|
T1734 |
Rabeprazole Sulfide
|
Rabeprazole Related Compound E |
Proton pump
,
Antibacterial
|
|
Rabeprazole Sulfide (Rabeprazole Related Compound E) is an antiulcer drug in the class of proton pump inhibitors. |
|
T6928 |
Pantoprazole
|
SKF96022,BY1023 |
Apoptosis
,
Proton pump
,
Autophagy
|
|
Pantoprazole (BY1023) is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. |
|
T0161 |
Pantoprazole Sodium Hydrate
|
SKF96022 sodium hydrate,BY1023 (sodium hydrate),SKF96022 (sodium hydrate) |
Apoptosis
,
Potassium Channel
,
Proton pump
,
Autophagy
|
|
Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. |
|
T6929 |
Pantoprazole sodium
|
Pantecta,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),BY-1023 sodium,Pantoloc |
Apoptosis
,
Others
,
Proton pump
,
HIF
,
Autophagy
|
|
Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, weak base that crosses the parietal cell membrane and enters... |
|
T17030 |
Tegoprazan
|
|
ATPase
,
Proton pump
|
|
Tegoprazan is a potassium-competitive acid blocker and is a potent, oral active, and highly selective inhibitor of gastric H+/K+-ATPase. That could control gastric acid secretion and motility (IC50: ranging from 0.29-0.5... |
|
T2404 |
Vonoprazan fumarate
|
TAK-438 |
ATPase
|
|
Vonoprazan fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase. |
|
T21254 |
Vonoprazan Fumarate
|
TAK-438,TAK 438,Vonoprazan Fumurate,TAK438 |
Proton pump
|
|
Vonoprazan Fumarate (TAK438) , a novel potassium-competitive acid blocker, inhibits gastric acid secretion. Vonoprazan Fumarate (TAK438) inhibited H+,K+-ATPase activity in porcine gastric microsomes with IC50 value of 19... |
|
T16865 |
SCH28080
|
|
ATPase
,
Proton pump
|
|
SCH28080 is a reversible and K+-competitive inhibitor of gastric H+/K+-ATPase with an IC50 value of 20 nM (rabbit microsomal membrane).SCH28080 is a potent inhibitor of acid secretion in vivo with anti-ulcer activity, an... |
|
T10435 |
Linaprazan
|
AZD0865 |
Potassium Channel
|
|
|
|
T28136 |
NC-1300-B
|
NC1300B,NC 1300 B |
ATPase
|
|
NC-1300-B inhibits H(+)-K(+)-ATPase and is used in the study of gastric ulcers. |
|
T9553 |
8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid
|
|
Others
|
|
8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-car is a H+/K+ ATPase inhibitor with IC50 of 0.38μM. |
|
T27812 |
Leminoprazole
|
|
ATPase
|
|
Leminoprazole is an orally available H+,K(+)-ATPase inhibitor that protects gastric mucosal cells from various cellular damages. |
|
T19826 |
Rabeprazole
|
LY307640 |
Potassium Channel
,
STAT
|
|
Rabeprazole (LY307640) is an H+/K+-ATPase inhibitor that inhibits cell proliferation in gastric epithelial cells by targeting STAT3-mediated glycolysis and can be used in the study of gastric ulcers. |
|
T13159 |
Tiludronate disodium
|
Tiludronic Acid disodium,Tiludronic acid disodium |
ATPase
|
|
Tiludronate disodium (Tiludronic acid disodium) is an osteoclast vacuolar H(+)-ATPase inhibitor with antiresorptive and anti-inflammatory properties. Tiludronate disodium can be used in studies about metabolic bone disor... |
|
T27371 |
FR-167356
|
FR167356,FR 167356 |
ATPase
|
|
FR-167356 is a specific inhibitor of a3 isoform vacuolar type H⁺-ATPase with IC50s of 170 nM, 370 nM and 220 nM for osteoclast plasma membranes, renal brush border membranes and macrophage microsomes. FR-167356 reduces b... |
|
T1651 |
Rabeprazole sodium
|
Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,Rebeprazole sodium,Aciphex Sodium |
Apoptosis
,
Proton pump
|
|
Rabeprazole sodium (Habeprazole Sodium) is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. The drug inhibits H(+)-K(+)-exch... |
|
T1756 |
Ilaprazole sodium
|
IY-81149 sodium |
Proton pump
,
TOPK
|
|
Ilaprazole sodium (IY-81149 sodium) , a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor. A weak base, Ilaprazole accumulates in the acidic environment of the secretory canaliculus... |
|
T20714 |
Levolansoprazole
|
(S)-Lansoprazole,(-)-Lansoprazole |
Proton pump
|
|
Levolansoprazole ((S)-Lansoprazole), a proton pump inhibitor, irreversibly inhibits H+/K+-stimulated ATPase pumps in parietal cells (IC50: 5.2 μM). It also inhibits acid formation in isolated canine parietal cells (IC50:... |
|
T11191 |
EN6
|
|
Proton pump
,
Autophagy
|
|
EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative ... |
|
T1756L |
Ilaprazole
|
IY81149,IY 81149,IY-81149 |
Proton pump
,
TOPK
|
|
Ilaprazole (IY-81149) is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also showed that Ilaprazole significantly prevented the developm... |
|
T8388 |
Vonoprazan
|
TAK-438 (free base) |
Proton pump
|
|
Vonoprazan (TAK-438 (free base)) is an orally active potassium-competitive acid blocker.Vonoprazan can be used for the treatment of gastroduodenal ulcer and reflux esophagitis |
|
T10221 |
Abeprazan hydrochloride
|
DWP14012 hydrochloride,Fexuprazan hydrochloride |
Proton pump
|
|
Abeprazan hydrochloride (Fexuprazan hydrochloride) is an effective reversible potassium-competitive acid blocker with oral activity, inhibiting H+, K+ -atPase by competitive binding to potassium ions without acid activat... |
|
T0674 |
Lansoprazole
|
A-65006,AG-1749 |
Proton pump
,
Phospholipase
,
Antibacterial
|
|
Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is fo... |
|
T2686 |
Esomeprazole Magnesium
|
(S)-Omeprazole magnesium,NEXIUM,(-)-Omeprazole magnesium |
ATPase
,
Proton pump
|
|
Esomeprazole Magnesium (NEXIUM) is the S-isomer of omeprazole, can reduce gastric acid secretion with selective and irreversible proton pump inhibitor activity.Esomeprazole magnesium acts as an exosome inhibitor by block... |
|
T8386 |
Esomeprazole Magnesium trihydrate
|
(S)-Omeprazole magnesium trihydrate |
Proton pump
|
|
Esomeprazole Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a proton pump inhibitor indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagit... |
|
T2686L |
Esomeprazole Sodium
|
(S)-Omeprazole sodium |
ATPase
,
Proton pump
|
|
Esomeprazole Sodium ((S)-Omeprazole sodium) is the S-isomer of omeprazole with selective and irreversible proton pump inhibitor activity.Esomeprazole acts as an exosome inhibitor by blocking the exosome release via the i... |
|
T0825 |
Ebselen
|
SPI-1005,PZ-51,CCG-39161 |
Phosphatase
,
Virus Protease
,
Calcium Channel
,
COX
,
HIV Protease
|
|
Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced b... |
|
T2093 |
PF 03716556
|
PF-3716556 |
ATPase
|
|
PF 03716556 (PF-3716556) , an effective and specific P-CAB (potassium-competitive acid blocker), is utilized for the treatment of gastroesophageal reflux disease. |
|
T12471 |
Picoprazole
|
|
Others
|
|
Picoprazole is a specific H+/K+-ATPase inhibitor (IC50 of 3.1±0.4 μM). |
|
T69455 |
NIK-12192
|
|
|
|
NIK-12192 is an indole derivative and inhibitor of vacuolar-H(+)-ATPase. |
|
T12822 |
S3337
|
|
Others
|
|
S3337 is an inhibitor of H+, K+-ATPase |
|
T16894 |
SKF96067
|
|
Others
|
|
SKF96067 is a reversible gastric H+/K+-ATPase inhibitor. |
|
T26450 |
A 80915A
|
A80915A,A-80915A |
|
|
A 80915A is A semi-naphthoquinone antibiotic from Streptomyces aculeolatus. It is a potent inhibitor of gastric (H(+)-K+)-ATPase. Inhibition by A80915A is dependent on the conformation of gastric (H(+)-K+)-ATPase, potass... |
|
T28563 |
Ro 18-5364
|
Ro-18-5364,Ro 185364 |
|
|
Ro 18-5364 is a potent inhibitor of the gastric (H+ + K+)-ATPase with an apparent Ki of 0.1 μM at pH 6. |
|
T12977 |
Soraprazan
|
BYK61359 |
Others
|
|
Soraprazan is a reversible, and fast-acting gastric H+/K+ ATPase inhibitor. |
|
T20660 |
Revaprazan
|
SB-641257,SB 641257,SB641257 |
|
|
Revaprazan is a novel, selective potassium-competitive acid blocker, to be specific, it reversibly inhibits gastric H(+)/K(+)-ATPase and shows effective acid suppression comparable to PPIs. |
|
T27092 |
CS-526
|
R-105266,R 105266,R105266 |
|
|
CS-526 is a proton pump inhibitor. The inhibitory mechanism of CS-526 on H+,K+-ATPase was a competitive antagonism to the K+ binding site of H+,K+-ATPase, and it was also a reversible inhibition. CS-526 has a potent anti... |
|
T23685 |
AHR-9294
|
|
|
|
AHR-9294 is a novel inhibitor of H, K-ATPase. It also antagonizes gastric HCl secretion in vivo. |
|
T30250 |
AZD0865
|
AZD-0865,AZD 0865 |
|
|
AZD0865 is an effective drug that inhibits gastric H(+), K(+) -ATPase activity and acid formation in vitro, with rapid onset. |
|
T28609 |
Rohitukine
|
NSC623611,NSC-623611,NSC 623611 |
|
|
Rohitukine is an anti-cancer agent. It modulates apoptosis pathways through gastrin antagonism and H(+) K (+)-ATPase inhibition. Rohitukine ia an antiadipogenic, antidyslipidemic, gastroprotective, antifertility, and ant... |
|
T69801 |
AU-461
|
|
|
|
AU-461 is a gastric H(+)/K(+) ATPase inhibitor which acts as an anti-ulcer agent. |
|
T36530 |
Pantoprazole sulfone
|
|
|
|
Pantoprazole sulfone is a metabolite of the gastric H+/K+ ATPase pump inhibitor pantoprazole . Pantoprazole is metabolized by the cytochrome P450 (CYP) isoforms CYP2C19 and CYP3A4 to form pantoprazole sulfone. |
|
T76374 |
SPAI-1
|
|
|
|
SPAI-1, a peptide isolated from porcine duodenum, serves as a specific inhibitor to monovalent cation transporting ATPases, effectively inhibiting Na+, K+-ATPase and H+, K+-ATPase while stimulating Mg2+-ATPase in vitro [... |
|
T10221L |
Abeprazan
|
DWP14012 |
Others
|
|
Abeprazan (DWP14012) is a potassium-competitive acid blocker and it is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases[1]. Abeprazan inhibits H+, K+- ATPase by rev... |
|
T37247 |
Pantoprazole Sulfide
|
|
|
|
Pantoprazole sulfide is a metabolite of the gastric H+/K+ ATPase pump inhibitor pantoprazole . Pantoprazole is metabolized by the cytochrome P450 (CYP) isomers CYP2C19 and CYP3A4 to form pantoprazole sulfide. |
|
T28156 |
Nepaprazole
|
TY-11345,TY11345,TY 11345 |
|
|
Nepaprazole is a proton pump inhibitor. TY-11345 potently inhibited H+/K(+)-ATPase activity in isolated rabbit gastric mucosal microsomes, and the inhibitory effect was enhanced under weak acid conditions, the IC50 being... |
|
T72812 |
(R)-Tegoprazan
|
|
|
|
(R)-Tegoprazan, a benzimidazole derivative, serves as a potent inhibitor of kidney H+/K+-ATPase, demonstrating significant efficacy with an IC50 of 98 nM against canine kidney Na+/K+-ATPase. This compound shows promise f... |
|
T61740 |
Esomeprazole hemistrontium
|
|
|
|
Esomeprazole hemistrontium, also known as (S)-Omeprazole, is a potent and orally active proton pump inhibitor that effectively reduces acid secretion by inhibiting the H+, K+-ATPase in gastric parietal cells. This compou... |
|
T61445 |
Tenatoprazole sodium
|
|
|
|
Tenatoprazole sodium (TU-199 sodium) is a potent proton pump inhibitor that effectively suppresses the activity of hog gastric H+/K+-ATPase, a vital enzymatic pump involved in acid secretion. It achieves this inhibition ... |
|
T62316 |
P-CAB agent 1
|
|
|
|
P-CAB agent 1 (compound B19) is a potassium-competitive acid blocker that acts on H+/K+-ATPase (IC50: 60.50 nM). P-CAB agent 1 can be used in the study of acid-related diseases (ARDs). |
