
TMPH-03390 TRPV2 Protein, Rat, Recombinant (His) Rat E. coli
Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce phys...
TMPH-01665 TIMP3 Protein, Human, Recombinant (His) Human E. coli
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to ac...
TMPY-00924 SMAC Protein, Human, Recombinant (His) Human E. coli
Apoptosis is an essential processes required for normal development and homeostasis of all metazoan organisms. Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric p...
TMPK-01387 EPhA3 Protein, Canine, Recombinant (His) Canine HEK293 Cells
Erythropoietin‑producing hepatocellular carcinoma cell surface type‑A receptor 3 (EPHA3) has been found to promote the proliferation and survival of prostate cancer (PCa) cell lines and prostate tumor development in nude...
TMPJ-01109 EIF4EBP2 Protein, Human, Recombinant (His) Human E. coli
Eukaryotic Translation Initiation Factor 4E-Binding Protein 2 (EIF4EBP2) is a member of the Eukaryotic Translation Initiation Factor 4E Binding Protein Family. EIF4EBP2 regulates eIF4E activity by preventing its assembly...
TMPH-02118 SCN1A Protein, Human, Recombinant (His) Human E. coli
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective chann...
TMPY-03058 SLITL2/VASN Protein, Human, Recombinant (His) Human HEK293 Cells
Vasorin is a typical type I membrane protein. It contains 1 EGF-like domain, 1 fibronectin type-III domain, 10 LRR (leucine-rich) repeats, 1 LRRCT domain and 1 LRRNT domain. Vasorin is predominantly expressed in vascular...
TMPJ-00661 PDCD5 Protein, Human, Recombinant (His) Human E. coli
Programmed Cell Death Protein 5 (PDCD5) is a member of the PDCD5 family. PDCD5 is expressed in tumor cells during apoptosis, independent of apoptosis-inducing stimuli. This protein may function in the process of apoptosi...
TMPJ-00887 NFKB1 Protein, Human, Recombinant (His) Human E. coli
The 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radica...
TMPH-02669 GJA1 Protein, Mouse, Recombinant (His & Myc) Mouse Baculovirus Insect Cells
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one...
TMPJ-00402 CD117 Protein, Human, Recombinant (hFc) Human HEK293 Cells
C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to ...
TMPJ-00177 BAFF/TNFSF13B Protein, Human, Recombinant (Avi & hFc), Biotinylated Human HEK293 Cells
B-cell activating factor (BAFF), also known as BLyS, TALL-1, THANK, and TNFSF13B, is a transmembrane glycoprotein in the TNF ligand superfamily. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), T...
TMPJ-01385 CLEC4E Protein, Human, Recombinant (His) Human HEK293 Cells
C-Type Lectin Domain Family 4 Member E (CLEC4E) is a 219 amino acid single-pass type II membrane protein that contains one C-type Lectin domain. It is expressed in monocytes, CLEC4E functions as a downstream target of C/...
TMPY-01824 Caspase-14 Protein, Human, Recombinant (His) Human E. coli
Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses...
TMPY-04540 S6K1/RPS6KB1 Protein, Human, Recombinant (GST) Human Baculovirus Insect Cells
PS6K, also known as RPS6KB1, is a serine/threonine-protein kinase. It belongs to the RSK (ribosomal s6 kinase) family. Members of this family function in signal transduction. PS6K is an isoform of p70 ribosomal S6 kinase...
TMPY-01769 4EBP1 Protein, Human, Recombinant (His) Human E. coli
The translational suppressor eIF4E binding protein-1, 4E-BP1 functions as a key regulator in cellular growth, differentiation, apoptosis and survival. The Eif4ebp1 gene, encoding 4E-BP1, is a direct target of a transcrip...
TMPH-01532 IKBKB Protein, Human, Recombinant (E. coli, His) Human E. coli
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. A...
TMPH-01531 IKBKB Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. A...
TMPY-04542 CDK2 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinas...
TL1A/TNFSF15 Protein, Mouse, Recombinant
TMPJ-00603
Species: Mouse
Expression System: E. coli
GM-CSF/CSF2 Protein, Human, Recombinant (E. coli)
TMPJ-01465
Species: Human
Expression System: E. coli
MKK4 Protein, Mouse, Recombinant (His & GST)
TMPY-04572
Species: Mouse
Expression System: Baculovirus Insect Cells
IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)
TMPY-06981
Species: Human
Expression System: E. coli
C-ABL/ABL1 Protein, Human, Recombinant (GST)
TMPY-04396
Species: Human
Expression System: Baculovirus Insect Cells
SAAL1 Protein, Mouse, Recombinant (His & Myc)
TMPH-02856
Species: Mouse
Expression System: E. coli
GNAI2 Protein, Mouse, Recombinant (His)
TMPH-02693
Species: Mouse
Expression System: E. coli
PRAK/MAPKAPK5 Protein, Human, Recombinant (Strep-II)
TMPK-00696
Species: Human
Expression System: Baculovirus Insect Cells
ODC1 Protein, Human, Recombinant (His)
TMPJ-00839
Species: Human
Expression System: E. coli
TRPV2 Protein, Rat, Recombinant (His)
TMPH-03390
Species: Rat
Expression System: E. coli
TIMP3 Protein, Human, Recombinant (His)
TMPH-01665
Species: Human
Expression System: E. coli
SMAC Protein, Human, Recombinant (His)
TMPY-00924
Species: Human
Expression System: E. coli
EPhA3 Protein, Canine, Recombinant (His)
TMPK-01387
Species: Canine
Expression System: HEK293 Cells
EIF4EBP2 Protein, Human, Recombinant (His)
TMPJ-01109
Species: Human
Expression System: E. coli
SCN1A Protein, Human, Recombinant (His)
TMPH-02118
Species: Human
Expression System: E. coli
SLITL2/VASN Protein, Human, Recombinant (His)
TMPY-03058
Species: Human
Expression System: HEK293 Cells
PDCD5 Protein, Human, Recombinant (His)
TMPJ-00661
Species: Human
Expression System: E. coli
NFKB1 Protein, Human, Recombinant (His)
TMPJ-00887
Species: Human
Expression System: E. coli
GJA1 Protein, Mouse, Recombinant (His & Myc)
TMPH-02669
Species: Mouse
Expression System: Baculovirus Insect Cells
CD117 Protein, Human, Recombinant (hFc)
TMPJ-00402
Species: Human
Expression System: HEK293 Cells
BAFF/TNFSF13B Protein, Human, Recombinant (Avi & hFc), Biotinylated
TMPJ-00177
Species: Human
Expression System: HEK293 Cells
CLEC4E Protein, Human, Recombinant (His)
TMPJ-01385
Species: Human
Expression System: HEK293 Cells
Caspase-14 Protein, Human, Recombinant (His)
TMPY-01824
Species: Human
Expression System: E. coli
S6K1/RPS6KB1 Protein, Human, Recombinant (GST)
TMPY-04540
Species: Human
Expression System: Baculovirus Insect Cells
4EBP1 Protein, Human, Recombinant (His)
TMPY-01769
Species: Human
Expression System: E. coli
IKBKB Protein, Human, Recombinant (E. coli, His)
TMPH-01532
Species: Human
Expression System: E. coli
IKBKB Protein, Human, Recombinant (His)
TMPH-01531
Species: Human
Expression System: Baculovirus Insect Cells
CDK2 Protein, Human, Recombinant (His)
TMPY-04542
Species: Human
Expression System: Baculovirus Insect Cells
カタログ番号 製品名
L1400 MAPK Inhibitor Library

365 compounds
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;
L6710 Anti-Inflammatory Traditional Chinese Medicine Compound Library

1246 compounds
A collection of 1246 TCM monomers with anti-inflammatory activity or targeting molecular therapeutic targets in inflammation, a powerful tool for drug discovery and mechanism study;