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Search Results for " MMP-7 "

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T72069	MMP-9-IN-7
	Acetamide, N-[2-[(5-chloro-2 methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]-inhibits pro-matrix metalloproteinase activation and can be used to prevent, treat or ameliorate MMP9 and/or MMP13-mediated syndromes.
T78181	MMP-7-IN-2		MMP , Others
	MMP-7-IN-2 acts as a selective and potent MMP7 inhibitor and can be used to study inflammatory responses and vascular-related diseases.		MMP , Others
T21806	HNHA		HDAC
	HNHA is an inhibitor of HDAC.		HDAC
T81778	MMP-7-IN-3		MMP
	MMP-7-IN-3 is a potent, selective MMP-7 inhibitor that effectively suppresses the progression of kidney fibrosis in a mouse model with unilateral ureteral obstruction [1].		MMP
T6885	Marimastat	BB2516,KB-R8898,TA2516	MMP
	Marimastat (BB2516) (BB-2516) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor. MMP-9 (IC50=3 nM), MMP-1 (IC50=5 nM), MMP-2 (IC50=6 nM), MMP-14 (IC50=9 nM)and MMP-7 (IC50=13 nM).		MMP
T14322	ARP-100	MMP-2 Inhibitor III	MMP
	ARP-100 (MMP-2 Inhibitor III) is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with the S1' pocket of MMP-2 and exhibits anti-invasive properties in an in vitro invasion ...		MMP
T36712	BPHA	MMP-2/MMP-9 Inhibitor II	MMP
	BPHA (MMP-2/MMP-9 Inhibitor II) is a potent, selective and orally active inhibitor of MMP-2, MMP-9 and MMP-14 with IC50s of 12 nM, 16 nM and 17 nM, respectively.BPHA does not inhibit MMP-1, -3 and -7 (IC50s of 974, >1000...		MMP
T6011	Batimastat	BB94	MMP
	Batimastat (BB94) (BB-94) is an effective, broad-spectrum matrix metalloprotease (MMP) inhibitor. Batimastat induces extracellular matrix degradation and inhibits angiogenesis, tumor growth and invasion, and metastasis.		MMP
TP1501L	CTTHWGFTLC, CYCLIC acetate(244082-19-7 free base)		MMP
	CTTHWGFTLC, CYCLIC acetate is an inhibitor for matrix metalloproteinases (MMP)-2 and MMP-9. It is also called type IV collagenase or gelatinase. Gelatinases are potential targets of therapeutic intervention in cancer, an...		MMP
T10461	Batimastat sodium salt	BB-94 sodium salt	MMP
			MMP
T36363	Dnp-RPLALWRS (trifluoroacetate salt)
	Dnp-RPLALWRS is a fluorogenic substrate for matrix metalloproteinase-7 (MMP-7). The activity of MMP-7 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-t...
T83759	MMP-3 Fluorogenic Substrate TFA	Mca-RPKPVE-Nval-WR-K(Dnp)-NH2,Matrix Metalloproteinase-3 Fluorogenic Substrate,Stromelysin-1 Fluorogenic Substrate
	MMP-3 Fluorogenic Substrate, a compound designed for matrix metalloproteinase-3 (MMP-3) activity quantification, releases 7-methoxycoumarin-4-acetyl (Mca) upon MMP-3 cleavage. Mca's fluorescence, with excitation and emis...
T37025	Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2	Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2
	Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14). Upon cleavage by MMP-14, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify MMP a...
T81777	MMP-9-IN-8
	MMP-9-IN-8 (Compound 3), an MMP-9 inhibitor, exhibits inhibitory activities of 42.16% at 10 μM and 58.28% at 50 μM. Additionally, MMP-9-IN-8 demonstrates anti-cancer properties, inducing apoptosis in MCF-7 cells with an ...
T37983	GM 1489
	GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. It reduces 5-aza-2'-deoxycytidine-induc...
T41079	MMP13-IN-2	MMP13-IN-2
	MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over...
T83708	Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA	Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 (Dpa = N-3-(2,4-dinitrophenyl)l-α,β-diaminopropionyl),FS-6
	Mca-KPLGL-Dap(Dnp)-AR-NH2 serves as a fluorogenic substrate specifically designed for matrix metalloproteinases (MMPs). This compound facilitates the quantification of MMP activity by releasing 7-methoxycoumarin-4-acetyl...
T36844	Inostamycin A
	Inostamycin A is a bacterial metabolite that has been found inStreptomycesand has anticancer activity.1It is an inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase (IC50= 0.02 μg/ml in A431 cell membranes)...

Compounds

Target: MMP, Others

Synonym: BB2516,KB-R8898,TA2516

Target: MMP

ARP-100

T14322

Synonym: MMP-2 Inhibitor III

Target: MMP

BPHA

T36712

Synonym: MMP-2/MMP-9 Inhibitor II

CTTHWGFTLC, CYCLIC acetate(244082-19-7 free base)

TP1501L

Synonym:

Target: MMP

Batimastat sodium salt

T10461

Synonym: BB-94 sodium salt

Target: MMP

Dnp-RPLALWRS (trifluoroacetate salt)

T36363

Synonym:

Target:

MMP-3 Fluorogenic Substrate TFA

T83759

Synonym: Mca-RPKPVE-Nval-WR-K(Dnp)-NH2,Matrix Metalloproteinase-3 Fluorogenic Substrate,Stromelysin-1 Fluorogenic Substrate

Target:

Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2

T37025

Synonym: Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2

Synonym: MMP13-IN-2

Target:

Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA

T83708

Synonym: Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 (Dpa = N-3-(2,4-dinitrophenyl)l-α,β-diaminopropionyl),FS-6

カタログ番号	製品名	別名	ターゲット
T4115	Auraptene	7-geranyloxycoumarin	MMP , BACE
	Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits le...		MMP , BACE
T5S1026	Apigenin-7-glucuronide	Apigenin 7-O-glucuronide	MMP
	Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) possesses multiple activities, including antioxidant, anti-inflammatory, and aldose reductase inhibitory activities, it can inhibit MMP activities (IC50s: 12.87, 22.39, 1...		MMP
T3850	Luteolin 7-O-glucuronide	Luteolin-7-glucuronide	MMP
	Luteolin 7-O-glucuronide (Luteolin-7-glucuronide) possesses antioxidant activities.		MMP
T5S0045	Isofraxidin	6,8-Dimethoxyumbelliferone,Phytodolor	MMP , ERK , p38 MAPK , TLR , COX
	1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the prote...		MMP , ERK , p38 MAPK , TLR , COX
T3729	Ethyl gallate	Nipagallin A,Phyllemblin,gallic acid ethyl ester	MMP , NF-κB , Akt , Antibacterial
	Ethyl gallate (gallic acid ethyl ester) obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-dependent manner. Ethyl gallate can inhib...		MMP , NF-κB , Akt , Antibacterial
TN4978	Scutellarein-7-O-glucoside		MMP
	Scutellarein-7-O-glucoside inhibites MMP-2 activity.		MMP

天然物製品

Auraptene

T4115

Synonym: 7-geranyloxycoumarin

Target: MMP, BACE

Apigenin-7-glucuronide

T5S1026

Synonym: Apigenin 7-O-glucuronide

Target: MMP

Luteolin 7-O-glucuronide

T3850

Synonym: Luteolin-7-glucuronide

Target: MMP

Isofraxidin

T5S0045

Synonym: 6,8-Dimethoxyumbelliferone,Phytodolor

Target: MMP, ERK, p38 MAPK, TLR, COX

Ethyl gallate

T3729

Synonym: Nipagallin A,Phyllemblin,gallic acid ethyl ester

Target: MMP, NF-κB, Akt, Antibacterial

Scutellarein-7-O-glucoside

TN4978

Synonym:

Target: MMP

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-01644	MMP-7 Protein, Human, Recombinant (GST)	Human	E. coli
	Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. MMP-7 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular w...
TMPH-03331	MMP-7 Protein, Rat, Recombinant (GST)	Rat	E. coli
	Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. MMP-7 Protein, Rat, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular wei...
TMPH-01665	TIMP3 Protein, Human, Recombinant (His)	Human	E. coli
	Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to ac...
TMPJ-01289	TIMP-4 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene, belongs to the protease inhibitor I35 (TIMP) family. The protein complexes with metalloproteinases (such as collagenases) and irreve...
TMPY-05250	CLEC3A Protein, Mouse, Recombinant (His)	Mouse	Baculovirus Insect Cells
	C-type lectin domain family 3 member A (CLEC3A) is a poorly characterized protein belonging to the superfamily of C-type lectins. Elevated CLEC3A expression may correlate with breast IDC metastatic potential and indicate...
TMPJ-00447	MMP-3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue rem...
TMPY-06036	FGFR1 Protein, Human, Recombinant (alpha (IIIb), His)	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.5 kDa and the accession number is P11362-7.
TMPY-00886	MMP-1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	MMP1, also known as MMP-1, contains 4 hemopexin-like domains and is a member of the matrix metalloproteinase (MMP) family. Matrix metalloproteases, also called matrixins, are zinc-dependent endopeptidases that are the ma...
TMPK-01371	IGFBP-7 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein that contains three protein domain modules. Human IGFBP-rp1 ...
TMPK-00828	Mucin-1/MUC1 Isoform Y Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire...
TMPK-00394	FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in num...
TMPK-00395	FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42 kDa and the accession number is P11362-7.
TMPY-06035	FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc)	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.7 kDa and the accession number is P11362-7.
TMPK-00393	FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42 kDa and the accession number is P11362-7.
TMPK-00392	FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in num...