keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 26,000 | |||
5 mg | 在庫あり | ¥ 66,000 | |||
10 mg | 在庫あり | ¥ 111,500 | |||
25 mg | 在庫あり | ¥ 178,500 | |||
50 mg | 在庫あり | ¥ 245,500 | |||
100 mg | 在庫あり | ¥ 328,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 59,500 |
説明 | Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells. |
In vitro | Sphondin inhibits IL-1beta-induced PGE(2) release in A549 cells;?this inhibition is mediated by suppressing of COX-2 expression, rather than by inhibiting COX-2 enzyme activity.?The inhibitory mechanism of sphondin on IL-1beta-induced COX-2 expression may be, at least in part, through suppression of NF-kappaB activity. Sphondin may have the therapeutic potential as an anti-inflammatory drug on airway inflammation[1]. |
In vivo | Sphondin, showed anti-proliferative activity and caused G2/M arrest at concentrations of 0.05-15.0 Μm[2]. |
植物由来 |
分子量 | 216.19 |
分子式 | C12H8O4 |
CAS No. | 483-66-9 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (138.77 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
sphondin 483-66-9 GPCR/G Protein Immunology/Inflammation Neuroscience Prostaglandin Receptor COX airway anti-inflammatory epithelial Cyclooxygenase pulmonary inflammation inhibit PGE2 A549 Inhibitor COX-2 inhibitor