|
T36315 |
NVS-PI3-4
|
NVS-PI3-4 |
|
|
NVS-PI3-4 is a highly selective inhibitor of the enzyme PI3Kγ. It is specifically designed for use in scientific investigations related to allergies, inflammatory conditions, and cancerous diseases[1][2]. |
|
T35526 |
PI3-Kinase α Inhibitor 2 (hydrochloride)
|
PI3-Kinase α Inhibitor 2 (hydrochloride) |
|
|
PI3-Kinase α Inhibitor 2 (hydrochloride) is a PI3-Kinase α inhibitor. |
|
T35525 |
PI3-Kinase α Inhibitor 2
|
PI3-Kinase α Inhibitor 2 |
|
|
Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kα, β, and δ are class 1A enzymes composed ... |
|
T1667 |
Tandutinib
|
MLN518,CT53518,NSC726292 |
Apoptosis
,
FLT
,
CSF-1R
,
PDGFR
,
Src
,
c-Kit
|
|
Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versu... |
|
T35530 |
IHMT-PI3Kδ-372
|
IHMT-PI3Kδ-372 |
PI3K
|
|
IHMT-PI3Kδ-372 is a selective inhibitor of PI3Kδ with an IC50 of 14 nM and can be used in studies about chronic obstructive pulmonary disease. |
|
T12365 |
PARP/PI3K-IN-1
|
|
PARP
,
PI3K
|
|
PARP/PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antiproliferative activities for the study of breast, pancreatic ... |
|
T1826 |
PI3K-IN-1
|
Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409 |
DNA-PK
,
PI3K
|
|
PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR. |
|
T10804 |
CHMFL-PI3KD-317
|
|
PI3K
,
PI4K
|
|
CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3Kα (IC50, ... |
|
T5831 |
Selective PI3Kδ Inhibitor 1
|
|
PI3K
|
|
Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM). |
|
T12462 |
PI3Kδ-IN-1
|
|
PI3K
|
|
PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM). |
|
T12589 |
PI3Kα/mTOR-IN-1
|
|
PI3K
,
mTOR
|
|
PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR. PI3Kα/mTOR-IN-1 shows an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 12.5 nM and 10.6 nM for mTOR and PI3Kα in a cell free assay , respectively. |
|
T77667 |
PI3Kδ-IN-16
|
|
Apoptosis
,
PI3K
|
|
PI3Kδ-IN-16 is a selective and potent PI3Kδ inhibitor with anticancer and antiproliferative activity, induces cell cycle arrest and apoptosis. |
|
T26252 |
PI3Kδ-IN-3
|
TC KHNS 11 |
PI3K
|
|
PI3Kδ-IN-3 (TC KHNS 11) is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function. |
|
T60196 |
IHMT-PI3Kδ-372 S-isomer
|
|
PI3K
|
|
IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM. IHMT-PI3Kδ-372 S-isomer shows high selectivity over other class I PI3Ks (56∼83 fold) and other protein kinases. IHMT-PI3Kδ-372 can ... |
|
T12459 |
PI3K/mTOR Inhibitor-2
|
|
PI3K
,
mTOR
|
|
|
|
T64392 |
PI3K-IN-46
|
|
PI3K
|
|
PI3K-IN-46 is a specific inhibitor of PI3Kγ. |
|
T60564 |
PI3K/Akt/mTOR-IN-2
|
|
Apoptosis
,
Akt
,
PI3K
,
mTOR
|
|
PI3K/Akt/mTOR-IN-2 is a potent PI3K/AKT/mTOR inhibitor.PI3K/Akt/mTOR-IN-2 has anticancer effects and is selective for MDA-MB-231 cells with an IC50 of 2.29 μM.PI3K/Akt/mTOR-IN-2 exhibits anticancer activity and induces c... |
|
T61618 |
PI3K-IN-38
|
|
PI3K
|
|
PI3K-IN-38 is an orally available and potent PI3K inhibitor with an IC50 value of 0.541 µM for PI3K-α. PI3K-IN-38 exhibits anticancer and anti-inflammatory activity and inhibits tumor growth in vivo. |
|
T62409 |
PI3K-IN-23
|
|
|
|
PI3K-IN-23 is a (E)-9-oxooctadec-10-en-12-ynoic acid analogue that promotes glucose uptake (EC50: 7.00 μM). |
|
T81467 |
PI3Kδ-IN-18
|
|
PI3K
|
|
Se15, a selective PI3Kδ inhibitor, exhibits potency with an IC50 value of less than 0.1nM and is utilized in autoimmune research [1]. |
|
T12455 |
PI3K/HDAC-IN-1
|
|
PI3K
|
|
PI3K/HDAC-IN-1 is a potent PI3K and HDAC dual inhibitor(IC50s of 8.1 nM and 1.4 nM, respectively). |
|
T12465 |
PI3Kγ inhibitor 2
|
|
PI3K
|
|
PI3Kγ inhibitor 2 is an orally bioavailable inhibitor of PI3Kγ(Ki of 4 nM). |
|
T79111 |
PI3Kγ inhibitor 7
|
|
PI3K
|
|
PI3Kγ Inhibitor 7 (compound 2) is a potent, orally active agent that selectively inhibits PI3Kγ with an IC50 of 3.42 nM and demonstrates antitumor activity [1]. It also exhibits varying inhibitory effects on other PI3K i... |
|
T72374 |
PI3K/mTOR Inhibitor-12
|
|
PI3K
|
|
PI3K/mTOR Inhibitor-12, a potent and selective orally active inhibitor, exhibits IC50 values of 0.06 nM for PI3Kα and 3.12 nM for mTOR, indicating significant antitumor activity with reduced liver toxicity [1]. |
|
T63957 |
PI3K-IN-29
|
|
|
|
PI3K-IN-29, a potent inhibitor of PI3K, exhibits substantial inhibition capabilities against U87MG, HeLa, and HL60 cells, with IC50 values of 0.264, 2.04, and 1.14 µM, respectively. It effectively blocks the PI3K/Akt sig... |
|
T35527 |
PI3Kα-IN-4
|
PI3Kα-IN-4 |
|
|
PI3Kα-IN-4 is a potent, selective, and orally active PI3Kα inhibitor, demonstrating an IC50 of 1.8 nM and exhibiting antitumor activity[1]. |
|
T73118 |
PI3K-IN-28
|
|
|
|
PI3K-IN-28 is a potent PI3K inhibitor demonstrating high efficacy and lower toxicity in MCF-10a models. It exhibits half-maximal inhibitory concentration (IC50, μM) values of 5.8, 2.3, and 7.9. With a selectivity index (... |
|
T78836 |
IHMT-PI3K-455
|
|
PI3K
|
|
IHMT-PI3K-455 (Compound 15u) is a potent, selective PI3Kγ/δ dual inhibitor, demonstrating oral activity, with IC50 values of 7.1 nM for PI3Kγ and 0.57 nM for PI3Kδ. This compound inhibits AKT phosphorylation and promotes... |
|
T72713 |
PI3K/VEGFR2-IN-1
|
|
PI3K
|
|
PI3K/VEGFR2-IN-1 is a potent dual inhibitor targeting both PI3K and VEGFR2 with IC50 values of 2.21 μM for PI3K and 68 μM for VEGFR2, respectively. This compound also induces apoptosis and is utilized in cancer research ... |
|
T62470 |
PI3K-IN-31
|
|
|
|
PI3K-IN-31 (Compound 6b) is a potent inhibitor of PI3K that acts on PI3Kα (IC50: 3.7 nM), PI3Kβ (IC50: 74 nM), PI3Kγ (IC50: 14.6 nM) and PI3Kδ (IC50: 9.9 nM). PI3K-IN-31 has shown anticancer activity. PI3K-IN-31 showed a... |
|
T28413 |
PI3KD/V-IN-01
|
PI3KD/V IN 01,PI3KD/VIN01 |
|
|
PI3KD/V-IN-01 is a potent ATP-competitive PI3Kδ/Vps34 dual inhibitor. |
|
T12460 |
PI3K/mTOR Inhibitor-1
|
|
PI3K
|
|
PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM) |
|
T72380 |
PI3K/mTOR Inhibitor-13
|
|
|
|
PI3K/mTOR Inhibitor-13, an orally active dual inhibitor targeting phosphoinositol 3-kinase (PI3K) and mTOR kinase, holds potential for treating sexual diseases, solid tumors, and idiopathic pulmonary fibrosis (IPF). |
|
T62073 |
PI3Kα-IN-6
|
|
|
|
PI3Kα-IN-6 (Compound 5b) is a PI3Kα inhibitor that exhibits anticancer effects without toxicity to normal cells. PI3Kα-IN-6 increases ROS production, decreases mitochondrial membrane potential and induces apoptosis. |
|
T62165 |
PI3Kγ inhibitor 4
|
|
|
|
PI3Kγ inhibitor 4 is a selective, potent, orally active PI3Kγ inhibitor (IC50: 40 nM). PI3Kγ inhibitor 4 is ~7-fold more selective for PI3Kγ than the α subtype, 43-fold more selective than the β subtype and 18-fold more ... |
|
T35488 |
(S)-PI3Kα-IN-4
|
(S)-PI3Kα-IN-4 |
|
|
(S)-PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM. (S)-PI3Kα-IN-4 shows 38.3-, 4.25-, and 4.93-fold selectivity for PI3Kα over PI3Kβ, PI3Kδ, and PI3Kγ, respectively. (S)-PI3Kα-IN-4 can be used for the... |
|
T64199 |
PI3KC2α-IN-3
|
|
|
|
PI3KC2α-IN-3 is a highly selective and potent PI3KC2α inhibitor with an IC50 value of 126 nM. PI3KC2α-IN-3 interacts with the ATP binding site of PI3KC2α and impairs endocytic membrane kinetics and membrane remodelling. ... |
|
T62779 |
PI3K-IN-35
|
|
|
|
PI3K-IN-35 (Compound 6l) is a highly selective inhibitor of PI3K, acting on PI3K-α (IC50: 13.98 μM), PI3K-β (IC50: 7.22 μM) and PI3K-δ (IC50: 10.94 μM). PI3K-IN-35 blocks the cell cycle in G2/M phase and induces apoptosi... |
|
T72227 |
PI3K/Akt/CREB activator 1
|
|
|
|
PI3K/Akt/CREB Activator 1 is a potent, orally active compound that acts as an activator for the PI3K/Akt/CREB pathway. It enhances neuronal proliferation, induces differentiation of Neuro-2a cells into neuron-like morpho... |
|
T24637 |
PI3K inhibitor C 96
|
PI3K IN C96,PI3K-IN-C96 |
|
|
PI3K inhibitor C 96 is an inhibitor of phosphatidylinositol 3-kinase. It shows effective activity against multiple myeloma in vitro and in vivo. |
|
T71272 |
PI3K/Akt-IN-C89
|
|
|
|
PI3K/Akt-IN-C89 is a novel Inhibitor of the PI3K-Akt Pathway, Inducing Autophagy of Female Germline Stem Cells. |
|
T63770 |
PI3K/mTOR Inhibitor-4
|
|
|
|
PI3K/mTOR Inhibitor-4 is an orally active pan-I PI3K/mTOR inhibitor. PI3K/mTOR Inhibitor-4 is an enzyme inhibitor that acts on PI3Kα (IC50: 0.63 nM), PI3Kγ (IC50: 22 nM), PI3Kδ (IC50: 9.2 nM) and mTOR (IC50: 13.85 nM). P... |
|
T63455 |
PI3K/Akt/mTOR-IN-3
|
|
|
|
PI3K/Akt/mTOR-IN-3 is a potent inhibitor of PI3K/Akt/mTOR. PI3K/Akt/mTOR-IN-3 inhibits the migration of MCF-7 cells (IC50: 0.77 μM), HeLa cells (IC50: 1.23 μM) and HepG2 cells (IC50: 4.57 μM). PI3K/Akt/mTOR-IN-3 inhibite... |
|
T72880 |
PI3K/AKT-IN-2
|
|
|
|
PI3K/AKT-IN-2, a dual inhibitor of PI3K and AKT, prevents the epithelial-mesenchymal transition (EMT) and promotes apoptosis. Additionally, it impedes tubulin polymerization. |
|
T40196 |
PI3Kγ inhibitor 5
|
|
|
|
PI3Kγ inhibitor 5 is a potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ), exhibiting an exceptional IC50 value of 34 nM. |
|
T12464 |
PI3Kγ inhibitor 1
|
|
PI3K
|
|
PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ. |
|
T39592 |
PI3Kδ-IN-9
|
PI3Kδ-IN-9 |
|
|
PI3Kδ-IN-9 is a selective PI3Kδ inhibitor with an IC 50 value of 3.8 nM. |
|
T63477 |
PI3Kα-IN-8
|
|
|
|
PI3Kα-IN-8 is a selective inhibitor of PI3Kα (IC50: 0.012 μM). PI3Kα-IN-8 increases intracellular levels of reactive oxygen species, decreases mitochondrial membrane potential, and induces apoptosis. |
|
T62408 |
PI3Kδ-IN-11
|
|
|
|
PI3Kδ-IN-11 is a potent and selective PI3Kδ inhibitor (IC50: 27.5 nM) that dose-dependently blocks PI3K/Akt pathway activity. PI3Kδ-IN-11 can be used in B- or T-cell-associated malignancy studies. |
|
T62948 |
PI3Kβ-IN-1
|
|
|
|
PI3Kβ-IN-1 is a selective, orally active PI3Kβ inhibitor (IC50: 2 nM). |
