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T11469 |
GSK-3484862
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DNA Methyltransferase
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GSK-3484862 is a non-covalent Dnmt1 inhibitor. It induces DNA hypomethylation to against cancer. |
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T77614 |
DpC
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Others
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DPC is an antitumor compound that inhibits cancer cell proliferation with an IC50 of 0.007-0.096 μM.DPC is involved in a variety of anticancer therapies and can be used in cancer research. |
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T8839 |
ICCB280
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Apoptosis
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Others
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ICCB280 was capable of inducing differentiation and apoptosis of ATRA-resistant patient blasts strongly signify that the activity of this compound can overcome resistance to other current therapies for AML with an unfavo... |
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T9498 |
BAY-8400
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DNA-PK
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BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase ( DNA-PK ) inhibitor ( IC 50 =81 nM) which shows synergistic efficacy in combination with targeted alpha therapies. BAY-8400 can be used for... |
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T3625 |
Bempedoic acid
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ETC1002,ESP-55016,ETC 1002,ETC-1002 |
ATP Citrate Lyase
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AMPK
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Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies. Bempedoic ... |
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T3579 |
PLX8394
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Raf
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PLX8394 is an orally active inhibitor of serine/threonine-protein kinase B-Raf (BRAF) protein. PLX8394 can selectively bind to and inhibit the activity of both wild-type and mutated forms of BRAF, then inhibit the prolif... |
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T27497 |
GSK-982
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GSK 982,GSK982 |
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GSK-982, an opioid receptor antagonist, has activity as potential therapies for obesity. |
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T40166 |
Bexirestrant
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Bexirestrant is an orally active ER-α degrader commonly employed in the research of antiestrogen and antineoplastic therapies. |
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T30236L |
Axelopran sulfate
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Axelopran sulfate is used in Oral Therapies for Opioid-induced Bowel Dysfunction in Patients with Chronic Noncancer Pain. |
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T71245 |
ARRY-502
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ARRY-502 is a CRTH2 antagonist. Regulation of cytokine activity is important in molecularly targeted therapies for asthma. |
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T71865 |
DSM43
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DSM43 is a dihydroorotate dehydrogenase (DHODH) inhibitor. Malaria puts at risk nearly half the world's population and causes high mortality in sub-Saharan Africa, while drug resistance threatens current therapies. The p... |
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T79340 |
GLS1 Inhibitor-7
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Glutaminase
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GLS1 Inhibitor-7 (compound 4d) serves as a GLS1 antagonist with an IC50 value of 46.7 μM, demonstrating potential applications in anticancer, antiaging, and antiobesity therapies [1]. |
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T70847 |
BMS-351
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BMS-351 is a potent and selective, nonsteroidal CYP17A1 lyase inhibitor with robust selectivity over steroidogenic CYPs 21A2 and 11B1. BMS-351 emerges as an outstanding preclinical candidate to treat CRPC and is likely t... |
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T69776 |
BAY-707 acetate
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BAY-707 is a substrate-competitive, highly potent and selective inhibitor of MTH1. Despite superior cellular target engagement and pharmacokinetic properties, inhibition of MTH1 with BAY-707 resulted in a clear lack of i... |
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T74337 |
DNA crosslinker 1 dihydrochloride
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DNA Crosslinker 1 (dihydrochloride) serves as a potent binder for the DNA minor groove, exhibiting a DNA binding affinity (ΔTm) of 1.1°C. This compound is utilized in research focused on anticancer therapies [1]. |
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T38910 |
MGluR2 antagonist 1
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mGluR2 antagonist 1 is a potent and selective class of negative allosteric modulator targeting the metabotropic glutamate receptor 2 (mGluR2) with high oral bioavailability. It displays a remarkable affinity for mGluR2, ... |
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T82296 |
GluN1(359-378)
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GluN1 (359-378) is an antibody targeting the N-methyl-D-aspartate receptor (NMDAR) capable of crossing the blood-brain barrier and is utilized in researching therapies for anti-NMDAR encephalitis that focus on the immune... |
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T79136 |
DGKζ-IN-1
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DGKζ-IN-1 (compound 9) is a DGKζ inhibitor with potential applications in cancer research, particularly for studying immunocyte activation and resistance to anti-PD-1/anti-PD-L1 antibody therapies [1]. |
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T79051 |
PCSK9-IN-15
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PCSK9-IN-15 (compound 5) is a potent inhibitor of proprotein convertase subtilisin/kexin 9 (PCSK9, K D <200 nM) that plays a crucial role in cholesterol metabolism by regulating blood levels of low-density lipoprotein ch... |
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T80578 |
Evunzekibart
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ATOR-1017 |
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Evunzekibart (ATOR-1017) is an Fc-γ receptor-dependent 4-1BB agonist and an IgG4 isotype antibody. It can function as a monotherapy or synergize with anti-PD1 therapies to promote anti-tumor effects. |
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T74879 |
306-N16B
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306-N16B is a lipid nanoparticle designed for the systemic co-delivery of Cas9 mRNA and sgRNA, facilitating the transport of mRNA to pulmonary endothelial cells. This compound is advantageous for research focused on geno... |
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T71578 |
Endoxifen mesylate
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Endoxifen, also known as N-desmethyl-4-hydroxytamoxifen, is a chemical that is under development for estrogen receptor-positive breast cancer. It is also being evaluated as an antipsychotic for treatment of mania and ot... |
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T70352 |
PH11
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PH11 is a novel Focal Adhesion Kinase (FAK) inhibitor. PH11 restores TRAIL apoptotic pathway in PANC-1 cells through down-regulation of c-FLIP via inhibition of FAK and the phosphatidylinositol-3 kinase (PI3K)/AKT path... |
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T68346 |
KRN383
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KRN383 also inhibited the proliferation of the ITD-positive cell lines with IC(50) values of < or =2.9 nM. A single oral administration of 80 mg/kg of KRN383 eradicated ITD-positive xenograft tumors in nude mice and prol... |
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T18522 |
PC Mal-NHS carbonate ester
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Others
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PC Mal-NHS carbonate ester is a cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1]. This chemical compound plays a crucial role in facilitating the conjugation of drugs to anti... |
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T30807 |
CG0009
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CG-0009,CG 0009 |
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CG0009 is a potent and highly selective glycogen synthase kinase 3 (GSK3) inhibitor that inhibitions proliferation, induces apoptosis, and activates the p53-Bax pathway in breast cancer cells through cyclin D1 depletion.... |
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T78528 |
ERX-41
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Others
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ERX-41 is an orally active, stereospecific small molecule that targets lysosomal acid lipase A (LIPA). It induces endoplasmic reticulum (ER) stress, leading to cell death independently of its LIPA activity yet reliant on... |
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T78520 |
CYT296
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Others
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CYT296 is a chromatin de-condensation agent that enhances the efficiency of induced pluripotent stem cell (iPSC) generation mediated by defined factors (OSKM) and promotes an open chromatin state in Mouse Embryonic Fibro... |
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T71467 |
Nemorubicin HCL
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Nemorubicin HCL is the salt form of Nemorubicin, also known as PNU152243A, a doxorubicin derivative that differs significantly from its parent drug in terms of spectrum of antitumor activity, metabolism and toxicity prof... |
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T72259 |
3-Chlorogentisyl alcohol
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3-Chlorogentisyl alcohol, characterized by its potent inhibitory action against E. coli β-glucuronidase with an IC(50) value of 0.74 µM and a K(i) value of 0.58 µM, demonstrates significant antiproliferative activity. Th... |
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T71206 |
Tiagabine-d6 hydrochloride
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Tiagabine-d6 is intended for use as an internal standard for the quantification of tiagabine by GC- or LC-MS. Tiagabine is an inhibitor of GABA transporter 1. It inhibits seizures induced by DMCM in mice. Tiagabine reduc... |
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T31828 |
AZD4694
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Flutafuranol,AZD 4694,NAV-4694,AZD-4694,NAV 4694,NAV4694 |
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Flutafuranol, also known as AZD 4694 and NAV4694, is a bio-active chemical. AZD4694 shows high affinity for beta-amyloid fibrils in vitro (K(d) = 2.3 +/- 0.3 nM). The fluorine-18 labeled AZD4694 may have potential for PE... |
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TMIH-0109 |
Bempedoic acid-d4
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Bempedoic acid-d4 is a deuterated compound of Bempedoic acid. Bempedoic acid has a CAS number of 738606-46-7. ETC-1002, also known as ESP-55016 and Bempedoic acid, is an orally available, once-daily LDL-C lowering small ... |
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T69831 |
RPR-200765A Mesylayte
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RPR-200765A is a potent and selective inhibitor of p38 MAP kinase (IC50 = 50 nM). It inhibits LPS-stimulated TNFalpha release both in vitro, from human monocytes (EC50 = 110 nM), and in vivo in Balb/c mice (ED50 = 6 mg/k... |
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T37736 |
N-cis-hexadec-9Z-enoyl-L-Homoserine lactone
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N-(2-oxotetrahydrofuran-3S-yl) Palmitoleyl Amide,N-cis-hexadec-9Z-enoyl-L-Homoserine lactone |
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Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm f... |
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T37741 |
N-hexadecanoyl-L-Homoserine lactone
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C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone |
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Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm fo... |
