検索結果

Search Results for " GDP "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

ライブラリー

カタログ番号	製品名	別名	ターゲット
T74041	GDP-L-fucose		Endogenous Metabolite
	GDP-L-fucose is a nucleotide sugar widely found in fungi and plants and is involved in both the slave and secondary remedial metabolic pathways.		Endogenous Metabolite
T7606	Guanosine 5'-diphosphate disodium salt	5'-GDP-Na2	Endogenous Metabolite
	Guanosine 5'-diphosphate disodium salt (5'-GDP-Na2) is a nucleoside diphosphate, is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulating the interleukin-6 (IL-6)/stat-3 pathway.		Endogenous Metabolite
T11382	GDP-α-D-mannose disodium		Others
	GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM).GDP-α-D-mannose disodium is the donor substrate for mannosy...		Others
T11383	GDP366		Survivin
			Survivin
T74042	GDP-L-fucose disodium
	GDP-L-fucose disodium, a nucleotide sugar, serves as a crucial substrate for fucose oligosaccharides biosynthesis by providing the fucose moiety. Its formation follows two metabolic pathways: the primary de novo pathway ...
T72120	Guanosine 5'-diphosphate sodium	GDP sodium
	Guanosine 5'-diphosphate (GDP) sodium is a nucleoside diphosphate known for activating the adenosine 5'-triphosphate-sensitive K+ channel and serving as a potential iron mobilizer by inhibiting the hepcidin-ferroportin i...
T8684	Sotorasib	AMG-510	Ras
	Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Sotorasib ...		Ras
T8369	Adagrasib	MRTX849	Ras
	Adagrasib (MRTX849) is an orally active and selective covalent inhibitor of KRAS G12C. Adagrasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Adagrasib ...		Ras
T31919	Gdpflrfamide	Gly-asp-pro-phe-leu-arg-phe-amide
	Gdpflrfamide is a neuropeptide that existed in the snail Lymnaea stagnalis.
T9198	SCH54292		Ras
	SCH-54292 is a GDP exchange inhibitor.		Ras
T8930	CID44216842	KUC103479N-02	CDK , Ras
	CID44216842 (KUC103479N-02) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC50s for Cdc42 WT...		CDK , Ras
T40192	DGTP	2'-Deoxyguanosine-5'-triphosphate	Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
	dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.		Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
T69529	BI-0474		Ras
	BI-0474 is a potent KRASG12C inhibitor that inhibits GDP-KRAS::SOS1 protein-protein interactions with an IC50 value of 7.0 nM.BI-0474 exhibits significant antiproliferative activity against NCI-H358 cells harboring the G...		Ras
T13983	0990CL		cAMP , Others
	0990CL is an effective heterotrimer Gαi subunit specific inhibitor, which can interact with purified Go± in GDP-bound state, and can block α2AR mediated cAMP regulation. In the cell model, low concentration of 0990CL cou...		cAMP , Others
T38170	RMC-0331	RM-023	Raf
	RMC-0331 (RM-023) is an orally available and potent SOS1 inhibitor.RMC-0331 has potential anticancer activity, blocking RAS activation by disrupting RAS-SOS1 interactions.		Raf
T7414	ARS-853		Apoptosis , Raf , Ras
	ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells		Apoptosis , Raf , Ras
T15485	HJC0197		cAMP , Ras
	HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 is an effective exchange protein. Which straightly activated by cAMP (Epac) antagonist (IC50=5.9 μM for Epac2).		cAMP , Ras
T64537	Guanosine 5′-diphospho-β-L-fucose sodium salt
	GDP-β-L-fucose is a metabolite in plant and animal. It used for microbe agglutination assay and agglutination inhibition assay. GDP-β-L-fucose is formed by the oxidation-reduction and epimerization of GDP-R-D-mannose in ...
T64000	MRTX-EX185
	MRTX-EX185 is an effective inhibitor of GDP-loaded KRAS and KRAS (G12D) with an IC50=90 nM for KRAS (G12D). MRTX-EX185 is also capable of binding GDP-loaded HRAS.
T75247	Mannose 1-phosphate
	Mannose 1-phosphate, an endogenous metabolite, serves as a substrate for the enzyme GDP-mannose pyrophosphorylase to synthesize GDP-Man [1].
T26394	6-Alkynyl-fucose	6-Alk-Fuc
	6-Alkynyl-fucose, a widely used fucosylation probe, acts by strongly inhibiting fucosylation and GDP-fucose synthetase FX and halting hepatoma invasion.
T63201	SOS1 activator 1
	SOS1 activator 1 is an activator of SOS1-mediated nucleotide exchange (Kd: 44 nM).SOS1 is a guanine nucleotide exchange factor that binds to Ras proteins and catalyzes the exchange of GDP for GTP on RAS, resulting in the...
T83817	Isoguanosine-5'-O-diphosphate sodium	isoGDP
	Isoguanosine-5'-O-diphosphate (isoGDP), an isomer of GDP and a phosphorylated variant of crotonoside, acts as a mitochondrial ATPase inhibitor, demonstrating effectiveness at a concentration of 3 µM (IC50 = 3 µM).
T75420	Alpha-1,3/4-Fucosyltransferase (α1,3/4FucT)
	alpha-1,3/4-Fucosyltransferase (α1,3/4FucT) (Hp3/4FT) can be found in Helicobacter pylori . alpha-1,3/4-Fucosyltransferase (α1,3/4FucT) catalyzes fucose transfer from donor GDP-beta-l-fucose to the GlcNAc [1] .
T80148	GRP (14-27) (human, porcine, canine)		Bombesin Receptor
	GRP (14-27) (human, porcine, canine) functions as a ligand for bombesin receptors, with its specific binding being inhibited by GTP and GDP, while GMP does not affect it [1].		Bombesin Receptor
T63927	KRAS G12C inhibitor 25
	KRAS G12C inhibitor 25 is an inhibitor of KRAS G12C. KRAS G12C inhibitor 25 inhibits the SOS1-assisted GDP/GTP exchange activity of KRAS-G12C mutants with an IC50 value of 0.48 nM.
T37154	7-Methylguanosine 5'-diphosphate sodium
	7-Methylguanosine 5’-diphosphate (7-Methyl-GDP) sodium, a cap analog, is utilized in the synthesis of mRNA cap analogues[1].
T82329	GDI2-IN-1
	GDI2-IN-1 (compound (+)-37), a GDP-dissociation inhibitor beta (GDI2) inhibitor, demonstrates potent inhibitory activity with an IC50 of 2.87 μM and a K D of 36 μM, and exhibits excellent in vivo antitumor efficacy in pa...
T38411	KRA-533
	KRA-533, a potent KRAS agonist, directly targets the GTP/GDP binding pocket within the KRAS protein, inhibiting GTP cleavage. This inhibition leads to the buildup of constitutively active GTP-bound KRAS, which subsequent...
T79928	Phosphomannose isomerase
	Phosphomannose isomerase, the initial enzyme in GDP-Man biosynthesis, catalytically facilitates the interconversion of fructose-6-phosphate (Fru6P) and mannose-6-phosphate (Man6P), playing a crucial role in cell wall syn...
T36740	Guanosine 5’-diphosphate (sodium salt hydrate)
	Guanosine 5’-diphosphate (GDP) is a purine nucleotide and biosynthetic precursor of guanosine 5’-triphosphate .1It has been used to study the conformations of GTPases.2GDP (100 μM) activates sulfonylurea receptor 2B (SUR...
T37422	Ras Inhibitory Peptide
	Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to t...

Compounds

GDP-L-fucose

T74041

Synonym:

Target: Endogenous Metabolite

Guanosine 5'-diphosphate disodium salt

T7606

Synonym: 5'-GDP-Na2

Target: Endogenous Metabolite

GDP-α-D-mannose disodium

GDP366

GDP-L-fucose disodium

T74042

Synonym:

Target:

Guanosine 5'-diphosphate sodium

T72120

Synonym: GDP sodium

Synonym: Gly-asp-pro-phe-leu-arg-phe-amide

Synonym: KUC103479N-02

Target: CDK, Ras

dGTP

T40192

Synonym: 2'-Deoxyguanosine-5'-triphosphate

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Target: Apoptosis, Raf, Ras

Guanosine 5′-diphospho-β-L-fucose sodium salt

Isoguanosine-5'-O-diphosphate sodium

T83817

Synonym: isoGDP

Target:

alpha-1,3/4-Fucosyltransferase (α1,3/4FucT)

T75420

Synonym:

Target:

GRP (14-27) (human, porcine, canine)

T80148

Synonym:

Target: Bombesin Receptor

KRAS G12C inhibitor 25

T63927

Synonym:

Target:

7-Methylguanosine 5'-diphosphate sodium

Phosphomannose isomerase

T79928

Synonym:

Target:

Guanosine 5’-diphosphate (sodium salt hydrate)

T36740

Synonym:

Target:

Ras Inhibitory Peptide

T37422

Synonym:

Target:

カタログ番号	製品名	別名	ターゲット
T7210	Guanosine 5'-diphosphate	GDP	Endogenous Metabolite
	Guanosine 5'-diphosphate (GDP) as Potential Iron Mobilizer, Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway.		Endogenous Metabolite
T65209	GDP-D-mannose disodium
	GDP-D-mannose disodium is a natural product for research related to life sciences and the catalog number is T65209.

天然物製品

Guanosine 5'-diphosphate

T7210

Synonym: GDP

Target: Endogenous Metabolite

GDP-D-mannose disodium

T65209

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-01111	TSTA3 Protein, Human, Recombinant (His)	Human	E. coli
	GDP-L-Fucose Synthase is a NADP(H)-binding protein. It catalyzes the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-dexoymannose to GDP-L-fucose. GDP-L-Fucose is the...
TMPH-01994	GDI2 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. GDI2 Protein, Human, Recombinant (His) is expressed in yeast with N...
TMPY-03122	GBP2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	GBP-2 belongs to the guanylate-binding protein (GBP) family. GBPs are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP). As GTPases induced by IFN-gamma (Interferon-inducible GTP...
TMPH-01209	DENND1A Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulat...
TMPY-02439	Rac2 Protein, Human, Recombinant (His)	Human	E. coli
	Ras-related C3 botulinum toxin substrate 2 (Rac2) is a small G-protein belonging to the Ras subfamily of the GTPase family. Rac2 acts as an "on / off" switch for signal transduction cascades and motilities. When GDP is a...
TMPY-04311	RAB11B Protein, Human, Recombinant (His)	Human	HEK293 Cells
	The two recurrent dominant mutations in RAB11B leading to a neurodevelopmental syndrome, likely caused by altered GDP/GTP binding that inactivate the protein and induce GEF binding and protein mislocalization.
TMPJ-01257	PMM1 Protein, Human, Recombinant (His)	Human	E. coli
	Phosphomannomutase 1 (PMM1) blongs to the eukaryotic PMM family. Phosphomannomutase 1 can catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. G...
TMPH-02694	GNG12 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GD...
TMPY-02805	GNGT1 Protein, Human, Recombinant (His)	Human	E. coli
	GNGT1 is a subunit of transducin. Heterotrimeric G proteins consist of alpha, beta, and gamma subunits. They are membrane-bound GTPases that are linked to 7-TM receptors. They function as signal transducers for the 7-tra...
TMPY-03611	PMM2 Protein, Human, Recombinant (His)	Human	E. coli
	Phosphomannomutase 2, also known as PMM2 and CDG1, belongs to the eukaryotic PMM family. Phosphomannomutase 2 catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate. Mannose 1-phosphate is a precursor ...
TMPH-01285	EEF1D Protein, Human, Recombinant (His)	Human	E. coli
	EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; Regulates induction of heat-shock-responsive g...
TMPH-03445	GSP1 Protein, S. cerevisiae, Recombinant (His)	Saccharomyces cerevisiae	P. pastoris (Yeast)
	GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Essential for cell viability. By analogy with Ras, Ran may be activated when GTP i...
TMPH-01553	GBP2 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to aut...
TMPH-02020	RGS17 Protein, Human, Recombinant (GST)	Human	E. coli
	Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G pro...
TMPH-01207	DOCK8 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally a...
TMPY-02802	GNG13 Protein, Human, Recombinant (His)	Human	E. coli
	GNG13 is a subunit of heterotrimeric G proteins which consist of alpha, beta, and gamma subunits. Heterotrimeric G proteins are membrane-bound GTPases that are linked to 7-TM receptors. They function as signal transducer...
TMPH-02334	RAB12 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bou...
TMPH-02623	DOCK8 Protein, Mouse, Recombinant (His)	Mouse	P. pastoris (Yeast)
	Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally a...
TMPH-02622	DOCK8 Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally a...
TMPY-03747	Fucose Mutarotase Protein, Human, Recombinant (His)	Human	E. coli
	FUOM, also known as fucose mutarotase and FucM, belongs to the RbsD / FucU family. FUOM is involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose has two isforms: alpha-L-fucose (29.5%) and beta-L-fu...
TMPJ-01126	RheB Protein, Human, Recombinant (GST)	Human	E. coli
	GTP-Binding Protein Rheb (RHEB) is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. Highest levels of RHEB can be foun...
TMPY-03500	ARL2BP Protein, Human, Recombinant (His)	Human	E. coli
	ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. ARL2BP binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activ...
TMPY-03430	RheB Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	RHEB is a recently discovered member of the Ras superfamily that may be involved in neural plasticity. This function is novel and not typically associated with the Ras proteins. RHEB gene is a member of the small GTPase ...
TMPY-03608	EEF1B2 Protein, Human, Recombinant (His)	Human	E. coli
	EF1B, also known as EEF1B2, is a translation elongation factor. It belongs to the EF-1-beta/EF-1-delta family. Elongation factors are a set of proteins that are used in protein synthesis in the cell. In the ribosome, the...
TMPY-01187	Rac1 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	RAC1 is a GTPase that belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal re...
TMPH-01524	KPNA1 Protein, Human, Recombinant (His)	Human	E. coli
	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate com...
TMPY-03487	NRAS Protein, Human, Recombinant (His)	Human	E. coli
	NRAS was discovered by researchers at the Institute of Cancer Research, funded by the Cancer Research Campaign (now Cancer Research UK). NRAS gene is a member of the Ras gene family. It is mapped on chromosome 1, and it ...
TMPY-01958	RhoA Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Transforming protein RhoA, also known as Rho cDNA clone 12, Ras homolog gene family member A, RHOA and ARH12, is a cell membrane and cytoplasm protein that belongs to the small GTPase superfamily and Rho family. The Rho ...
TMPY-02220	HRAS Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	HRas, also known as HRAS, belongs to the small GTPase superfamily, Ras family, and is widely expressed. It functions in signal transduction pathways. HRas can bind GTP and GDP, and they have intrinsic GTPase activity. It...
TMPH-02873	RAB10 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bou...